Yuchun Du
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Professor
Also affiliated: University of Nebraska–Lincoln (2000–2006); Tongji University (2016–2018); Los Alamos National Laboratory (2004–2005); University of Lisbon (2001); University of California, Los Angeles (2005); University of New Mexico (2004); Saga University (2000–2002); Rutgers Cancer Institute (2009)
Faculty Researcher
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Yuchun Du investigates molecular mechanisms underlying cancer development and progression, with a particular focus on triple-negative breast cancer and pancreatic cancer. His work has explored the therapeutic potential of novel agents, including bioconjugated chlorin-based metal–organic frameworks for targeted photodynamic therapy. Du's research also examines the effects of specific compounds, such as ipomoeassin F, on protein synthesis and cancer cell growth, investigating its role in blocking endoplasmic reticulum molecular chaperones. He has also conducted proteomic analyses to identify key proteins and pathways affected by 17-β-estradiol in breast cancer cells, contributing to an understanding of cell division and apoptosis.
In addition to cancer research, Du studies viral interactions and host responses. He has investigated the interplay between RuvB-Like Protein 2 and the NS1 Protein of Influenza A Virus, examining its influence on apoptosis and the counterbalancing effect of type I interferons. This work is supported by federal funding, including a $430,721 grant from the NIH/National Institute of Allergy and Infectious Diseases to study the role of RNA helicase DDX1 in influenza A virus replication. Du's research network includes collaborators such as Brihget Sicairos and Qingyang Zhang at the University of Arkansas at Fayetteville, and Samuel G. Mackintosh at the University of Arkansas for Medical Sciences.
With an h-index of 23 and over 1,100 citations from 49 publications, Du is recognized as a highly cited researcher. His laboratory maintains an active website, indicating ongoing research activities.
Metrics
- h-index: 23
- Publications: 49
- Citations: 1,148
Selected Publications
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Effect of Ipomoeassin F on the Synthesis of Membrane and Secretory Proteins in Triple-Negative Breast Cancer Cells (2025)
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Proteomic Analysis Reveals Major Proteins and Pathways That Mediate the Effect of 17-β-Estradiol in Cell Division and Apoptosis in Breast Cancer MCF7 Cells (2024)
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Proteomic analysis reveals the dominant effect of ipomoeassin F on the synthesis of membrane and secretory proteins in triple-negative breast cancer cells (2024)
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Additional file 2 of A comprehensive analysis of different types of databases reveals that CDH1 mRNA and E-cadherin protein are not downregulated in most carcinoma tissues and carcinoma cell lines (2023)
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ER translocon inhibitor ipomoeassin F inhibits triple-negative breast cancer growth via blocking ER molecular chaperones (2023)
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A comprehensive analysis of different types of databases reveals that CDH1 mRNA and E-cadherin protein are not downregulated in most carcinoma tissues and carcinoma cell lines (2023)
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RuvB-Like Protein 2 Interacts with the NS1 Protein of Influenza A Virus and Affects Apoptosis That Is Counterbalanced by Type I Interferons (2021)
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A Bioconjugated Chlorin-Based Metal–Organic Framework for Targeted Photodynamic Therapy of Triple Negative Breast and Pancreatic Cancers (2021)
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Ring Expansion Leads to a More Potent Analogue of Ipomoeassin F (2020)
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Maltotriose Conjugated Metal–Organic Frameworks for Selective Targeting and Photodynamic Therapy of Triple Negative Breast Cancer Cells and Tumor Associated Macrophages (2020)
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Upregulation of CD73 Confers Acquired Radioresistance and is Required for Maintaining Irradiation-selected Pancreatic Cancer Cells in a Mesenchymal State (2019)
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Model-free feature screening for categorical outcomes: Nonlinear effect detection and false discovery rate control (2019)
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Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation (2019)
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Abstract P6-08-11: Histone acetyltransferase 1 interacts with estrogen receptor alpha (ERα) and affects the transcriptional activity of ERα in breast cancer cells (2017)
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Abstract B05: Ecto-5’-nucleotidase (CD73) confers radioresistance in pancreatic cancer (2016)
Federal Grants 2 $1,030,590 total
Collaboration Network
Top Collaborators
- A comprehensive analysis of different types of databases reveals that CDH1 mRNA and E-cadherin protein are not downregulated in most carcinoma tissues and carcinoma cell lines
- Proteomic Analysis Reveals Major Proteins and Pathways That Mediate the Effect of 17-β-Estradiol in Cell Division and Apoptosis in Breast Cancer MCF7 Cells
- Additional file 2 of A comprehensive analysis of different types of databases reveals that CDH1 mRNA and E-cadherin protein are not downregulated in most carcinoma tissues and carcinoma cell lines
- Proteomic analysis reveals the dominant effect of ipomoeassin F on the synthesis of membrane and secretory proteins in triple-negative breast cancer cells
- Effect of Ipomoeassin F on the Synthesis of Membrane and Secretory Proteins in Triple-Negative Breast Cancer Cells
- ER translocon inhibitor ipomoeassin F inhibits triple-negative breast cancer growth via blocking ER molecular chaperones
- Proteomic analysis reveals the dominant effect of ipomoeassin F on the synthesis of membrane and secretory proteins in triple-negative breast cancer cells
- Proteomic analysis reveals the dominant effect of ipomoeassin F on the synthesis of membrane and secretory proteins in triple-negative breast cancer cells
- Effect of Ipomoeassin F on the Synthesis of Membrane and Secretory Proteins in Triple-Negative Breast Cancer Cells
- Proteomic analysis reveals the dominant effect of ipomoeassin F on the synthesis of membrane and secretory proteins in triple-negative breast cancer cells
- Proteomic analysis reveals the dominant effect of ipomoeassin F on the synthesis of membrane and secretory proteins in triple-negative breast cancer cells
- Effect of Ipomoeassin F on the Synthesis of Membrane and Secretory Proteins in Triple-Negative Breast Cancer Cells
- RuvB-Like Protein 2 Interacts with the NS1 Protein of Influenza A Virus and Affects Apoptosis That Is Counterbalanced by Type I Interferons
- Effect of Ipomoeassin F on the Synthesis of Membrane and Secretory Proteins in Triple-Negative Breast Cancer Cells
- A comprehensive analysis of different types of databases reveals that CDH1 mRNA and E-cadherin protein are not downregulated in most carcinoma tissues and carcinoma cell lines
- Additional file 2 of A comprehensive analysis of different types of databases reveals that CDH1 mRNA and E-cadherin protein are not downregulated in most carcinoma tissues and carcinoma cell lines
- ER translocon inhibitor ipomoeassin F inhibits triple-negative breast cancer growth via blocking ER molecular chaperones
- Effect of Ipomoeassin F on the Synthesis of Membrane and Secretory Proteins in Triple-Negative Breast Cancer Cells
- Proteomic Analysis Reveals Major Proteins and Pathways That Mediate the Effect of 17-β-Estradiol in Cell Division and Apoptosis in Breast Cancer MCF7 Cells
- Proteomic analysis reveals the dominant effect of ipomoeassin F on the synthesis of membrane and secretory proteins in triple-negative breast cancer cells
- A Bioconjugated Chlorin-Based Metal–Organic Framework for Targeted Photodynamic Therapy of Triple Negative Breast and Pancreatic Cancers
- A Bioconjugated Chlorin-Based Metal–Organic Framework for Targeted Photodynamic Therapy of Triple Negative Breast and Pancreatic Cancers
- A Bioconjugated Chlorin-Based Metal–Organic Framework for Targeted Photodynamic Therapy of Triple Negative Breast and Pancreatic Cancers
- A Bioconjugated Chlorin-Based Metal–Organic Framework for Targeted Photodynamic Therapy of Triple Negative Breast and Pancreatic Cancers
- A Bioconjugated Chlorin-Based Metal–Organic Framework for Targeted Photodynamic Therapy of Triple Negative Breast and Pancreatic Cancers
- A Bioconjugated Chlorin-Based Metal–Organic Framework for Targeted Photodynamic Therapy of Triple Negative Breast and Pancreatic Cancers
- A Bioconjugated Chlorin-Based Metal–Organic Framework for Targeted Photodynamic Therapy of Triple Negative Breast and Pancreatic Cancers
- A Bioconjugated Chlorin-Based Metal–Organic Framework for Targeted Photodynamic Therapy of Triple Negative Breast and Pancreatic Cancers
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