Mahmoud Kiaei

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UAMS

Also affiliated: NewYork–Presbyterian Hospital (2004–2011); Cornell University (2002–2011); Konkuk University (2006); University of Arkansas Medical Center (2018–2023); Weill Cornell Medicine (2002–2013); Icahn School of Medicine at Mount Sinai (2004)

33 h-index 56 pubs 4,949 cited

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ORCID

OverviewAI-generated summary

Mahmoud Kiaei's research focuses on understanding the molecular mechanisms underlying neurodegenerative diseases, particularly amyotrophic lateral sclerosis (ALS). His work utilizes a combination of computational and experimental approaches to investigate the structural and functional consequences of genetic mutations associated with ALS. This includes in silico studies to predict how mutations in proteins like profilin-1 and TUBA4A affect protein structure and interactions with potential therapeutic agents, such as riluzole and edaravone.

Kiaei also employs biochemical techniques, including hydrogen/deuterium exchange mass spectrometry, to detect structural and conformational changes in mutant proteins in vitro and in vivo. His research has explored the potential of RNA as a biomarker for ALS and investigated the aggregation of mutant profilin-1. Collaborations with researchers at the University of Arkansas for Medical Sciences and the University of Arkansas at Fayetteville contribute to his ongoing investigations. Kiaei's publication record includes studies on disease models, protein structure, and the development of therapeutic strategies for neurological disorders.

Metrics

h-index: 33
Publications: 56
Citations: 4,949

Selected Publications

A systematic review of emerging technologies to enhance the treatment of ovarian cancer (2023)

Pharmaceutical Development and Technology 3 citations DOI OpenAlex
In silico analysis of TUBA4A mutations in Amyotrophic Lateral Sclerosis to define mechanisms of microtubule disintegration (2023)

Scientific Reports 14 citations DOI OpenAlex
Correction to: RNA as a Source of Biomarkers for Amyotrophic Lateral Sclerosis (2022)

Metabolic Brain Disease DOI OpenAlex
Detection of Structural and Conformational Changes in ALS-Causing Mutant Profilin1 With Hydrogen/Deuterium Exchange Mass Spectrometry and Bioinformatics Techniques (2021)

Research Square 4 citations DOI OpenAlex
RNA as a source of biomarkers for amyotrophic lateral sclerosis (2021)

Metabolic Brain Disease 4 citations DOI OpenAlex
Mutant Profilin1 Aggregation in Amyotrophic Lateral Sclerosis: An in Vivo Biochemical Analysis (2021)

Basic and Clinical Neuroscience Journal 4 citations DOI OpenAlex
In silico studies reveal structural deviations of mutant profilin-1 and interaction with riluzole and edaravone in amyotrophic lateral sclerosis (2021)

Scientific Reports 30 citations DOI OpenAlex
Detection of structural and conformational changes in ALS-causing mutant profilin-1 with hydrogen/deuterium exchange mass spectrometry and bioinformatics techniques (2021)

Metabolic Brain Disease 6 citations DOI OpenAlex
Changes in biophysical characteristics of PFN1 due to mutation causing amyotrophic lateral sclerosis (2018)

Metabolic Brain Disease 14 citations DOI OpenAlex
RNA-Seq Analysis of Spinal Cord Tissues from hPFN1G118V Transgenic Mouse Model of ALS at Pre-symptomatic and End-Stages of Disease (2018)

Scientific Reports 13 citations DOI OpenAlex
ALS-causing mutations in profilin-1 alter its conformational dynamics: A computational approach to explain propensity for aggregation (2018)

Scientific Reports 19 citations DOI OpenAlex
Antisense-mediated reduction of EphA4 in the adult CNS does not improve the function of mice with amyotrophic lateral sclerosis (2018)

Neurobiology of Disease 30 citations DOI OpenAlex
Mutant Profilin1 transgenic mice recapitulate cardinal features of motor neuron disease (2016)

Human Molecular Genetics 90 citations DOI OpenAlex
Profilin1 biology and its mutation, actin(g) in disease (2016)

Cellular and Molecular Life Sciences 123 citations DOI OpenAlex
A retrospective review of the progress in amyotrophic lateral sclerosis drug discovery over the last decade and a look at the latest strategies (2015)

Expert Opinion on Drug Discovery 31 citations DOI OpenAlex