Robert E. Gawley
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Also affiliated: University of North Carolina at Chapel Hill (2002); Merck & Co., Inc., Rahway, NJ, USA (United States) (2013); University of Miami (1980–2009); Stockholm University (2002); William & Mary (2002); Duke University (1975); Florida International University (2002–2007); University of Exeter (2004); ETH Zurich (1994–1995); AlbaNova (2004); Laboratory of Organic Chemistry (1994); Virginia Institute of Marine Science (2002); KTH Royal Institute of Technology (2002); Eckerd College (2002); University of Sheffield (2004–2009)
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Robert E. Gawley's research has focused on the development and application of asymmetric synthesis methodologies, particularly in the creation of complex organic molecules. His work has explored catalytic dynamic resolutions and the use of chiral ligands in enantioselective transformations. Investigations have included the alkylation of lithiated piperidines and pyrrolidines, leading to the synthesis of stereochemically defined piperidine derivatives. He has also studied the application of copper carbenoids for the enantioselective hydrosilylation of ketones.
Gawley has published extensively on these topics, with a career publication count of 196 and an h-index of 38, indicating significant impact in his field. His research has received considerable attention, as evidenced by over 4,200 citations. His work has contributed to the synthesis of various biologically relevant compounds, including alkaloids and pharmaceutical agents.
His publications span several decades, with the earliest notable work in the 1990s on titanium ligands for enantioselective additions and the stereochemistry of piperidine alkylations. More recent work has focused on the application of catalytic dynamic resolution to the asymmetric synthesis of substituted piperidines and related compounds, contributing to the formal synthesis of natural products and pharmaceuticals.
Metrics
- h-index: 38
- Publications: 196
- Citations: 4,229
Selected Publications
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Double-Asymmetric Hydrogenation Strategy for the Reduction of 1,1-Diaryl Olefins Applied to an Improved Synthesis of CuIPhEt, a C2-Symmetric N-Heterocyclic Carbenoid (2013)
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Oxidations (2012)
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ChemInform Abstract: Catalytic Dynamic Resolution Applied to the Synthesis of 2,6‐Disubstituted Piperidines: Preparation of (+)‐Lupetidine and (‐)‐Epidihydropinidine. (2012)
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Introduction, General Principles, and Glossary of Stereochemical Terms (2012)
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Practical Aspects of Asymmetric Synthesis (2012)
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Aldol and Michael Additions of Allyls, Enolates, and Enolate Equivalents (2012)
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1,2- and 1,4-Additions to C=X Bonds (2012)
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Cycloadditions and Rearrangements (2012)
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Enolate, Azaenolate, and Organolithium Alkylations (2012)
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Dynamics of Catalytic Resolution of 2-Lithio-N-Boc-piperidine by Ligand Exchange (2012)
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Synthetic Applications and Inversion Dynamics of Configurationally Stable 2-Lithio-2-arylpyrrolidines and -piperidines (2012)
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Formal synthesis of the bisbenzylisoquinoline alkaloid berbamunine by asymmetric substitution of chiral organolithium compounds (2011)
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Catalytic Dynamic Resolution Applied to the Synthesis of 2,6-Disubstituted Piperidines: Preparation of (+)-Lupetidine and (–)-Epidihydropinidine (2011)
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Design and Synthesis of C2-Symmetric N-Heterocyclic Carbene Precursors and Metal Carbenoids (2011)
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Application of a C2-Symmetric Copper Carbenoid in the Enantioselective Hydrosilylation of Dialkyl and Aryl–Alkyl Ketones (2011)
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