Yuchun Du Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

Federal Grant PI High Impact

Professor

University of Arkansas at Fayetteville

faculty

23 h-index 49 pubs 1,117 cited

Research Areas

Cancer-related molecular mechanisms research Influenza Virus Research Studies Protein Structure and Dynamics Nanoparticles: synthesis and applications Metabolomics and Mass Spectrometry Studies Cancer Treatment and Pharmacology RNA and protein synthesis mechanisms

Links

ORCID Lab Website

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OverviewAI-generated summary

Yuchun Du, a professor at the University of Arkansas at Fayetteville, investigates molecular mechanisms underlying cancer development and viral replication. His research has focused on triple-negative breast cancer, exploring therapeutic strategies such as photodynamic therapy using bioconjugated chlorin-based metal–organic frameworks. Du's work also delves into the role of endoplasmic reticulum translocon inhibitors, like ipomoeassin F, in blocking cancer cell growth by interfering with protein synthesis pathways. He has also examined the interaction of RuvB-Like Protein 2 with the NS1 protein of Influenza A virus, and its impact on apoptosis, which is counterbalanced by type I interferons. His research utilizes proteomic analysis to identify key proteins and pathways involved in cellular processes, including cell division and apoptosis, particularly in response to hormonal influences like 17-β-estradiol in breast cancer cells.

Metrics

  • h-index: 23
  • Publications: 49
  • Citations: 1,117

Selected Publications

  • Effect of Ipomoeassin F on the Synthesis of Membrane and Secretory Proteins in Triple-Negative Breast Cancer Cells (2025) DOI
  • Proteomic Analysis Reveals Major Proteins and Pathways That Mediate the Effect of 17-β-Estradiol in Cell Division and Apoptosis in Breast Cancer MCF7 Cells (2024) DOI
  • Proteomic analysis reveals the dominant effect of ipomoeassin F on the synthesis of membrane and secretory proteins in triple-negative breast cancer cells (2024) DOI
  • Additional file 2 of A comprehensive analysis of different types of databases reveals that CDH1 mRNA and E-cadherin protein are not downregulated in most carcinoma tissues and carcinoma cell lines (2023) DOI
  • ER translocon inhibitor ipomoeassin F inhibits triple-negative breast cancer growth via blocking ER molecular chaperones (2023) DOI
  • A comprehensive analysis of different types of databases reveals that CDH1 mRNA and E-cadherin protein are not downregulated in most carcinoma tissues and carcinoma cell lines (2023) DOI
  • RuvB-Like Protein 2 Interacts with the NS1 Protein of Influenza A Virus and Affects Apoptosis That Is Counterbalanced by Type I Interferons (2021) DOI
  • A Bioconjugated Chlorin-Based Metal–Organic Framework for Targeted Photodynamic Therapy of Triple Negative Breast and Pancreatic Cancers (2021) DOI

Federal Grants 1 $430,721 total

NIH/National Institute of Allergy and Infectious Diseases Contact PI Aug 2022 - Jul 2026

Role of RNA helicase DDX1 in influenza A virus replication

National Institute of Allergy and Infectious Diseases $430,721 R15

Collaborators

Researchers in the database who share publications

Brihget Sicairos University of Arkansas at Fayetteville 5 shared publications Qingyang Zhang University of Arkansas at Fayetteville 2 shared publications Samuel G. Mackintosh University of Arkansas for Medical Sciences 1 shared publication Jianhong Zhou University of Arkansas at Fayetteville 1 shared publication Zachary McConnell University of Arkansas at Fayetteville 1 shared publication Christopher Salmon University of Arkansas at Fayetteville 1 shared publication M. Hassan Beyzavi University of Arkansas at Fayetteville 1 shared publication John Ozdemir University of Arkansas at Fayetteville 1 shared publication

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