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Institution-verified
Presence
Current · Arkansas
Last published
2025
Sources
Institutional record
Refreshed
2026-10-05
C
Cesar Compadre
Sourced from institutional research profiles (UAMS TRI or ARA).
Professor
28 h-index
86 pubs
2,540 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Cesar Compadre's research investigates the structure-activity relationships of natural compounds, particularly those with potential pharmacological or physiological effects. His work has explored plant-derived compounds, including steviol glycosides from the *Stevia* genus, examining their properties as sweetening agents and their metabolic activation. Compadre has also studied ellagic acid derivatives for their potential to inhibit bacterial biofilm formation and enhance antibiotic efficacy. Additionally, his research has touched upon the structural analysis of allergens, such as the major peanut allergen Ara h 1, to understand IgE-binding sites and potential degradation pathways.
His investigations have utilized various models, including animal studies with mice, to explore disease mechanisms and the effects of specific compounds. Compadre's publication record includes work on mutagenicity, the discovery of intensely sweet compounds through historical literature review, and the development of phytochemical screening procedures for specific plant compounds. His scholarly output is reflected in a h-index of 28 and over 2,540 citations across 86 publications, indicating sustained contributions to his fields of study.
Metrics
- h-index: 28
- Publications: 86
- Citations: 2,540
Positions
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CSO 2023–presentTocol Pharmaceuticals LLC ORCID
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Professor 1988–presentUniversity of Arkansas for Medical Sciences Pharmaceutical Sciences Institutional directory
Selected Publications
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Machine Learning–Enhanced Quantitative Structure-Activity Relationship Modeling for DNA Polymerase Inhibitor Discovery: Algorithm Development and Validation (2025)
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DNA Polymerase Inhibitor Discovery Using Machine Learning-Enhanced QSAR Modeling (2025)
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Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects (2023)
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466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator (2023)
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Parthenolide induces rapid thiol oxidation that leads to ferroptosis in hepatocellular carcinoma cells (2022)
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Analysis of Plant–Plant Interactions Reveals the Presence of Potent Antileukemic Compounds (2022)
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Yoga therapy knowledge in third-year pharmacy students: An education intervention (2021)
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Synthesis, Crystallography, and Anti-Leukemic Activity of the Amino Adducts of Dehydroleucodine (2020)
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Antioxidant Tocols as Radiation Countermeasures (Challenges to be Addressed to Use Tocols as Radiation Countermeasures in Humans) (2018)
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Corrigendum to ‘Synthesis of (2R,8′S,3′E)-δ-tocodienol, a tocoflexol family member designed to have a superior pharmacokinetic profile compared to δ-tocotrienol’ [Tetrahedron 72 (2016) 4001–4006] (2016)
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Synthesis of (2R,8′S,3′E)-δ-tocodienol, a tocoflexol family member designed to have a superior pharmacokinetic profile compared to δ-tocotrienol (2016)
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Corrigendum to “Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity” [J. Ethnopharmacol. 137 (2011) 1055–1059] (2016)
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Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa, Demonstrates Cytotoxic Activity against Human Leukemia Cells (2016)
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Effects of Tocols Rich Fraction Isolated from Rice Bran Oil Deodorizer Distillate on Plasma and Hepatic Lipid Concentrations in Rats (2015)
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Tocotrienol-Rich Fraction from Rice Bran Demonstrates Potent Radiation Protection Activity (2015)
Grants & Funding
As listed on this researcher's institutional profile.
- Early Events in Alzheimer Pathogenesis NIH
- Unwed Birth Prevention for Teenagers of Hispanic Heritage in Sevier County Arkansas Department of Health & Human Services
- Developing Countermeasures for Acute Respiratory Distress Produced by Lunar Dust National Aeronautics & Space Administration via Arkansas Space Grant Consortium
- La Casa Latino Tobacco Free Coalition (subcontract with UAPB) Arkansas Department of Health via University of Arkansas at Pine Bluff
- Latino Smoke-Free Coalition Arkansas Department of Health & Human Services via University of Arkansas at Pine Bluff
Collaboration Network
Top Collaborators
Philip J. Breen
University of Arkansas for Medical Sciences
15 shared publications
In database
- Antimicrobial Activity of Cetylpyridinium Chloride Washes against Pathogenic Bacteria on Beef Surfaces
- Elimination of Salmonella Contamination from Poultry Tissues by Cetylpyridinium Chloride Solutions
- Quaternary Ammonium Compounds Inhibit and Reduce the Attachment of Viable Salmonella typhimurium to Poultry Tissues
- Antioxidant Tocols as Radiation Countermeasures (Challenges to be Addressed to Use Tocols as Radiation Countermeasures in Humans)
- Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity
Showing 5 of 15 shared publications
Martin Hauer‐Jensen
University of Arkansas for Medical Sciences
7 shared publications
In database
- γ-Tocotrienol Protects against Mitochondrial Dysfunction and Renal Cell Death
- Effects of Late Administration of Pentoxifylline and Tocotrienols in an Image-Guided Rat Model of Localized Heart Irradiation
- Molecular Dynamics Guided Design of Tocoflexol: A New Radioprotectant Tocotrienol with Enhanced Bioavailability
- Synthesis of (2R,8′S,3′E)-δ-tocodienol, a tocoflexol family member designed to have a superior pharmacokinetic profile compared to δ-tocotrienol
- Tocotrienol-Rich Fraction from Rice Bran Demonstrates Potent Radiation Protection Activity
Showing 5 of 7 shared publications
Omar Malagón
Universidad Técnica Particular de Loja (EC)
7 shared publications
- Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity
- Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa, Demonstrates Cytotoxic Activity against Human Leukemia Cells
- Synthesis, Crystallography, and Anti-Leukemic Activity of the Amino Adducts of Dehydroleucodine
- Sesquiterpene Lactones of Gynoxys verrucosa and their Anti-MRSA Activity
- Corrigendum to “Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity” [J. Ethnopharmacol. 137 (2011) 1055–1059]
Showing 5 of 7 shared publications
Shraddha H. Thakkar
University of Arkansas for Medical Sciences (US)
5 shared publications
- Antioxidant Tocols as Radiation Countermeasures (Challenges to be Addressed to Use Tocols as Radiation Countermeasures in Humans)
- Molecular Dynamics Guided Design of Tocoflexol: A New Radioprotectant Tocotrienol with Enhanced Bioavailability
- Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects
- EXPLORING HYDROPHOBIC BINDING SURFACES USING COMFA AND FLEXIBLE HYDROPHOBIC LIGANDS
- 466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator
Nükhet Aykin‐Burns
University of Arkansas for Medical Sciences
5 shared publications
In database
- Antioxidant Tocols as Radiation Countermeasures (Challenges to be Addressed to Use Tocols as Radiation Countermeasures in Humans)
- Parthenolide induces rapid thiol oxidation that leads to ferroptosis in hepatocellular carcinoma cells
- Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects
- Tocotrienol-Rich Fraction from Rice Bran Demonstrates Potent Radiation Protection Activity
- 466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator
Paola E. Ordóñez
Universidad Yachay Tech (EC)
5 shared publications
- Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity
- Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa, Demonstrates Cytotoxic Activity against Human Leukemia Cells
- Synthesis, Crystallography, and Anti-Leukemic Activity of the Amino Adducts of Dehydroleucodine
- Corrigendum to “Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity” [J. Ethnopharmacol. 137 (2011) 1055–1059]
- Analysis of Plant–Plant Interactions Reveals the Presence of Potent Antileukemic Compounds
Cassandra Leah Quave
University of Arkansas for Medical Sciences (US)
5 shared publications
- Ellagic Acid Derivatives from Rubus ulmifolius Inhibit Staphylococcus aureus Biofilm Formation and Improve Response to Antibiotics
- Quercus cerris extracts limit Staphylococcus aureus biofilm formation
- Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity
- Inhibition of Biofilm Formation in Staphylococcus aureus Isolates by Quercus cerris Extracts
- Corrigendum to “Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity” [J. Ethnopharmacol. 137 (2011) 1055–1059]
Xiang Zhou
John L. McClellan Memorial Veterans Hospital (US)
5 shared publications
- Antimicrobial Activity of Cetylpyridinium Chloride Washes against Pathogenic Bacteria on Beef Surfaces
- Liquid chromatography determination of residue levels on apples treated with cetylpyridinium chloride
- High-performance liquid chromatography determination of residue levels on chicken carcasses treated with cetylpyridinium chloride
- Determination of albuterol in plasma after aerosol inhalation by gas chromatography-mass spectrometry with selected-ion monitoring
- Synthesis of13C,2H3-salmeterol: an analytical internal standard for pharmacokinetic studies
Darin E. Jones
University of Arkansas for Medical Sciences
5 shared publications
In database
- Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa, Demonstrates Cytotoxic Activity against Human Leukemia Cells
- Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects
- Synthesis, Crystallography, and Anti-Leukemic Activity of the Amino Adducts of Dehydroleucodine
- Analysis of Plant–Plant Interactions Reveals the Presence of Potent Antileukemic Compounds
- 466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator
Awantika Singh
University of Arkansas for Medical Sciences (US)
4 shared publications
- Effects of Late Administration of Pentoxifylline and Tocotrienols in an Image-Guided Rat Model of Localized Heart Irradiation
- Molecular Dynamics Guided Design of Tocoflexol: A New Radioprotectant Tocotrienol with Enhanced Bioavailability
- MOLECULAR MODELING ANALYSIS OF THE INHIBITION OF MITOCHONDRIAL CYTOCHROME BC1 COMPLEX ACTIVITY BY TOCOL DERIVATIVES
- 466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator
Marjan Boerma
University of Arkansas for Medical Sciences
4 shared publications
In database
- Effects of Late Administration of Pentoxifylline and Tocotrienols in an Image-Guided Rat Model of Localized Heart Irradiation
- Molecular Dynamics Guided Design of Tocoflexol: A New Radioprotectant Tocotrienol with Enhanced Bioavailability
- Synthesis of (2R,8′S,3′E)-δ-tocodienol, a tocoflexol family member designed to have a superior pharmacokinetic profile compared to δ-tocotrienol
- Corrigendum to ‘Synthesis of (2R,8′S,3′E)-δ-tocodienol, a tocoflexol family member designed to have a superior pharmacokinetic profile compared to δ-tocotrienol’ [Tetrahedron 72 (2016) 4001–4006]
Kimberly J. Krager
University of Arkansas for Medical Sciences
4 shared publications
In database
- Antioxidant Tocols as Radiation Countermeasures (Challenges to be Addressed to Use Tocols as Radiation Countermeasures in Humans)
- Parthenolide induces rapid thiol oxidation that leads to ferroptosis in hepatocellular carcinoma cells
- Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects
- Tocotrienol-Rich Fraction from Rice Bran Demonstrates Potent Radiation Protection Activity
Mark S. Smeltzer
University of Arkansas for Medical Sciences
4 shared publications
In database
- Ellagic Acid Derivatives from Rubus ulmifolius Inhibit Staphylococcus aureus Biofilm Formation and Improve Response to Antibiotics
- Quercus cerris extracts limit Staphylococcus aureus biofilm formation
- Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity
- Corrigendum to “Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity” [J. Ethnopharmacol. 137 (2011) 1055–1059]
Rosa L. Lopez de Compadre
University of Arkansas for Medical Sciences (US)
4 shared publications
- STRUCTURE‐ACTIVITY STUDIES OF PHOTOACTIVATED ANTIVIRAL AND CYTOTOXIC TRICYCLIC THIOPHENES
- Synthesis and comparative molecular field analysis (CoMFA) of argentatin B derivatives as growth inhibitors of human cancer cell lines
- Comparison of CoMFA Models for Salmonella Typhimurium TA98, TA100+TA98+S9 and TA100+S9 Mutagenicity of Nitroaromatics
- Quantitative Structure-Activity Relationship Analysis of Natural Products: Phototoxic Thiophenes
Hamid Salari
University of Arkansas for Medical Sciences (US)
4 shared publications
- Elimination of Salmonella Contamination from Poultry Tissues by Cetylpyridinium Chloride Solutions
- Quaternary Ammonium Compounds Inhibit and Reduce the Attachment of Viable Salmonella typhimurium to Poultry Tissues
- Liquid chromatography determination of residue levels on apples treated with cetylpyridinium chloride
- High-performance liquid chromatography determination of residue levels on chicken carcasses treated with cetylpyridinium chloride
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