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Biography and Research Information
OverviewAI-generated summary
Lauren C. Morehead's research focuses on the role of metabolism in cancer, particularly the impact of methionine restriction on immune checkpoint inhibitor efficacy. Studies have investigated differences in cell death pathways related to methionine and cysteine depletion, and the characterization of methionine dependence in melanoma cells. Morehead has also explored the chemical inhibition of DNA-PKcs and its effect on T cell activation and cytotoxicity. Additionally, research has examined the induction of major histocompatibility complex class I antigen presentation by resveratrol in melanoma, and a case report on theophylline's correction of sinus node dysfunction in lithium toxicity.
Morehead's work involves collaborations with several faculty members at the University of Arkansas for Medical Sciences, including Alan J. Tackett, Isabelle R. Miousse, Brian Koss, and Katherine Wallis, with whom she has co-authored multiple publications. Her scholarship includes an h-index of 6, 21 total publications, and 118 total citations.
Metrics
- h-index: 6
- Publications: 21
- Citations: 121
Selected Publications
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A Teenager With a Painful Arm Nodule: Answer (2025)
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A Teenager With a Painful Arm Nodule: Challenge (2025)
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EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma (2025)
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Histopathologic Features in Urticaria and Urticarial Variants: Plasma Cells Should Be Rare (2025)
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Impact of the Society for Pediatric Dermatology Mentorship Award Program on Careers in Pediatric Dermatology: Workforce Implications (2024)
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Oral theophylline corrects sinus node dysfunction in acute on chronic lithium toxicity: case report and systematic review of lithium-induced Sinus node dysfunction (2024)
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Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma (2023)
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Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model (2023)
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Characterization of methionine dependence in melanoma cells (2023)
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Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells (2023)
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Abstract LB041: EZH2 and ATF6 sense metabolic stress to balance MHC class I antigen presentation in melanoma (2023)
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Increased response to immune checkpoint inhibitors with dietary methionine restriction (2023)
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Characterization of methionine dependence in melanoma cells (2023)
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Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction (2023)
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Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4 <sup>+</sup> helper and CD8 <sup>+</sup> effector T cells (2022)
Collaboration Network
Top Collaborators
Alan J. Tackett
University of Arkansas for Medical Sciences
10 shared publications
In database
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model
- Characterization of methionine dependence in melanoma cells
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction
- Increased response to immune checkpoint inhibitors with dietary methionine restriction
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
Showing 5 of 10 shared publications
Isabelle R. Miousse
University of Arkansas for Medical Sciences
9 shared publications
In database
- Differences in cell death in methionine versus cysteine depletion
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model
- Characterization of methionine dependence in melanoma cells
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction
- Increased response to immune checkpoint inhibitors with dietary methionine restriction
Showing 5 of 9 shared publications
Brian Koss
University of Arkansas for Medical Sciences
7 shared publications
In database
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
- Abstract 1577: Caloric restriction mimetics as adjuvant to immune checkpoint inhibitors for treatment of melanoma
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- Abstract 6131: Harnessing resveratrol-mediated restoration of MHC-I in melanoma to enhance immunotherapy
Showing 5 of 7 shared publications
Katherine Wallis
University of Arkansas for Medical Sciences
6 shared publications
In database
- Differences in cell death in methionine versus cysteine depletion
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction
- Increased response to immune checkpoint inhibitors with dietary methionine restriction
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
Showing 5 of 6 shared publications
Sarita Garg
University of Arkansas for Medical Sciences
6 shared publications
In database
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model
- Characterization of methionine dependence in melanoma cells
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction
- Increased response to immune checkpoint inhibitors with dietary methionine restriction
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
Showing 5 of 6 shared publications
Jordan T. Bird
University of Arkansas for Medical Sciences (US)
3 shared publications
- Differences in cell death in methionine versus cysteine depletion
- Characterization of methionine dependence in melanoma cells
- Characterization of methionine dependence in melanoma cells
Stephanie D. Byrum
University of Arkansas for Medical Sciences
3 shared publications
In database
- Differences in cell death in methionine versus cysteine depletion
- Characterization of methionine dependence in melanoma cells
- Characterization of methionine dependence in melanoma cells
Eric R. Siegel
University of Arkansas for Medical Sciences
3 shared publications
In database
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction
- Increased response to immune checkpoint inhibitors with dietary methionine restriction
Billie Heflin
University of Arkansas for Medical Sciences
3 shared publications
In database
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- Abstract LB041: EZH2 and ATF6 sense metabolic stress to balance MHC class I antigen presentation in melanoma
Daniel Fil
University of Arkansas for Medical Sciences
3 shared publications
In database
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
Markus D. Boos
University of Washington (US)
3 shared publications
- Impact of the Society for Pediatric Dermatology Mentorship Award Program on Careers in Pediatric Dermatology: Workforce Implications
- A Teenager With a Painful Arm Nodule: Challenge
- A Teenager With a Painful Arm Nodule: Answer
Ana Clara P. Azevedo‐Pouly
University of Arkansas for Medical Sciences
2 shared publications
In database
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4 <sup>+</sup> helper and CD8 <sup>+</sup> effector T cells
Lauren Appell
Arkansas Children's Hospital
2 shared publications
In database
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4 <sup>+</sup> helper and CD8 <sup>+</sup> effector T cells
Lyle Burdine
University of Arkansas for Medical Sciences (US)
2 shared publications
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4 <sup>+</sup> helper and CD8 <sup>+</sup> effector T cells
Lora J. Rogers
University of Arkansas for Medical Sciences
2 shared publications
In database
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4 <sup>+</sup> helper and CD8 <sup>+</sup> effector T cells
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