Jeanne Y. Wei
Department Chairperson
Also affiliated: Brigham and Women's Hospital (1985–2009); National Institutes of Health (1984); Beth Israel Deaconess Medical Center (1984–2002); Cleveland Clinic (2009); Harvard University (1982–2002); University of Kentucky (2013); Innsbruck Medical University (2009); Johns Hopkins University (1978–1982); Universität Innsbruck (2009); Washington University in St. Louis (2009); University of Arkansas Medical Center (2005–2025); Johns Hopkins Medicine (1978–1982); Veterans Health Administration (1990–1995); MetroWest Medical Center (1999); McLean Hospital (1999); VA Boston Healthcare System (1985–2009); Boston Scientific (United States) (2009); University of Illinois Chicago (1979–1982); University of Chicago (2002); Central Arkansas Veterans Healthcare System (2004–2019); Mercy Hospital (2009); Geriatric Research Education and Clinical Center (1992); National Institute of Nursing Research (2013); Washington Adventist Hospital (2009); Hebrew SeniorLife (1993); Lehigh Valley Hospital (2009); Institute on Aging (2012); National Institute on Aging (1980–1981); South Texas Veterans Health Care System (2002); Cardiovascular Research Foundation (2009); Mercy Hospital (2009); Johns Hopkins Hospital (1978–1980); Mercy Angiography Unit (2009); Massachusetts Institute of Technology (1987)
Department Chairs, College of Medicine
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Jeanne Y. Wei, M.D., Ph.D., is the Jackson T. Stephens Professor of Geriatrics and Chair of the Reynolds Department of Geriatrics at the University of Arkansas for Medical Sciences (UAMS) College of Medicine. She also serves as the Executive Director of the Reynolds Institute on Aging (RIOA) and sees patients in the Thomas and Lyon Longevity Clinic. Dr. Wei's research focuses on the aging cardiovascular system. She has maintained continuous NIH funding for over 30 years and has served on NIH peer review study sections and the National Institute on Aging (NIA) Board of Scientific Counselors.
Dr. Wei's academic background includes M.D. and Ph.D. degrees from the University of Illinois, followed by residency and fellowship training at Johns Hopkins Hospital and a staff fellowship at the National Institute on Aging. Prior to joining UAMS in 2002, she held faculty positions at Harvard Medical School and Beth Israel Hospital in Boston, where she directed the Division on Aging and the Gerontology Division, respectively.
With an h-index of 57 and over 14,500 citations across 659 publications, Dr. Wei is recognized as a highly cited researcher. Her work has explored various aspects of aging, including gait variability, fractal dynamics of gait, and the cardiovascular system in older adults. Key collaborators at UAMS include Gohar Azhar, Pankaj Patyal, Ambika Verma, and Shakshi Sharma.
Research Overview
Jeanne Y. Wei, M.D., Ph.D., Jackson T. Stephens Professor of Geriatrics, College of Medicine, University of Arkansas for Medical Sciences (UAMS), is Chair, Reynolds Department of Geriatrics & Executive Director of the Reynolds Institute on Aging (RIOA). Dr. Wei is board certified in internal medicine, geriatrics & cardiovascular medicine and sees patients in the Thomas and Lyon Longevity Clinic at RIOA. After obtaining M.D. and Ph.D. degrees from the University of Illinois, Dr. Wei completed an internal medicine residency and cardiology fellowship at the Johns Hopkins Hospital as well as a staff fellowship in Gerontology at NIH/NIA in Baltimore, MD. She then joined the faculty at Harvard Medical School and Beth Israel Hospital in Boston, and became director of the Division on Aging at Harvard and chief of the Gerontology Division Beth Israel Deaconess Medical Center. In 2002, she joined the faculty at UAMS. She has received continuous NIH funding for more than 30 years. Her major research interests include the aging cardiovascular system. Dr. Wei has served on NIH peer review study sections, National Institute on Aging (NIA) and was chairman of the NIA Board of Scientific Counselors. In addition, she has served on advisory boards of research foundations, pharmaceutical companies and the FDA. She has published more than 200 scientific articles, served on multiple editorial boards and is a reviewer of 34 peer-review scientific journals. She has authored six books, including one geriatrics textbook, and AGING WELL: The Complete Guide to Physical and Emotional Health, a health guide for the general public. Jeanne has more than 35 years of experience in caring for patients, training future geriatricians and cardiologists, conducting geriatric and gerontological research, mentoring geriatric fellows and junior faculty members, and developing academic programs and initiatives. A gifted teacher, Dr. Wei received the 'Outstanding Clinical Educator Award' from Harvard Medical School in 2000 and the 'Outstanding Woman Faculty Award' from the UAMS College of Medicine in 2005. She is recognized nationally and internationally for her contributions to aging research.
Metrics
- h-index: 57
- Publications: 657
- Citations: 14,544
Positions
-
Executive Director, Professor and Chair 2009–presentUniversity of Arkansas for Medical Sciences Department of Geriatrics ORCID
-
Department Chairperson publications 2003–2026University of Arkansas for Medical Sciences Department Chairs, College of Medicine Institutional directory
Selected Publications
-
Baseline proteomic biomarkers for predicting chemotherapy-induced cardiotoxicity in breast cancer patients (2026)
-
Opinions towards Aging in the Marshallese Community residing in Northwest Arkansas (2025)
-
RETRACTED: Duloxetine, an SNRI, Targets pSTAT3 Signaling: In-Silico, RNA-Seq and In-Vitro Evidence for a Pleiotropic Mechanism of Pain Relief (2025)
-
Mitochondrial Dynamics in Aging Heart (2025)
-
Alternative Splicing of Serum Response Factor Reveals Isoform-Specific Remodeling in Cardiac Diseases (2025)
-
Differential microRNA profiling of the Marshallese population in Arkansas reveals a higher association with chronic diseases (2025)
-
Porphyromonas gingivalis-Lipopolysaccharide Induced Caspase-4 Dependent Noncanonical Inflammasome Activation Drives Alzheimer’s Disease Pathologies (2025)
-
Cardiac-specific overexpression of serum response factor regulates age-associated decline in mitochondrial function (2025)
-
DIFFERENTIAL EFFECT OF SIRT1 ON MITOCHONDRIAL FUNCTION: INSIGHTS INTO MITOCHONDRIAL RESPIRATORY COMPLEXES (2024)
-
P. GINGIVALIS-LPS PROMOTES AD/ADRD VIA CASPASE-4-MEDIATED NONCANONICAL INFLAMMASOME PATHWAY (2024)
-
The Long-Term Cardiovascular Risks of Duloxetine Use in Older Adults: A Retrospective Medical Record-Based Adverse Drug Reaction Assessment (2024)
-
Missed Insights for Earlier Management of Parkinson’s Disease and the Value of Dopamine Transporter (DAT) Scans (2024)
-
Neutrophil Biomarkers Can Predict Cardiotoxicity of Anthracyclines in Breast Cancer (2024)
-
The Role of Sirtuin-1 Isoforms in Regulating Mitochondrial Function (2024)
-
RNA sequencing of formalin fixed paraffin-embedded heart tissue provides transcriptomic information about chemotherapy-induced cardiotoxicity (2024)
Grants & Funding
As listed on this researcher's institutional profile.
- Transcription Regulation in the Aging Heart NIH Principal Investigator
- PRagmatic EValuation of evENTS And Benefits of Lipid-lowering in oldEr adults (PREVENTABLE) (IRB 274254) NIH/Nat. Inst. on Aging via Duke University Principal Investigator
- Escitalopram for Agitation in Alzheimer's Disease (S-CitAD) (IRB 274855) NIH/Nat. Inst. on Aging via Johns Hopkins University Principal Investigator
- Predicting CHD Events in Black and White Women NIH Co-Investigator
- Subcontract w/Essential Blends, LLC: UpBeat Phase 2 NIH/Nat. Inst. on Aging via Essential Blends, LLC Co-Investigator
- GLORIA-AF; Global Registry on Long-Term Oral Anti-thrombotic Treatment in Patient Boehringer Ingleheim Pharmaceuticals, Inc. Principal Investigator
- DAABHS SOR III OPAL Narcan Drug Project Substance Abuse & Mental Health Services Administration via Arkansas Department of Human Services Principal Investigator
- Consortium w/Essential: Nutritional Therapy in the Elderly with Heart Failure- Resubmission NIH/Nat. Inst. on Aging via Essential Blends, LLC Co-Investigator
- EFFECT OF AGE ON CARDIOVASCULAR REFLEX FUNCTION NIH Principal Investigator
- State Opioid Response Grant Substance Abuse & Mental Health Services Administration via Arkansas Department of Human Services Principal Investigator
- HARVARD INSTITUTIONAL RESEARCH TRAINING PROGRAM ON AGING NIH Co-Principal Investigator
- Harvard Older Americans Independence Center NIH Co-Principal Investigator
- ORTHOSTATIC HYPOTENSION IN OLDER PERSONS NIH Principal Investigator
- Care Coordination and Home Telehealth Program for Older Adults with Cardiovascular Disease NIH/Nat. Inst. on Aging via Environment and Health Group, Inc. Co-Investigator
- Arkansas Claude Pepper Older Americans Independence Center at UAMS NIH Principal Investigator
- BASIC MECHANISMS OF AGING AND AGE-RELATED DISEASES NIH Principal Investigator
- HARVARD MENTORED CLINICAL SCIENTIST DEVELOPMENT PROGRAM NIH Co-Principal Investigator
- The PREVENTABLE Physical Performance Ancillary Study (Frailty) (IRB 276495) NIH/Nat. Inst. on Aging via Boston VA Research Institute, Inc. Principal Investigator
- GERIATRIC RESEARCH AND TRAINING NIH Principal Investigator
- Sub-Contract with Beth Israel Deaconess Medical Center/Harvard Medical Center: Myocardial Aging and Altered Transcription Regulation (PI Dr. Konstanti NIH/Nat. Inst. on Aging Principal Investigator
- State Targeted Response (STR) No-Cost Extension AR Dept of Human Services/Division of Aging and Adult Services Principal Investigator
- HARVARD NATHAN SHOCK CENTER IN BASIC BIOLOGY OF AGING NIH Co-Principal Investigator
- TCIA Sustainment and Scalability - Platforms for Quantitative Imaging Informatics in Precision Medicine NIH Co-Investigator
Collaboration Network
Top Collaborators
- The Expression of microRNA and microRNA Clusters in the Aging Heart
- Hydration health literacy in the elderly
- Trends in Percutaneous Endoscopic Gastrostomy Placement in the Elderly From 1993 to 2003
- Exposure to High or Low Glucose Levels Accelerates the Appearance of Markers of Endothelial Cell Senescence and Induces Dysregulation of Nitric Oxide Synthase
- Valine improves mitochondrial function and protects against oxidative stress
Showing 5 of 55 shared publications
- The Expression of microRNA and microRNA Clusters in the Aging Heart
- Exposure to High or Low Glucose Levels Accelerates the Appearance of Markers of Endothelial Cell Senescence and Induces Dysregulation of Nitric Oxide Synthase
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Identification of a Novel Serum Response Factor Cofactor in Cardiac Gene Regulation
Showing 5 of 34 shared publications
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
- Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells
- Inhibitors of Rho/MRTF/SRF Transcription Pathway Regulate Mitochondrial Function
Showing 5 of 16 shared publications
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
- Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells
- Inhibitors of Rho/MRTF/SRF Transcription Pathway Regulate Mitochondrial Function
Showing 5 of 16 shared publications
- Immune response proteins as predictive biomarkers of doxorubicin-induced cardiotoxicity in breast cancer patients
- Biomarkers of inflammation, hypercoagulability and endothelial injury predict early asymptomatic doxorubicin-induced cardiotoxicity in breast cancer patients.
- Transcriptome Profiling of Peripheral Blood Cells Identifies Potential Biomarkers for Doxorubicin Cardiotoxicity in a Rat Model
- Circulating miRNA Profiles of Doxorubicin-induced Cardiotoxicity in Breast Cancer Patients.
- Dantrolene Attenuates Cardiotoxicity of Doxorubicin Without Reducing its Antitumor Efficacy in a Breast Cancer Model
Showing 5 of 11 shared publications
- Immune response proteins as predictive biomarkers of doxorubicin-induced cardiotoxicity in breast cancer patients
- Biomarkers of inflammation, hypercoagulability and endothelial injury predict early asymptomatic doxorubicin-induced cardiotoxicity in breast cancer patients.
- Transcriptome Profiling of Peripheral Blood Cells Identifies Potential Biomarkers for Doxorubicin Cardiotoxicity in a Rat Model
- Circulating miRNA Profiles of Doxorubicin-induced Cardiotoxicity in Breast Cancer Patients.
- Dantrolene Attenuates Cardiotoxicity of Doxorubicin Without Reducing its Antitumor Efficacy in a Breast Cancer Model
Showing 5 of 11 shared publications
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Mitochondrial Dynamics in Aging Heart
- The Role of Sirtuin-1 Isoforms in Regulating Mitochondrial Function
- L-VALINE TREATMENT IMPROVES CELLULAR MITOCHONDRIAL FUNCTION
Showing 5 of 11 shared publications
- Hydration health literacy in the elderly
- Feasibility of Conducting a 6-Months Long Home-based Exercise Program with Protein Supplementation in Elderly Community-dwelling Individuals with Heart Failure
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
- Disparity and Multimorbidity in Heart Failure Patients Over the Age of 80
- Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome
Showing 5 of 9 shared publications
- Daily Consumption of a Specially Formulated Essential Amino Acid-Based Dietary Supplement Improves Physical Performance in Older Adults With Low Physical Functioning
- Consumption of a Specially-Formulated Mixture of Essential Amino Acids Promotes Gain in Whole-Body Protein to a Greater Extent than a Complete Meal Replacement in Older Women with Heart Failure
- Nutritional Supplementation with Essential Amino Acids and Phytosterols May Reduce Risk for Metabolic Syndrome and Cardiovascular Disease in Overweight Individuals with Mild Hyperlipidemia.
- Do anabolic nutritional supplements stimulate human growth hormone secretion in elderly women with heart failure?
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
Showing 5 of 7 shared publications
- Exposure to High or Low Glucose Levels Accelerates the Appearance of Markers of Endothelial Cell Senescence and Induces Dysregulation of Nitric Oxide Synthase
- Overexpression of p49/STRAP alters cellular cytoskeletal structure and gross anatomy in mice
- MicroRNA Clusters in the Adult Mouse Heart: Age-Associated Changes
- Does p49/STRAP, a SRF-binding protein (SRFBP1), modulate cardiac mitochondrial function in aging?
- Elevated oxygen consumption rate in response to acute low-glucose stress: Metformin restores rate to normal level
Showing 5 of 6 shared publications
- Trends in Percutaneous Endoscopic Gastrostomy Placement in the Elderly From 1993 to 2003
- Cardiopulmonary Resuscitation Requiring Extracorporeal Membrane Oxygenation in the Elderly
- Status Epilepticus among Older Adults in the United States
- Trends in Hospital Discharge Disposition for Elderly Patients with Infective Endocarditis: 1993 to 2003
- Outcomes for Hospitalized Older Adults with Down Syndrome in the United States
Showing 5 of 6 shared publications
- Identification of a Novel Serum Response Factor Cofactor in Cardiac Gene Regulation
- Model of functional cardiac aging: young adult mice with mild overexpression of serum response factor
- Zipzap/p200 is a novel zinc finger protein contributing to cardiac gene regulation
- Alternative splicing and nonsense-mediated mRNA decay regulate gene expression of serum response factor
- Identification of a subunit of NADH-dehydrogenase as a p49/STRAP-binding protein
Showing 5 of 6 shared publications
- A qualitative study of older adults' facilitators, barriers, and cues to action to engage in falls prevention using health belief model constructs
- Older Adults’ Perceptions and Recommendations Regarding a Falls Prevention Self-Management Plan Template Based on the Health Belief Model: A Mixed-Methods Study
- Older Adults' Perceptions Regarding the Role of Physical Therapists in Fall Prevention: A Qualitative Investigation
- Differential microRNA profiling of the Marshallese population in Arkansas reveals a higher association with chronic diseases
- 21083 Perceptions on the Role of Physical Therapy Providers for Falls Prevention: A Qualitative Investigation
Showing 5 of 6 shared publications
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
- Neutrophil Biomarkers Can Predict Cardiotoxicity of Anthracyclines in Breast Cancer
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
- Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome
Showing 5 of 6 shared publications
- Daily Consumption of a Specially Formulated Essential Amino Acid-Based Dietary Supplement Improves Physical Performance in Older Adults With Low Physical Functioning
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
- Quality Improvement in Delirium Health Literacy in Older Adult Patients and Their Caregivers Attending a Geriatric Clinic
- Correction to: Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement versus whey protein in low physical functioning older adults
- Opinions towards Aging in the Marshallese Community residing in Northwest Arkansas
Similar Researchers
Based on overlapping research topics