Robert R. Wolfe
Professor
Also affiliated: Rutgers, The State University of New Jersey (1970–1991); University of Vermont (1983–1993); University of Southern California (2003); James Madison University (2019); West Virginia University (1985); Louisiana State University (1976–1978); Tufts University (1980–1993); University of Copenhagen (2008); University of Iowa (2021); Brigham and Women's Hospital (1982); Fundación Juan March (2004); Clarke University (1986); University of Colorado Hospital (1978–2003); Boston Children's Hospital (2002–2009); Tufts Medical Center (1980); Joslin Diabetes Center (1986); National Institutes of Health (1988); University of Denver (1992); Fitzsimons Army Medical Center (1977–1979); Shriners Hospitals for Children - Erie (1979–2007); Juniper Networks (United States) (2006); TE Connectivity (Switzerland) (2000); Harvard University (1978–1989); University of Connecticut (2003–2006); University of Alaska Fairbanks (2019); University of Trieste (2000); Johns Hopkins University (1984); University of California, Santa Barbara (1975–1976); Baylor University (1964–1966); University of California, Los Angeles (1967–1970); Texas A&M University at Galveston (1989–2010); Oregon Health & Science University (1996); The Aerospace Corporation (1971–1975); East Carolina University (1986); University of Colorado Boulder (1974–1990); Ajinomoto (United States) (2005); Vanderbilt University (1993); University of Washington (2022); Keio University (1989); Washington University in St. Louis (1995–2003); Queen's University (2022); Purdue University West Lafayette (2008); University of Utah (1979); University of Arkansas Medical Center (2008–2021); UCLA Health (1968–1969); Johns Hopkins Medicine (1984); Tulane Medical Center (1976); John Sealy Hospital (2006); Beth Israel Deaconess Hospital (1989); UCLA Medical Center (1968–1969); University Medical Center New Orleans (1976–1978); Shriners Hospitals for Children - Galveston (1984–2010); Harvard University Press (1985); Denver Health Medical Center (1974); Galveston College (1987–2010); University of California System (1986); Center for Information Technology (1998); Yale University (1985–1986); Michigan Public Health Institute (2000); University of Colorado Health (1981–1997); Massachusetts General Hospital (1978–1989); United States Army (2019); Palo Alto Veterans Institute for Research (1990); Novem (Netherlands) (2005); National Institute of Diabetes and Digestive and Kidney Diseases (1988); University of Texas Health Science Center at Dallas (1986); Children's Hospital Colorado (1977–2012); Central Arkansas Veterans Healthcare System (2008); Denver VA Medical Center (1974–1978); Biology of Infection (2001); Hospital General de Granollers (1998); Jean Mayer Human Nutrition Research Center on Aging (1993); Eunice Kennedy Shriver Center (1980); Baim Institute for Clinical Research (1982); Burn Institute (1978–1998); Shriners Hospitals for Children - Boston (2007–2008); United States Army Institute of Surgical Research (2004); National Aeronautics and Space Administration (1996); Duke Medical Center (2008–2022); Essential Research (United States) (2017–2020); Center for Translational Molecular Medicine (2008); Louisiana Department of Natural Resources (2019); Institute on Aging (2007–2026); St. Anthony Hospital (1976); Public Works Research Institute (2003); Shriners Hospitals for Children (1994–2010); Texas Medical Board (2005–2007); Ajinomoto (Japan) (2003–2006); Scripps MD Anderson Cancer Center (2024); Pediatrics and Genetics (1974); Texas Children's Hospital (1964–1966); Denver School of Nursing (1987); Johnson Space Center (2006); National Cattlemen's Beef Association (2009); Community Hospital (2019); Riddet Institute (2018); October 6 University (2003); Surfactant Associates (2001); Abbott Nutrition (United States) (2013); Transnational Press London (1990); University of Oklahoma Health Sciences Center (2008); Massey University (2016–2018); University of Colorado Anschutz Medical Campus (1991); The University of Texas Medical Branch at Galveston (1985–2010); Monash University (2012–2025); Stony Brook University (1996); Massachusetts Institute of Technology (1978–1993); Donaldson (United States) (2009); Virginia Commonwealth University Medical Center (1993); International School of Management (2001); Augustana College (1997); University of Pennsylvania (1988); Ludwig-Maximilians-Universität München (1989–1990); University of California, Davis (1988); The University of Texas at Austin (1996); Michigan State University (2023); University of Colorado Colorado Springs (1994); Texas A&M University (2014–2020); University of Colorado Denver (1974–2012); Philadelphia University (1979); University of California, Berkeley (1990–1991); University of Lausanne (1983); American College of Surgeons (1997)
Faculty Researcher
Geriatrics, College of Medicine
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Robert R. Wolfe is a Professor in the Geriatrics division at the University of Arkansas for Medical Sciences, College of Medicine. With a distinguished career marked by extensive scholarship, Wolfe holds an h-index of 132 and has authored over 1,054 publications, accumulating more than 64,446 citations. His research primarily investigates the interplay between nutrition, muscle physiology, and physical performance, particularly in older adults and in the context of surgical recovery. He has explored the effects of essential amino acid supplementation on muscle mass, strength, and physical function, as well as the role of specific metabolic pathways like the Warburg, Cori-cycle, and Crabtree effects in health and disease. His work also extends to animal models, examining the impact of myostatin inhibition and dietary interventions on muscle quality and strength in mice. Wolfe's recent publications address topics ranging from pre- and post-surgical nutrition to the broader implications of dietary protein quality and the metabolic underpinnings of cancer. He maintains an active research group and collaborates with several colleagues at the University of Arkansas for Medical Sciences, including Arny A. Ferrando, David N. Church, David D. Church, and Gohar Azhar, with whom he has co-authored numerous publications.
Metrics
- h-index: 132
- Publications: 1055
- Citations: 65,483
Selected Publications
-
Understanding Dietary Protein Quality: Digestible Indispensable Amino Acid Scores and Beyond (2025)
-
Crossover Trial of Exogenous Ketones on Cardiometabolic Endpoints in Heart Failure With Preserved Ejection Fraction (2025)
-
A new concept to establish protein requirements (2025)
-
Effect of 3 Different Daily Protein Intakes in a 2-Meal Eating Pattern on Protein Turnover in Middle Age and Older Adults: A Randomized Controlled Trial (2024)
-
Consideration of the role of protein quality in determining dietary protein recommendations (2024)
-
Toward a Dynamic Model of Indispensable Amino Acid Requirements of the Adult Human: A Factorial Estimate of Oxidative Amino Acid Losses (2024)
-
The anabolic response to a ground beef patty and soy-based meat alternative: a randomized controlled trial (2024)
-
Consuming Whey Protein with Added Essential Amino Acids, Not Carbohydrate, Maintains Postexercise Anabolism While Underfed (2024)
-
Free essential amino acid feeding improves endurance during resistance training via DRP1‐dependent mitochondrial remodelling (2024)
-
Inhibitory Regulation of FOXO1 in PPARδ Expression Drives Mitochondrial Dysfunction and Insulin Resistance (2024)
-
Stimulation of muscle protein synthesis with low-dose amino acid composition in older individuals (2024)
-
Metabolic effects of an essential amino acid supplement in adolescents with <scp>PCOS</scp> and obesity (2024)
-
Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome (2024)
-
The Importance of Dietary Protein Quality in Mid- to High-Income Countries (2024)
-
International Society of Sports Nutrition Position Stand: Effects of essential amino acid supplementation on exercise and performance (2023)
Grants & Funding
As listed on this researcher's institutional profile.
- Nutritional Countermeasures to Ameliorate Losses in Muscle Mass and Function National Space Biomedical Research Institute via Baylor College of Medicine Principal Investigator
- Ferrando: Effect of Dietary Protein Intake Pattern on Skeletal Muscle in Older Individuals National Dairy Council Co-Investigator
- EXERCISE EFFECTS ON PROTEIN METABOLISM NIH Principal Investigator
- Wolfe SubK-Vanderbilt Tracer Course 2018 - Continuation NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases via Vanderbilt University Principal Investigator
- Wolfe-KIWI Sub w/Massey: Speeding Up a Slow Protein for Muscle Mass with Hayward Kiwi fruit Zespri Group Limited via Massey University Principal Investigator
- PROTOCOL #2: The Effect of Frequent EAA Ingestion on Resting Energy Expenditure and 24hr Muscle Protein Synthesis NOVARTIS Pharmaceuticals Corporation Principal Investigator
- RES-DZ-01-03 Study in Septic-shock ICU Patients in Which Arginine was Infused to Improve Their Condition-Nicolaas Deitz, Co-I NOVARTIS Pharmaceuticals Corporation Principal Investigator
- Protein Kinetic Response to Calorie Deprivation: U.S. Army Research Institute of Environmental Medicine Principal Investigator
- Stable Isotope Analytical Core for Studies in Human Metabolism NIH Principal Investigator
- Protocol 3: Use of Dietery Nucleotides to Stimulate tRNA Synthesis for Enhanced Protein Synthesis in Chronic Wasting of Elderly NOVARTIS Pharmaceuticals Corporation Principal Investigator
- MUSCLE PROTEIN METABOLISM AND NUTRITION IN THE ELDERLY NIH Principal Investigator
- ENERGY EXPENDITURE IN BURNED PATIENTS NIH Principal Investigator
- Dose Response to peptide mixture enriched with branched chain amino acids: A Pilot Study Glanbia Nutritionals Principal Investigator
- Protocol No. CT-12-0012 entitled “Determination of the Optimal Infusion Rate of Amino Acids in Seriously Ill Patients Baxter Healthcare Corporation Principal Investigator
- Arkansas Claude Pepper Older Americans Independence Center at UAMS NIH Co-Investigator
- ASSESSMENT OF SUBSTRATE KINETIC ANALYSIS USING TRACERS NIH Principal Investigator
- Nutritional Stimulation of Muscle Protein Synthesis and Metabolic Rate After Bariatric Surgery NIH Principal Investigator
- Skeletal Muscle Protein synthesis in healthy elderly after bolus intake of a high whey-protein leucine-rich oral nutritional supplement Spa.1/C/A AKA Danone Research Principal Investigator
- Comparison of Medical Nutritional Supplements With or Without AN777 in Elderly Men Abbott, Inc. Principal Investigator
- Amino Acids and Pediatric Hepatic Steatosis NIH Principal Investigator
- Wolfe - Subcontract w Case Western - Isotope Tracers in Metabolic Research NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases via Case Western Reserve University Principal Investigator
- Wolfe-FORTE: Effects of Fortetropin on Skeletal Muscle Protein Fractional Synthetic Rate in Older Men and Women MYOS RENS via University of California, Berkeley Principal Investigator
- Muscle preservation during weight loss in older, overweight individuals NIH Principal Investigator
- Substrate Cycling in Energy Metabolism NIH Principal Investigator
- THE ROLE OF SUBSTRATE CYCLING IN ENERGY METABOLISM NIH Principal Investigator
- “Evaluation of an Oral Nutritional Supplement Containing AN777 in Older Hospitalized Patients - BK33” Abbott, Inc. Principal Investigator
- Amino Acids and Muscle Protein Synthesis NIH Principal Investigator
- Consortium w/Essential: Nutritional Therapy in the Elderly with Heart Failure- Resubmission NIH/Nat. Inst. on Aging via Essential Blends, LLC Principal Investigator
- Subcontract w/Essential Blends, LLC: UpBeat Phase 2 NIH/Nat. Inst. on Aging via Essential Blends, LLC Principal Investigator
- Optimal Amino Acid Nutrition in Sepsis NIH Co-Principal Investigator
- Sub w/Vanderbilt: 2017 T-Course Isotope Tracers in Metabolic Research NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases via Vanderbilt University Principal Investigator
- EXERCISE, LIPOLYSIS AND FAT OXIDATION NIH Principal Investigator
- MODELING IN METABOLISM AND NUTRITION NIH Principal Investigator
- GLUCOSE METABOLISM IN SEPTIC PATIENTS NIH Principal Investigator
Collaboration Network
Top Collaborators
- Pre- and Post-Surgical Nutrition for Preservation of Muscle Mass, Strength, and Functionality Following Orthopedic Surgery
- International Society of Sports Nutrition Position Stand: Effects of essential amino acid supplementation on exercise and performance
- Daily Consumption of a Specially Formulated Essential Amino Acid-Based Dietary Supplement Improves Physical Performance in Older Adults With Low Physical Functioning
- Essential amino acid-enriched whey enhances post-exercise whole-body protein balance during energy deficit more than iso-nitrogenous whey or a mixed-macronutrient meal: a randomized, crossover study
- Tracing metabolic flux to assess optimal dietary protein and amino acid consumption
Showing 5 of 14 shared publications
- International Society of Sports Nutrition Position Stand: Effects of essential amino acid supplementation on exercise and performance
- Essential amino acid-enriched whey enhances post-exercise whole-body protein balance during energy deficit more than iso-nitrogenous whey or a mixed-macronutrient meal: a randomized, crossover study
- Consideration of the role of protein quality in determining dietary protein recommendations
- Understanding Dietary Protein Quality: Digestible Indispensable Amino Acid Scores and Beyond
- Whole-body protein kinetic models to quantify the anabolic response to dietary protein consumption
Showing 5 of 12 shared publications
- Mitoribosomal defects aggravate liver cancer via aberrant glycolytic flux and T cell exhaustion
- Myostatin Inhibition-Induced Increase in Muscle Mass and Strength Was Amplified by Resistance Exercise Training, and Dietary Essential Amino Acids Improved Muscle Quality in Mice
- Tracing metabolic flux in vivo: basic model structures of tracer methodology
- Essential Amino Acid-Enriched Diet Alleviates Dexamethasone-Induced Loss of Muscle Mass and Function through Stimulation of Myofibrillar Protein Synthesis and Improves Glucose Metabolism in Mice
- Tracing metabolic flux to assess optimal dietary protein and amino acid consumption
Showing 5 of 11 shared publications
- Mitoribosomal defects aggravate liver cancer via aberrant glycolytic flux and T cell exhaustion
- Myostatin Inhibition-Induced Increase in Muscle Mass and Strength Was Amplified by Resistance Exercise Training, and Dietary Essential Amino Acids Improved Muscle Quality in Mice
- Tracing metabolic flux in vivo: basic model structures of tracer methodology
- Essential Amino Acid-Enriched Diet Alleviates Dexamethasone-Induced Loss of Muscle Mass and Function through Stimulation of Myofibrillar Protein Synthesis and Improves Glucose Metabolism in Mice
- Tracing metabolic flux to assess optimal dietary protein and amino acid consumption
Showing 5 of 11 shared publications
- Mitoribosomal defects aggravate liver cancer via aberrant glycolytic flux and T cell exhaustion
- Myostatin Inhibition-Induced Increase in Muscle Mass and Strength Was Amplified by Resistance Exercise Training, and Dietary Essential Amino Acids Improved Muscle Quality in Mice
- Tracing metabolic flux in vivo: basic model structures of tracer methodology
- Essential Amino Acid-Enriched Diet Alleviates Dexamethasone-Induced Loss of Muscle Mass and Function through Stimulation of Myofibrillar Protein Synthesis and Improves Glucose Metabolism in Mice
- Balanced Free Essential Amino Acids and Resistance Exercise Training Synergistically Improve Dexamethasone-Induced Impairments in Muscle Strength, Endurance, and Insulin Sensitivity in Mice
Showing 5 of 7 shared publications
- Daily Consumption of a Specially Formulated Essential Amino Acid-Based Dietary Supplement Improves Physical Performance in Older Adults With Low Physical Functioning
- The anabolic response to a ground beef patty and soy-based meat alternative: a randomized controlled trial
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
- Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome
- Correction to: Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement versus whey protein in low physical functioning older adults
Showing 5 of 6 shared publications
- The Importance of Dietary Protein Quality in Mid- to High-Income Countries
- Consideration of the role of protein quality in determining dietary protein recommendations
- Understanding Dietary Protein Quality: Digestible Indispensable Amino Acid Scores and Beyond
- Whole-body protein kinetic models to quantify the anabolic response to dietary protein consumption
- Toward a Dynamic Model of Indispensable Amino Acid Requirements of the Adult Human: A Factorial Estimate of Oxidative Amino Acid Losses
- Pre- and Post-Surgical Nutrition for Preservation of Muscle Mass, Strength, and Functionality Following Orthopedic Surgery
- International Society of Sports Nutrition Position Stand: Effects of essential amino acid supplementation on exercise and performance
- The anabolic response to a ground beef patty and soy-based meat alternative: a randomized controlled trial
- Continuous oral stable isotope ingestion to measure whole-body protein turnover
- Effect of 3 Different Daily Protein Intakes in a 2-Meal Eating Pattern on Protein Turnover in Middle Age and Older Adults: A Randomized Controlled Trial
- Daily Consumption of a Specially Formulated Essential Amino Acid-Based Dietary Supplement Improves Physical Performance in Older Adults With Low Physical Functioning
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
- Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome
- Correction to: Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement versus whey protein in low physical functioning older adults
- Myostatin Inhibition-Induced Increase in Muscle Mass and Strength Was Amplified by Resistance Exercise Training, and Dietary Essential Amino Acids Improved Muscle Quality in Mice
- Essential Amino Acid-Enriched Diet Alleviates Dexamethasone-Induced Loss of Muscle Mass and Function through Stimulation of Myofibrillar Protein Synthesis and Improves Glucose Metabolism in Mice
- Balanced Free Essential Amino Acids and Resistance Exercise Training Synergistically Improve Dexamethasone-Induced Impairments in Muscle Strength, Endurance, and Insulin Sensitivity in Mice
- Free essential amino acid feeding improves endurance during resistance training via DRP1‐dependent mitochondrial remodelling
- Essential Amino Acid-Enriched Diet Alleviates Dexamethasone-Induced Loss of Muscle Mass and Function through Stimulation of Myofibrillar Protein Synthesis and Improves Glucose Metabolism in Mice
- Balanced Free Essential Amino Acids and Resistance Exercise Training Synergistically Improve Dexamethasone-Induced Impairments in Muscle Strength, Endurance, and Insulin Sensitivity in Mice
- Inhibitory Regulation of FOXO1 in PPARδ Expression Drives Mitochondrial Dysfunction and Insulin Resistance
- Free essential amino acid feeding improves endurance during resistance training via DRP1‐dependent mitochondrial remodelling
- International Society of Sports Nutrition Position Stand: Effects of essential amino acid supplementation on exercise and performance
- Essential amino acid-enriched whey enhances post-exercise whole-body protein balance during energy deficit more than iso-nitrogenous whey or a mixed-macronutrient meal: a randomized, crossover study
- Consuming Whey Protein with Added Essential Amino Acids, Not Carbohydrate, Maintains Postexercise Anabolism While Underfed
- Daily Consumption of a Specially Formulated Essential Amino Acid-Based Dietary Supplement Improves Physical Performance in Older Adults With Low Physical Functioning
- Perioperative amino acid infusion reestablishes muscle net balance during total hip arthroplasty
- Equivalent servings of free-range reindeer promote greater net protein balance compared to commercial beef
- Daily Consumption of a Specially Formulated Essential Amino Acid-Based Dietary Supplement Improves Physical Performance in Older Adults With Low Physical Functioning
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
- Correction to: Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement versus whey protein in low physical functioning older adults
- Myostatin Inhibition-Induced Increase in Muscle Mass and Strength Was Amplified by Resistance Exercise Training, and Dietary Essential Amino Acids Improved Muscle Quality in Mice
- Essential Amino Acid-Enriched Diet Alleviates Dexamethasone-Induced Loss of Muscle Mass and Function through Stimulation of Myofibrillar Protein Synthesis and Improves Glucose Metabolism in Mice
- Balanced Free Essential Amino Acids and Resistance Exercise Training Synergistically Improve Dexamethasone-Induced Impairments in Muscle Strength, Endurance, and Insulin Sensitivity in Mice
Similar Researchers
Based on overlapping research topics