Match tier
Confirmed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-09
N
Nicholas Perry Greene
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Federal Grant PI
High Impact
Professor and Director of the Exercise Science Research Center
Also affiliated: University of South Carolina (2006); Texas A&M University System (2013); Norsk Hydro (Germany) (2007); Baylor Scott & White Health (2007); University of Virginia (2011–2013); Southern Illinois University Edwardsville (2016); Texas A&M University (2007–2016)
30 h-index
183 pubs
4,071 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Nicholas Perry Greene's research investigates the molecular mechanisms underlying skeletal muscle adaptation and atrophy, particularly in the context of cancer cachexia and diet-induced obesity. His work has explored the role of PGC-1α in regulating skeletal muscle hypertrophy and mitochondrial quality control, examining how these processes are affected by factors such as resistance training and Western diet consumption. Greene's studies have also focused on the contribution of autophagy to exercise-induced muscle adaptations and physical performance improvements.
Further research by Greene has delved into the development of skeletal muscle wasting in tumor-bearing mice, investigating protein imbalances and mitochondrial degeneration that precede atrophy. He has also examined sex-based differences in muscle metabolism and atrophy. His laboratory is actively engaged in understanding and developing targeted approaches for the prevention of cancer cachexia, as evidenced by his role as PI on a recent NIH-funded project.
Greene holds an h-index of 30 with over 4,000 citations across his 183 publications. He collaborates extensively with researchers at the University of Arkansas at Fayetteville, including Francielly Morena da Silva, Tyrone A. Washington, Ana Regina Cabrera, and Eleanor R. Schrems.
Metrics
- h-index: 30
- Publications: 183
- Citations: 4,071
Positions
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Professor and Director of the Exercise Science Research Center 2022–presentUniversity of Arkansas Department of Health, Human Performance and Recreation ORCID
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Associate Professor 2019–presentUniversity of Arkansas Fayetteville Health, Human Performance and Recreation ORCID
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Assistant Professor 2013–2019University of Arkansas Fayetteville Health, Human Performance and Recreation ORCID
Selected Publications
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Exercise training prior to and during cancer in mice preserves muscle mass, reduces tumour weight and suppresses molecular mediators of cachexia (2026)
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The Age‐Dependent Resident Myonuclear Multi‐Omic Response to an Acute Skeletal Muscle Hypertrophic Stimulus in Mice (2026)
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Exercise-induced antioxidant programming in oxidative muscle: a critical IL1β-NBR1-p62 axis (2026)
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Skeletal muscle methylome-transcriptome disruptions during the onset and progression of colorectal cancer-induced cachexia (2025)
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The Age-Dependent Resident Myonuclear Multi-Omic Response to a Skeletal Muscle Hypertrophic Stimulus (2025)
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Transcriptomic analysis demonstrates moderators of muscle quality are altered in age-related sarcopenic obesity (2025)
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Promoting mitochondrial fusion is protective against cancer-induced muscle detriments in males and females (2025)
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Landscape of clinical trials in cancer cachexia: assessment of trends from 1995–2024 (2025)
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Mitochondrial-targeted plastoquinone therapy prevents early onset muscle weakness that occurs before atrophy during ovarian cancer (2025)
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Sustained Accumulation of Molecular Clock Suppressors Period 1 and Period 2 Promotes C2C12 Myotube Atrophy Through an Autocrine-Mediated Mechanism With Relevance to Androgen Deprivation-Induced Limb Muscle Mass Loss (2025)
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Global mitophagy inhibition via BNIP3 ablation is not sufficient to alleviate skeletal muscle impairments in male and female tumor-bearing mice (2025)
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Myocellular adaptations to short‐term weighted wheel‐running exercise are largely conserved during C26‐tumour induction in male and female mice (2025)
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Landscape of Clinical Trials in Cancer Cachexia: Assessment of Trends From 1995-2024 (2025)
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The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth (2024)
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Transcriptional analysis of cancer cachexia: conserved and unique features across preclinical models and biological sex (2024)
Federal Grants 1 $313,850 total
NIH
Contact PI
Jul 2020 - Jun 2026
DEVELOPMENT OF TARGETED APPROACHES IN PREVENTION OF CANCER-CACHEXIA
Collaboration Network
Top Collaborators
Tyrone A. Washington
University of Arkansas at Fayetteville
90 shared publications
In database
- Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour‐bearing mice
- Protein imbalance in the development of skeletal muscle wasting in tumour‐bearing mice
- Mitochondrial quality control, promoted by PGC-1α, is dysregulated by Western diet-induced obesity and partially restored by moderate physical activity in mice
- Diet‐induced obesity alters anabolic signalling in mice at the onset of skeletal muscle regeneration
- Cancer cachexia-induced muscle atrophy: evidence for alterations in microRNAs important for muscle size
Showing 5 of 90 shared publications
Jacob L. Brown
University of Arkansas at Fayetteville (US)
56 shared publications
- Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour‐bearing mice
- Protein imbalance in the development of skeletal muscle wasting in tumour‐bearing mice
- Mitochondrial quality control, promoted by PGC-1α, is dysregulated by Western diet-induced obesity and partially restored by moderate physical activity in mice
- Diet‐induced obesity alters anabolic signalling in mice at the onset of skeletal muscle regeneration
- Cancer cachexia-induced muscle atrophy: evidence for alterations in microRNAs important for muscle size
Showing 5 of 56 shared publications
Megan E. Rosa‐Caldwell
University of Arkansas at Fayetteville
55 shared publications
In database
- Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour‐bearing mice
- Muscle metabolism and atrophy: let’s talk about sex
- Protein imbalance in the development of skeletal muscle wasting in tumour‐bearing mice
- Muscle weakness precedes atrophy during cancer cachexia and is linked to muscle-specific mitochondrial stress
- Cancer cachexia-induced muscle atrophy: evidence for alterations in microRNAs important for muscle size
Showing 5 of 55 shared publications
Richard Perry
University of Arkansas at Fayetteville (US)
52 shared publications
- Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour‐bearing mice
- Protein imbalance in the development of skeletal muscle wasting in tumour‐bearing mice
- Mitochondrial quality control, promoted by PGC-1α, is dysregulated by Western diet-induced obesity and partially restored by moderate physical activity in mice
- Diet‐induced obesity alters anabolic signalling in mice at the onset of skeletal muscle regeneration
- Cancer cachexia-induced muscle atrophy: evidence for alterations in microRNAs important for muscle size
Showing 5 of 52 shared publications
David E. Lee
University of Arkansas at Fayetteville (US)
49 shared publications
- Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour‐bearing mice
- Protein imbalance in the development of skeletal muscle wasting in tumour‐bearing mice
- Mitochondrial quality control, promoted by PGC-1α, is dysregulated by Western diet-induced obesity and partially restored by moderate physical activity in mice
- Cancer cachexia-induced muscle atrophy: evidence for alterations in microRNAs important for muscle size
- microRNA‐16 Is Downregulated During Insulin Resistance and Controls Skeletal Muscle Protein Accretion
Showing 5 of 49 shared publications
Lemuel A. Brown
University of Michigan
45 shared publications
In database
- Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour‐bearing mice
- Protein imbalance in the development of skeletal muscle wasting in tumour‐bearing mice
- Mitochondrial quality control, promoted by PGC-1α, is dysregulated by Western diet-induced obesity and partially restored by moderate physical activity in mice
- Diet‐induced obesity alters anabolic signalling in mice at the onset of skeletal muscle regeneration
- Cancer cachexia-induced muscle atrophy: evidence for alterations in microRNAs important for muscle size
Showing 5 of 45 shared publications
Wesley S. Haynie
University of Arkansas at Fayetteville
33 shared publications
In database
- Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour‐bearing mice
- Protein imbalance in the development of skeletal muscle wasting in tumour‐bearing mice
- Hepatic alterations during the development and progression of cancer cachexia
- Transcriptomic analysis of the development of skeletal muscle atrophy in cancer-cachexia in tumor-bearing mice
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
Showing 5 of 33 shared publications
Seongkyun Lim
University of Arkansas at Fayetteville
31 shared publications
In database
- Multi-transcriptome analysis following an acute skeletal muscle growth stimulus yields tools for discerning global and MYC regulatory networks
- Development and progression of cancer cachexia: Perspectives from bench to bedside
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- A molecular signature defining exercise adaptation with ageing and in vivo partial reprogramming in skeletal muscle
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
Showing 5 of 31 shared publications
Francielly Morena da Silva
University of Arkansas at Fayetteville
29 shared publications
In database
- Multi-transcriptome analysis following an acute skeletal muscle growth stimulus yields tools for discerning global and MYC regulatory networks
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- A molecular signature defining exercise adaptation with ageing and in vivo partial reprogramming in skeletal muscle
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
Showing 5 of 29 shared publications
Michael P. Wiggs
Baylor University (US)
27 shared publications
- Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour‐bearing mice
- Protein imbalance in the development of skeletal muscle wasting in tumour‐bearing mice
- Muscle weakness precedes atrophy during cancer cachexia and is linked to muscle-specific mitochondrial stress
- Cancer cachexia-induced muscle atrophy: evidence for alterations in microRNAs important for muscle size
- microRNA‐16 Is Downregulated During Insulin Resistance and Controls Skeletal Muscle Protein Accretion
Showing 5 of 27 shared publications
Ana Regina Cabrera
University of Arkansas at Fayetteville
27 shared publications
In database
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
Showing 5 of 27 shared publications
Kevin A. Murach
University of Arkansas at Fayetteville
23 shared publications
In database
- Multi-transcriptome analysis following an acute skeletal muscle growth stimulus yields tools for discerning global and MYC regulatory networks
- A molecular signature defining exercise adaptation with ageing and in vivo partial reprogramming in skeletal muscle
- Exercise Counteracts the Deleterious Effects of Cancer Cachexia
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth
Showing 5 of 23 shared publications
Eleanor R. Schrems
University of Arkansas at Fayetteville
21 shared publications
In database
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
Showing 5 of 21 shared publications
Megan E. Rosa
University of Arkansas at Fayetteville (US)
17 shared publications
- Mitochondrial quality control, promoted by PGC-1α, is dysregulated by Western diet-induced obesity and partially restored by moderate physical activity in mice
- microRNA‐16 Is Downregulated During Insulin Resistance and Controls Skeletal Muscle Protein Accretion
- Differential Responses to Leucine Supplementation in Young and Aged Mice at the Onset of Skeletal Muscle Regeneration
- Sarcopenic Obesity Alters Ecm-related Gene Expression In Mouse Skeletal Muscle
- Timecourse Of Alterations In Myofiber CSA And Oxidative Phenotype In Progression Of Cancer-cachexia
Showing 5 of 17 shared publications
Ronald G. Jones
University of Arkansas at Fayetteville
12 shared publications
In database
- A molecular signature defining exercise adaptation with ageing and in vivo partial reprogramming in skeletal muscle
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth
- Muscle weakness and mitochondrial stress occur before severe metastasis in a novel mouse model of ovarian cancer cachexia
- Transcriptional analysis of cancer cachexia: conserved and unique features across preclinical models and biological sex
Showing 5 of 12 shared publications
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