David Wayne Ussery
Professor of Genetics
Also affiliated: Kunming University of Science and Technology (2018); Universitat de Miguel Hernández d'Elx (2012); Oklahoma State University (2025–2026); Universidade Federal do Rio de Janeiro (2015); Oak Ridge National Laboratory (2011–2017); Siriraj Hospital (2018); University of New Mexico (1984); Copenhagen Business School (2006); University of Oslo (2007–2011); Washington University in St. Louis (2009); Mahidol University (2018); University of South Florida (1994); University of Arkansas Medical Center (2025); John Radcliffe Hospital (1994–1997); Moffitt Cancer Center (1994); University of Oxford (1994–1997); Molecular Microbiology and Genomics Consultants (Germany) (2017–2018); University of Cincinnati (1991); University of Tennessee at Knoxville (2014–2015); University of California, Davis (2009); Texas A&M University (1992–1996); Technical University of Denmark (1999–2016)
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
David Ussery's research focuses on the bioinformatic analysis of bacterial genomes, a field he has engaged with since 1995. He previously led the Arkansas Center for Genomic Epidemiology and Medicine at the University of Arkansas, from 2016 to 2025. During his tenure, his group was responsible for sequencing the first reported COVID-19 Omicron variant in Arkansas in December 2021. His work has also involved developing methodologies for pathogen monitoring in wastewater.
Ussery has a history of teaching graduate courses in bioinformatics and has conducted numerous international workshops on comparative genomics. His research network includes collaborators in the United Kingdom, Denmark, Norway, Germany, and Belgium. He has published extensively, with over 368 publications and a citation count exceeding 26,000, and holds an h-index of 62. His work has been recognized with designations such as an ARA Academy member and a highly cited researcher.
Metrics
- h-index: 62
- Publications: 371
- Citations: 27,019
Positions
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Professor of Genomics 2025–presentOklahoma State University Department of Physiological Sciences, College of Veterinary Medicine ORCID
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Professor of Genetics publications 2016–2026University of Arkansas for Medical Sciences Institutional directory
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Oklahoma State University publications 2025–2026ORCID
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professor 2016–2025University of Arkansas for Medical Sciences Department of Biomedical Informatics ORCID
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Comparative Genomics group leader 2013–2016Oak Ridge National Laboratory Biosciences Division ORCID
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Comparative Genomics group leader 1997–2014Technical University of Denmark Center for Biological Sequence Analysis CBS ORCID
Selected Publications
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A randomized double-blind placebo-controlled phase I/II clinical trial of a human papillomavirus therapeutic vaccine, PepCan, for reducing head and neck squamous cell carcinoma recurrence (2026)
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A Randomized Double-Blind Placebo-Controlled Phase I/II Clinical Trial of a Human Papillomavirus Therapeutic Vaccine, PepCan, for Reducing Head and Neck Cancer Recurrence (2026)
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A Tracts of Homozygosity Approach Identifies Methylation-Regulated <i>CSMD1</i> Expression Targets in Non–Small Cell Lung Cancers Related to Smoking Behavior (2025)
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Using machine learning to predict the severity of salmonella infection (2025)
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Abstract 1923: A tract of homozygosity analysis reveals methylation-driven <i>CSMD1</i> expression in non-small cell lung cancers (2025)
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A Randomized Double-Blind Phase 2 Clinical Trial Treating Cervical Intraepithelial Neoplasia 2/3 with PepCan or <i>Candida</i> (2025)
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Investigating the origins of the mutational signatures in cancer (2025)
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C.S. Lewis Philosopher — Who Changed My Life. Notes on the Margins of The Magician's Twin (2024)
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Review 1: "Emergence of Transmissible SARS-CoV-2 Variants with Decreased Sensitivity to Antivirals in Immunocompromised Patients with Persistent Infections" (2024)
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Reviews of "Emergence of Transmissible SARS-CoV-2 Variants with Decreased Sensitivity to Antivirals in Immunocompromised Patients with Persistent Infections" (2024)
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DNA structural features and variability of complete MHC locus sequences (2024)
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Immune responses in a phase 2 clinical trial of peptide-based therapeutic human papillomavirus vaccine, PepCan, versus <i>Candida</i> adjuvant alone in treating cervical intraepithelial neoplasia 2/3. (2024)
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Genomic surveillance of SARS-CoV-2 using long-range PCR primers (2024)
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Review of: "Can the definitions of SARS-Cov-2 and Covid-19 stand up to epistemological scrutiny?" (2023)
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Review of: "Evolution of new variants of SARS-CoV-2 during the pandemic: mutation-limited or selection-limited?" (2023)
ARA Academy 2016 ARA Scholar
Collaboration Network
Top Collaborators
- Decoding the epitranscriptional landscape from native RNA sequences
- Complete genomic and transcriptional landscape analysis using third-generation sequencing: a case study of Saccharomyces cerevisiae CEN.PK113-7D
- PARP1 Is Up-Regulated in Non-small Cell Lung Cancer Tissues in the Presence of the Cyanobacterial Toxin Microcystin
- Case of Microcephaly after Congenital Infection with Asian Lineage Zika Virus, Thailand
- Viral Phylogenomics Using an Alignment-Free Method: A Three-Step Approach to Determine Optimal Length of k-mer
Showing 5 of 32 shared publications
- Decoding the epitranscriptional landscape from native RNA sequences
- Complete genomic and transcriptional landscape analysis using third-generation sequencing: a case study of Saccharomyces cerevisiae CEN.PK113-7D
- PARP1 Is Up-Regulated in Non-small Cell Lung Cancer Tissues in the Presence of the Cyanobacterial Toxin Microcystin
- Case of Microcephaly after Congenital Infection with Asian Lineage Zika Virus, Thailand
- Rapid Sequencing of Multiple RNA Viruses in Their Native Form
Showing 5 of 20 shared publications
- Decoding the epitranscriptional landscape from native RNA sequences
- Complete genomic and transcriptional landscape analysis using third-generation sequencing: a case study of Saccharomyces cerevisiae CEN.PK113-7D
- PARP1 Is Up-Regulated in Non-small Cell Lung Cancer Tissues in the Presence of the Cyanobacterial Toxin Microcystin
- Case of Microcephaly after Congenital Infection with Asian Lineage Zika Virus, Thailand
- Rapid Sequencing of Multiple RNA Viruses in Their Native Form
Showing 5 of 20 shared publications
- Decoding the epitranscriptional landscape from native RNA sequences
- Mash-based analyses of Escherichia coli genomes reveal 14 distinct phylogroups
- Mechanisms linking preterm birth to onset of cardiovascular disease later in adulthood
- Case of Microcephaly after Congenital Infection with Asian Lineage Zika Virus, Thailand
- The first three waves of the Covid-19 pandemic hint at a limited genetic repertoire for SARS-CoV-2
Showing 5 of 18 shared publications
- Decoding the epitranscriptional landscape from native RNA sequences
- Mash-based analyses of Escherichia coli genomes reveal 14 distinct phylogroups
- The first three waves of the Covid-19 pandemic hint at a limited genetic repertoire for SARS-CoV-2
- Suggested mechanisms for Zika virus causing microcephaly: what do the genomes tell us?
- Decoding the Epitranscriptional Landscape from Native RNA Sequences
Showing 5 of 13 shared publications
- Case of Microcephaly after Congenital Infection with Asian Lineage Zika Virus, Thailand
- Viral Phylogenomics Using an Alignment-Free Method: A Three-Step Approach to Determine Optimal Length of k-mer
- Suggested mechanisms for Zika virus causing microcephaly: what do the genomes tell us?
- Two Cases of Vancomycin-Resistant Enterococcus faecium Bacteremia With Development of Daptomycin-Resistant Phenotype and its Detection Using Oxford Nanopore Sequencing
- Genomic characterization of mumps viruses from a large-scale mumps outbreak in Arkansas, 2016
Showing 5 of 11 shared publications
- Mash-based analyses of Escherichia coli genomes reveal 14 distinct phylogroups
- Genomic characterization of mumps viruses from a large-scale mumps outbreak in Arkansas, 2016
- Comparative genomics of hepatitis A virus, hepatitis C virus, and hepatitis E virus provides insights into the evolutionary history of Hepatovirus species
- 16S rRNA Gene Amplicon Profiling of Baby and Adult Captive Elephants in Thailand
- What can we learn from over 100,000 Escherichia coli genomes?
Showing 5 of 7 shared publications
- Complete genomic and transcriptional landscape analysis using third-generation sequencing: a case study of Saccharomyces cerevisiae CEN.PK113-7D
- PARP1 Is Up-Regulated in Non-small Cell Lung Cancer Tissues in the Presence of the Cyanobacterial Toxin Microcystin
- Suggested mechanisms for Zika virus causing microcephaly: what do the genomes tell us?
- Genomic characterization of mumps viruses from a large-scale mumps outbreak in Arkansas, 2016
- dBBQs: dataBase of Bacterial Quality scores
Showing 5 of 6 shared publications
- Mash-based analyses of Escherichia coli genomes reveal 14 distinct phylogroups
- Two Cases of Vancomycin-Resistant Enterococcus faecium Bacteremia With Development of Daptomycin-Resistant Phenotype and its Detection Using Oxford Nanopore Sequencing
- Genomic characterization of mumps viruses from a large-scale mumps outbreak in Arkansas, 2016
- What can we learn from over 100,000 Escherichia coli genomes?
- Complete Genome Sequences of Four Isolates of Vancomycin-Resistant Enterococcus faecium with the vanA Gene and Two Daptomycin Resistance Mutations, Obtained from Two Inpatients with Prolonged Bacteremia
Showing 5 of 6 shared publications
- A novel Cas9-targeted long-read assay for simultaneous detection of IDH1/2 mutations and clinically relevant MGMT methylation in fresh biopsies of diffuse glioma
- Genomic characterization of mumps viruses from a large-scale mumps outbreak in Arkansas, 2016
- Three Complete Genome Sequences of Genotype G Mumps Virus from the 2016 Outbreak in Arkansas, USA
- Conservation of Two-Component Signal Transduction Systems in E. coli, Salmonella, and Across 100,000 Bacteria of Various Bacterial Phyla
- Is amplification bias consequential in transposon sequencing (TnSeq) assays? A case study with a Staphylococcus aureus TnSeq library subjected to PCR-based and amplification-free enrichment methods
- Rapid Sequencing of Multiple RNA Viruses in Their Native Form
- 16S rRNA Gene Amplicon Profiling of Baby and Adult Captive Elephants in Thailand
- Genomic surveillance of SARS-CoV-2 using long-range PCR primers
- Genomic Surveillance of SARS-CoV-2 Using Long-Range PCR Primers
- Severe Acute Respiratory Syndrome Coronavirus-2 Lambda Variant Collected from a Child from Arkansas and Sequenced
- A peptide-based human papillomavirus therapeutic vaccine, PepCan, or <i>Candida</i> adjuvant alone in treatment of cervical intraepithelial neoplasia 2/3 (CIN2/3).
- A Randomized Double-Blind Phase 2 Clinical Trial Treating Cervical Intraepithelial Neoplasia 2/3 with PepCan or <i>Candida</i>
- Immune responses in a phase 2 clinical trial of peptide-based therapeutic human papillomavirus vaccine, PepCan, versus <i>Candida</i> adjuvant alone in treating cervical intraepithelial neoplasia 2/3.
- A Randomized Double-Blind Placebo-Controlled Phase I/II Clinical Trial of a Human Papillomavirus Therapeutic Vaccine, PepCan, for Reducing Head and Neck Cancer Recurrence
- A randomized double-blind placebo-controlled phase I/II clinical trial of a human papillomavirus therapeutic vaccine, PepCan, for reducing head and neck squamous cell carcinoma recurrence
- A peptide-based human papillomavirus therapeutic vaccine, PepCan, or <i>Candida</i> adjuvant alone in treatment of cervical intraepithelial neoplasia 2/3 (CIN2/3).
- A Randomized Double-Blind Phase 2 Clinical Trial Treating Cervical Intraepithelial Neoplasia 2/3 with PepCan or <i>Candida</i>
- Immune responses in a phase 2 clinical trial of peptide-based therapeutic human papillomavirus vaccine, PepCan, versus <i>Candida</i> adjuvant alone in treating cervical intraepithelial neoplasia 2/3.
- A Randomized Double-Blind Placebo-Controlled Phase I/II Clinical Trial of a Human Papillomavirus Therapeutic Vaccine, PepCan, for Reducing Head and Neck Cancer Recurrence
- A randomized double-blind placebo-controlled phase I/II clinical trial of a human papillomavirus therapeutic vaccine, PepCan, for reducing head and neck squamous cell carcinoma recurrence
- Two Cases of Vancomycin-Resistant Enterococcus faecium Bacteremia With Development of Daptomycin-Resistant Phenotype and its Detection Using Oxford Nanopore Sequencing
- Genome-Based Comparison of Clostridioides difficile: Average Amino Acid Identity Analysis of Core Genomes
- Complete Genome Sequences of Four Isolates of Vancomycin-Resistant Enterococcus faecium with the vanA Gene and Two Daptomycin Resistance Mutations, Obtained from Two Inpatients with Prolonged Bacteremia
- Draft Genome Sequences of 48 Vancomycin-Resistant Enterococcus faecium Strains Isolated from Inpatients with Bacteremia and Urinary Tract Infection
- Decoding the epitranscriptional landscape from native RNA sequences
- Rapid Sequencing of Multiple RNA Viruses in Their Native Form
- Decoding the Epitranscriptional Landscape from Native RNA Sequences
- Complete Genome and Plasmid Sequences of Escherichia coli Type Strain ATCC 11775
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