Tsigereda Weldemichael

Researcher

University of Arkansas for Medical Sciences

unknown

3 h-index 5 pubs 63 cited

Research Areas

Cancer Treatment and Pharmacology Molecular Biology Techniques and Applications Synthetic Biology Applications Pharmacological Effects and Toxicity Studies Bioinformatics and Genomic Networks Drug-Induced Hepatotoxicity and Protection

Links

ORCID

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OverviewAI-generated summary

Tsigereda Weldemichael's research focuses on the development of therapeutic strategies and understanding molecular mechanisms across various biological systems. Her recent work includes investigating the efficacy of oligonucleotide delivery through lipid conjugation, with implications for clinical outcomes. She has also explored the redesign of evolutionary conserved network motifs for synthetic biology applications. In the realm of oncology, Weldemichael has contributed to identifying novel compounds that potently inhibit FLT3-ITD mutations, including those resistant to existing therapies like gilteritinib. Her research also extends to investigating the potential of insect-microbe-based laccases for industrial and biotechnological applications, as well as exploring how EET-based therapeutics can mitigate damage to glomerular cells associated with sorafenib treatment. Weldemichael collaborates with researchers such as Phuc Tran and Abdul H. Khan at the University of Arkansas for Medical Sciences.

Metrics

  • h-index: 3
  • Publications: 5
  • Citations: 63

Selected Publications

  • EET-Based Therapeutics Mitigate Sorafenib-Associated Glomerular Cell Damage (2025) DOI
  • Insect‐Microbe‐Based Laccase: Untapped Natural Resource for Industrial and Biotechnological Applications (2025) DOI
  • An imidazo[1,2-a]pyridine-pyridine derivative potently inhibits FLT3-ITD and FLT3-ITD secondary mutants, including gilteritinib-resistant FLT3-ITD/F691L (2023) DOI
  • Delivery of Oligonucleotides: Efficiency with Lipid Conjugation and Clinical Outcome (2022) DOI

Collaborators

Researchers in the database who share publications

Phuc Tran University of Arkansas for Medical Sciences 2 shared publications Abdul H. Khan University of Arkansas for Medical Sciences 1 shared publication Shobanbabu Bommagani University of Arkansas for Medical Sciences 1 shared publication Abhishek Mishra University of Arkansas for Medical Sciences 1 shared publication Darin E. Jones University of Arkansas for Medical Sciences 1 shared publication John D. Imig University of Arkansas for Medical Sciences 1 shared publication Donald J. Johann University of Arkansas for Medical Sciences 1 shared publication Samaneh Goorani University of Arkansas for Medical Sciences 1 shared publication

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