Robert R. Wolfe
Professor
Also affiliated: Rutgers, The State University of New Jersey (1975); University of Vermont (1983–1993); University of Southern California (2003); James Madison University (2019–2021); West Virginia University (1985); Louisiana State University (1976–1978); Tufts University (1980–1993); University of Copenhagen (2008); University of Iowa (2021); Brigham and Women's Hospital (1982–1986); Boston Children's Hospital (1981); Tufts Medical Center (1980); Joslin Diabetes Center (1986); National Institutes of Health (1988–1998); Fitzsimons Army Medical Center (1977–1979); Universities Space Research Association (2006); St. Luke's Episcopal Hospital (1964); United States Department of Agriculture (1993); The University of Texas MD Anderson Cancer Center (2024); Harvard University (1978–1989); University of Connecticut (2003–2009); University of Alaska Fairbanks (2019–2020); University of Trieste (2000); Johns Hopkins University (1984); University of California, Santa Barbara (1975–1976); Baylor University (1964–1966); University of California, Los Angeles (1967–1970); Oregon Health & Science University (1996); Baylor College of Medicine (1964–1966); East Carolina University (1986); University of Colorado Boulder (1990); Vanderbilt University (1992–1993); Keio University (1989); Washington University in St. Louis (1979–2003); VA Palo Alto Health Care System (1986); Purdue University West Lafayette (2008); University of Utah (1979); University of Arkansas Medical Center (2007–2022); Johns Hopkins Medicine (1984); University Medical Center New Orleans (1976–1978); Shriners Hospitals for Children - Galveston (1986–2010); University of Vermont Medical Center (1986); United States Pharmacopeial Convention (2016); Yale University (1985–1988); Maastricht University (2008); University of Colorado Health (1985–1997); Massachusetts General Hospital (1978–1989); United States Army (2019); National Institute of Diabetes and Digestive and Kidney Diseases (1988); University of Texas Health Science Center at Dallas (1986); Children's Hospital Colorado (2009–2012); Central Arkansas Veterans Healthcare System (2008); Shriners Hospitals for Children - Boston (1982–2008); United States Army Institute of Surgical Research (2004); National Aeronautics and Space Administration (1996); Duke Medical Center (2008–2022); University of Iowa Health Care (2021); Shriners Hospitals for Children (1993–2010); Ajinomoto (Japan) (2003–2006); Texas Children's Hospital (1964–1966); Johnson Space Center (1996–2006); Johns Hopkins Hospital (1984); National Cattlemen's Beef Association (2009); Riddet Institute (2016–2018); Abbott Nutrition (United States) (2013); Alaska Division of Geological and Geophysical Surveys (2017); University of Oklahoma Health Sciences Center (2008); Massey University (2016–2018); University of Colorado Anschutz (1978–1993); The University of Texas Medical Branch at Galveston (1984–2010); Monash University (2012–2025); Stony Brook University (1996); Massachusetts Institute of Technology (1978–1993); Virginia Commonwealth University Medical Center (1993); Louisiana State University Health Sciences Center New Orleans (1976–1978); University of Pennsylvania (1988); Ludwig-Maximilians-Universität München (1989–1990); University of California, Davis (1988); The University of Texas at Austin (1993–1996); Texas A&M University (2012–2020); University of Colorado Denver (1974–2012); University of California, Berkeley (1990–1991); Stanford University (1990); University of Lausanne (1983)
Geriatrics, College of Medicine
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Robert R. Wolfe, Professor in the Department of Geriatrics at the University of Arkansas for Medical Sciences College of Medicine, has a research focus on metabolism, particularly in the context of skeletal muscle physiology and aging. His work investigates the regulation of fat and carbohydrate metabolism, the kinetics of muscle protein synthesis and breakdown, and the impact of factors such as exercise intensity, duration, and resistance training on these processes in humans.
His research has explored the role of essential amino acids, especially leucine, in stimulating muscle protein anabolism in elderly adults. Wolfe has also studied the effects of physiological stressors like bed rest on skeletal muscle in healthy older adults. His publications address broader topics including cachexia and hypoalbuminemia, highlighting their pathogenesis and clinical significance.
Wolfe is a highly cited researcher with an h-index of 133 and over 1000 publications. He leads a research group and has a history of collaboration with several researchers at the University of Arkansas for Medical Sciences, including Arny A. Ferrando, David N. Church, Gohar Azhar, and Elisabet Børsheim.
Metrics
- h-index: 133
- Publications: 1021
- Citations: 65,741
Positions
-
Jane and Ed Warmack Chair in Nutritional Longevity 2010–presentUniversity of Arkansas Medical Center Geriatrics ORCID
-
Professor 2006–presentUniversity of Arkansas for Medical Sciences Geriatrics, College of Medicine Institutional directory
-
Director 2006–2022University of Arkansas for Medical Sciences Center for Translational Research in Aging and Longevity ORCID
-
John H. Sealy Distinguished Chair in Clinical Research 2003–2006The University of Texas Medical Branch at Galveston ORCID
-
Professor 1986–2006The University of Texas Medical Branch at Galveston Surgery and Anesthesiology ORCID
-
Chief 1983–2006Shriners Hospitals for Children - Galveston Metabolism Unit ORCID
-
Associate Professor 1983–1986The University of Texas Medical Branch at Galveston Surgery and Anesthesiology ORCID
Selected Publications
-
Understanding Dietary Protein Quality: Digestible Indispensable Amino Acid Scores and Beyond (2025)
-
Crossover Trial of Exogenous Ketones on Cardiometabolic Endpoints in Heart Failure With Preserved Ejection Fraction (2025)
-
A new concept to establish protein requirements (2025)
-
Effect of 3 Different Daily Protein Intakes in a 2-Meal Eating Pattern on Protein Turnover in Middle Age and Older Adults: A Randomized Controlled Trial (2024)
-
Consideration of the role of protein quality in determining dietary protein recommendations (2024)
-
Toward a Dynamic Model of Indispensable Amino Acid Requirements of the Adult Human: A Factorial Estimate of Oxidative Amino Acid Losses (2024)
-
The anabolic response to a ground beef patty and soy-based meat alternative: a randomized controlled trial (2024)
-
Consuming Whey Protein with Added Essential Amino Acids, Not Carbohydrate, Maintains Postexercise Anabolism While Underfed (2024)
-
Free essential amino acid feeding improves endurance during resistance training via DRP1‐dependent mitochondrial remodelling (2024)
-
Inhibitory Regulation of FOXO1 in PPARδ Expression Drives Mitochondrial Dysfunction and Insulin Resistance (2024)
-
Stimulation of muscle protein synthesis with low-dose amino acid composition in older individuals (2024)
-
Metabolic effects of an essential amino acid supplement in adolescents with <scp>PCOS</scp> and obesity (2024)
-
Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome (2024)
-
The Importance of Dietary Protein Quality in Mid- to High-Income Countries (2024)
-
International Society of Sports Nutrition Position Stand: Effects of essential amino acid supplementation on exercise and performance (2023)
Grants & Funding
As listed on this researcher's institutional profile.
- Nutritional Countermeasures to Ameliorate Losses in Muscle Mass and Function National Space Biomedical Research Institute via Baylor College of Medicine Principal Investigator
- Ferrando: Effect of Dietary Protein Intake Pattern on Skeletal Muscle in Older Individuals National Dairy Council Co-Investigator
- EXERCISE EFFECTS ON PROTEIN METABOLISM NIH Principal Investigator
- Wolfe SubK-Vanderbilt Tracer Course 2018 - Continuation NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases via Vanderbilt University Principal Investigator
- Wolfe-KIWI Sub w/Massey: Speeding Up a Slow Protein for Muscle Mass with Hayward Kiwi fruit Zespri Group Limited via Massey University Principal Investigator
- PROTOCOL #2: The Effect of Frequent EAA Ingestion on Resting Energy Expenditure and 24hr Muscle Protein Synthesis NOVARTIS Pharmaceuticals Corporation Principal Investigator
- RES-DZ-01-03 Study in Septic-shock ICU Patients in Which Arginine was Infused to Improve Their Condition-Nicolaas Deitz, Co-I NOVARTIS Pharmaceuticals Corporation Principal Investigator
- Protein Kinetic Response to Calorie Deprivation: U.S. Army Research Institute of Environmental Medicine Principal Investigator
- Stable Isotope Analytical Core for Studies in Human Metabolism NIH Principal Investigator
- Protocol 3: Use of Dietery Nucleotides to Stimulate tRNA Synthesis for Enhanced Protein Synthesis in Chronic Wasting of Elderly NOVARTIS Pharmaceuticals Corporation Principal Investigator
- MUSCLE PROTEIN METABOLISM AND NUTRITION IN THE ELDERLY NIH Principal Investigator
- ENERGY EXPENDITURE IN BURNED PATIENTS NIH Principal Investigator
- Dose Response to peptide mixture enriched with branched chain amino acids: A Pilot Study Glanbia Nutritionals Principal Investigator
- Protocol No. CT-12-0012 entitled “Determination of the Optimal Infusion Rate of Amino Acids in Seriously Ill Patients Baxter Healthcare Corporation Principal Investigator
- Arkansas Claude Pepper Older Americans Independence Center at UAMS NIH Co-Investigator
- ASSESSMENT OF SUBSTRATE KINETIC ANALYSIS USING TRACERS NIH Principal Investigator
- Nutritional Stimulation of Muscle Protein Synthesis and Metabolic Rate After Bariatric Surgery NIH Principal Investigator
- Skeletal Muscle Protein synthesis in healthy elderly after bolus intake of a high whey-protein leucine-rich oral nutritional supplement Spa.1/C/A AKA Danone Research Principal Investigator
- Comparison of Medical Nutritional Supplements With or Without AN777 in Elderly Men Abbott, Inc. Principal Investigator
- Amino Acids and Pediatric Hepatic Steatosis NIH Principal Investigator
- Wolfe - Subcontract w Case Western - Isotope Tracers in Metabolic Research NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases via Case Western Reserve University Principal Investigator
- Wolfe-FORTE: Effects of Fortetropin on Skeletal Muscle Protein Fractional Synthetic Rate in Older Men and Women MYOS RENS via University of California, Berkeley Principal Investigator
- Muscle preservation during weight loss in older, overweight individuals NIH Principal Investigator
- Substrate Cycling in Energy Metabolism NIH Principal Investigator
- THE ROLE OF SUBSTRATE CYCLING IN ENERGY METABOLISM NIH Principal Investigator
- “Evaluation of an Oral Nutritional Supplement Containing AN777 in Older Hospitalized Patients - BK33” Abbott, Inc. Principal Investigator
- Amino Acids and Muscle Protein Synthesis NIH Principal Investigator
- Consortium w/Essential: Nutritional Therapy in the Elderly with Heart Failure- Resubmission NIH/Nat. Inst. on Aging via Essential Blends, LLC Principal Investigator
- Subcontract w/Essential Blends, LLC: UpBeat Phase 2 NIH/Nat. Inst. on Aging via Essential Blends, LLC Principal Investigator
- Optimal Amino Acid Nutrition in Sepsis NIH Co-Principal Investigator
- Sub w/Vanderbilt: 2017 T-Course Isotope Tracers in Metabolic Research NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases via Vanderbilt University Principal Investigator
- EXERCISE, LIPOLYSIS AND FAT OXIDATION NIH Principal Investigator
- MODELING IN METABOLISM AND NUTRITION NIH Principal Investigator
- GLUCOSE METABOLISM IN SEPTIC PATIENTS NIH Principal Investigator
Collaboration Network
Top Collaborators
- Functional Impact of 10 Days of Bed Rest in Healthy Older Adults
- EAA supplementation to increase nitrogen intake improves muscle function during bed rest in the elderly
- Muscle protein synthesis in cancer patients can be stimulated with a specially formulated medical food
- Acute Energy Deprivation Affects Skeletal Muscle Protein Synthesis and Associated Intracellular Signaling Proteins in Physically Active Adults
- Essential Amino Acids and Protein Synthesis: Insights into Maximizing the Muscle and Whole-Body Response to Feeding
Showing 5 of 21 shared publications
- Optimizing Protein Intake in Adults: Interpretation and Application of the Recommended Dietary Allowance Compared with the Acceptable Macronutrient Distribution Range
- Essential Amino Acids and Protein Synthesis: Insights into Maximizing the Muscle and Whole-Body Response to Feeding
- Protein quality as determined by the Digestible Indispensable Amino Acid Score: evaluation of factors underlying the calculation: Table 1
- The anabolic response to a meal containing different amounts of protein is not limited by the maximal stimulation of protein synthesis in healthy young adults
- Update on maximal anabolic response to dietary protein
Showing 5 of 16 shared publications
- Essential Amino Acids and Protein Synthesis: Insights into Maximizing the Muscle and Whole-Body Response to Feeding
- Muscle Protein Synthesis and Whole-Body Protein Turnover Responses to Ingesting Essential Amino Acids, Intact Protein, and Protein-Containing Mixed Meals with Considerations for Energy Deficit
- International Society of Sports Nutrition Position Stand: Effects of essential amino acid supplementation on exercise and performance
- Essential amino acid-enriched whey enhances post-exercise whole-body protein balance during energy deficit more than iso-nitrogenous whey or a mixed-macronutrient meal: a randomized, crossover study
- Consideration of the role of protein quality in determining dietary protein recommendations
Showing 5 of 14 shared publications
- Essential Amino Acids and Protein Synthesis: Insights into Maximizing the Muscle and Whole-Body Response to Feeding
- Mitoribosomal defects aggravate liver cancer via aberrant glycolytic flux and T cell exhaustion
- Myostatin Inhibition-Induced Increase in Muscle Mass and Strength Was Amplified by Resistance Exercise Training, and Dietary Essential Amino Acids Improved Muscle Quality in Mice
- Tracing metabolic flux in vivo: basic model structures of tracer methodology
- Essential Amino Acid-Enriched Diet Alleviates Dexamethasone-Induced Loss of Muscle Mass and Function through Stimulation of Myofibrillar Protein Synthesis and Improves Glucose Metabolism in Mice
Showing 5 of 12 shared publications
- Effect of β-hydroxy-β-methylbutyrate (HMB) on lean body mass during 10 days of bed rest in older adults
- Arginine de novo and nitric oxide production in disease states
- Muscle protein synthesis in cancer patients can be stimulated with a specially formulated medical food
- Is there a maximal anabolic response to protein intake with a meal?
- Postprandial muscle protein synthesis is higher after a high whey protein, leucine-enriched supplement than after a dairy-like product in healthy older people: a randomized controlled trial
Showing 5 of 8 shared publications
- Acute Energy Deprivation Affects Skeletal Muscle Protein Synthesis and Associated Intracellular Signaling Proteins in Physically Active Adults
- Essential Amino Acids and Protein Synthesis: Insights into Maximizing the Muscle and Whole-Body Response to Feeding
- Muscle Protein Synthesis and Whole-Body Protein Turnover Responses to Ingesting Essential Amino Acids, Intact Protein, and Protein-Containing Mixed Meals with Considerations for Energy Deficit
- International Society of Sports Nutrition Position Stand: Effects of essential amino acid supplementation on exercise and performance
- Essential amino acid-enriched whey enhances post-exercise whole-body protein balance during energy deficit more than iso-nitrogenous whey or a mixed-macronutrient meal: a randomized, crossover study
Showing 5 of 7 shared publications
- The anabolic response to a meal containing different amounts of protein is not limited by the maximal stimulation of protein synthesis in healthy young adults
- Daily Consumption of a Specially Formulated Essential Amino Acid-Based Dietary Supplement Improves Physical Performance in Older Adults With Low Physical Functioning
- The anabolic response to a ground beef patty and soy-based meat alternative: a randomized controlled trial
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
- Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome
Showing 5 of 7 shared publications
- Protein quality as determined by the Digestible Indispensable Amino Acid Score: evaluation of factors underlying the calculation: Table 1
- Factors contributing to the selection of dietary protein food sources
- The Importance of Dietary Protein Quality in Mid- to High-Income Countries
- Consideration of the role of protein quality in determining dietary protein recommendations
- Understanding Dietary Protein Quality: Digestible Indispensable Amino Acid Scores and Beyond
Showing 5 of 7 shared publications
- Mitoribosomal defects aggravate liver cancer via aberrant glycolytic flux and T cell exhaustion
- Myostatin Inhibition-Induced Increase in Muscle Mass and Strength Was Amplified by Resistance Exercise Training, and Dietary Essential Amino Acids Improved Muscle Quality in Mice
- Tracing metabolic flux in vivo: basic model structures of tracer methodology
- Essential Amino Acid-Enriched Diet Alleviates Dexamethasone-Induced Loss of Muscle Mass and Function through Stimulation of Myofibrillar Protein Synthesis and Improves Glucose Metabolism in Mice
- Balanced Free Essential Amino Acids and Resistance Exercise Training Synergistically Improve Dexamethasone-Induced Impairments in Muscle Strength, Endurance, and Insulin Sensitivity in Mice
Showing 5 of 7 shared publications
- Essential Amino Acids and Protein Synthesis: Insights into Maximizing the Muscle and Whole-Body Response to Feeding
- Pre- and Post-Surgical Nutrition for Preservation of Muscle Mass, Strength, and Functionality Following Orthopedic Surgery
- International Society of Sports Nutrition Position Stand: Effects of essential amino acid supplementation on exercise and performance
- The anabolic response to a ground beef patty and soy-based meat alternative: a randomized controlled trial
- Continuous oral stable isotope ingestion to measure whole-body protein turnover
Showing 5 of 6 shared publications
- Functional Impact of 10 Days of Bed Rest in Healthy Older Adults
- Protein, weight management, and satiety
- Role of dietary protein in the sarcopenia of aging
- EAA supplementation to increase nitrogen intake improves muscle function during bed rest in the elderly
- Whey protein ingestion in elderly persons results in greater muscle protein accrual than ingestion of its constituent essential amino acid content
- Muscle protein synthesis in cancer patients can be stimulated with a specially formulated medical food
- The anabolic response to a meal containing different amounts of protein is not limited by the maximal stimulation of protein synthesis in healthy young adults
- Daily Consumption of a Specially Formulated Essential Amino Acid-Based Dietary Supplement Improves Physical Performance in Older Adults With Low Physical Functioning
- Perioperative amino acid infusion reestablishes muscle net balance during total hip arthroplasty
- Equivalent servings of free-range reindeer promote greater net protein balance compared to commercial beef
- Cachexia: A new definition
- EAA supplementation to increase nitrogen intake improves muscle function during bed rest in the elderly
- Bed Rest Promotes Reductions in Walking Speed, Functional Parameters, and Aerobic Fitness in Older, Healthy Adults
- Nutrition and the Assessment of Sarcopenia
- Metabolic Effects of Late Dinner in Healthy Volunteers—A Randomized Crossover Clinical Trial
- The potential role of beef and nutrients found in beef on outcomes of wellbeing in healthy adults 50 years of age and older: A systematic review of randomized controlled trials
- Breastfeeding duration modifies the association between maternal weight status and offspring dietary palmitate oxidation
- Comparison of Arterial-Venous Balance and Tracer Incorporation Methods for Measuring Muscle Fractional Synthesis and Fractional Breakdown Rates
- Essential Amino Acids and Protein Synthesis: Insights into Maximizing the Muscle and Whole-Body Response to Feeding
- Muscle Protein Synthesis and Whole-Body Protein Turnover Responses to Ingesting Essential Amino Acids, Intact Protein, and Protein-Containing Mixed Meals with Considerations for Energy Deficit
- Essential amino acid-enriched whey enhances post-exercise whole-body protein balance during energy deficit more than iso-nitrogenous whey or a mixed-macronutrient meal: a randomized, crossover study
- Consuming Whey Protein with Added Essential Amino Acids, Not Carbohydrate, Maintains Postexercise Anabolism While Underfed
Similar Researchers
Based on overlapping research topics