Duah Alkam

Researcher

University of Arkansas for Medical Sciences

faculty

10 h-index 28 pubs 465 cited

Research Areas

Cancer-related molecular mechanisms research Molecular Biology Techniques and Applications Microbial infections and disease research Cancer Immunotherapy and Biomarkers SARS-CoV-2 and COVID-19 Research Epigenetics and DNA Methylation Multiple Myeloma Research and Treatments Bioinformatics and Genomic Networks

Links

ORCID Research Group

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OverviewAI-generated summary

Duah Alkam is a researcher whose work investigates molecular mechanisms across various biological systems. Recent publications include studies on quantitative proteomics using the proteoDA package, integration of multi-omics data to understand triple-negative breast cancer, and epigenetic regulation of integrin β-7 in multiple myeloma. Alkam's research also extends to microbial pathogenesis, examining how mutations in *purR* affect *Staphylococcus aureus* virulence factors, and the use of human lung slice platforms to study SARS-CoV-2 infection and antiviral efficacy.

Further research interests include the development of one-pot methods for multiomics analysis, and exploring novel immunotherapies for cancer. This includes repurposing the MMR vaccine for cancer immunotherapy and enhancing immune responses in hepatocellular carcinoma with oncolytic viruses and immune checkpoint blockade. Alkam has a scholarly impact indicated by an h-index of 10, 28 total publications, and 465 total citations.

Metrics

h-index: 10
Publications: 28
Citations: 465

Selected Publications

Rare SNP in the HELB gene interferes with RPA interaction and cellular function of HELB (2025) DOI
IP-to-MS: An Unbiased Workflow for Antigen Profiling (2025) DOI
An ex vivo human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy (2024) DOI
One-pot method for preparing DNA, RNA, and protein for multiomics analysis (2024) DOI
An ex vivo human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy (2023) DOI
Proteogenomics Analysis to Identify Acquired Resistance-Specific Alterations in Melanoma PDXs on MAPKi Therapy (2023) DOI
Expression of integrin β-7 is epigenetically enhanced in multiple myeloma subgroups with high-risk cytogenetics (2023) DOI
Repurposing live attenuated trivalent MMR vaccine as cost-effective cancer immunotherapy (2022) DOI
Proteogenomics Reference Database Protocol v1 (2022) DOI
Proteogenomics Reference Database Protocol v1 (2022) DOI
Proteogenomics analysis to identify acquired resistance-specific alterations in melanoma PDXs on MAPKi therapy (2022) DOI
Is amplification bias consequential in transposon sequencing (TnSeq) assays? A case study with a Staphylococcus aureus TnSeq library subjected to PCR-based and amplification-free enrichment methods (2021) DOI
Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer (2021) DOI
The Increased Accumulation of Staphylococcus aureus Virulence Factors Is Maximized in a purR Mutant by the Increased Production of SarA and Decreased Production of Extracellular Proteases (2021) DOI