Kelly E. Mercer
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Also affiliated: St. Jude Children's Research Hospital (2004); United States Food and Drug Administration (2022–2026); Eastern Virginia Medical School (2002); University of Arkansas Medical Center (2018); Oklahoma Medical Research Foundation (2016); Arkansas Children's Nutrition Center (2011–2024); Arkansas Children's Research Institute (2020–2022); University of Colorado Anschutz (2016); California State University, Long Beach (2012); Louisiana State University Health Sciences Center New Orleans (2016–2018); Texas A&M University (2018)
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Kelly E. Mercer's research investigates the impact of diet on the gut microbiome and its subsequent effects on host metabolism and health. Mercer has studied how neonatal diets, specifically breast milk versus formula, alter fecal microbiota and metabolome profiles in infants. Further research has explored how formula-driven microbiota shifts influence tryptophan metabolism in the neonatal porcine colon. Additionally, Mercer has examined the influence of maternal high-fat diets on offspring liver steatosis in mice, noting sexually dimorphic patterns and associations with changes in gut microbial ecology.
Mercer's work also extends to the molecular mechanisms of cellular transport and drug resistance. Previous research has focused on the stem cell marker Bcrp/ABCG2 and its role in hypoxic cell survival, as well as the transporter Mrp4's role in conferring resistance to chemotherapy and protecting the brain. Other investigations have identified mammalian mitochondrial porphyrin transporters and explored functional genetic variants in sulfotransferase isoform 1A1 (SULT1A1) and their impact on enzymatic activity. Mercer's scholarship metrics include an h-index of 25, 89 total publications, and 3,554 total citations, designating them as a highly cited researcher.
Metrics
- h-index: 25
- Publications: 89
- Citations: 3,556
Selected Publications
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Dissecting Sex‐Specific Pathology in K18‐hACE2 Transgenic Mice Infected With Different SARS‐CoV‐2 Variants (2025)
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Novel odd-chain cyclopropane fatty acids: detection in a mammalian lipidome and uptake by hepatosplanchnic tissues (2024)
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Enhanced virulence and waning vaccine-elicited antibodies account for breakthrough infections caused by SARS-CoV-2 delta and beyond (2022)
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Applying imaging mass spectrometry to define the N-glycan profiles of co-localized virus and immune cell infiltrates in post-COVID-19 infected lung autopsy tissues (2022)
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Rats with high aerobic capacity display enhanced transcriptional adaptability and upregulation of bile acid metabolism in response to an acute high‐fat diet (2022)
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Circulating microRNAs Are Associated With Metabolic Markers in Adolescents With Hepatosteatosis (2022)
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Soy Formula Is Not Estrogenic and Does Not Result in Reproductive Toxicity in Male Piglets: Results from a Controlled Feeding Study (2022)
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Exercise training and diet-induced weight loss increase markers of hepatic bile acid (BA) synthesis and reduce serum total BA concentrations in obese women (2021)
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Markers of branched-chain amino acid catabolism are not affected by exercise training in pregnant women with obesity (2021)
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Circulating miRNA Signatures Associated with Insulin Resistance in Adolescents with Obesity (2020)
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Early Infant Formula Feeding Impacts Urinary Metabolite Profile at 3 Months of Age (2020)
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Fibroblast Growth Factor-21 to Adiponectin Ratio: A Potential Biomarker to Monitor Liver Fat in Children With Obesity (2020)
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Divergence in aerobic capacity impacts bile acid metabolism in young women (2020)
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Net release and uptake of xenometabolites across intestinal, hepatic, muscle, and renal tissue beds in healthy conscious pigs (2020)
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Xenometabolite signatures in the UC Davis type 2 diabetes mellitus rat model revealed using a metabolomics platform enriched with microbe-derived metabolites (2020)
Collaboration Network
Top Collaborators
- Formula diet alters small intestine morphology, microbial abundance and reduces VE-cadherin and IL-10 expression in neonatal porcine model
- Vitamin D Supplementation Protects against Bone Loss Associated with Chronic Alcohol Administration in Female Mice
- Susceptibility of L-FABP−/− mice to oxidative stress in early-stage alcoholic liver
- Alcohol Consumption, Wnt/β-Catenin Signaling, and Hepatocarcinogenesis
- Short Term Feeding of a High Fat Diet Exerts an Additive Effect on Hepatocellular Damage and Steatosis in Liver-Specific PTEN Knockout Mice
Showing 5 of 27 shared publications
- Neonatal diet alters fecal microbiota and metabolome profiles at different ages in infants fed breast milk or formula
- Formula diet driven microbiota shifts tryptophan metabolism from serotonin to tryptamine in neonatal porcine colon
- Formula diet alters small intestine morphology, microbial abundance and reduces VE-cadherin and IL-10 expression in neonatal porcine model
- Early Postnatal Diets Affect the Bioregional Small Intestine Microbiome and Ileal Metabolome in Neonatal Pigs
- Vitamin D Supplementation Protects against Bone Loss Associated with Chronic Alcohol Administration in Female Mice
Showing 5 of 20 shared publications
- Neonatal diet alters fecal microbiota and metabolome profiles at different ages in infants fed breast milk or formula
- Formula diet driven microbiota shifts tryptophan metabolism from serotonin to tryptamine in neonatal porcine colon
- Formula diet alters small intestine morphology, microbial abundance and reduces VE-cadherin and IL-10 expression in neonatal porcine model
- Early Postnatal Diets Affect the Bioregional Small Intestine Microbiome and Ileal Metabolome in Neonatal Pigs
- Xenometabolite signatures in the UC Davis type 2 diabetes mellitus rat model revealed using a metabolomics platform enriched with microbe-derived metabolites
Showing 5 of 17 shared publications
- Neonatal diet alters fecal microbiota and metabolome profiles at different ages in infants fed breast milk or formula
- Formula diet driven microbiota shifts tryptophan metabolism from serotonin to tryptamine in neonatal porcine colon
- Maternal High-Fat Diet Programs Offspring Liver Steatosis in a Sexually Dimorphic Manner in Association with Changes in Gut Microbial Ecology in Mice
- Formula diet alters small intestine morphology, microbial abundance and reduces VE-cadherin and IL-10 expression in neonatal porcine model
- Obesity leads to distinct metabolomic signatures in follicular fluid of women undergoing in vitro fertilization
Showing 5 of 14 shared publications
- Neonatal diet alters fecal microbiota and metabolome profiles at different ages in infants fed breast milk or formula
- Formula diet driven microbiota shifts tryptophan metabolism from serotonin to tryptamine in neonatal porcine colon
- Maternal High-Fat Diet Programs Offspring Liver Steatosis in a Sexually Dimorphic Manner in Association with Changes in Gut Microbial Ecology in Mice
- Obesity leads to distinct metabolomic signatures in follicular fluid of women undergoing in vitro fertilization
- Early Postnatal Diets Affect the Bioregional Small Intestine Microbiome and Ileal Metabolome in Neonatal Pigs
Showing 5 of 13 shared publications
- Neonatal diet alters fecal microbiota and metabolome profiles at different ages in infants fed breast milk or formula
- Early Postnatal Diets Affect the Bioregional Small Intestine Microbiome and Ileal Metabolome in Neonatal Pigs
- Exercise training and diet-induced weight loss increase markers of hepatic bile acid (BA) synthesis and reduce serum total BA concentrations in obese women
- Xenometabolite signatures in the UC Davis type 2 diabetes mellitus rat model revealed using a metabolomics platform enriched with microbe-derived metabolites
- Diabetes-associated alterations in the cecal microbiome and metabolome are independent of diet or environment in the UC Davis Type 2 Diabetes Mellitus Rat model
Showing 5 of 13 shared publications
- Formula diet alters small intestine morphology, microbial abundance and reduces VE-cadherin and IL-10 expression in neonatal porcine model
- Alcohol Consumption, Wnt/β-Catenin Signaling, and Hepatocarcinogenesis
- Short Term Feeding of a High Fat Diet Exerts an Additive Effect on Hepatocellular Damage and Steatosis in Liver-Specific PTEN Knockout Mice
- Soy protein isolate inhibits hepatic tumor promotion in mice fed a high-fat liquid diet
- Soy Protein Isolate Protects Against Ethanol-Mediated Tumor Progression in Diethylnitrosamine-Treated Male Mice
Showing 5 of 11 shared publications
- Neonatal diet alters fecal microbiota and metabolome profiles at different ages in infants fed breast milk or formula
- Formula diet driven microbiota shifts tryptophan metabolism from serotonin to tryptamine in neonatal porcine colon
- Maternal High-Fat Diet Programs Offspring Liver Steatosis in a Sexually Dimorphic Manner in Association with Changes in Gut Microbial Ecology in Mice
- Formula diet alters small intestine morphology, microbial abundance and reduces VE-cadherin and IL-10 expression in neonatal porcine model
- Early Postnatal Diets Affect the Bioregional Small Intestine Microbiome and Ileal Metabolome in Neonatal Pigs
Showing 5 of 10 shared publications
- Neonatal diet alters fecal microbiota and metabolome profiles at different ages in infants fed breast milk or formula
- Obesity leads to distinct metabolomic signatures in follicular fluid of women undergoing in vitro fertilization
- Early Postnatal Diets Affect the Bioregional Small Intestine Microbiome and Ileal Metabolome in Neonatal Pigs
- Exercise training and diet-induced weight loss increase markers of hepatic bile acid (BA) synthesis and reduce serum total BA concentrations in obese women
- Xenometabolite signatures in the UC Davis type 2 diabetes mellitus rat model revealed using a metabolomics platform enriched with microbe-derived metabolites
Showing 5 of 10 shared publications
- Partial Protection by Dietary Antioxidants Against Ethanol‐Induced Osteopenia and Changes in Bone Morphology in Female Mice
- Soy protein isolate inhibits hepatic tumor promotion in mice fed a high-fat liquid diet
- NOX4 Deletion in Male Mice Exacerbates the Effect of Ethanol on Trabecular Bone and Osteoblastogenesis
- Soy Protein Isolate Protects Against Ethanol-Mediated Tumor Progression in Diethylnitrosamine-Treated Male Mice
- Knockout of the Gsta4 Gene in Male Mice Leads to an Altered Pattern of Hepatic Protein Carbonylation and Enhanced Inflammation Following Chronic Consumption of an Ethanol Diet
Showing 5 of 8 shared publications
- Circulating miRNA Signatures Associated with Insulin Resistance in Adolescents with Obesity
- Circulating microRNAs Are Associated With Metabolic Markers in Adolescents With Hepatosteatosis
- Modulating Sterol Concentrations in Infant Formula Influences Cholesterol Absorption and Synthesis in the Neonatal Piglet
- Fibroblast Growth Factor-21 to Adiponectin Ratio: A Potential Biomarker to Monitor Liver Fat in Children With Obesity
- Divergence in aerobic capacity impacts bile acid metabolism in young women
Showing 5 of 8 shared publications
- Vitamin D Supplementation Protects against Bone Loss Associated with Chronic Alcohol Administration in Female Mice
- Loss of Functional NADPH Oxidase 2 Protects Against Alcohol‐Induced Bone Resorption in Female p47phox −/− Mice
- Partial Protection by Dietary Antioxidants Against Ethanol‐Induced Osteopenia and Changes in Bone Morphology in Female Mice
- NOX4 Deletion in Male Mice Exacerbates the Effect of Ethanol on Trabecular Bone and Osteoblastogenesis
- Reactive Oxygen Species Differentially Regulate Bone Turnover in an Age-Specific Manner in Catalase Transgenic Female Mice
Showing 5 of 7 shared publications
- Formula diet alters small intestine morphology, microbial abundance and reduces VE-cadherin and IL-10 expression in neonatal porcine model
- Female mice lacking p47phoxhave altered adipose tissue gene expression and are protected against high fat-induced obesity
- Infant Formula Feeding Increases Hepatic Cholesterol 7α Hydroxylase (CYP7A1) Expression and Fecal Bile Acid Loss in Neonatal Piglets
- Soy Protein Isolate Protects Against Ethanol-Mediated Tumor Progression in Diethylnitrosamine-Treated Male Mice
- Diet Supplementation with Soy Protein Isolate, but Not the Isoflavone Genistein, Protects Against Alcohol-Induced Tumor Progression in DEN-Treated Male Mice
Showing 5 of 7 shared publications
- Susceptibility of L-FABP−/− mice to oxidative stress in early-stage alcoholic liver
- Short Term Feeding of a High Fat Diet Exerts an Additive Effect on Hepatocellular Damage and Steatosis in Liver-Specific PTEN Knockout Mice
- Increased 4-hydroxynonenal protein adducts in male GSTA4–4/PPAR-α double knockout mice enhance injury during early stages of alcoholic liver disease
- Knockout of the Gsta4 Gene in Male Mice Leads to an Altered Pattern of Hepatic Protein Carbonylation and Enhanced Inflammation Following Chronic Consumption of an Ethanol Diet
- Liver-Specific Deletion of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Significantly Ameliorates Chronic EtOH-Induced Increases in Hepatocellular Damage
Showing 5 of 6 shared publications
- Susceptibility of L-FABP−/− mice to oxidative stress in early-stage alcoholic liver
- Short Term Feeding of a High Fat Diet Exerts an Additive Effect on Hepatocellular Damage and Steatosis in Liver-Specific PTEN Knockout Mice
- Increased 4-hydroxynonenal protein adducts in male GSTA4–4/PPAR-α double knockout mice enhance injury during early stages of alcoholic liver disease
- Knockout of the Gsta4 Gene in Male Mice Leads to an Altered Pattern of Hepatic Protein Carbonylation and Enhanced Inflammation Following Chronic Consumption of an Ethanol Diet
- Liver-Specific Deletion of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Significantly Ameliorates Chronic EtOH-Induced Increases in Hepatocellular Damage
Showing 5 of 6 shared publications
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