Jeanne Y. Wei
Department Chairperson
faculty
Department Chairs, College of Medicine
Research Areas
Biography and Research Information
OverviewAI-generated summary
Jeanne Y. Wei, M.D., Ph.D., holds the Jackson T. Stephens Professorship of Geriatrics in the College of Medicine at the University of Arkansas for Medical Sciences (UAMS). She also serves as Chair of the Reynolds Department of Geriatrics and Executive Director of the Reynolds Institute on Aging (RIOA). Dr. Wei's clinical certifications include internal medicine, geriatrics, and cardiovascular medicine. Her research interests primarily focus on the aging cardiovascular system, and she has maintained continuous NIH funding for over 30 years. She has held significant roles in scientific review, including serving on NIH peer review study sections and chairing the NIA Board of Scientific Counsel. Dr. Wei earned her M.D. and Ph.D. degrees from the University of Illinois and completed her residency and cardiology fellowship at Johns Hopkins Hospital, followed by a staff fellowship in Gerontology at NIH/NIA. Prior to joining UAMS in 2002, she was on the faculty at Harvard Medical School and Beth Israel Hospital in Boston, where she directed the Division on Aging and was chief of the Gerontology Division at Beth Israel Deaconess Medical Center.
Research Overview
Jeanne Y. Wei, M.D., Ph.D., Jackson T. Stephens Professor of Geriatrics, College of Medicine, University of Arkansas for Medical Sciences (UAMS), is Chair, Reynolds Department of Geriatrics & Executive Director of the Reynolds Institute on Aging (RIOA). Dr. Wei is board certified in internal medicine, geriatrics & cardiovascular medicine and sees patients in the Thomas and Lyon Longevity Clinic at RIOA. After obtaining M.D. and Ph.D. degrees from the University of Illinois, Dr. Wei completed an internal medicine residency and cardiology fellowship at the Johns Hopkins Hospital as well as a staff fellowship in Gerontology at NIH/NIA in Baltimore, MD. She then joined the faculty at Harvard Medical School and Beth Israel Hospital in Boston, and became director of the Division on Aging at Harvard and chief of the Gerontology Division Beth Israel Deaconess Medical Center. In 2002, she joined the faculty at UAMS. She has received continuous NIH funding for more than 30 years. Her major research interests include the aging cardiovascular system. Dr. Wei has served on NIH peer review study sections, National Institute on Aging (NIA) and was chairman of the NIA Board of Scientific Counselors. In addition, she has served on advisory boards of research foundations, pharmaceutical companies and the FDA. She has published more than 200 scientific articles, served on multiple editorial boards and is a reviewer of 34 peer-review scientific journals. She has authored six books, including one geriatrics textbook, and AGING WELL: The Complete Guide to Physical and Emotional Health, a health guide for the general public. Jeanne has more than 35 years of experience in caring for patients, training future geriatricians and cardiologists, conducting geriatric and gerontological research, mentoring geriatric fellows and junior faculty members, and developing academic programs and initiatives. A gifted teacher, Dr. Wei received the 'Outstanding Clinical Educator Award' from Harvard Medical School in 2000 and the 'Outstanding Woman Faculty Award' from the UAMS College of Medicine in 2005. She is recognized nationally and internationally for her contributions to aging research.
Metrics
- h-index: 57
- Publications: 662
- Citations: 14,345
Selected Publications
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Opinions towards Aging in the Marshallese Community residing in Northwest Arkansas (2025)
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Duloxetine, an SNRI, Targets pSTAT3 Signaling: In-Silico, RNA-Seq and In-Vitro Evidence for a Pleiotropic Mechanism of Pain Relief (2025)
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Mitochondrial Dynamics in Aging Heart (2025)
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Alternative Splicing of Serum Response Factor Reveals Isoform-Specific Remodeling in Cardiac Diseases (2025)
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Differential microRNA profiling of the Marshallese population in Arkansas reveals a higher association with chronic diseases (2025)
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Porphyromonas gingivalis-Lipopolysaccharide Induced Caspase-4 Dependent Noncanonical Inflammasome Activation Drives Alzheimer’s Disease Pathologies (2025)
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Cardiac-specific overexpression of serum response factor regulates age-associated decline in mitochondrial function (2025)
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DIFFERENTIAL EFFECT OF SIRT1 ON MITOCHONDRIAL FUNCTION: INSIGHTS INTO MITOCHONDRIAL RESPIRATORY COMPLEXES (2024)
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P. GINGIVALIS-LPS PROMOTES AD/ADRD VIA CASPASE-4-MEDIATED NONCANONICAL INFLAMMASOME PATHWAY (2024)
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The Long-Term Cardiovascular Risks of Duloxetine Use in Older Adults: A Retrospective Medical Record-Based Adverse Drug Reaction Assessment (2024)
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Missed Insights for Earlier Management of Parkinson’s Disease and the Value of Dopamine Transporter (DAT) Scans (2024)
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Neutrophil Biomarkers Can Predict Cardiotoxicity of Anthracyclines in Breast Cancer (2024)
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The Role of Sirtuin-1 Isoforms in Regulating Mitochondrial Function (2024)
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RNA sequencing of formalin fixed paraffin-embedded heart tissue provides transcriptomic information about chemotherapy-induced cardiotoxicity (2024)
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Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells (2024)
Grants & Funding
- Transcription Regulation in the Aging Heart NIH Principal Investigator
- PRagmatic EValuation of evENTS And Benefits of Lipid-lowering in oldEr adults (PREVENTABLE) (IRB 274254) NIH/Nat. Inst. on Aging - Pass Through: Duke University Principal Investigator
- Escitalopram for Agitation in Alzheimer's Disease (S-CitAD) (IRB 274855) NIH/Nat. Inst. on Aging - Pass Through: Johns Hopkins University Principal Investigator
- Predicting CHD Events in Black and White Women NIH Co-Investigator
- Subcontract w/Essential Blends, LLC: UpBeat Phase 2 NIH/Nat. Inst. on Aging - Pass Through: Essential Blends, LLC Co-Investigator
- GLORIA-AF; Global Registry on Long-Term Oral Anti-thrombotic Treatment in Patient Boehringer Ingleheim Pharmaceuticals, Inc. Principal Investigator
- DAABHS SOR III OPAL Narcan Drug Project Substance Abuse & Mental Health Services Administration - Pass Through: Arkansas Department of Human Services Principal Investigator
- Consortium w/Essential: Nutritional Therapy in the Elderly with Heart Failure- Resubmission NIH/Nat. Inst. on Aging - Pass Through: Essential Blends, LLC Co-Investigator
Collaboration Network
Top Collaborators
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Daily Consumption of a Specially Formulated Essential Amino Acid-Based Dietary Supplement Improves Physical Performance in Older Adults With Low Physical Functioning
- Alternative Splicing Increases Sirtuin Gene Family Diversity and Modulates Their Subcellular Localization and Function
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
Showing 5 of 37 shared publications
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Alternative Splicing Increases Sirtuin Gene Family Diversity and Modulates Their Subcellular Localization and Function
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
- Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells
Showing 5 of 21 shared publications
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
- Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells
- Inhibitors of Rho/MRTF/SRF Transcription Pathway Regulate Mitochondrial Function
Showing 5 of 16 shared publications
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
- Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells
- Inhibitors of Rho/MRTF/SRF Transcription Pathway Regulate Mitochondrial Function
Showing 5 of 16 shared publications
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- The Role of Sirtuin-1 Isoforms in Regulating Mitochondrial Function
- Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome
- Quality Improvement in Delirium Health Literacy in Older Adult Patients and Their Caregivers Attending a Geriatric Clinic
Showing 5 of 11 shared publications
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
- Does Superior Bone Health Promote a Longer Lifespan?
- Disparity and Multimorbidity in Heart Failure Patients Over the Age of 80
- Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome
- Quality Improvement in Delirium Health Literacy in Older Adult Patients and Their Caregivers Attending a Geriatric Clinic
Showing 5 of 10 shared publications
- Alternative Splicing Increases Sirtuin Gene Family Diversity and Modulates Their Subcellular Localization and Function
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
- The Role of Sirtuin-1 Isoforms in Regulating Mitochondrial Function
- Sirtuin-1 isoforms differentially regulate mitochondrial function
- A Study of C2C12 Myoblast Bioenergetics in Response to the CCG-1423 Rho A Inhibitor
Showing 5 of 6 shared publications
- A qualitative study of older adults' facilitators, barriers, and cues to action to engage in falls prevention using health belief model constructs
- Older Adults’ Perceptions and Recommendations Regarding a Falls Prevention Self-Management Plan Template Based on the Health Belief Model: A Mixed-Methods Study
- Older Adults' Perceptions Regarding the Role of Physical Therapists in Fall Prevention: A Qualitative Investigation
- Differential microRNA profiling of the Marshallese population in Arkansas reveals a higher association with chronic diseases
- 21083 Perceptions on the Role of Physical Therapy Providers for Falls Prevention: A Qualitative Investigation
- Daily Consumption of a Specially Formulated Essential Amino Acid-Based Dietary Supplement Improves Physical Performance in Older Adults With Low Physical Functioning
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
- Quality Improvement in Delirium Health Literacy in Older Adult Patients and Their Caregivers Attending a Geriatric Clinic
- Correction to: Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement versus whey protein in low physical functioning older adults
- Daily Consumption of a Specially Formulated Essential Amino Acid-Based Dietary Supplement Improves Physical Performance in Older Adults With Low Physical Functioning
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
- Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome
- Correction to: Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement versus whey protein in low physical functioning older adults
- A qualitative study of older adults' facilitators, barriers, and cues to action to engage in falls prevention using health belief model constructs
- Older Adults’ Perceptions and Recommendations Regarding a Falls Prevention Self-Management Plan Template Based on the Health Belief Model: A Mixed-Methods Study
- Older Adults' Perceptions Regarding the Role of Physical Therapists in Fall Prevention: A Qualitative Investigation
- 21083 Perceptions on the Role of Physical Therapy Providers for Falls Prevention: A Qualitative Investigation
- A qualitative study of older adults' facilitators, barriers, and cues to action to engage in falls prevention using health belief model constructs
- Older Adults’ Perceptions and Recommendations Regarding a Falls Prevention Self-Management Plan Template Based on the Health Belief Model: A Mixed-Methods Study
- Older Adults' Perceptions Regarding the Role of Physical Therapists in Fall Prevention: A Qualitative Investigation
- 21083 Perceptions on the Role of Physical Therapy Providers for Falls Prevention: A Qualitative Investigation
- A qualitative study of older adults' facilitators, barriers, and cues to action to engage in falls prevention using health belief model constructs
- Older Adults’ Perceptions and Recommendations Regarding a Falls Prevention Self-Management Plan Template Based on the Health Belief Model: A Mixed-Methods Study
- Older Adults' Perceptions Regarding the Role of Physical Therapists in Fall Prevention: A Qualitative Investigation
- 21083 Perceptions on the Role of Physical Therapy Providers for Falls Prevention: A Qualitative Investigation
- A qualitative study of older adults' facilitators, barriers, and cues to action to engage in falls prevention using health belief model constructs
- Older Adults’ Perceptions and Recommendations Regarding a Falls Prevention Self-Management Plan Template Based on the Health Belief Model: A Mixed-Methods Study
- Older Adults' Perceptions Regarding the Role of Physical Therapists in Fall Prevention: A Qualitative Investigation
- 21083 Perceptions on the Role of Physical Therapy Providers for Falls Prevention: A Qualitative Investigation
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
- Neutrophil Biomarkers Can Predict Cardiotoxicity of Anthracyclines in Breast Cancer
- Correction to: Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement versus whey protein in low physical functioning older adults
- Differential microRNA profiling of the Marshallese population in Arkansas reveals a higher association with chronic diseases
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