Q
Qiang Fu
High Impact
Assistant Research Professor
faculty
Internal Med, College of Medicine
25 h-index
61 pubs
2,894 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Qiang Fu's research investigates mechanisms of bone loss and regeneration, with a particular focus on the cellular and molecular factors influencing bone health. His work has explored the role of non-coding RNAs, such as LncRNA ROR and miR-145-5p, in regulating osteoblast proliferation and apoptosis, processes critical for maintaining bone mass in conditions like osteoporosis. Fu has also examined the impact of specific protein expressions, like osteoprotegerin, on bone resorption dynamics, especially in the context of treatment discontinuation for conditions such as denosumab-induced osteoporosis.
Further studies by Fu delve into the cellular components of bone, refining the identification of mesenchymal cell types within murine periosteal and endosteal regions. His research extends to the effects of external factors on bone metabolism, including the impact of ionizing radiation on osteoclast mitochondrial function and subsequent bone loss in mice. Investigations into autophagy, specifically the loss of chaperone-mediated autophagy, have also been linked to reduced vertebral cancellous bone mass in his work. Fu's broader interests include the role of short-chain fatty acids in metabolic syndrome, with an emphasis on their influence on immunity and inflammation, and the interplay between gut microbiota and blood cell counts in patients with immune thrombocytopenia.
Metrics
- h-index: 25
- Publications: 61
- Citations: 2,894
Selected Publications
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Mechanisms of mitochondrial reactive oxygen species action in bone mesenchymal cells (2025)
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Potent suppression of bone remodeling by denosumab does not blunt the anabolic response to romosozumab in mice (2025)
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Sirtuin-3 promotes osteoclast maturation and bone loss by regulating mitochondrial ROS production during ionizing radiation exposure (2025)
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Mechanisms of mitochondrial reactive oxygen species action in bone mesenchymal cells (2025)
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Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsiveness (2025)
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Refining the identity of mesenchymal cell types associated with murine periosteal and endosteal bone (2024)
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A framework for defining mesenchymal cell types associated with murine periosteal and endosteal bone (2023)
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Reduced osteoprotegerin expression by osteocytes may contribute to rebound resorption after denosumab discontinuation (2023)
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A Rab33b missense mouse model for Smith-McCort dysplasia shows bone resorption defects and altered protein glycosylation (2023)
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Loss of chaperone-mediated autophagy is associated with low vertebral cancellous bone mass (2022)
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Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice (2022)
Grants & Funding
- Synergistic Radioprotection of Gastrointestinal Tract by Gamma-Tocotrienol (GT3) and Statins: Efficacy and Mechanisms Uniformed Services University of the Health Sciences - Pass Through: Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. Co-Investigator
- Evaluation of IPW-5371, a TGFRI kinase inhibitor, dosed as a single agent or in combination with G-CSF, as a medical countermeasure against the delayed effects of total body irradiation in mice - Continuation NIH/Nat. Inst. of Allergy & Infectious Diseases - Pass Through: Innovation Pathways Principal Investigator
- Osteocyte Control of Bone Remodeling NIH/Nat. Inst. of Arthritis & Musculoskeletal & Skin Diseases Principal Investigator
- Osteocyte Control of Bone Remodeling NIH/Nat. Inst. of Arthritis & Musculoskeletal & Skin Diseases Co-Investigator
- Advanced Development of Gamma-Tocotrienol as a Radiation Countermeasure US Department of Defense - Pass Through: Armed Forces Radiobiology Research Institute Co-Investigator
- Center for Musculoskeletal Disease Research (CMDR) NIH/Nat. Inst. of General Medical Sciences Principal Investigator
- Endonuclease-targeted radioprotection NIH/Nat. Inst. of Allergy & Infectious Diseases - Pass Through: Duke University Co-Investigator
- Center for Musculoskeletal Disease Research (CMDR) NIH/Nat. Inst. of General Medical Sciences Principal Investigator
Collaboration Network
Top Collaborators
Ha‐Neui Kim
6 shared publications
In database
- Refining the identity of mesenchymal cell types associated with murine periosteal and endosteal bone
- Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice
- A framework for defining mesenchymal cell types associated with murine periosteal and endosteal bone
- Sirtuin-3 promotes osteoclast maturation and bone loss by regulating mitochondrial ROS production during ionizing radiation exposure
- Mechanisms of mitochondrial reactive oxygen species action in bone mesenchymal cells
Showing 5 of 6 shared publications
Charles A. O’Brien
University of Arkansas for Medical Sciences
6 shared publications
In database
- Reduced osteoprotegerin expression by osteocytes may contribute to rebound resorption after denosumab discontinuation
- Refining the identity of mesenchymal cell types associated with murine periosteal and endosteal bone
- A framework for defining mesenchymal cell types associated with murine periosteal and endosteal bone
- Potent suppression of bone remodeling by denosumab does not blunt the anabolic response to romosozumab in mice
- Mechanisms of mitochondrial reactive oxygen species action in bone mesenchymal cells
Showing 5 of 6 shared publications
Intawat Nookaew
5 shared publications
In database
- Reduced osteoprotegerin expression by osteocytes may contribute to rebound resorption after denosumab discontinuation
- Refining the identity of mesenchymal cell types associated with murine periosteal and endosteal bone
- A framework for defining mesenchymal cell types associated with murine periosteal and endosteal bone
- Mechanisms of mitochondrial reactive oxygen species action in bone mesenchymal cells
- Mechanisms of mitochondrial reactive oxygen species action in bone mesenchymal cells
Maria Almeida
5 shared publications
In database
- Refining the identity of mesenchymal cell types associated with murine periosteal and endosteal bone
- Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsiveness
- A framework for defining mesenchymal cell types associated with murine periosteal and endosteal bone
- Mechanisms of mitochondrial reactive oxygen species action in bone mesenchymal cells
- Mechanisms of mitochondrial reactive oxygen species action in bone mesenchymal cells
Melda Onal
University of Arkansas for Medical Sciences
4 shared publications
In database
- Refining the identity of mesenchymal cell types associated with murine periosteal and endosteal bone
- Loss of chaperone-mediated autophagy is associated with low vertebral cancellous bone mass
- Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsiveness
- A framework for defining mesenchymal cell types associated with murine periosteal and endosteal bone
Jeff D. Thostenson
University of Arkansas for Medical Sciences
3 shared publications
In database
- Reduced osteoprotegerin expression by osteocytes may contribute to rebound resorption after denosumab discontinuation
- Sirtuin-3 promotes osteoclast maturation and bone loss by regulating mitochondrial ROS production during ionizing radiation exposure
- Potent suppression of bone remodeling by denosumab does not blunt the anabolic response to romosozumab in mice
Jinhu Xiong
University of Arkansas for Medical Sciences
3 shared publications
In database
- Refining the identity of mesenchymal cell types associated with murine periosteal and endosteal bone
- Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsiveness
- A framework for defining mesenchymal cell types associated with murine periosteal and endosteal bone
Cecile Bustamante-Gomez
University of Arkansas for Medical Sciences
3 shared publications
In database
- Refining the identity of mesenchymal cell types associated with murine periosteal and endosteal bone
- A framework for defining mesenchymal cell types associated with murine periosteal and endosteal bone
- Potent suppression of bone remodeling by denosumab does not blunt the anabolic response to romosozumab in mice
Ana I. Coelho
University of Arkansas for Medical Sciences
3 shared publications
In database
- Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsiveness
- Mechanisms of mitochondrial reactive oxygen species action in bone mesenchymal cells
- Mechanisms of mitochondrial reactive oxygen species action in bone mesenchymal cells
Md Mohsin Ali
University of Arkansas for Medical Sciences (US)
3 shared publications
- Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsiveness
- Mechanisms of mitochondrial reactive oxygen species action in bone mesenchymal cells
- Mechanisms of mitochondrial reactive oxygen species action in bone mesenchymal cells
Aaron Warren
University of Arkansas for Medical Sciences
3 shared publications
In database
- Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsiveness
- Mechanisms of mitochondrial reactive oxygen species action in bone mesenchymal cells
- Mechanisms of mitochondrial reactive oxygen species action in bone mesenchymal cells
Rupak Pathak
University of Arkansas for Medical Sciences
2 shared publications
In database
- Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice
- Differential Recovery of Small Intestinal Segments after Partial-Body Irradiation in Non-Human Primates
James F. Markmann
California University of Pennsylvania (US)
2 shared publications
- Interleukin-27 in liver xenotransplantation: A rational target to mitigate ischemia reperfusion injury and increase xenograft survival
- Influence of the Blockage of TNFα and Its Receptors on Bregs-TLR-Induced Allograft Survival
Christian LeGuern
Massachusetts General Hospital (US)
2 shared publications
- Interleukin-27 in liver xenotransplantation: A rational target to mitigate ischemia reperfusion injury and increase xenograft survival
- Influence of the Blockage of TNFα and Its Receptors on Bregs-TLR-Induced Allograft Survival
Kimberly Richardson
University of Arkansas for Medical Sciences (US)
2 shared publications
- Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice
- Sirtuin-3 promotes osteoclast maturation and bone loss by regulating mitochondrial ROS production during ionizing radiation exposure
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