Jesús Delgado‐Calle

Federal Grant PI High Impact

Assistant Professor

University of Arkansas for Medical Sciences

faculty

29 h-index 191 pubs 3,464 cited

Research Areas

Multiple Myeloma Research and Treatments Bone Metabolism and Diseases Cancer-related molecular mechanisms research Receptor Mechanisms and Signaling Immune Response and Inflammation Bone health and treatments Pharmacological Effects and Toxicity Studies Cancer Treatment and Pharmacology

Links

ORCID Lab Website

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OverviewAI-generated summary

Jesús Delgado‐Calle's research focuses on the intricate signaling mechanisms within the bone marrow microenvironment, particularly in the context of multiple myeloma and bone metastasis. His work investigates the roles of osteocytes and Notch signaling in promoting tumor growth and bone destruction. He has received funding from the NIH/National Cancer Institute for two grants totaling over $1.3 million, focusing on the contribution of osteocytes to the musculoskeletal effects of multiple myeloma and the development of bone-targeted therapies for the disease.

Delgado‐Calle's publications explore the multifunctional role of Notch signaling in multiple myeloma, including how Notch3 signaling between myeloma cells and osteocytes drives tumor progression and bone damage. His research also examines how targeting Notch inhibitors can reduce tumor growth and bone destruction while mitigating gut toxicity. Furthermore, his work has identified senescent osteocytes that trigger bone destruction in breast cancer metastasis and investigated Notch3-CXCL12-driven signaling axes that promote chemoresistance in multiple myeloma.

His scholarship metrics include an h-index of 29, 191 total publications, and 3,464 total citations, designating him as a highly cited researcher. He actively collaborates with several researchers at the University of Arkansas for Medical Sciences, including Hayley M. Sabol, Teresita Bellido, Aric Anloague, and Japneet Kaur, with whom he has co-authored numerous publications.

Metrics

h-index: 29
Publications: 191
Citations: 3,464

Selected Publications

Paracrine activity of Smurf1-silenced mesenchymal stem cells enhances bone regeneration and reduces bone loss in postmenopausal osteoporosis (2025) DOI
A novel CCL3-HMGB1 signaling axis regulating osteocyte RANKL expression in multiple myeloma (2024) DOI
Senolytics deplete senescent osteocytes and improve bone health in metastatic breast cancer (2024) DOI
Single-cell Transcriptome Analysis Identifies Senescent Osteocytes as Contributors to Bone Destruction in Breast Cancer Metastasis (2024) DOI
Osteocytes and Paget’s Disease of Bone (2024) DOI
A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma (2024) DOI
Pharmacologic targeting of the p62 ZZ domain enhances both anti-tumor and bone-anabolic effects of bortezomib in multiple myeloma (2023) DOI
Engineering a Pro-Osteogenic Secretome through the Transient Silencing of the Gene Encoding Secreted Frizzled Related Protein 1 (2023) DOI
Osteocytes: New Kids on the Block for Cancer in Bone Therapy (2023) DOI
Data from Targeting Notch Inhibitors to the Myeloma Bone Marrow Niche Decreases Tumor Growth and Bone Destruction without Gut Toxicity (2023) DOI
Editorial: The role of the bone marrow microenvironment in multiple myeloma evolution and therapy (2023) DOI
CReSIL: accurate identification of extrachromosomal circular DNA from long-read sequences (2022) DOI
Abstract 5672: Notch3 signaling between myeloma cells and osteocytes in the tumor niche promotes tumor growth and bone destruction (2022) DOI
Abstract 5675: Pathological crosstalk between osteocytes and breast cancer cells in bone metastasis (2022) DOI
Accurate Identification of Extrachromosomal Circular DNA from Long-read Sequences (2022) DOI