Alexis N. Roach

Graduate Research Assistant, Ph.D. Student

UAMS

Also affiliated: Arkansas Children's Hospital (2024–2025); Texas College (2021); Texas A&M University (2021–2023)

Graduate Student Researcher

6 h-index 14 pubs 149 cited

Research Areas

Biomedical Subjects

Links

ORCID Research Group

OverviewAI-generated summary

Alexis N. Roach's research investigates the effects of paternal alcohol exposure on offspring development and health, utilizing a mouse model. Studies have focused on intergenerational impacts, including effects on fetoplacental growth and the development of craniofacial growth deficiencies. Roach's work also examines the role of sperm epigenetics, specifically chromatin alterations during epididymal maturation and the persistence of sperm RNA changes following alcohol cessation, correlating these with mitochondrial dysfunction. Further research explores how maternal background influences the penetrance of growth phenotypes and placental adaptations in offspring of alcohol-exposed males. Additional investigations have looked into the association between paternal alcohol exposure and an increased incidence of hepatocellular carcinoma in offspring, as well as decreased in vitro fertilization embryo survival rates. Roach has also co-authored research on a medical case study involving an infant with δ-aminolevulinic acid dehydratase deficient porphyria.

Metrics

h-index: 6
Publications: 14
Citations: 149

Selected Publications

Correction: Profound hypotonia in an infant with δ-aminolevulinic acid dehydratase deficient porphyria (2025)

European Journal of Human Genetics DOI OpenAlex
Profound hypotonia in an infant with δ-aminolevulinic acid dehydratase deficient porphyria (2024)

European Journal of Human Genetics 2 citations DOI OpenAlex
04145 Profound hypotonia in a newborn with Biallelic δ-Aminolevulinic Acid Dehydratase (ALAD) mutations (2024)

DOI OpenAlex