John P. Culver
Researcher
Also affiliated: University of Kentucky (2009–2024); University of Strathclyde (2006); Western Kentucky University (2005)
Faculty Researcher
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
John P. Culver studies the mechanisms of vesicular monoamine transporter-2 (VMAT2) inhibition. His recent publication in 2024 investigated the VMAT2 inhibitor JPC-141, demonstrating its ability to prevent methamphetamine-induced dopamine toxicity and block methamphetamine self-administration in rat models. This research contributes to understanding the neurobiological effects of stimulants and potential therapeutic strategies for substance abuse. Culver's work utilizes animal models to explore the impact of pharmacological agents on dopamine systems, which are implicated in addiction and neurodegenerative diseases. His h-index is 6 with 17 total publications and 97 citations. He has collaborated with researchers at the University of Arkansas for Medical Sciences, including Peter A. Crooks, Justin R. Nickell, Cassie M. Chandler, and A. George Wilson.
Metrics
- h-index: 6
- Publications: 17
- Citations: 99
Selected Publications
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Vesicular monoamine transporter-2 inhibitor JPC-141 prevents methamphetamine-induced dopamine toxicity and blocks methamphetamine self-administration in rats (2024)
Collaboration Network
Top Collaborators
- Vesicular monoamine transporter-2 inhibitor JPC-141 prevents methamphetamine-induced dopamine toxicity and blocks methamphetamine self-administration in rats
- Vesicular monoamine transporter-2 inhibitor JPC-141 prevents methamphetamine-induced dopamine toxicity and blocks methamphetamine self-administration in rats
- Vesicular monoamine transporter-2 inhibitor JPC-141 prevents methamphetamine-induced dopamine toxicity and blocks methamphetamine self-administration in rats
- Vesicular monoamine transporter-2 inhibitor JPC-141 prevents methamphetamine-induced dopamine toxicity and blocks methamphetamine self-administration in rats
- Vesicular monoamine transporter-2 inhibitor JPC-141 prevents methamphetamine-induced dopamine toxicity and blocks methamphetamine self-administration in rats
- Vesicular monoamine transporter-2 inhibitor JPC-141 prevents methamphetamine-induced dopamine toxicity and blocks methamphetamine self-administration in rats
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