Jun Gao

This is a likely match — the affiliation was inferred from OpenAlex, ORCID, and web sources but has not been fully confirmed. Treat with appropriate caution.

Researcher

UAMS

Also affiliated: University of Kansas (1996); Dalian Medical University (2018); Chinese Academy of Medical Sciences & Peking Union Medical College (2005); Liaoning Academy of Agricultural Sciences (2014); Huaiyin Institute of Technology (2021–2022); Arkansas Department of Agriculture (2014)

Faculty Researcher

15 h-index 34 pubs 710 cited

Research Areas

Biomedical Subjects

Links

ORCID

OverviewAI-generated summary

Jun Gao's research focuses on the molecular mechanisms of DNA and RNA helicases, particularly their roles in unwinding G-quadruplex structures and their involvement in viral replication. His work has investigated how these helicases interact with nucleic acids, including G-rich single-stranded DNA and RNA, and how these interactions influence cellular processes. Recent publications detail the function of specific helicases, such as the eukaryotic Pif1 helicase and the Hepatitis C virus nonstructural protein NS3, in remodeling protein-nucleic acid complexes and unfolding viral RNA structures. Gao also studies the broader family of RNA helicases in the context of viral propagation in humans. His research collaborations at the University of Arkansas for Medical Sciences include extensive work with Kevin D. Raney, Alicia K. Byrd, and John C. Marecki. Gao has published 34 papers with an h-index of 15 and 695 citations.

Metrics

h-index: 15
Publications: 34
Citations: 710

Selected Publications

Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge (2024)

Nature Communications 9 citations DOI OpenAlex
Two residues in the DNA binding site of Pif1 helicase are essential for nuclear functions but dispensable for mitochondrial respiratory growth (2024)

Nucleic Acids Research 2 citations DOI OpenAlex
Pif1 Helicase Mediates Remodeling of Protein-Nucleic Acid Complexes by Promoting Dissociation of Sub1 from G-Quadruplex DNA and Cdc13 from G-Rich Single-Stranded DNA (2023)

Biochemistry 9 citations DOI OpenAlex
Hepatitis C virus nonstructural protein NS3 unfolds viral G-quadruplex RNA structures (2022)

Journal of Biological Chemistry 11 citations DOI OpenAlex
RNA helicases required for viral propagation in humans (2021)

The Enzymes 23 citations DOI OpenAlex
A structural feature of Dda helicase which enhances displacement of streptavidin and <i>trp</i> repressor from <scp>DNA</scp> (2021)

Protein Science 8 citations DOI OpenAlex
G-quadruplex DNA inhibits unwinding activity but promotes liquid–liquid phase separation by the DEAD-box helicase Ded1p (2021)

Chemical Communications 12 citations DOI OpenAlex
G-Quadruplex loops regulate PARP-1 enzymatic activation (2020)

Nucleic Acids Research 75 citations DOI OpenAlex
DEAD-box RNA helicases Dbp2, Ded1 and Mss116 bind to G-quadruplex nucleic acids and destabilize G-quadruplex RNA (2019)

Chemical Communications 39 citations DOI OpenAlex
A fast approach to detect gene–gene synergy (2017)

Scientific Reports 9 citations DOI OpenAlex
A biochemical and biophysical model of G-quadruplex DNA recognition by positive coactivator of transcription 4 (2017)

Journal of Biological Chemistry 14 citations DOI OpenAlex
Yeast Sub1 and human PC4 are G-quadruplex binding proteins that suppress genome instability at co-transcriptionally formed G4 DNA (2017)

Nucleic Acids Research 60 citations DOI OpenAlex
The Structural Recognition of G‐quadruplex DNA by PC4: How Does a ssDNA Binding Protein Decide? (2016)

The FASEB Journal DOI OpenAlex
Yeast transcription co-activator Sub1 and its human homolog PC4 preferentially bind to G-quadruplex DNA (2015)

Chemical Communications 50 citations DOI OpenAlex
Binding of the transcription factor Atf1 to promoters serves as a barrier to phase nucleosome arrays and avoid cryptic transcription (2014)

Nucleic Acids Research 19 citations DOI OpenAlex