Jin‐Ran Chen

Federal Grant PI High Impact

Researcher

University of Arkansas

Faculty Researcher

31 h-index 99 pubs 3,372 cited

Research Areas

Biomedical Subjects

Links

ORCID Research Group UAMS TRI Profile

OverviewAI-generated summary

Jin-Ran Chen's research focuses on understanding the molecular mechanisms underlying bone health and disease, particularly in the context of conditions like multiple myeloma and osteoporosis. His work investigates how various biological factors, including specific genes and dietary components, influence bone cell function and overall bone metabolism. Chen has explored the role of GPR109A in mediating the effects of hippuric acid on osteoclastogenesis and bone resorption in mice, as well as how NEK2 expression in myeloid progenitors impacts T cell immunity in multiple myeloma. Another area of his investigation involves the influence of Nox4 expression in osteo-progenitors on bone development during early life.

His research also extends to the impact of maternal diet on offspring bone development, examining epigenetic modifications such as H3K27me3 and H3K27ac in bone following a high-fat maternal diet. Furthermore, Chen has studied the potential of phenolic acids to prevent bone loss and bone marrow adipogenesis induced by sex-steroid deficiency. His scholarship includes 99 publications, with an h-index of 31 and over 3,300 citations, indicating a significant impact in his field. He leads a research group and has received federal funding for his work, including a $330,316 grant from the NIH/National Cancer Institute for research on novel NEK2 signaling pathways in myeloma progression.

Metrics

h-index: 31
Publications: 99
Citations: 3,372

Selected Publications

Soy Isoflavones Prevent Bone Quality Loss Induced by High‐Fat Diet in Rats Through Epigenetic Modifications (2025)

1 citation DOI OpenAlex
Sex dependent effects of GPR109A gene deletion in myeloid cells on bone development in mice (2025)

Scientific Reports DOI OpenAlex
Soy Isoflavones Prevent Loss of Bone Quality Associated With High Fat Diet in Rats Through Ameliorating Epigenetic Modifications in Bone (2025)

Current Developments in Nutrition DOI OpenAlex
Acetate derived from metabolism of ethanol affects gene expression in bone and contributes to delays in chondrogenic differentiation (2025)

Toxicological Sciences 1 citation DOI OpenAlex
Sex-dependent effect of GPR109A gene deletion in myeloid cells on bone development in mice (2025)

Research Square DOI OpenAlex
Cystatin M/E Ameliorates Multiple Myeloma-Induced Hyper Osteolytic Bone Resorption (2025)

Cancers 1 citation DOI OpenAlex
Cystatin M/E ameliorates bone resorption through increasing osteoclastic cell estrogen influx (2024)

Research Square 1 citation DOI OpenAlex
Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice (2024)

The Journal of Nutritional Biochemistry 10 citations DOI OpenAlex
High NEK2 expression in myeloid progenitors suppresses T cell immunity in multiple myeloma (2023)

Cell Reports Medicine 17 citations DOI OpenAlex
A gene signature can predict risk of MGUS progressing to multiple myeloma (2023)

Journal of Hematology & Oncology 14 citations DOI OpenAlex
Decreased bone resorption in Ezh2 myeloid cell conditional knockout mouse model (2023)

The FASEB Journal 12 citations DOI OpenAlex
A Gene Signature Can Predict Risk of MGUS Progressing to Multiple Myeloma (2023)

SSRN Electronic Journal DOI OpenAlex
A longitudinal observational study of skeletal development between ages 3 mo and 6 y in children fed human milk, milk formula, or soy formula (2023)

American Journal of Clinical Nutrition 6 citations DOI OpenAlex
Exploring GPR109A Receptor Interaction with Hippuric Acid Using MD Simulations and CD Spectroscopy (2022)

International Journal of Molecular Sciences 8 citations DOI OpenAlex
Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice (2022)

Epigenetics 14 citations DOI OpenAlex