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Presence Current · Arkansas
Last published 2024
Sources OpenAlex · ORCID
Refreshed 2026-08-20

En Huang

Federal Grant PI

Associate Professor

Also affiliated: Wuhan Polytechnic University (2018); Brown University (2005); Ghent University (2021); The Ohio State University (2012–2024); Temple University (2022)

Faculty Researcher

Environmental Health Sciences, College of Public Health

18 h-index 48 pubs 970 cited

  • Anti-Bacterial Agents
  • Microbial Sensitivity Tests
  • Lipopeptides
  • Humans
  • Paenibacillus
  • Escherichia coli
  • Bacteriocins
  • Animals
  • Klebsiella pneumoniae
  • Carbapenems
  • Antimicrobial Cationic Peptides
  • Molecular Sequence Data
  • Genome, Bacterial
  • Escherichia coli O157
  • Cefiderocol

Biography and Research Information

OverviewAI-generated summary

En Huang researches the development of natural antimicrobial compounds to enhance food safety and quality. This work includes discovering and characterizing natural antimicrobial peptides, such as bacteriocins, and lipopeptides using chemical and genetic methods. These agents have potential applications as natural food preservatives, animal feed additives, or novel antibiotics against drug-resistant bacteria.

Huang also investigates the transmission, ecology, and evolution of foodborne pathogens and spoilage microorganisms. This research utilizes genomic, transcriptomic, and metagenomic approaches. Huang's work on cefiderocol resistance in carbapenem-resistant pathogens has been supported by a $1 grant from the NIH/National Institute of Allergy and Infectious Diseases, with Huang serving as PI.

With a career h-index of 18 and 957 citations across 48 publications, Huang actively collaborates with researchers at the University of Arkansas for Medical Sciences, including Sun Hee Moon (7 shared publications) and Se‐Ran Jun (5 shared publications). Huang maintains an active lab website and is a recently active researcher.

Metrics

  • h-index: 18
  • Publications: 48
  • Citations: 970

Selected Publications

  • Genomic analysis, culturing optimization, and characterization of Escherichia bacteriophage OSYSP, previously studied as effective pathogen control on fresh produce (2024)
    Frontiers in Microbiology 2 citations DOI OpenAlex
  • Treatment-emergent cefiderocol resistance in carbapenem-resistant <i>Acinetobacter baumannii</i> is associated with insertion sequence IS <i>Aba36</i> in the siderophore receptor <i>pirA</i> (2024)
    Antimicrobial Agents and Chemotherapy 25 citations DOI OpenAlex
  • A Multidrug-Resistant Extended-Spectrum Beta-Lactamase (ESBL)-Producing Enterobacter hormaechei Strain from Mixed Sprouts (2024)
    Current Microbiology 3 citations DOI OpenAlex
  • Thermal Inactivation of Escherichia Phage OSYSP and Host Strain Escherichia coli O157:H7 EDL933: A Comparative Kinetic Analysis (2024)
    Journal of Food Protection 4 citations DOI OpenAlex
  • Lytic Escherichia phage OSYSP acts additively and synergistically with gaseous ozone against Escherichia coli O157:H7 on spinach leaves (2023)
    Scientific Reports 10 citations DOI OpenAlex
  • Carbapenem resistance in the food supply chain (2023)
    Journal of Food Protection 25 citations DOI OpenAlex
  • Cefiderocol Resistance in Klebsiella pneumoniae Is Linked to SHV Extended-Spectrum β-Lactamase Activities and Functional Loss of the Outer Membrane Porin OmpK35 (2023)
    Microbiology Spectrum 27 citations DOI OpenAlex
  • Complete Genome Sequence of a Non-Carbapenemase-Producing Carbapenem-Resistant Providencia rettgeri Strain Isolated from a Clinical Urine Sample in Arkansas (2022)
    Microbiology Resource Announcements 1 citation DOI OpenAlex
  • Cefiderocol heteroresistance in Klebsiella pneumoniae is linked to mutations in the siderophore receptor cirA and β-lactamase activities (2022)
    International Journal of Antimicrobial Agents 21 citations DOI OpenAlex
  • Nanopore Sequencing for Detection and Characterization of Phosphorothioate Modifications in Native DNA Sequences (2022)
    Frontiers in Microbiology 5 citations DOI OpenAlex
  • Enzymatically-crosslinked gelatin hydrogels containing paenipeptin and clarithromycin against carbapenem-resistant pathogen in murine skin wound infection (2021)
    BMC Microbiology 3 citations DOI OpenAlex
  • Isolation of AmpC- and extended spectrum β-lactamase-producing Enterobacterales from fresh vegetables in the United States (2021)
    Food Control 27 citations DOI OpenAlex
  • Isolation and characterisation of carbapenemase-producing and polymyxin B-resistant Enterobacter bugandensis from a vegetable (2021)
    Journal of Global Antimicrobial Resistance 11 citations DOI OpenAlex
  • Applications in food technology: antimicrobial peptides (2021)
    Elsevier eBooks 4 citations DOI OpenAlex
  • Detection and Discrimination of DNA Adducts Differing in Size, Regiochemistry, and Functional Group by Nanopore Sequencing (2020)
    Chemical Research in Toxicology 35 citations DOI OpenAlex

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Federal Grants 1 $1 total

NIH Contact PI Sep 2024 - Sep 2025

Mechanisms of cefiderocol nonsusceptibility and resistance evolution in carbapenem-resistant pathogens

National Institute of Allergy and Infectious Diseases $1 R01

Grants & Funding

As listed on this researcher's institutional profile. Federal awards with verified records are shown above.

  • Novel linear lipopeptide paenipeptins sensitize multidrug-resistant Gram-negative pathogens to antibiotics - Continuation Year 2020-2021 NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
  • Real-Time High Resolution Method for Genomic Surveillance of ESKAPE pathogens NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
  • Platelet-Leukocyte Axis in Patients with Chronic Kidney Disease Dialysis Clinic, Inc. Principal Investigator
  • Assessment of antibiotic resistance in fresh vegetables from farm to fork National Institute of Food and Agriculture Principal Investigator

Collaboration Network

38 Collaborators 9 Institutions 1 Country

Top Collaborators

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