G
Gohar Azhar Institution-verified
Sourced from institutional research profiles (UAMS TRI or ARA).
High Impact
Researcher
faculty
32 h-index
533 pubs
3,110 cited
Research Areas
Biography and Research Information
OverviewAI-generated summary
Gohar Azhar's research group at the University of Arkansas for Medical Sciences investigates the molecular mechanisms underlying cellular function and disease, with a particular focus on mitochondrial health and aging. Recent work has explored the role of specific nutrients, such as valine, in improving mitochondrial function and protecting against oxidative stress. Studies have also examined how microbial components, like lipopolysaccharides from P. gingivalis, can induce mitochondrial dysfunction and neuroinflammation through oxidative stress pathways. The group has investigated the impact of dietary interventions, including essential amino acid-based supplements, on physical performance in older adults. Further research has delved into the regulation of gene expression, including the impact of inhibitors on mitochondrial functions and the role of alternative splicing in diversifying gene families like Sirtuins. Azhar has a substantial publication record with 525 total publications and 3,062 citations, reflected in a high-impact researcher designation and an h-index of 32. Collaborations include extensive work with Jeanne Y. Wei (37 shared publications), Pankaj Patyal (21 shared publications), Ambika Verma (20 shared publications), and Shakshi Sharma (13 shared publications), all within the University of Arkansas for Medical Sciences.
Metrics
- h-index: 32
- Publications: 533
- Citations: 3,110
Selected Publications
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Biology of Aging I Antisense Oligonucleotide-Mediated SRF Reduction Ameliorates Mitochondrial Dysfunction in Cardiac Aging (2025)
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Dysregulation of SRF-Regulated Genes Accelerates the Development of Myocardial Aging (2025)
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Assessment of Caregiver Stress Across Dementia and Non-Dementia Groups (2025)
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Isoform-specific roles of SIRT2 in regulating mitochondrial gene expression (2025)
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P. gingivalis-LPS Activates the Alzheimer’s Disease-Associated Amyloid Secretase Pathway via Caspase-4 (2025)
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Opinions towards Aging in the Marshallese Community residing in Northwest Arkansas (2025)
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Duloxetine, an SNRI, Targets pSTAT3 Signaling: In-Silico, RNA-Seq and In-Vitro Evidence for a Pleiotropic Mechanism of Pain Relief (2025)
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Mitochondrial Dynamics in Aging Heart (2025)
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Alternative Splicing of Serum Response Factor Reveals Isoform-Specific Remodeling in Cardiac Diseases (2025)
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Differential microRNA profiling of the Marshallese population in Arkansas reveals a higher association with chronic diseases (2025)
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Porphyromonas gingivalis-Lipopolysaccharide Induced Caspase-4 Dependent Noncanonical Inflammasome Activation Drives Alzheimer’s Disease Pathologies (2025)
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Cardiac-specific overexpression of serum response factor regulates age-associated decline in mitochondrial function (2025)
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DIFFERENTIAL EFFECT OF SIRT1 ON MITOCHONDRIAL FUNCTION: INSIGHTS INTO MITOCHONDRIAL RESPIRATORY COMPLEXES (2024)
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P. GINGIVALIS-LPS PROMOTES AD/ADRD VIA CASPASE-4-MEDIATED NONCANONICAL INFLAMMASOME PATHWAY (2024)
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Effect of 3 Different Daily Protein Intakes in a 2-Meal Eating Pattern on Protein Turnover in Middle Age and Older Adults: A Randomized Controlled Trial (2024)
Grants & Funding
Collaboration Network
Top Collaborators
Jeanne Y. Wei
Institute on Aging
44 shared publications
In database
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Daily Consumption of a Specially Formulated Essential Amino Acid-Based Dietary Supplement Improves Physical Performance in Older Adults With Low Physical Functioning
- Alternative Splicing Increases Sirtuin Gene Family Diversity and Modulates Their Subcellular Localization and Function
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
Showing 5 of 44 shared publications
Xiaomin Zhang
Institute on Aging (US)
23 shared publications
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Alternative Splicing Increases Sirtuin Gene Family Diversity and Modulates Their Subcellular Localization and Function
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
- Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells
Showing 5 of 23 shared publications
Pankaj Patyal
University of Arkansas for Medical Sciences
19 shared publications
In database
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
- Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells
- Inhibitors of Rho/MRTF/SRF Transcription Pathway Regulate Mitochondrial Function
Showing 5 of 19 shared publications
Ambika Verma
Institute on Aging
18 shared publications
In database
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
- Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells
- Inhibitors of Rho/MRTF/SRF Transcription Pathway Regulate Mitochondrial Function
Showing 5 of 18 shared publications
Shakshi Sharma
University of Arkansas for Medical Sciences
13 shared publications
In database
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- The Role of Sirtuin-1 Isoforms in Regulating Mitochondrial Function
- Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome
- Quality Improvement in Delirium Health Literacy in Older Adult Patients and Their Caregivers Attending a Geriatric Clinic
Showing 5 of 13 shared publications
Amanda Pangle
Institute on Aging
12 shared publications
In database
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
- Does Superior Bone Health Promote a Longer Lifespan?
- Disparity and Multimorbidity in Heart Failure Patients Over the Age of 80
- Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome
- Quality Improvement in Delirium Health Literacy in Older Adult Patients and Their Caregivers Attending a Geriatric Clinic
Showing 5 of 12 shared publications
Fathima S. Ameer
Institute on Aging (US)
7 shared publications
- Alternative Splicing Increases Sirtuin Gene Family Diversity and Modulates Their Subcellular Localization and Function
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
- The Role of Sirtuin-1 Isoforms in Regulating Mitochondrial Function
- Sirtuin-1 isoforms differentially regulate mitochondrial function
- A Study of C2C12 Myoblast Bioenergetics in Response to the CCG-1423 Rho A Inhibitor
Showing 5 of 7 shared publications
Robert R. Wolfe
Institute on Aging
6 shared publications
In database
- Daily Consumption of a Specially Formulated Essential Amino Acid-Based Dietary Supplement Improves Physical Performance in Older Adults With Low Physical Functioning
- The anabolic response to a ground beef patty and soy-based meat alternative: a randomized controlled trial
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
- Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome
- Correction to: Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement versus whey protein in low physical functioning older adults
Showing 5 of 6 shared publications
Karen Coker
University of Arkansas for Medical Sciences
5 shared publications
In database
- Daily Consumption of a Specially Formulated Essential Amino Acid-Based Dietary Supplement Improves Physical Performance in Older Adults With Low Physical Functioning
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
- Quality Improvement in Delirium Health Literacy in Older Adult Patients and Their Caregivers Attending a Geriatric Clinic
- Correction to: Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement versus whey protein in low physical functioning older adults
- A Response to: Quality Improvement in Delirium Health Literacy in Older Adult Patients and Their Caregivers Attending a Geriatric Clinic [Response to Letter]
Priya Mendiratta
University of Arkansas for Medical Sciences (US)
5 shared publications
- Does Superior Bone Health Promote a Longer Lifespan?
- Quality Improvement in Delirium Health Literacy in Older Adult Patients and Their Caregivers Attending a Geriatric Clinic
- The PBAR Protocol: Antipsychotic Medication Reduction in the Nursing Home
- HEALTHCARE DISPARITY IN THE ASSESSMENT OF DEMENTIA IN THE PRIMARY CARE SETTING
- A Response to: Quality Improvement in Delirium Health Literacy in Older Adult Patients and Their Caregivers Attending a Geriatric Clinic [Response to Letter]
Wei Zhang
University of Arkansas at Little Rock
4 shared publications
In database
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
- Neutrophil Biomarkers Can Predict Cardiotoxicity of Anthracyclines in Breast Cancer
- Correction to: Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement versus whey protein in low physical functioning older adults
- Differential microRNA profiling of the Marshallese population in Arkansas reveals a higher association with chronic diseases
Yingni Che
University of Arkansas for Medical Sciences (US)
4 shared publications
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
- Neutrophil Biomarkers Can Predict Cardiotoxicity of Anthracyclines in Breast Cancer
- Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome
- Correction to: Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement versus whey protein in low physical functioning older adults
Sayed Aliul Hasan Abdi
University of Arkansas for Medical Sciences
4 shared publications
In database
- The Long-Term Cardiovascular Risks of Duloxetine Use in Older Adults: A Retrospective Medical Record-Based Adverse Drug Reaction Assessment
- Alternative Splicing of Serum Response Factor Reveals Isoform-Specific Remodeling in Cardiac Diseases
- Mitochondrial Dynamics in Aging Heart
- Duloxetine, an SNRI, Targets pSTAT3 Signaling: In-Silico, RNA-Seq and In-Vitro Evidence for a Pleiotropic Mechanism of Pain Relief
Arny A. Ferrando
Institute on Aging
3 shared publications
In database
- Daily Consumption of a Specially Formulated Essential Amino Acid-Based Dietary Supplement Improves Physical Performance in Older Adults With Low Physical Functioning
- The anabolic response to a ground beef patty and soy-based meat alternative: a randomized controlled trial
- Effect of 3 Different Daily Protein Intakes in a 2-Meal Eating Pattern on Protein Turnover in Middle Age and Older Adults: A Randomized Controlled Trial
Jasmine Crane
Institute on Aging
3 shared publications
In database
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
- Sirtuin-1 isoforms differentially regulate mitochondrial function
- Sirtuin gene isoforms and genomic sequences of mouse and humans: Divergence across species
Similar Researchers
Based on overlapping research topics
Ambika Verma
University of Arkansas for Medical Sciences
Mitochondrial Function and Pathology
Neuroinflammation and Neurodegeneration Mechanisms
Nutrition and Health in Aging
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University of Arkansas for Medical Sciences
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Edward T. Schmid
Arkansas State University
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Pankaj Patyal
University of Arkansas for Medical Sciences
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Katie Wood
University of Arkansas at Fayetteville
Mitochondrial Function and Pathology
Diet and metabolism studies
Health Sciences Research and Education
Katie M Wood
University of Arkansas at Fayetteville
Mitochondrial Function and Pathology
Diet and metabolism studies
Health Sciences Research and Education