Lindsay Pack

Senior Analytical Chemist/Lab Manager

UAMS primary NCTR

Also affiliated: Arkansas Children's Hospital (2016–2022); United States Food and Drug Administration (2012); Arkansas Children's Nutrition Center (2016–2026); Arkansas Department of Health (2010–2011)

Staff Researcher

13 h-index 30 pubs 599 cited

Research Areas

Biomedical Subjects

Links

ORCID Research Group

OverviewAI-generated summary

Lindsay Pack's research focuses on the intersection of metabolomics, gut microbiome, and various physiological states. Her work investigates how factors such as maternal obesity, exercise, and diet influence metabolic markers, including bile acids and branched-chain amino acids, particularly in the context of infant growth and maternal health. Pack has also explored the role of specific microbial elements, such as the diadenylate cyclase CdaA in bacterial virulence, and has contributed to understanding lipid metabolism through the detection of novel fatty acids. Her research extends to disease progression, examining colonic epithelial hypoxia in diabetes models and the potential therapeutic effects of compounds like elamipretide in polycystic kidney disease. Pack is recognized for her expertise in untargeted metabolomics, including the optimization of analytical methods using Orbitrap mass spectrometry for plasma analysis. She has published 29 papers, accumulating 569 citations, with an h-index of 12. Her collaborations include 13 shared publications with Renny S. Lan.

Metrics

h-index: 13
Publications: 30
Citations: 599

Selected Publications

Circulating short- and medium-chain fatty acids in pregnancy and associations with maternal and infant metabolism, inflammation, and body composition (2026)

Scientific Reports 1 citation DOI OpenAlex
Evaluation of Ion Source Parameters and Liquid Chromatography Methods for Plasma Untargeted Metabolomics Using Orbitrap Mass Spectrometer (2024)

SSRN Electronic Journal DOI OpenAlex
Ion Source Optimization and Lc Separation Method Development for Comprehensive Untargeted Metabolomics Using Orbitrap Mass Spectrometer (2023)

SSRN Electronic Journal DOI OpenAlex
Associations between maternal obesity and offspring gut microbiome in the first year of life (2022)

Pediatric Obesity 49 citations DOI OpenAlex
Infant intakes of human milk branched chain amino acids are negatively associated with infant growth and influenced by maternal body mass index (2021)

Pediatric Obesity 13 citations DOI OpenAlex
The Diadenylate Cyclase CdaA Is Critical for Borrelia turicatae Virulence and Physiology (2021)

Infection and Immunity 20 citations DOI OpenAlex
Neonatal diet alters fecal microbiota and metabolome profiles at different ages in infants fed breast milk or formula (2020)

American Journal of Clinical Nutrition 115 citations DOI OpenAlex
Infant Formula Feeding Increases Hepatic Cholesterol 7α Hydroxylase (CYP7A1) Expression and Fecal Bile Acid Loss in Neonatal Piglets (2018)

Journal of Nutrition 18 citations DOI OpenAlex
Early Postnatal Diets Affect the Bioregional Small Intestine Microbiome and Ileal Metabolome in Neonatal Pigs (2017)

Journal of Nutrition 49 citations DOI OpenAlex
Genotoxicity and gene expression analyses of liver and lung tissues of mice treated with titanium dioxide nanoparticles (2016)

Mutagenesis 63 citations DOI OpenAlex
Genotoxicity of TiO2 anatase nanoparticles in B6C3F1 male mice evaluated using Pig-a and flow cytometric micronucleus assays (2012)

Mutation Research/Genetic Toxicology and Environmental Mutagenesis 42 citations DOI OpenAlex
Quantitative Measurement of Plasma 3-Hydroxyisovaleryl Carnitine by LC-MS/MS as a Novel Biomarker of Biotin Status in Humans (2010)

Analytical Chemistry 26 citations DOI OpenAlex