Match tier
Confirmed
Presence
Current · Arkansas
Last published
2025
Sources
OpenAlex · ORCID
Refreshed
2026-10-08
Y
Yuchun Du
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Federal Grant PI
High Impact
Professor
Also affiliated: University of North Carolina at Chapel Hill (2009); University of Nebraska–Lincoln (2000–2006); Los Alamos National Laboratory (2004–2005); University of California, Los Angeles (2005); Saga University (2000–2002); Rutgers Cancer Institute (2009); University of New Mexico Health Sciences Center (2004); Universidade Técnica de Lisboa (2001); University of California, Davis (2004)
23 h-index
46 pubs
1,123 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Yuchun Du's research focuses on molecular mechanisms underlying cellular processes, particularly in the context of cancer and viral infections. His work has investigated the role of specific proteins and signaling pathways in disease progression and cellular response.
His publications include studies on the overexpression of PUMA and its effect on reactive oxygen species and stathmin degradation in colorectal cancer cells. He has also explored the interaction of ipomoeassin F with Sec61α to inhibit protein translocation and the identification of heat shock proteins interacting with estrogen receptor alpha (ERα), including a biochemical characterization of the ERα-Hsp70 interaction. Further research has examined the interaction of ERα with mitochondrial protein HADHB and its impact on beta-oxidation activity. In the realm of viral infections, Du's work includes identifying proteins that interact with influenza A viral proteins, such as hnRNP A2/B1's interaction with NS1, which inhibits virus replication. He has also investigated proteome alterations in human alveolar macrophages in response to influenza A virus infection.
Du has received federal funding from the NIH/National Institute of Allergy and Infectious Diseases for his work on the role of RNA helicase DDX1 in influenza A virus replication, as well as from the NSF as a Co-PI on a project focused on mathematical and computational frameworks for predicting mutation-induced perturbations in molecular recognition. His scholarship metrics include an h-index of 23, 49 total publications, and 1,153 total citations, designating him as a highly cited researcher.
Metrics
- h-index: 23
- Publications: 46
- Citations: 1,123
Positions
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Professor 2007–presentUniversity of Arkansas at Fayetteville Biological Sciences ORCID
Selected Publications
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Effect of Ipomoeassin F on the Synthesis of Membrane and Secretory Proteins in Triple-Negative Breast Cancer Cells (2025)
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Proteomic Analysis Reveals Major Proteins and Pathways That Mediate the Effect of 17-β-Estradiol in Cell Division and Apoptosis in Breast Cancer MCF7 Cells (2024)
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Proteomic analysis reveals the dominant effect of ipomoeassin F on the synthesis of membrane and secretory proteins in triple-negative breast cancer cells (2024)
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Additional file 2 of A comprehensive analysis of different types of databases reveals that CDH1 mRNA and E-cadherin protein are not downregulated in most carcinoma tissues and carcinoma cell lines (2023)
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ER translocon inhibitor ipomoeassin F inhibits triple-negative breast cancer growth via blocking ER molecular chaperones (2023)
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A comprehensive analysis of different types of databases reveals that CDH1 mRNA and E-cadherin protein are not downregulated in most carcinoma tissues and carcinoma cell lines (2023)
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RuvB-Like Protein 2 Interacts with the NS1 Protein of Influenza A Virus and Affects Apoptosis That Is Counterbalanced by Type I Interferons (2021)
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A Bioconjugated Chlorin-Based Metal–Organic Framework for Targeted Photodynamic Therapy of Triple Negative Breast and Pancreatic Cancers (2021)
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Ring Expansion Leads to a More Potent Analogue of Ipomoeassin F (2020)
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Maltotriose Conjugated Metal–Organic Frameworks for Selective Targeting and Photodynamic Therapy of Triple Negative Breast Cancer Cells and Tumor Associated Macrophages (2020)
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Upregulation of CD73 Confers Acquired Radioresistance and is Required for Maintaining Irradiation-selected Pancreatic Cancer Cells in a Mesenchymal State (2019)
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Model-free feature screening for categorical outcomes: Nonlinear effect detection and false discovery rate control (2019)
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Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation (2019)
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Abstract P6-08-11: Histone acetyltransferase 1 interacts with estrogen receptor alpha (ERα) and affects the transcriptional activity of ERα in breast cancer cells (2017)
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Abstract B05: Ecto-5’-nucleotidase (CD73) confers radioresistance in pancreatic cancer (2016)
Federal Grants 2 $1,030,590 total
NIH
Contact PI
Aug 2022 - Jul 2026
Collaboration Network
Top Collaborators
Jianhong Zhou
University of Arkansas at Fayetteville (US)
14 shared publications
- Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation
- Systematic Proteomic Identification of the Heat Shock Proteins (Hsp) that Interact with Estrogen Receptor Alpha (ERα) and Biochemical Characterization of the ERα-Hsp70 Interaction
- Estrogen Receptor Alpha Interacts with Mitochondrial Protein HADHB and Affects Beta-Oxidation Activity
- Total Synthesis and Biological Evaluation of Ipomoeassin F and Its Unnatural 11R-Epimer
- Proteome Alterations in Primary Human Alveolar Macrophages in Response to Influenza A Virus Infection
Showing 5 of 14 shared publications
Wei Shi
Ball State University (US)
7 shared publications
- Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation
- Total Synthesis and Biological Evaluation of Ipomoeassin F and Its Unnatural 11R-Epimer
- Ring Expansion Leads to a More Potent Analogue of Ipomoeassin F
- ER translocon inhibitor ipomoeassin F inhibits triple-negative breast cancer growth via blocking ER molecular chaperones
- Proteomic analysis reveals the dominant effect of ipomoeassin F on the synthesis of membrane and secretory proteins in triple-negative breast cancer cells
Showing 5 of 7 shared publications
Brihget Sicairos
University of Arkansas at Fayetteville
6 shared publications
In database
- Upregulation of CD73 Confers Acquired Radioresistance and is Required for Maintaining Irradiation-selected Pancreatic Cancer Cells in a Mesenchymal State
- A comprehensive analysis of different types of databases reveals that CDH1 mRNA and E-cadherin protein are not downregulated in most carcinoma tissues and carcinoma cell lines
- Proteomic Analysis Reveals Major Proteins and Pathways That Mediate the Effect of 17-β-Estradiol in Cell Division and Apoptosis in Breast Cancer MCF7 Cells
- Additional file 2 of A comprehensive analysis of different types of databases reveals that CDH1 mRNA and E-cadherin protein are not downregulated in most carcinoma tissues and carcinoma cell lines
- Proteomic analysis reveals the dominant effect of ipomoeassin F on the synthesis of membrane and secretory proteins in triple-negative breast cancer cells
Showing 5 of 6 shared publications
Yimeng Wang
University of Arkansas at Fayetteville (US)
5 shared publications
- Proteome Alterations in Primary Human Alveolar Macrophages in Response to Influenza A Virus Infection
- hnRNP A2/B1 interacts with influenza A viral protein NS1 and inhibits virus replication potentially through suppressing NS1 RNA/protein levels and NS1 mRNA nuclear export
- Immunoadjuvant effects of bacterial genomic DNA and CpG oligodeoxynucleotides on avian influenza virus subtype H5N1 inactivated oil emulsion vaccine in chicken
- Inhibition of Type I Interferon Production via Suppressing IKK-Gamma Expression: A New Strategy for Counteracting Host Antiviral Defense by Influenza A Viruses?
- RuvB-Like Protein 2 Interacts with the NS1 Protein of Influenza A Virus and Affects Apoptosis That Is Counterbalanced by Type I Interferons
Zhenqi Zhou
University of Arkansas at Fayetteville (US)
5 shared publications
- Systematic Proteomic Identification of the Heat Shock Proteins (Hsp) that Interact with Estrogen Receptor Alpha (ERα) and Biochemical Characterization of the ERα-Hsp70 Interaction
- Estrogen Receptor Alpha Interacts with Mitochondrial Protein HADHB and Affects Beta-Oxidation Activity
- Estrogen receptor beta interacts and colocalizes with HADHB in mitochondria
- Proteomic Analysis Reveals Major Proteins and Pathways That Mediate the Effect of 17-β-Estradiol in Cell Division and Apoptosis in Breast Cancer MCF7 Cells
- Abstract P6-08-11: Histone acetyltransferase 1 interacts with estrogen receptor alpha (ERα) and affects the transcriptional activity of ERα in breast cancer cells
Guanghui Zong
University of Maryland, College Park (US)
4 shared publications
- Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation
- Total Synthesis and Biological Evaluation of Ipomoeassin F and Its Unnatural 11R-Epimer
- Ring Expansion Leads to a More Potent Analogue of Ipomoeassin F
- ER translocon inhibitor ipomoeassin F inhibits triple-negative breast cancer growth via blocking ER molecular chaperones
Zhijian Hu
Northwell Health (US)
4 shared publications
- Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation
- Total Synthesis and Biological Evaluation of Ipomoeassin F and Its Unnatural 11R-Epimer
- Ring Expansion Leads to a More Potent Analogue of Ipomoeassin F
- Proteomic analysis reveals the dominant effect of ipomoeassin F on the synthesis of membrane and secretory proteins in triple-negative breast cancer cells
Jianhong Zhou
University of Arkansas at Fayetteville
4 shared publications
In database
- hnRNP A2/B1 interacts with influenza A viral protein NS1 and inhibits virus replication potentially through suppressing NS1 RNA/protein levels and NS1 mRNA nuclear export
- Inhibition of Type I Interferon Production via Suppressing IKK-Gamma Expression: A New Strategy for Counteracting Host Antiviral Defense by Influenza A Viruses?
- RuvB-Like Protein 2 Interacts with the NS1 Protein of Influenza A Virus and Affects Apoptosis That Is Counterbalanced by Type I Interferons
- Effect of Ipomoeassin F on the Synthesis of Membrane and Secretory Proteins in Triple-Negative Breast Cancer Cells
Qingyang Zhang
University of Arkansas at Fayetteville
4 shared publications
In database
- Model-free feature screening for categorical outcomes: Nonlinear effect detection and false discovery rate control
- Proteomic analysis reveals the dominant effect of ipomoeassin F on the synthesis of membrane and secretory proteins in triple-negative breast cancer cells
- Proteomic analysis reveals the dominant effect of ipomoeassin F on the synthesis of membrane and secretory proteins in triple-negative breast cancer cells
- Effect of Ipomoeassin F on the Synthesis of Membrane and Secretory Proteins in Triple-Negative Breast Cancer Cells
Ahmed E. Dhamad
University of Arkansas at Fayetteville (US)
2 shared publications
- Systematic Proteomic Identification of the Heat Shock Proteins (Hsp) that Interact with Estrogen Receptor Alpha (ERα) and Biochemical Characterization of the ERα-Hsp70 Interaction
- Abstract P6-08-11: Histone acetyltransferase 1 interacts with estrogen receptor alpha (ERα) and affects the transcriptional activity of ERα in breast cancer cells
Anna Nguyen
University of Arkansas at Fayetteville (US)
2 shared publications
- Upregulation of CD73 Confers Acquired Radioresistance and is Required for Maintaining Irradiation-selected Pancreatic Cancer Cells in a Mesenchymal State
- Abstract B05: Ecto-5’-nucleotidase (CD73) confers radioresistance in pancreatic cancer
Sarah O’Keefe
University of Manchester (GB)
2 shared publications
- Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation
- Ring Expansion Leads to a More Potent Analogue of Ipomoeassin F
Stephen High
University of Manchester (GB)
2 shared publications
- Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation
- Ring Expansion Leads to a More Potent Analogue of Ipomoeassin F
Yoshie Sakamaki
University of Arkansas at Fayetteville
2 shared publications
In database
- A Bioconjugated Chlorin-Based Metal–Organic Framework for Targeted Photodynamic Therapy of Triple Negative Breast and Pancreatic Cancers
- Maltotriose Conjugated Metal–Organic Frameworks for Selective Targeting and Photodynamic Therapy of Triple Negative Breast Cancer Cells and Tumor Associated Macrophages
John Ozdemir
University of Arkansas at Fayetteville
2 shared publications
In database
- A Bioconjugated Chlorin-Based Metal–Organic Framework for Targeted Photodynamic Therapy of Triple Negative Breast and Pancreatic Cancers
- Maltotriose Conjugated Metal–Organic Frameworks for Selective Targeting and Photodynamic Therapy of Triple Negative Breast Cancer Cells and Tumor Associated Macrophages
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