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Institution-verified
Presence
Current · Arkansas
Last published
2026
Sources
Institutional record
Refreshed
2026-08-15
I
Intawat Nookaew
Sourced from institutional research profiles (UAMS TRI or ARA).
High Impact
Professor
Also affiliated: Kunming University of Science and Technology (2018); Oak Ridge National Laboratory (2014–2021); Pennsylvania State University (2012); Siriraj Hospital (2017–2025); Mahidol University (2017–2025); University of Arkansas Medical Center (2020–2026); Novo Nordisk Foundation (2012); Molecular Microbiology and Genomics Consultants (Germany) (2017–2018); Institute for Musculoskeletal Health (2025); Winthrop Rockefeller Foundation (2019–2025); Institute of Informatics of the Slovak Academy of Sciences (2025); Arkansas Department of Agriculture (2025); King Mongkut's University of Technology Thonburi (2007–2013); Chalmers University of Technology (2010–2020); University of Gothenburg (2012–2013); Technical University of Denmark (2010–2013)
Faculty Researcher
Biomedical Informatics, College of Medicine
57 h-index
349 pubs
18,559 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Intawat Nookaew's research focuses on the application of bioinformatics and computational biology to understand complex biological systems, with a particular emphasis on genomics, transcriptomics, and the microbiome. His work has explored diverse areas, including the characterization of extrachromosomal circular DNA in the human germline and its association with recombination, as well as genome assembly for species such as the black tiger shrimp (*Penaeus monodon*) to identify growth-associated genes. Nookaew also investigates the development and application of computational tools for biological data analysis, such as CReSIL for identifying extrachromosomal circular DNA from long-read sequences.
His research has extended to studying disease mechanisms and physiological processes in various model organisms and humans. This includes investigating the molecular underpinnings of bone loss in mice and the role of osteoprotegerin in bone resorption following denosumab discontinuation. Furthermore, Nookaew has contributed to understanding metabolic profiles in conditions like autism spectrum disorders and has examined transcriptomic landscapes in disease contexts, such as chronic kidney disease affecting cortical bone. His work is supported by a substantial publication record, with over 346 publications and an h-index of 57, reflecting his significant contributions to the field. He actively collaborates with researchers at the University of Arkansas for Medical Sciences, including Thidathip Wongsurawat and Piroon Jenjaroenpun.
Metrics
- h-index: 57
- Publications: 349
- Citations: 18,559
Selected Publications
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The Aging Landscape by <scp>scRNAseq</scp> of Mesenchymal Lineage Cells in Mouse Bone (2025)
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Healing of lytic lesions and restoration of bone health in multiple myeloma through sclerostin inhibition (2025)
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Mechanisms of mitochondrial reactive oxygen species action in bone mesenchymal cells (2025)
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Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength (2025)
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LC-QTOF-MS <sup>E</sup> with MS <sup>1</sup> -based precursor ion quantification and SiMD-assisted identification enhances human urine metabolite analysis (2025)
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Oat bran fiber protects against radiation-induced disruption of gut barrier dynamics and mucosal damage (2025)
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The DigH glycosyl hydrolase is conditionally required for daughter cell separation in <i>Escherichia coli</i> (2025)
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Intrinsic p53 activation restricts gammaherpesvirus driven germinal center B cell expansion during latency establishment (2025)
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A Randomized Double-Blind Phase 2 Clinical Trial Treating Cervical Intraepithelial Neoplasia 2/3 with PepCan or <i>Candida</i> (2025)
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Investigating the origins of the mutational signatures in cancer (2025)
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Single-Cell Transcriptomic Analysis Identifies Senescent Osteocytes That Trigger Bone Destruction in Breast Cancer Metastasis (2024)
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CAIM: coverage-based analysis for identification of microbiome (2024)
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Sensitivity and specificity of Nanopore sequencing for detecting carbapenem and 3rd-generation cephalosporin-resistant Enterobacteriaceae in urine samples: Real-time simulation with public antimicrobial resistance gene database (2024)
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Single-cell Transcriptome Analysis Identifies Senescent Osteocytes as Contributors to Bone Destruction in Breast Cancer Metastasis (2024)
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Refining the identity of mesenchymal cell types associated with murine periosteal and endosteal bone (2024)
Collaboration Network
Top Collaborators
Piroon Jenjaroenpun
Siriraj Hospital
13 shared publications
In database
- Circular DNA in the human germline and its association with recombination
- A chromosome‐level assembly of the black tiger shrimp ( <i>Penaeus monodon</i> ) genome facilitates the identification of growth‐associated genes
- CReSIL: accurate identification of extrachromosomal circular DNA from long-read sequences
- Comparative Analysis of PacBio and Oxford Nanopore Sequencing Technologies for Transcriptomic Landscape Identification of Penaeus monodon
- Native RNA or cDNA Sequencing for Transcriptomic Analysis: A Case Study on Saccharomyces cerevisiae
Showing 5 of 13 shared publications
Thidathip Wongsurawat
Siriraj Hospital
13 shared publications
In database
- Circular DNA in the human germline and its association with recombination
- A chromosome‐level assembly of the black tiger shrimp ( <i>Penaeus monodon</i> ) genome facilitates the identification of growth‐associated genes
- Comparative Analysis of PacBio and Oxford Nanopore Sequencing Technologies for Transcriptomic Landscape Identification of Penaeus monodon
- Native RNA or cDNA Sequencing for Transcriptomic Analysis: A Case Study on Saccharomyces cerevisiae
- Cell-Free DNA Analysis by Whole-Exome Sequencing for Hepatocellular Carcinoma: A Pilot Study in Thailand
Showing 5 of 13 shared publications
Maria Almeida
University of Arkansas for Medical Sciences
8 shared publications
In database
- Neutralization of oxidized phospholipids attenuates age‐associated bone loss in mice
- Refining the identity of mesenchymal cell types associated with murine periosteal and endosteal bone
- Mmp13 deletion in mesenchymal cells increases bone mass and may attenuate the cortical bone loss caused by estrogen deficiency
- The NAD salvage pathway in mesenchymal cells is indispensable for skeletal development in mice
- Single-Cell Transcriptomic Analysis Identifies Senescent Osteocytes That Trigger Bone Destruction in Breast Cancer Metastasis
Showing 5 of 8 shared publications
Visanu Wanchai
Institute for Musculoskeletal Health
7 shared publications
In database
- CReSIL: accurate identification of extrachromosomal circular DNA from long-read sequences
- Native RNA or cDNA Sequencing for Transcriptomic Analysis: A Case Study on Saccharomyces cerevisiae
- Refining the identity of mesenchymal cell types associated with murine periosteal and endosteal bone
- High NEK2 expression in myeloid progenitors suppresses T cell immunity in multiple myeloma
- Two SARS-CoV-2 Genome Sequences of Isolates from Rural U.S. Patients Harboring the D614G Mutation, Obtained Using Nanopore Sequencing
Showing 5 of 7 shared publications
Natthaya Chuaypen
Chulalongkorn University (TH)
7 shared publications
- Cell-Free DNA Analysis by Whole-Exome Sequencing for Hepatocellular Carcinoma: A Pilot Study in Thailand
- Transcriptomic Analyses Reveal Long Non-Coding RNA in Peripheral Blood Mononuclear Cells as a Novel Biomarker for Diagnosis and Prognosis of Hepatocellular Carcinoma
- Identification of BHLHE40 expression in peripheral blood mononuclear cells as a novel biomarker for diagnosis and prognosis of hepatocellular carcinoma
- Long-term benefit of DAAs on gut dysbiosis and microbial translocation in HCV-infected patients with and without HIV coinfection
- Improvement of Gut Diversity and Composition After Direct-Acting Antivirals in Hepatitis C Virus–Infected Patients With or Without Human Immunodeficiency Virus Coinfection
Showing 5 of 7 shared publications
Charles A. O’Brien
University of Arkansas for Medical Sciences
7 shared publications
In database
- Reduced osteoprotegerin expression by osteocytes may contribute to rebound resorption after denosumab discontinuation
- Refining the identity of mesenchymal cell types associated with murine periosteal and endosteal bone
- The NAD salvage pathway in mesenchymal cells is indispensable for skeletal development in mice
- Single-Cell Transcriptomic Analysis Identifies Senescent Osteocytes That Trigger Bone Destruction in Breast Cancer Metastasis
- CRISPR interference provides increased cell type-specificity compared to the Cre-loxP system
Showing 5 of 7 shared publications
Pisit Tangkijvanich
Chulalongkorn University (TH)
5 shared publications
- Cell-Free DNA Analysis by Whole-Exome Sequencing for Hepatocellular Carcinoma: A Pilot Study in Thailand
- Transcriptomic Analyses Reveal Long Non-Coding RNA in Peripheral Blood Mononuclear Cells as a Novel Biomarker for Diagnosis and Prognosis of Hepatocellular Carcinoma
- Identification of BHLHE40 expression in peripheral blood mononuclear cells as a novel biomarker for diagnosis and prognosis of hepatocellular carcinoma
- Long-term benefit of DAAs on gut dysbiosis and microbial translocation in HCV-infected patients with and without HIV coinfection
- Improvement of Gut Diversity and Composition After Direct-Acting Antivirals in Hepatitis C Virus–Infected Patients With or Without Human Immunodeficiency Virus Coinfection
Elena Ambrogini
Central Arkansas Veterans Healthcare System
5 shared publications
In database
- Reduced osteoprotegerin expression by osteocytes may contribute to rebound resorption after denosumab discontinuation
- Neutralization of oxidized phospholipids attenuates age‐associated bone loss in mice
- Single-Cell Transcriptomic Analysis Identifies Senescent Osteocytes That Trigger Bone Destruction in Breast Cancer Metastasis
- A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma
- Single-cell Transcriptome Analysis Identifies Senescent Osteocytes as Contributors to Bone Destruction in Breast Cancer Metastasis
Jesús Delgado‐Calle
University of Arkansas for Medical Sciences
5 shared publications
In database
- CReSIL: accurate identification of extrachromosomal circular DNA from long-read sequences
- Notch3 signaling between myeloma cells and osteocytes in the tumor niche promotes tumor growth and bone destruction
- Single-Cell Transcriptomic Analysis Identifies Senescent Osteocytes That Trigger Bone Destruction in Breast Cancer Metastasis
- A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma
- Single-cell Transcriptome Analysis Identifies Senescent Osteocytes as Contributors to Bone Destruction in Breast Cancer Metastasis
Ha‐Neui Kim
University of Arkansas for Medical Sciences
5 shared publications
In database
- Refining the identity of mesenchymal cell types associated with murine periosteal and endosteal bone
- Piezo1 stimulates mitochondrial function via <scp>cAMP</scp> signaling
- Mmp13 deletion in mesenchymal cells increases bone mass and may attenuate the cortical bone loss caused by estrogen deficiency
- The NAD salvage pathway in mesenchymal cells is indispensable for skeletal development in mice
- The Aging Landscape by <scp>scRNAseq</scp> of Mesenchymal Lineage Cells in Mouse Bone
David W. Ussery
University of Arkansas for Medical Sciences
4 shared publications
In database
- Two SARS-CoV-2 Genome Sequences of Isolates from Rural U.S. Patients Harboring the D614G Mutation, Obtained Using Nanopore Sequencing
- Investigating the origins of the mutational signatures in cancer
- Is amplification bias consequential in transposon sequencing (TnSeq) assays? A case study with a Staphylococcus aureus TnSeq library subjected to PCR-based and amplification-free enrichment methods
- A peptide-based human papillomavirus therapeutic vaccine, PepCan, or <i>Candida</i> adjuvant alone in treatment of cervical intraepithelial neoplasia 2/3 (CIN2/3).
Michela Palmieri
Central Arkansas Veterans Healthcare System
4 shared publications
In database
- Reduced osteoprotegerin expression by osteocytes may contribute to rebound resorption after denosumab discontinuation
- Neutralization of oxidized phospholipids attenuates age‐associated bone loss in mice
- A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma
- Single-cell Transcriptome Analysis Identifies Senescent Osteocytes as Contributors to Bone Destruction in Breast Cancer Metastasis
Gunnar Boysen
University of Arkansas for Medical Sciences
4 shared publications
In database
- Current and Future Methodology for Quantitation and Site-Specific Mapping the Location of DNA Adducts
- Exploiting nanopore sequencing for characterization and grading of <i>IDH</i>‐mutant gliomas
- Investigating the origins of the mutational signatures in cancer
- Nanopore Sequencing for Detection and Characterization of Phosphorothioate Modifications in Native DNA Sequences
Hayley M. Sabol
University of Arkansas for Medical Sciences
4 shared publications
In database
- Notch3 signaling between myeloma cells and osteocytes in the tumor niche promotes tumor growth and bone destruction
- Single-Cell Transcriptomic Analysis Identifies Senescent Osteocytes That Trigger Bone Destruction in Breast Cancer Metastasis
- A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma
- Single-cell Transcriptome Analysis Identifies Senescent Osteocytes as Contributors to Bone Destruction in Breast Cancer Metastasis
Cody Ashby
University of Arkansas for Medical Sciences
4 shared publications
In database
- CST6 suppresses osteolytic bone disease in multiple myeloma by blocking osteoclast differentiation
- High NEK2 expression in myeloid progenitors suppresses T cell immunity in multiple myeloma
- Notch3 signaling between myeloma cells and osteocytes in the tumor niche promotes tumor growth and bone destruction
- A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma
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