Robert W. Williams
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professor and chair
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Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Robert W. Williams' research focuses on the genetic basis of complex traits and disease mechanisms. He has a significant publication record, with over 880 publications and more than 37,000 citations, reflected in his h-index of 96. His work has investigated quantitative trait loci and their influence on phenotypes in various model organisms, including mice and *Drosophila*.
His research has explored areas such as the genetic architecture of gene expression, the role of mitonuclear protein imbalance in longevity, and the genetic variants affecting human brain structures. Williams has also contributed to the development and utilization of research resources like the Collaborative Cross, a mouse model designed for genetic analysis of complex traits. His laboratory maintains an active website, and he has collaborated with researchers such as Mary A. Phillips from the University of Arkansas for Medical Sciences on shared publications.
Metrics
- h-index: 96
- Publications: 880
- Citations: 37,533
Positions
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professor and chair 1989–presentUniversity of Tennessee Health Science Center Genetics, Genomics and Informatics ORCID
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professor and chairArkansas State University ORCID
Selected Publications
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Open problems in ageing science: a roadmap for biogerontology (2025)
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Progress, challenges and future directions in marine organic-walled dinoflagellate cyst research: New insights from an international workshop (2025)
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The Duke Mouse Brain Atlas: MRI and light sheet microscopy stereotaxic atlas of the mouse brain (2025)
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Inbred rat heredity and sex affect oral oxycodone self-administration and augmented intake in long sessions: correlations with anxiety and novelty-seeking (2025)
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Male and female behavioral variability and morphine response in C57BL/6J, DBA/2J, and their BXD progeny following chronic stress exposure (2024)
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Building pangenome graphs (2024)
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A revamped rat reference genome improves the discovery of genetic diversity in laboratory rats (2024)
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GenomeMUSter mouse genetic variation service enables multitrait, multipopulation data integration and analysis (2024)
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Scalable, accessible and reproducible reference genome assembly and evaluation in Galaxy (2024)
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ACNP 62nd Annual Meeting: Poster Abstracts P251 – P500 (2023)
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Increased development of T-bet+CD11c+ B cells predisposes to lupus in females: Analysis in BXD2 mouse and genetic crosses (2023)
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A rapid workflow for neuron counting in combined light sheet microscopy and magnetic resonance histology (2023)
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DNA methylation networks underlying mammalian traits (2023)
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Universal DNA methylation age across mammalian tissues (2023)
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IGFBPL1 is a master driver of microglia homeostasis and resolution of neuroinflammation in glaucoma and brain tauopathy (2023)
Collaboration Network
Top Collaborators
- The Collaborative Cross, a community resource for the genetic analysis of complex traits
- Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function
- A new set of BXD recombinant inbred lines from advanced intercross populations in mice
- Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'
- Murine Gut Microbiota Is Defined by Host Genetics and Modulates Variation of Metabolic Traits
Showing 5 of 50 shared publications
- GeneNetwork: A Toolbox for Systems Genetics
- A platform for experimental precision medicine: The extended BXD mouse family
- Joint mouse–human phenome-wide association to test gene function and disease risk
- Genetic Variation in the Social Environment Contributes to Health and Disease
- Alcohol trait and transcriptional genomic analysis of C57BL/6 substrains
Showing 5 of 22 shared publications
- A platform for experimental precision medicine: The extended BXD mouse family
- Building pangenome graphs
- Building pangenome graphs
- A natural mutator allele shapes mutation spectrum variation in mice
- Merged magnetic resonance and light sheet microscopy of the whole mouse brain
Showing 5 of 16 shared publications
- Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function
- Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'
- WebQTL: Web-Based Complex Trait Analysis
- The Collaborative Cross at Oak Ridge National Laboratory: developing a powerful resource for systems genetics
- WebQTL: rapid exploratory analysis of gene expression and genetic networks for brain and behavior
Showing 5 of 14 shared publications
- The Collaborative Cross, a community resource for the genetic analysis of complex traits
- Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function
- Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'
- The Collaborative Cross at Oak Ridge National Laboratory: developing a powerful resource for systems genetics
- Reproducibility and replicability of rodent phenotyping in preclinical studies
Showing 5 of 14 shared publications
- Strain Differences in Stress Responsivity Are Associated with Divergent Amygdala Gene Expression and Glutamate-Mediated Neuronal Excitability
- GeneNetwork: A Toolbox for Systems Genetics
- Joint mouse–human phenome-wide association to test gene function and disease risk
- Variation in Mouse Basolateral Amygdala Volume is Associated With Differences in Stress Reactivity and Fear Learning
- Dissection of a QTL Hotspot on Mouse Distal Chromosome 1 that Modulates Neurobehavioral Phenotypes and Gene Expression
Showing 5 of 13 shared publications
- Mitonuclear protein imbalance as a conserved longevity mechanism
- Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals
- Murine Gut Microbiota Is Defined by Host Genetics and Modulates Variation of Metabolic Traits
- Systems Genetics of Metabolism: The Use of the BXD Murine Reference Panel for Multiscalar Integration of Traits
- Metabolic Networks of Longevity
Showing 5 of 13 shared publications
- Building pangenome graphs
- Building pangenome graphs
- Facilitating Complex Trait Analysis via Reduced Complexity Crosses
- GeneCup: mining PubMed and GWAS catalog for gene–keyword relationships
- Deep sequencing of a large family of isogenic mice enables complex variants discovery and accurate phenotype mapping
Showing 5 of 8 shared publications
- Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function
- Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'
- WebQTL: Web-Based Complex Trait Analysis
- WebQTL: rapid exploratory analysis of gene expression and genetic networks for brain and behavior
- Genetic Correlates of Gene Expression in Recombinant Inbred Strains: A Relational Model System to Explore Neurobehavioral Phenotypes
Showing 5 of 7 shared publications
- Genetic and Environmental Control of Variation in Retinal Ganglion Cell Number in Mice
- PolymiRTS Database: linking polymorphisms in microRNA target sites with complex traits
- Natural Variation in Neuron Number in Mice Is Linked to a Major Quantitative Trait Locus on Chr 11
- Genetic control of retinal projections in inbred strains of albino mice
- Structure of clonal and polyclonal cell arrays in chimeric mouse retina.
Showing 5 of 7 shared publications
- Growth cones, dying axons, and developmental fluctuations in the fiber population of the cat's optic nerve
- Prenatal development of retinocollicular projections in the cat: an anterograde tracer transport study
- Uniformity of cell distribution in the ganglion cell layer of prenatal cat retina: Implications for mechanisms of retinal development
- Formation of Retinal Ganglion Cell Topography During Prenatal Development
- Binocular interaction in the fetal cat regulates the size of the ganglion cell population
Showing 5 of 6 shared publications
- The genetic structure of recombinant inbred mice: high-resolution consensus maps for complex trait analysis
- PolymiRTS Database: linking polymorphisms in microRNA target sites with complex traits
- Genetic architecture of the mouse hippocampus: identification of gene loci with selective regional effects
- Genetic Segregation of Spontaneous Erosive Arthritis and Generalized Autoimmune Disease in the BXD2 Recombinant Inbred Strain of Mice
- Age-related thymic involution in C57BL/6J × DBA/2J recombinant-inbred mice maps to mouse chromosomes 9 and 10
Showing 5 of 6 shared publications
- Murine Gut Microbiota Is Defined by Host Genetics and Modulates Variation of Metabolic Traits
- Dissection of a QTL Hotspot on Mouse Distal Chromosome 1 that Modulates Neurobehavioral Phenotypes and Gene Expression
- Gene expression in the mouse eye: an online resource for genetics using 103 strains of mice.
- Complex Control of GABA(A) Receptor Subunit mRNA Expression: Variation, Covariation, and Genetic Regulation
- Detection, Validation, and Downstream Analysis of Allelic Variation in Gene Expression
Showing 5 of 6 shared publications
- Ethanol-Responsive Brain Region Expression Networks: Implications for Behavioral Responses to Acute Ethanol in DBA/2J versus C57BL/6J Mice
- Genetic Dissection of Acute Ethanol Responsive Gene Networks in Prefrontal Cortex: Functional and Mechanistic Implications
- Alcohol trait and transcriptional genomic analysis of C57BL/6 substrains
- KCNN Genes that Encode Small-Conductance Ca2+-Activated K+ Channels Influence Alcohol and Drug Addiction
- A Transposon in Comt Generates mRNA Variants and Causes Widespread Expression and Behavioral Differences among Mice
Showing 5 of 6 shared publications
- Murine Gut Microbiota Is Defined by Host Genetics and Modulates Variation of Metabolic Traits
- Systems Genetics of Metabolism: The Use of the BXD Murine Reference Panel for Multiscalar Integration of Traits
- A platform for experimental precision medicine: The extended BXD mouse family
- Joint mouse–human phenome-wide association to test gene function and disease risk
- Multiomic profiling of the liver across diets and age in a diverse mouse population
Showing 5 of 6 shared publications
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