Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Binyam Belachew's research focuses on molecular mechanisms underlying viral replication and host-pathogen interactions, with a particular emphasis on RNA helicases. His work investigates the role of these enzymes in viral propagation within human hosts. Belachew has published on the function of RNA helicases in human viruses and the specific activity of hepatitis C virus (HCV) nonstructural protein NS3 in unfolding viral RNA structures. He has also explored the alignment of helicases on single-stranded DNA and its effect on activity. Belachew collaborates with researchers at the University of Arkansas for Medical Sciences, including Kevin D. Raney, Jun Gao, and Alicia K. Byrd, contributing to a shared body of work in virology and molecular biology.
Metrics
- h-index: 4
- Publications: 6
- Citations: 106
Selected Publications
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Hepatitis C virus nonstructural protein NS3 unfolds viral G-quadruplex RNA structures (2022)
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Alignment of helicases on single-stranded DNA increases activity (2022)
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RNA helicases required for viral propagation in humans (2021)
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Pyrrolo[2,3-d]pyrimidine derivatives as inhibitors of RET: Design, synthesis and biological evaluation (2020)
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Discovery of SP-96, the first non-ATP-competitive Aurora Kinase B inhibitor, for reduced myelosuppression (2020)
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Function and Mechanism of Hepatitis C Virus Non‐structural Protein 3 (HCV NS3) Unfolding of Viral G‐quadruplex RNA Structures (2019)
Collaboration Network
Top Collaborators
- RNA helicases required for viral propagation in humans
- Hepatitis C virus nonstructural protein NS3 unfolds viral G-quadruplex RNA structures
- Alignment of helicases on single-stranded DNA increases activity
- RNA helicases required for viral propagation in humans
- Hepatitis C virus nonstructural protein NS3 unfolds viral G-quadruplex RNA structures
- Hepatitis C virus nonstructural protein NS3 unfolds viral G-quadruplex RNA structures
- Alignment of helicases on single-stranded DNA increases activity
- RNA helicases required for viral propagation in humans
- Alignment of helicases on single-stranded DNA increases activity
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