Thallapuranam Krishnaswamy Suresh Kumar Data-verified
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Assistant Professor
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Biography and Research Information
OverviewAI-generated summary
Thallapuranam Krishnaswamy Suresh Kumar is an Assistant Professor at the University of Arkansas at Fayetteville. His research primarily focuses on understanding the molecular mechanisms underlying protein structure, stability, and function, with a particular emphasis on fibroblast growth factors (FGFs) and their interactions. He has investigated the forces governing the thermal unfolding and stabilization of human acidic fibroblast growth factor (FGF1), including the role of heparin binding in these processes. His work also extends to computational methods, such as restrained umbrella sampling simulations, for estimating binding affinities.
Kumar is the Principal Investigator on a grant from the NIH/National Institute of General Medical Sciences for $435,226, which supports research into hyperstable FGF1-FGF2 based therapeutic formulations for wound care. His research group also explores broader biological questions, including the roles of gut bacteria and diet in health, and the microenvironmental factors influencing cancer states and therapeutic opportunities, as indicated by his recent publications.
With 276 total publications and an h-index of 34, Kumar has a significant publication record. He collaborates with several researchers at the University of Arkansas at Fayetteville, including Vivek Govind Kumar, Shilpi Agrawal, Mahmoud Moradi, and Mercede Furr, with whom he has co-authored multiple publications. His work is recognized by his designation as a highly cited researcher.
Metrics
- h-index: 31
- Publications: 239
- Citations: 3,504
Selected Publications
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One-step purification of a bioactive PAK1-derived peptide (2025)
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Signaling of Mitogenic and Metabolic Activities by Fibroblast Growth Factors (2025)
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Pathology and Therapeutic Significance of Fibroblast Growth Factors (2025)
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Decoding FGF/FGFR Signaling: Insights into Biological Functions and Disease Relevance (2024)
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Structural Stability Comparisons Between Natural and Engineered Group II Chaperonins: Are Crenarchaeal “Heat Shock” Proteins Also “pH Shock” Resistant? (2024)
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Overexpression and Purification of Mitogenic and Metabolic Fibroblast Growth Factors (2024)
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A Review of Rattlesnake Venoms (2023)
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Foreword I (2023)
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cpSRP43 Is Both Highly Flexible and Stable: Structural Insights Using a Combined Experimental and Computational Approach (2023)
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A Simple Purification Method for Heat-Stable Recombinant Low Molecular Weight Proteins and Peptides Via GST-Fusion Products (2023)
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Binding affinity estimation from restrained umbrella sampling simulations (2022)
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Amyloidogenesis: What Do We Know So Far? (2022)
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Binding Affinity Estimation from Restrained Umbrella Sampling Simulations (2022)
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Design and characterization of a FGF1‐FGF21 chimeric protein with increased stability and enhanced antidiabetic activities (2022)
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Characterization of the Structure, Stability, Bioactivity of Recombinant FGF19 (2022)
Federal Grants 1 $435,226 total
Hyperstable FGF1-FGF2 based therapeutic formulation for wound care
Collaboration Network
Top Collaborators
- Binding affinity estimation from restrained umbrella sampling simulations
- Characterization of the structural forces governing the reversibility of the thermal unfolding of the human acidic fibroblast growth factor
- Mechanistic Picture for Monomeric Human Fibroblast Growth Factor 1 Stabilization by Heparin Binding
- Transient local secondary structure in the intrinsically disordered C-term of the Albino3 insertase
- Binding Affinity Estimation from Restrained Umbrella Sampling Simulations
Showing 5 of 9 shared publications
- Binding affinity estimation from restrained umbrella sampling simulations
- Characterization of the structural forces governing the reversibility of the thermal unfolding of the human acidic fibroblast growth factor
- Mechanistic Picture for Monomeric Human Fibroblast Growth Factor 1 Stabilization by Heparin Binding
- Binding Affinity Estimation from Restrained Umbrella Sampling Simulations
- Binding Affinity Estimation From Restrained Umbrella Sampling Simulations
Showing 5 of 8 shared publications
- Binding affinity estimation from restrained umbrella sampling simulations
- Characterization of the structural forces governing the reversibility of the thermal unfolding of the human acidic fibroblast growth factor
- Mechanistic Picture for Monomeric Human Fibroblast Growth Factor 1 Stabilization by Heparin Binding
- Transient local secondary structure in the intrinsically disordered C-term of the Albino3 insertase
- Binding Affinity Estimation from Restrained Umbrella Sampling Simulations
Showing 5 of 8 shared publications
- Transient local secondary structure in the intrinsically disordered C-term of the Albino3 insertase
- cpSRP43 Is Both Highly Flexible and Stable: Structural Insights Using a Combined Experimental and Computational Approach
- Stability Comparisons between Natural versus Engineered Archaeal Heat-Shock Proteins
- Stability Comparisons between Natural versus Engineered Archaeal Heat‐Shock Proteins
- cpSRP43 is both highly flexible and stable: Structural insights using a combined experimental and computational approach
Showing 5 of 6 shared publications
- Simplification of the purification of heat stable recombinant low molecular weight proteins and peptides from GST-fusion products
- Transient local secondary structure in the intrinsically disordered C-term of the Albino3 insertase
- A Simple Purification Method for Heat-Stable Recombinant Low Molecular Weight Proteins and Peptides Via GST-Fusion Products
- One-step purification of a bioactive PAK1-derived peptide
- Natural Bridged Bicyclic Peptide Macrobiomolecules from Celosia argentea and Amanita phalloides
- Structural and biological aspects of natural bridged macrobicyclic peptides from marine resources
- A Comprehensive Review on Therapeutic Potentials of Natural CyclicPeptides
- Synthesis, Characterization and Biological Evaluation of some Novel 2-Substituted Aminothiazoles
- Decoding FGF/FGFR Signaling: Insights into Biological Functions and Disease Relevance
- Stability Comparisons between Natural versus Engineered Archaeal Heat-Shock Proteins
- Stability Comparisons between Natural versus Engineered Archaeal Heat‐Shock Proteins
- Structural Stability Comparisons Between Natural and Engineered Group II Chaperonins: Are Crenarchaeal “Heat Shock” Proteins Also “pH Shock” Resistant?
- Transient local secondary structure in the intrinsically disordered C-term of the Albino3 insertase
- cpSRP43 Is Both Highly Flexible and Stable: Structural Insights Using a Combined Experimental and Computational Approach
- Site-specific labeling and functional efficiencies of human fibroblast growth Factor-1 with a range of fluorescent Dyes in the flexible N-Terminal region and a rigid β-turn region
- cpSRP43 is both highly flexible and stable: Structural insights using a combined experimental and computational approach
- Simplification of the purification of heat stable recombinant low molecular weight proteins and peptides from GST-fusion products
- A Simple Purification Method for Heat-Stable Recombinant Low Molecular Weight Proteins and Peptides Via GST-Fusion Products
- One-step purification of a bioactive PAK1-derived peptide
- Stability Comparisons between Natural versus Engineered Archaeal Heat-Shock Proteins
- Stability Comparisons between Natural versus Engineered Archaeal Heat‐Shock Proteins
- Structural Stability Comparisons Between Natural and Engineered Group II Chaperonins: Are Crenarchaeal “Heat Shock” Proteins Also “pH Shock” Resistant?
- Stability Comparisons between Natural versus Engineered Archaeal Heat-Shock Proteins
- Stability Comparisons between Natural versus Engineered Archaeal Heat‐Shock Proteins
- Structural Stability Comparisons Between Natural and Engineered Group II Chaperonins: Are Crenarchaeal “Heat Shock” Proteins Also “pH Shock” Resistant?
- Decoding FGF/FGFR Signaling: Insights into Biological Functions and Disease Relevance
- Pathology and Therapeutic Significance of Fibroblast Growth Factors
- Characterization of the Structure, Stability, Bioactivity of Recombinant FGF19
- Decoding FGF/FGFR Signaling: Insights into Biological Functions and Disease Relevance
- Pathology and Therapeutic Significance of Fibroblast Growth Factors
- Exploring the Metabolic and Mitogenic Potential of a Hyper-Stable Variant of FGF1
- Simplification of the purification of heat stable recombinant low molecular weight proteins and peptides from GST-fusion products
- A Simple Purification Method for Heat-Stable Recombinant Low Molecular Weight Proteins and Peptides Via GST-Fusion Products
- Simplification of the purification of heat stable recombinant low molecular weight proteins and peptides from GST-fusion products
- A Simple Purification Method for Heat-Stable Recombinant Low Molecular Weight Proteins and Peptides Via GST-Fusion Products
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