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2026
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2026-10-06
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Baitang Ning
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Also affiliated: Qingdao University (2020); United States Department of Health and Human Services (2010–2012); United States Food and Drug Administration (2006–2026); Chinese Academy of Medical Sciences & Peking Union Medical College (2007); First Affiliated Hospital of Guangzhou Medical University (2021); National Cancer Institute (2021); Cancer Hospital of Chinese Academy of Medical Sciences (2007); State Key Laboratory of Respiratory Disease (2021); Guangzhou Institute of Respiratory Health (2021); Western University of Health Sciences (2008)
44 h-index
164 pubs
11,273 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Baitang Ning's research focuses on the application and evaluation of high-throughput molecular profiling technologies, particularly in the context of toxicological research and predictive modeling. Ning has been involved in significant consortia, including the MicroArray Quality Control (MAQC) project and the Sequencing Quality Control (SQC) Consortium, which aimed to assess the reproducibility and accuracy of gene expression measurements from microarray and RNA sequencing platforms. These projects have generated substantial data on common practices for developing and validating predictive models based on these technologies.
Further investigations have explored the accuracy, reproducibility, and information content of RNA-sequencing technologies, including single-cell RNA-seq. Ning's work also extends to comparing different profiling methods, such as RNA-seq and microarray-based models, for their utility in clinical endpoint prediction. Additionally, research has examined the expression of drug-metabolizing enzymes in human hepatic cell lines and primary hepatocytes, and investigated functional genetic variants associated with disease risk, such as cyclooxygenase-2 and esophageal cancer.
Ning has a notable publication record with 167 total publications and over 11,000 citations, reflected in an h-index of 45. Key collaborators include Joe Meehan, Bohu Pan, and Weigong Ge, with whom Ning has co-authored numerous publications at the National Center for Toxicological Research.
Metrics
- h-index: 44
- Publications: 164
- Citations: 11,273
Selected Publications
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SARS-CoV-2 Spike Protein’s Structural Dynamics Affect the Activity of the Bebtelovimab Antibody (2026)
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Microphysiological systems as an emerging in vitro approach for the evaluation of drug absorption, distribution, metabolism, and excretion and toxicity (2025)
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Identification of Genetic Risk Factors Associated With Herbal and Dietary Supplement–Induced Acute Liver Failure Using Whole Exome Sequencing Analysis (2025)
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DILIrank dataset for QSAR modeling of drug-induced liver injury (2023)
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Pharmacological Effects of Ketoconazole in the Treatment of Steroidogenesis Suppression via CYP17A1 Inhibition May Involve MicroRNA Regulation (2023)
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Additional file 3 of Assessing reproducibility of inherited variants detected with short-read whole genome sequencing (2022)
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Additional file 13 of Assessing reproducibility of inherited variants detected with short-read whole genome sequencing (2022)
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Additional file 5 of Assessing reproducibility of inherited variants detected with short-read whole genome sequencing (2022)
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Additional file 15 of Assessing reproducibility of inherited variants detected with short-read whole genome sequencing (2022)
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Additional file 10 of Assessing reproducibility of inherited variants detected with short-read whole genome sequencing (2022)
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Additional file 9 of Assessing reproducibility of inherited variants detected with short-read whole genome sequencing (2022)
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Additional file 11 of Assessing reproducibility of inherited variants detected with short-read whole genome sequencing (2022)
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Additional file 1 of Assessing reproducibility of inherited variants detected with short-read whole genome sequencing (2022)
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Additional file 6 of Assessing reproducibility of inherited variants detected with short-read whole genome sequencing (2022)
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Additional file 12 of Assessing reproducibility of inherited variants detected with short-read whole genome sequencing (2022)
Collaboration Network
Top Collaborators
Weida Tong
National Center for Toxicological Research
45 shared publications
In database
- The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements
- A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium
- The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models
- An investigation of biomarkers derived from legacy microarray data for their utility in the RNA-seq era
- Next-generation sequencing and its applications in molecular diagnostics
Showing 5 of 45 shared publications
Lei Guo
National Center for Toxicological Research
32 shared publications
In database
- A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium
- A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
- Similarities and Differences in the Expression of Drug-Metabolizing Enzymes between Human Hepatic Cell Lines and Primary Human Hepatocytes
- Cross-platform comparison of SYBR® Green real-time PCR with TaqMan PCR, microarrays and other gene expression measurement technologies evaluated in the MicroArray Quality Control (MAQC) study
- Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity
Showing 5 of 32 shared publications
Dianke Yu
Qingdao University (CN)
27 shared publications
- Suppression of CYP2C9 by MicroRNA hsa-miR-128-3p in Human Liver Cells and Association with Hepatocellular Carcinoma
- Micrornas as Pharmacogenomic Biomarkers for Drug Efficacy and Drug Safety Assessment
- Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans
- Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis
- MicroRNA hsa-miR-370-3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation
Showing 5 of 27 shared publications
Huixiao Hong
National Center for Toxicological Research
27 shared publications
In database
- A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium
- The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models
- A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
- Comparison of RNA-seq and microarray-based models for clinical endpoint prediction
- An investigation of biomarkers derived from legacy microarray data for their utility in the RNA-seq era
Showing 5 of 27 shared publications
Leming M. Shi
National Center for Toxicological Research (US)
26 shared publications
- The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements
- The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements
- The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models
- Similarities and Differences in the Expression of Drug-Metabolizing Enzymes between Human Hepatic Cell Lines and Primary Human Hepatocytes
- Next-generation sequencing and its applications in molecular diagnostics
Showing 5 of 26 shared publications
Dongying Li
National Center for Toxicological Research
21 shared publications
In database
- Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- Biochemical features and mutations of key proteins in SARS-CoV-2 and their impacts on RNA therapeutics
- The role of hepatic cytochrome P450s in the cytotoxicity of sertraline
- Mitochondrial dysfunction and apoptosis underlie the hepatotoxicity of perhexiline
Showing 5 of 21 shared publications
Rebecca L. Kusko
19 shared publications
- Toward best practice in cancer mutation detection with whole-genome and whole-exome sequencing
- Assessing reproducibility of inherited variants detected with short-read whole genome sequencing
- The international MAQC Society launches to enhance reproducibility of high-throughput technologies
- Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions
- FDA-led consortium studies advance quality control of targeted next generation sequencing assays for precision oncology
Showing 5 of 19 shared publications
Andreas Scherer
University of Helsinki (FI)
19 shared publications
- Toward best practice in cancer mutation detection with whole-genome and whole-exome sequencing
- The SEQC2 epigenomics quality control (EpiQC) study
- Assessing reproducibility of inherited variants detected with short-read whole genome sequencing
- Author Correction: The SEQC2 epigenomics quality control (EpiQC) study
- The SEQC2 Epigenomics Quality Control (EpiQC) Study: Comprehensive Characterization of Epigenetic Methods, Reproducibility, and Quantification
Showing 5 of 19 shared publications
Si Chen
National Center for Toxicological Research
18 shared publications
In database
- Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity
- Micrornas as Pharmacogenomic Biomarkers for Drug Efficacy and Drug Safety Assessment
- Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans
- Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis
- MicroRNA hsa-miR-370-3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation
Showing 5 of 18 shared publications
Luyao Ren
Fudan University (CN)
18 shared publications
- Toward best practice in cancer mutation detection with whole-genome and whole-exome sequencing
- Establishing community reference samples, data and call sets for benchmarking cancer mutation detection using whole-genome sequencing
- Assessing reproducibility of inherited variants detected with short-read whole genome sequencing
- Establishing reference samples for detection of somatic mutations and germline variants with NGS technologies
- Additional file 14 of Assessing reproducibility of inherited variants detected with short-read whole genome sequencing
Showing 5 of 18 shared publications
Jonathan Foox
Cornell University (US)
18 shared publications
- The SEQC2 epigenomics quality control (EpiQC) study
- Assessing reproducibility of inherited variants detected with short-read whole genome sequencing
- Author Correction: The SEQC2 epigenomics quality control (EpiQC) study
- The SEQC2 Epigenomics Quality Control (EpiQC) Study: Comprehensive Characterization of Epigenetic Methods, Reproducibility, and Quantification
- Additional file 14 of Assessing reproducibility of inherited variants detected with short-read whole genome sequencing
Showing 5 of 18 shared publications
William H. Tolleson
National Center for Toxicological Research
17 shared publications
In database
- Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity
- Micrornas as Pharmacogenomic Biomarkers for Drug Efficacy and Drug Safety Assessment
- Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans
- Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis
- MicroRNA hsa-miR-29a-3p modulates CYP2C19 in human liver cells
Showing 5 of 17 shared publications
Tieliu Shi
Capital Medical University (CN)
17 shared publications
- Single-Cell RNA-Seq Technologies and Related Computational Data Analysis
- A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
- X-CNV: genome-wide prediction of the pathogenicity of copy number variations
- Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans
- MicroRNA hsa-miR-370-3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation
Showing 5 of 17 shared publications
Kelci J. Miclaus
SAS Institute (United States) (US)
17 shared publications
- Technical Reproducibility of Genotyping SNP Arrays Used in Genome-Wide Association Studies
- Assessing reproducibility of inherited variants detected with short-read whole genome sequencing
- Assessing sources of inconsistencies in genotypes and their effects on genome-wide association studies with HapMap samples
- Additional file 14 of Assessing reproducibility of inherited variants detected with short-read whole genome sequencing
- Additional file 2 of Assessing reproducibility of inherited variants detected with short-read whole genome sequencing
Showing 5 of 17 shared publications
Gökhan Yavaş
National Center for Toxicological Research (US)
17 shared publications
- Assessing reproducibility of inherited variants detected with short-read whole genome sequencing
- Challenges, Solutions, and Quality Metrics of Personal Genome Assembly in Advancing Precision Medicine
- Abstract 1556: Algorithms for discovery of somatic single nucleotide mutation display specific artifacts and different detection capabilities under the effect of read coverage and sample heterogeneity
- Additional file 14 of Assessing reproducibility of inherited variants detected with short-read whole genome sequencing
- Additional file 2 of Assessing reproducibility of inherited variants detected with short-read whole genome sequencing
Showing 5 of 17 shared publications
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