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OverviewAI-generated summary
Sean H. Adams' research investigates the physiological and molecular mechanisms underlying metabolic diseases, with a particular focus on obesity, diet, and their impact on various bodily systems. His work has explored sex differences in skeletal muscle, examining fiber type, capillarity, and transcriptomics in mouse models. Adams has also studied the effects of exercise and diet-induced weight loss on hepatic bile acid synthesis and serum concentrations in obese women, as well as how diet influences serum protein glycosylation in women at risk for cardiometabolic disease.
Further research by Adams has delved into the functions of myoglobin, considering its roles as a delivery vehicle for oxygen and fuels, a metabolic sensor, and its potential involvement in brown adipose tissue, utilizing myoglobin knockout mice. His investigations also encompass the assessment of insulin sensitivity and postprandial triglyceridemic responses using a mixed macronutrient tolerance test. Adams has contributed to studies on the effects of blueberry phytochemicals on cell models of inflammation and oxidative stress. His scholarly output includes over 230 publications, with an h-index of 48 and more than 11,500 citations, designating him as a highly cited researcher.
Metrics
- h-index: 48
- Publications: 231
- Citations: 11,611
Selected Publications
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Abstract 1547 Innovative Insights into Myoglobin-Metabolite Interactions and Muscle Cell Bioenergetics (2025)
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Cardiorespiratory Fitness Associates with Blood Pressure and Metabolic Health of Children—The Arkansas Active Kids Study (2021)
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Predictors of Platelet Mitochondria Respiration in Children – The Arkansas Active Kids Study (2021)
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Metabolic physiology and skeletal muscle phenotypes in male and female myoglobin knockout mice (2021)
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On the potential role of globins in brown adipose tissue: a novel conceptual model and studies in myoglobin knockout mice (2021)
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Human Milk-Fed Piglets Have a Distinct Small Intestine and Circulatory Metabolome Profile Relative to That of Milk Formula-Fed Piglets (2021)
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Two SARS-CoV-2 Genome Sequences of Isolates from Rural U.S. Patients Harboring the D614G Mutation, Obtained Using Nanopore Sequencing (2021)
Collaboration Network
Top Collaborators
Sree V. Chintapalli
University of Arkansas for Medical Sciences
11 shared publications
In database
- Sex differences in skeletal muscle revealed through fiber type, capillarity, and transcriptomics profiling in mice
- A versatile delivery vehicle for cellular oxygen and fuels or metabolic sensor? A review and perspective on the functions of myoglobin
- On the potential role of globins in brown adipose tissue: a novel conceptual model and studies in myoglobin knockout mice
- Myoglobin Interaction with Lactate Rapidly Releases Oxygen: Studies on Binding Thermodynamics, Spectroscopy, and Oxygen Kinetics
- Metabolic physiology and skeletal muscle phenotypes in male and female myoglobin knockout mice
Showing 5 of 11 shared publications
Brian D. Piccolo
University of Arkansas for Medical Sciences
7 shared publications
In database
- Progression of diabetes is associated with changes in the ileal transcriptome and ileal‐colon morphology in the UC Davis Type 2 Diabetes Mellitus rat
- Exercise training modifies xenometabolites in gut and circulation of lean and obese adults
- Novel odd-chain cyclopropane fatty acids: detection in a mammalian lipidome and uptake by hepatosplanchnic tissues
- C‐section increases cecal abundance of the archetypal bile acid and glucocorticoid modifying <i>Lachnoclostridium [clostridium] scindens</i> in mice
- Beyond Butyrate – Xenometabolomics Reveals Hundreds of Metabolites and Fiber Type-Specific Signatures in Human Stool Cultures
Showing 5 of 7 shared publications
Adepu Kiran Kumar
6 shared publications
In database
- A versatile delivery vehicle for cellular oxygen and fuels or metabolic sensor? A review and perspective on the functions of myoglobin
- Myoglobin Interaction with Lactate Rapidly Releases Oxygen: Studies on Binding Thermodynamics, Spectroscopy, and Oxygen Kinetics
- Myoglobin–Pyruvate Interactions: Binding Thermodynamics, Structure–Function Relationships, and Impact on Oxygen Release Kinetics
- Computational Analysis Reveals Unique Binding Patterns of Oxygenated and Deoxygenated Myoglobin to the Outer Mitochondrial Membrane
- Myoglobin: A versatile age-old oxygen carrying hemoprotein and its emerging role in metabolite regulation in diverse tissues
Showing 5 of 6 shared publications
Andriy Anishkin
University of Arkansas for Medical Sciences
6 shared publications
In database
- A versatile delivery vehicle for cellular oxygen and fuels or metabolic sensor? A review and perspective on the functions of myoglobin
- Myoglobin Interaction with Lactate Rapidly Releases Oxygen: Studies on Binding Thermodynamics, Spectroscopy, and Oxygen Kinetics
- Myoglobin–Pyruvate Interactions: Binding Thermodynamics, Structure–Function Relationships, and Impact on Oxygen Release Kinetics
- Computational Analysis Reveals Unique Binding Patterns of Oxygenated and Deoxygenated Myoglobin to the Outer Mitochondrial Membrane
- Molecular insights into myoglobin binding patterns with the outer mitochondrial membrane: A comparison of oxygenated and deoxygenated states
Showing 5 of 6 shared publications
Kikumi D. Ono‐Moore
Arkansas Children's Nutrition Center (US)
5 shared publications
- Sex differences in skeletal muscle revealed through fiber type, capillarity, and transcriptomics profiling in mice
- Exercise training and diet-induced weight loss increase markers of hepatic bile acid (BA) synthesis and reduce serum total BA concentrations in obese women
- Two SARS-CoV-2 Genome Sequences of Isolates from Rural U.S. Patients Harboring the D614G Mutation, Obtained Using Nanopore Sequencing
- On the potential role of globins in brown adipose tissue: a novel conceptual model and studies in myoglobin knockout mice
- Metabolic physiology and skeletal muscle phenotypes in male and female myoglobin knockout mice
John W. Newman
University of California, Davis (US)
5 shared publications
- Exercise training and diet-induced weight loss increase markers of hepatic bile acid (BA) synthesis and reduce serum total BA concentrations in obese women
- Effects of a diet based on the Dietary Guidelines on vascular health and TMAO in women with cardiometabolic risk factors
- Assessing Insulin Sensitivity and Postprandial Triglyceridemic Response Phenotypes With a Mixed Macronutrient Tolerance Test
- The Dietary Biomarkers Development Consortium: An Initiative for Discovery and Validation of Dietary Biomarkers for Precision Nutrition
- Corrigendum to “The Dietary Biomarkers Development Consortium: An Initiative for Discovery and Validation of Dietary Biomarkers for Precision Nutrition. [Current Developments in Nutrition, Volume 9, Issue 5, May 2025, 107435]”
K. C. Kent Lloyd
University of California, Davis (US)
5 shared publications
- Sex differences in skeletal muscle revealed through fiber type, capillarity, and transcriptomics profiling in mice
- On the potential role of globins in brown adipose tissue: a novel conceptual model and studies in myoglobin knockout mice
- Metabolic physiology and skeletal muscle phenotypes in male and female myoglobin knockout mice
- The mouse metabolic phenotyping center (MMPC) live consortium: an NIH resource for in vivo characterization of mouse models of diabetes and obesity
- Exploring the role of peripheral nerves in trauma-induced heterotopic ossification
Trina A. Knotts
University of California, Davis (US)
5 shared publications
- Exploring the role of peripheral nerves in trauma-induced heterotopic ossification
- Cyclopropane xenolipids resemble monounsaturated fatty acids and modulate peroxisome proliferator-activated receptors
- Not All Saturated Fatty Acids Are Equal – The Case of Cyclopropane Fatty Acid Xenolipids
- Beyond Butyrate – Xenometabolomics Reveals Hundreds of Metabolites and Fiber Type-Specific Signatures in Human Stool Cultures
- DNA extraction and virome processing methods strongly influence recovered human gut viral community characteristics
Nancy L. Keim
Agricultural Research Service (US)
4 shared publications
- Exercise training and diet-induced weight loss increase markers of hepatic bile acid (BA) synthesis and reduce serum total BA concentrations in obese women
- Diet affects glycosylation of serum proteins in women at risk for cardiometabolic disease
- Effects of a diet based on the Dietary Guidelines on vascular health and TMAO in women with cardiometabolic risk factors
- Assessing Insulin Sensitivity and Postprandial Triglyceridemic Response Phenotypes With a Mixed Macronutrient Tolerance Test
Eva C. Diaz
Arkansas Children's Nutrition Center
4 shared publications
In database
- Cardiorespiratory Fitness Associates with Blood Pressure and Metabolic Health of Children—The Arkansas Active Kids Study
- Elevated LDL-C, high blood pressure, and low peak VO2 associate with platelet mitochondria function in children—The Arkansas Active Kids Study
- Predictors of Platelet Mitochondria Respiration in Children – The Arkansas Active Kids Study
- Phenolic Metabolite Profiling in Children's Plasma and Urine Following Short-Term Supplementation With Wild Blueberry Powder
Elisabet Børsheim
Arkansas Children's Nutrition Center
4 shared publications
In database
- Cardiorespiratory Fitness Associates with Blood Pressure and Metabolic Health of Children—The Arkansas Active Kids Study
- Elevated LDL-C, high blood pressure, and low peak VO2 associate with platelet mitochondria function in children—The Arkansas Active Kids Study
- Predictors of Platelet Mitochondria Respiration in Children – The Arkansas Active Kids Study
- Prenatal Exercise Training Alters Plasma Metabolite Responses To Acute Exercise In Pregnant Women With Obesity
Becky Moody
Arkansas Children's Nutrition Center (US)
4 shared publications
- Progression of diabetes is associated with changes in the ileal transcriptome and ileal‐colon morphology in the UC Davis Type 2 Diabetes Mellitus rat
- Exercise training modifies xenometabolites in gut and circulation of lean and obese adults
- C‐section increases cecal abundance of the archetypal bile acid and glucocorticoid modifying <i>Lachnoclostridium [clostridium] scindens</i> in mice
- Xenometabolomics reveals metabolic functional guilds unique to specific inulin subtypes in human gut microbiota cultures
Dipendra Bhandari
Arkansas Children's Nutrition Center (US)
4 shared publications
- Myoglobin Interaction with Lactate Rapidly Releases Oxygen: Studies on Binding Thermodynamics, Spectroscopy, and Oxygen Kinetics
- Myoglobin–Pyruvate Interactions: Binding Thermodynamics, Structure–Function Relationships, and Impact on Oxygen Release Kinetics
- Computational Analysis Reveals Unique Binding Patterns of Oxygenated and Deoxygenated Myoglobin to the Outer Mitochondrial Membrane
- Molecular insights into myoglobin binding patterns with the outer mitochondrial membrane: A comparison of oxygenated and deoxygenated states
Renny S. Lan
University of Arkansas for Medical Sciences
4 shared publications
In database
- Exercise training modifies xenometabolites in gut and circulation of lean and obese adults
- Novel odd-chain cyclopropane fatty acids: detection in a mammalian lipidome and uptake by hepatosplanchnic tissues
- Prenatal Exercise Training Alters Plasma Metabolite Responses To Acute Exercise In Pregnant Women With Obesity
- Xenometabolomics reveals metabolic functional guilds unique to specific inulin subtypes in human gut microbiota cultures
Jean Debédat
4 shared publications
- Novel odd-chain cyclopropane fatty acids: detection in a mammalian lipidome and uptake by hepatosplanchnic tissues
- Cyclopropane xenolipids resemble monounsaturated fatty acids and modulate peroxisome proliferator-activated receptors
- Not All Saturated Fatty Acids Are Equal – The Case of Cyclopropane Fatty Acid Xenolipids
- Beyond Butyrate – Xenometabolomics Reveals Hundreds of Metabolites and Fiber Type-Specific Signatures in Human Stool Cultures
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