Y
Yuchun Du Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Federal Grant PI
High Impact
Professor
faculty
23 h-index
49 pubs
1,130 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Yuchun Du's research focuses on cancer biology and viral mechanisms. As a Professor at the University of Arkansas at Fayetteville, Du has investigated the proteomic and molecular underpinnings of various cancers, including triple-negative breast cancer and pancreatic cancer. This work has involved exploring novel therapeutic approaches, such as bioconjugated metal-organic frameworks for targeted photodynamic therapy, and studying the effects of specific compounds like ipomoeassin F on protein synthesis and cancer cell growth.
Further research by Du has delved into the molecular interactions within cancer cells, including the role of CDH1 mRNA and E-cadherin protein in carcinoma tissues and cell lines, and the impact of 17-β-estradiol on cell division and apoptosis in breast cancer cells. In parallel, Du's work has examined the interactions between host cellular machinery and viral components, specifically investigating the role of RuvB-Like Protein 2 in its interaction with the NS1 Protein of Influenza A Virus and its subsequent effect on apoptosis, a process counterbalanced by type I interferons. Du is the Principal Investigator on a $430,721 NIH/National Institute of Allergy and Infectious Diseases grant studying the role of RNA helicase DDX1 in influenza A virus replication. Du's scholarship metrics include an h-index of 23, 49 total publications, and 1,121 total citations.
Metrics
- h-index: 23
- Publications: 49
- Citations: 1,130
Selected Publications
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Effect of Ipomoeassin F on the Synthesis of Membrane and Secretory Proteins in Triple-Negative Breast Cancer Cells (2025)
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Proteomic Analysis Reveals Major Proteins and Pathways That Mediate the Effect of 17-β-Estradiol in Cell Division and Apoptosis in Breast Cancer MCF7 Cells (2024)
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Proteomic analysis reveals the dominant effect of ipomoeassin F on the synthesis of membrane and secretory proteins in triple-negative breast cancer cells (2024)
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Additional file 2 of A comprehensive analysis of different types of databases reveals that CDH1 mRNA and E-cadherin protein are not downregulated in most carcinoma tissues and carcinoma cell lines (2023)
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ER translocon inhibitor ipomoeassin F inhibits triple-negative breast cancer growth via blocking ER molecular chaperones (2023)
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A comprehensive analysis of different types of databases reveals that CDH1 mRNA and E-cadherin protein are not downregulated in most carcinoma tissues and carcinoma cell lines (2023)
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RuvB-Like Protein 2 Interacts with the NS1 Protein of Influenza A Virus and Affects Apoptosis That Is Counterbalanced by Type I Interferons (2021)
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A Bioconjugated Chlorin-Based Metal–Organic Framework for Targeted Photodynamic Therapy of Triple Negative Breast and Pancreatic Cancers (2021)
Federal Grants 1 $430,721 total
NIH/National Institute of Allergy and Infectious Diseases
Contact PI
Aug 2022 - Jul 2026
Collaboration Network
Top Collaborators
Jianhong Zhou
University of Arkansas at Fayetteville (US)
6 shared publications
- Proteomic Analysis Reveals Major Proteins and Pathways That Mediate the Effect of 17-β-Estradiol in Cell Division and Apoptosis in Breast Cancer MCF7 Cells
- Supplementary Figure 1 from Acquisition of Resistance of Pancreatic Cancer Cells to 2-Methoxyestradiol Is Associated with the Upregulation of Manganese Superoxide Dismutase
- Supplementary Figure 1 from Acquisition of Resistance of Pancreatic Cancer Cells to 2-Methoxyestradiol Is Associated with the Upregulation of Manganese Superoxide Dismutase
- Data from Acquisition of Resistance of Pancreatic Cancer Cells to 2-Methoxyestradiol Is Associated with the Upregulation of Manganese Superoxide Dismutase
- Data from Acquisition of Resistance of Pancreatic Cancer Cells to 2-Methoxyestradiol Is Associated with the Upregulation of Manganese Superoxide Dismutase
Showing 5 of 6 shared publications
Brihget Sicairos
University of Arkansas at Fayetteville
5 shared publications
In database
- A comprehensive analysis of different types of databases reveals that CDH1 mRNA and E-cadherin protein are not downregulated in most carcinoma tissues and carcinoma cell lines
- Proteomic Analysis Reveals Major Proteins and Pathways That Mediate the Effect of 17-β-Estradiol in Cell Division and Apoptosis in Breast Cancer MCF7 Cells
- Additional file 2 of A comprehensive analysis of different types of databases reveals that CDH1 mRNA and E-cadherin protein are not downregulated in most carcinoma tissues and carcinoma cell lines
- Proteomic analysis reveals the dominant effect of ipomoeassin F on the synthesis of membrane and secretory proteins in triple-negative breast cancer cells
- Effect of Ipomoeassin F on the Synthesis of Membrane and Secretory Proteins in Triple-Negative Breast Cancer Cells
Wei Shi
Ball State University (US)
3 shared publications
- ER translocon inhibitor ipomoeassin F inhibits triple-negative breast cancer growth via blocking ER molecular chaperones
- Proteomic analysis reveals the dominant effect of ipomoeassin F on the synthesis of membrane and secretory proteins in triple-negative breast cancer cells
- Effect of Ipomoeassin F on the Synthesis of Membrane and Secretory Proteins in Triple-Negative Breast Cancer Cells
Jianhong Zhou
University of Arkansas at Fayetteville
2 shared publications
In database
- RuvB-Like Protein 2 Interacts with the NS1 Protein of Influenza A Virus and Affects Apoptosis That Is Counterbalanced by Type I Interferons
- Effect of Ipomoeassin F on the Synthesis of Membrane and Secretory Proteins in Triple-Negative Breast Cancer Cells
Shorna Alam
2 shared publications
- A comprehensive analysis of different types of databases reveals that CDH1 mRNA and E-cadherin protein are not downregulated in most carcinoma tissues and carcinoma cell lines
- Additional file 2 of A comprehensive analysis of different types of databases reveals that CDH1 mRNA and E-cadherin protein are not downregulated in most carcinoma tissues and carcinoma cell lines
Zhijian Hu
Feinstein Institute for Medical Research (US)
2 shared publications
- ER translocon inhibitor ipomoeassin F inhibits triple-negative breast cancer growth via blocking ER molecular chaperones
- Effect of Ipomoeassin F on the Synthesis of Membrane and Secretory Proteins in Triple-Negative Breast Cancer Cells
Qingyang Zhang
University of Arkansas at Fayetteville (US)
2 shared publications
- Proteomic analysis reveals the dominant effect of ipomoeassin F on the synthesis of membrane and secretory proteins in triple-negative breast cancer cells
- Effect of Ipomoeassin F on the Synthesis of Membrane and Secretory Proteins in Triple-Negative Breast Cancer Cells
Yoshie Sakamaki
University of Arkansas at Fayetteville
1 shared publication
In database
- A Bioconjugated Chlorin-Based Metal–Organic Framework for Targeted Photodynamic Therapy of Triple Negative Breast and Pancreatic Cancers
John Ozdemir
University of Arkansas at Fayetteville
1 shared publication
In database
- A Bioconjugated Chlorin-Based Metal–Organic Framework for Targeted Photodynamic Therapy of Triple Negative Breast and Pancreatic Cancers
Zachary Heidrick
University of Arkansas at Fayetteville
1 shared publication
In database
- A Bioconjugated Chlorin-Based Metal–Organic Framework for Targeted Photodynamic Therapy of Triple Negative Breast and Pancreatic Cancers
Anthony Azzun
University of Arkansas at Fayetteville (US)
1 shared publication
- A Bioconjugated Chlorin-Based Metal–Organic Framework for Targeted Photodynamic Therapy of Triple Negative Breast and Pancreatic Cancers
Olivia Watson
University of Arkansas at Fayetteville (US)
1 shared publication
- A Bioconjugated Chlorin-Based Metal–Organic Framework for Targeted Photodynamic Therapy of Triple Negative Breast and Pancreatic Cancers
Miu Tsuji
University of Arkansas at Fayetteville (US)
1 shared publication
- A Bioconjugated Chlorin-Based Metal–Organic Framework for Targeted Photodynamic Therapy of Triple Negative Breast and Pancreatic Cancers
Christopher Salmon
University of Arkansas at Fayetteville
1 shared publication
In database
- A Bioconjugated Chlorin-Based Metal–Organic Framework for Targeted Photodynamic Therapy of Triple Negative Breast and Pancreatic Cancers
Arvind Sinha
University of Arkansas at Fayetteville (US)
1 shared publication
- A Bioconjugated Chlorin-Based Metal–Organic Framework for Targeted Photodynamic Therapy of Triple Negative Breast and Pancreatic Cancers
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