Igor P. Pogribny
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Also affiliated: University of Lethbridge (2004–2010); University of North Carolina at Chapel Hill (2014); Louisiana State University (1999); Roswell Park Comprehensive Cancer Center (2008); Arkansas Children's Hospital (1999); University of Minnesota (2014); Russian Academy of Sciences (2004); United States Food and Drug Administration (1995–2025); University Hospital Centre Zagreb (2004); George Washington University (2004); Vanderbilt University (2004); Saginaw Valley State University (1999); Veterans Health Administration (2004); Central Arkansas Veterans Healthcare System (2011); Department of Biological Sciences (2004); National Cancer Institute (2006); Vavilov Institute of General Genetics (2004); Centre international de recherche sur le cancer (2018); The Ohio State University (2006); University of Tennessee at Knoxville (2006); Vanderbilt University Medical Center (2004); Texas A&M University (2017)
Research Areas
Biomedical Subjects
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Biography and Research Information
OverviewAI-generated summary
Igor P. Pogribny's research focuses on the molecular mechanisms underlying toxicology and disease, with a particular emphasis on epigenetics and DNA methylation. His work has investigated the role of altered folate metabolism in conditions such as Down syndrome and has explored the connection between homocysteine levels, S-adenosylhomocysteine, and DNA hypomethylation as potential epigenetic mechanisms for disease pathology. Pogribny has also examined the involvement of microRNAs in drug resistance in cancer cells, specifically in breast cancer and hepatocellular carcinoma.
His research has involved studies in various model organisms, including rodents and plants, to understand transgenerational effects on genome stability and methylation. Pogribny has a substantial publication record, with over 290 publications and a high citation count, reflecting significant contributions to his field. He has collaborated extensively with researchers at the National Center for Toxicological Research, including Volodymyr Tryndyak and Frederick A. Beland, on numerous projects. Pogribny is recognized as a highly cited researcher and an ARA Academy member.
Metrics
- h-index: 76
- Publications: 292
- Citations: 18,238
Selected Publications
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AMPK‐Dependent Epigenetic Regulation of Metabolism Mediates the Anti‐Cancer Action of Pterostilbene in Hepatocellular Carcinoma (2025)
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Mediation analysis of the molecular phenotypes in a severe MASH-like liver injury mouse model (2025)
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Signature gene expression model for quantitative evaluation of MASH-like liver injury in mice (2025)
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A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice (2024)
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Cellular and molecular alterations in a human hepatocellular in vitro model of nonalcoholic fatty liver disease development and stratification (2023)
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Abstract 6017: Exposure-related DNA methylation and gene expression changes in mammary glands of Sprague Dawley rats treated with lorcaserin (2023)
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Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice (2023)
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Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice (2022)
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Assessment of the effects of organic vs. inorganic arsenic and mercury in Caenorhabditis elegans (2022)
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Epigenetic aberrations of gene expression in a rat model of hepatocellular carcinoma (2022)
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Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet (2022)
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Epigenetic changes induced in mice liver by methionine-supplemented and methionine-deficient diets (2022)
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Erratum to: Butyrate-containing structured lipids act on HDAC4, HDAC6, DNA damage and telomerase activity during promotion of experimental hepatocarcinogenesis (2021)
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Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: An update of a systematic literature review (2021)
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The DEN and CCl 4 ‐Induced Mouse Model of Fibrosis and Inflammation‐Associated Hepatocellular Carcinoma (2021)
ARA Academy 2023 ARA Fellow
Dr. Pogribny is a distinguished scientist specializing in molecular toxicology and carcinogenesis. He earned his M.D. with honors from Ivano-Frankivsk National Medical University in Ukraine and a Ph.D. in Biochemistry/Oncology from Kyiv National Medical University. Since 2003, he has served as a research biologist and senior biomedical researcher at NCTR.
Policy Impact
Distinguished federal scientist at NCTR advancing understanding of chemical carcinogenesis, supporting the FDA's regulatory mission and public health protection from Arkansas.
Growth Areas
['Population Health Innovations & Clinical Research']
Resources
Collaboration Network
Top Collaborators
- Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
- Alterations of microRNAs and their targets are associated with acquired resistance of MCF‐7 breast cancer cells to cisplatin
- E‐cadherin transcriptional down‐regulation by epigenetic and microRNA‐200 family alterations is related to mesenchymal and drug‐resistant phenotypes in human breast cancer cells
- Role of ferritin alterations in human breast cancer cells
- Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet
Showing 5 of 88 shared publications
- E‐cadherin transcriptional down‐regulation by epigenetic and microRNA‐200 family alterations is related to mesenchymal and drug‐resistant phenotypes in human breast cancer cells
- DNA hypomethylation in the origin and pathogenesis of human diseases
- Role of ferritin alterations in human breast cancer cells
- Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet
- Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice
Showing 5 of 87 shared publications
- Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet
- Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice
- Role of epigenetic aberrations in the development and progression of human hepatocellular carcinoma
- Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: A systematic literature review
- The DEN and CCl4‐Induced Mouse Model of Fibrosis and Inflammation‐Associated Hepatocellular Carcinoma
Showing 5 of 50 shared publications
- MicroRNA-152-mediated dysregulation of hepatic transferrin receptor 1 in liver carcinogenesis
- Cerebellar Oxidative DNA Damage and Altered DNA Methylation in the BTBR T+tf/J Mouse Model of Autism and Similarities with Human Post Mortem Cerebellum
- Effect of methionine‐deficient and methionine‐supplemented diets on the hepatic one‐carbon and lipid metabolism in mice
- Interstrain differences in the severity of liver injury induced by a choline‐ and folate‐deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism
- MicroRNA deregulation in nonalcoholic steatohepatitis-associated liver carcinogenesis
Showing 5 of 37 shared publications
- Increase in Plasma Homocysteine Associated with Parallel Increases in Plasma S-Adenosylhomocysteine and Lymphocyte DNA Hypomethylation
- Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome
- Elevation in S-Adenosylhomocysteine and DNA Hypomethylation: Potential Epigenetic Mechanism for Homocysteine-Related Pathology
- Intracellular S-Adenosylhomocysteine Concentrations Predict Global DNA Hypomethylation in Tissues of Methyl-Deficient Cystathionine β-Synthase Heterozygous Mice
- Homocysteine Metabolism in Children with Down Syndrome: In Vitro Modulation
Showing 5 of 29 shared publications
- Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
- Alterations of microRNAs and their targets are associated with acquired resistance of MCF‐7 breast cancer cells to cisplatin
- Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location
- Irradiation induces DNA damage and modulates epigenetic effectors in distant bystander tissue in vivo
- Role of ferritin alterations in human breast cancer cells
Showing 5 of 29 shared publications
- Increase in Plasma Homocysteine Associated with Parallel Increases in Plasma S-Adenosylhomocysteine and Lymphocyte DNA Hypomethylation
- Elevation in S-Adenosylhomocysteine and DNA Hypomethylation: Potential Epigenetic Mechanism for Homocysteine-Related Pathology
- Homocysteine Metabolism in Children with Down Syndrome: In Vitro Modulation
- Measurement of Plasma and Intracellular S-Adenosylmethionine and S-Adenosylhomocysteine Utilizing Coulometric Electrochemical Detection: Alterations with Plasma Homocysteine and Pyridoxal 5′-Phosphate Concentrations
- Genome hypermethylation in Pinus silvestris of Chernobyl—a mechanism for radiation adaptation?
Showing 5 of 27 shared publications
- Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location
- Irradiation induces DNA damage and modulates epigenetic effectors in distant bystander tissue in vivo
- Role of epigenetic effectors in maintenance of the long-term persistent bystander effect in spleen in vivo
- Fractionated Low-Dose Radiation Exposure Leads to Accumulation of DNA Damage and Profound Alterations in DNA and Histone Methylation in the Murine Thymus
- Epigenetic dysregulation underlies radiation-induced transgenerational genome instability in vivo
Showing 5 of 23 shared publications
- Alterations of microRNAs and their targets are associated with acquired resistance of MCF‐7 breast cancer cells to cisplatin
- Role of ferritin alterations in human breast cancer cells
- Complex epigenetic regulation of Engrailed-2 (EN-2) homeobox gene in the autism cerebellum
- MicroRNA-152-mediated dysregulation of hepatic transferrin receptor 1 in liver carcinogenesis
- Overexpression of LINE-1 Retrotransposons in Autism Brain
Showing 5 of 19 shared publications
- Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet
- Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice
- Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency
- Histone H3 lysine 9 and H4 lysine 20 trimethylation and the expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in hepatocarcinogenesis induced by methyl deficiency in rats
- Down‐regulation of the microRNAs miR‐34a, miR‐127, and miR‐200b in rat liver during hepatocarcinogenesis induced by a methyl‐deficient diet
Showing 5 of 19 shared publications
- Increase in Plasma Homocysteine Associated with Parallel Increases in Plasma S-Adenosylhomocysteine and Lymphocyte DNA Hypomethylation
- Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome
- Elevation in S-Adenosylhomocysteine and DNA Hypomethylation: Potential Epigenetic Mechanism for Homocysteine-Related Pathology
- Homocysteine Metabolism in Children with Down Syndrome: In Vitro Modulation
- Measurement of Plasma and Intracellular S-Adenosylmethionine and S-Adenosylhomocysteine Utilizing Coulometric Electrochemical Detection: Alterations with Plasma Homocysteine and Pyridoxal 5′-Phosphate Concentrations
Showing 5 of 18 shared publications
- Methyl Deficiency, Alterations in Global Histone Modifications, and Carcinogenesis
- Molecular Mechanisms of Fibrosis-Associated Promotion of Liver Carcinogenesis
- Coupling global methylation and gene expression profiles reveal key pathophysiological events in liver injury induced by a methyl‐deficient diet
- The tumor-promoting activity of 2-acetylaminofluorene is associated with disruption of the p53 signaling pathway and the balance between apoptosis and cell proliferation☆
- Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice
Showing 5 of 16 shared publications
- Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans
- MicroRNA deregulation in nonalcoholic steatohepatitis-associated liver carcinogenesis
- Quantitative comparison of in vitro genotoxicity between metabolically competent HepaRG cells and HepG2 cells using the high-throughput high-content CometChip assay
- Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
- Effect of aflatoxin B1, benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells
Showing 5 of 13 shared publications
- Irradiation induces DNA damage and modulates epigenetic effectors in distant bystander tissue in vivo
- MicroRNA-mediated drug resistance in breast cancer
- Estrogen-Induced Rat Breast Carcinogenesis is Characterized by Alterations in DNA Methylation, Histone Modifications, and Aberrant microRNA Expression
- Epigenetic dysregulation underlies radiation-induced transgenerational genome instability in vivo
- In Vivo Bystander Effect: Cranial X-Irradiation Leads to Elevated DNA Damage, Altered Cellular Proliferation and Apoptosis, and Increased p53 Levels in Shielded Spleen
Showing 5 of 11 shared publications
- The DEN and CCl4‐Induced Mouse Model of Fibrosis and Inflammation‐Associated Hepatocellular Carcinoma
- Molecular Mechanisms of Fibrosis-Associated Promotion of Liver Carcinogenesis
- Interstrain Differences in the Liver Effects of Trichloroethylene in a Multistrain Panel of Inbred Mice
- Genetic and epigenetic changes in fibrosis‐associated hepatocarcinogenesis in mice
- The DEN and CCl 4 ‐Induced Mouse Model of Fibrosis and Inflammation‐Associated Hepatocellular Carcinoma
Showing 5 of 10 shared publications
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