Match tier
Confirmed
Presence
Current · Arkansas
Last published
2022
Sources
OpenAlex · ORCID
Refreshed
2026-08-20
S
Shilpa Iyer
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Federal Grant PI
Associate Professor
Also affiliated: University of Pennsylvania (2016)
Faculty Researcher
1 h-index
3 pubs
37 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Shilpa Iyer investigates the role of mitochondrial function in human disease, particularly focusing on pediatric mitochondrial disorders and their impact on development. Her research utilizes induced pluripotent stem cells (iPSCs) derived from patients to study cellular phenotypes and disease mechanisms. A significant area of her work involves quantifying mitochondrial morphology and bioenergetics in patient-derived cells, including fibroblasts and iPSCs, to understand disease severity and potential therapeutic targets.
Iyer is the Principal Investigator on a $606,257 grant from the NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development. This funding supports research into the metabolic regulation of Multiple Organ Dysfunction Syndrome (MODS) in pediatric mitochondrial disorders. Her recent publications explore quantitative analysis of mitochondrial dynamics, bioenergetics health index ratios, and the effects of cell-permeable succinate on mitochondrial function in the context of Leigh syndrome, a severe neurological disorder.
Her work also involves developing and applying computational tools, such as MitoCellPhe, for analyzing mitochondrial morphologies in single cells and cell clusters. Iyer collaborates with several researchers at the University of Arkansas at Fayetteville, including Raj R. Rao, Fibi Meshrkey, Bibhuti Ballav Saikia, and Joshua Stabach, with whom she has multiple shared publications, indicating a collaborative research environment.
Metrics
- h-index: 1
- Publications: 3
- Citations: 37
Selected Publications
-
Evaluation of Human Stem Cell Conditioned Medium and Culture Conditions on Alleviating Elastase-Compromised Human Aortic Smooth Muscle Cell Function (2026)
-
Mitochondrial morphology in human fibroblasts and induced pluripotent stem cells in Leigh syndrome: A comparative analysis (2026)
-
Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A) (2026)
-
Additional file 4 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A) (2026)
-
Additional file 3 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A) (2026)
-
Additional file 4 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A) (2026)
-
Additional file 5 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A) (2026)
-
Additional file 1 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A) (2026)
-
Additional file 2 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A) (2026)
-
Additional file 3 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A) (2026)
-
Additional file 1 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A) (2026)
-
Additional file 5 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A) (2026)
-
Additional file 2 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A) (2026)
-
Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A) (2026)
-
Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A) (2026)
Federal Grants 1 $606,257 total
NIH
Contact PI
Aug 2023 - May 2028
Metabolic regulation of MODS in pediatric mitochondrial disorders
Collaboration Network
Top Collaborators
Fibi Meshrkey
University of Kansas
18 shared publications
In database
- Quantitative analysis of mitochondrial morphologies in human induced pluripotent stem cells for Leigh syndrome
- MitoCellPhe reveals mitochondrial morphologies in single fibroblasts and clustered stem cells
- Induced pluripotent stem cells derived from patients carrying mitochondrial mutations exhibit altered bioenergetics and aberrant differentiation potential
- Induced pluripotent stem cell models for mitochondrial disorders
- List of contributors
Showing 5 of 18 shared publications
Joshua Stabach
University of Arkansas at Fayetteville
15 shared publications
In database
- Quantifying Mitochondrial Dynamics in Patient Fibroblasts with Multiple Developmental Defects and Mitochondrial Disorders
- Induced pluripotent stem cells derived from patients carrying mitochondrial mutations exhibit altered bioenergetics and aberrant differentiation potential
- Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
- Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
- Additional file 2 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
Showing 5 of 15 shared publications
Bibhuti Ballav Saikia
University of Arkansas at Fayetteville
15 shared publications
In database
- The Saga of Endocrine FGFs
- Induced pluripotent stem cells derived from patients carrying mitochondrial mutations exhibit altered bioenergetics and aberrant differentiation potential
- Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
- Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
- Additional file 2 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
Showing 5 of 15 shared publications
Kelly M. Scheulin
14 shared publications
- Induced pluripotent stem cells derived from patients carrying mitochondrial mutations exhibit altered bioenergetics and aberrant differentiation potential
- Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
- Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
- Additional file 2 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
- Additional file 5 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
Showing 5 of 14 shared publications
Franklin D. West
13 shared publications
- Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
- Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
- Additional file 2 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
- Additional file 5 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
- Additional file 1 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
Showing 5 of 13 shared publications
Raj R. Rao
University of Arkansas at Fayetteville
10 shared publications
In database
- Quantitative analysis of mitochondrial morphologies in human induced pluripotent stem cells for Leigh syndrome
- MitoCellPhe reveals mitochondrial morphologies in single fibroblasts and clustered stem cells
- Induced pluripotent stem cells derived from patients carrying mitochondrial mutations exhibit altered bioenergetics and aberrant differentiation potential
- Cell-Permeable Succinate Increases Mitochondrial Membrane Potential and Glycolysis in Leigh Syndrome Patient Fibroblasts
- The Challenges and Prospects of Smooth Muscle Tissue Engineering
Showing 5 of 10 shared publications
Raj R. Rao
University of Arkansas at Fayetteville
10 shared publications
In database
- Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
- Additional file 2 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
- Additional file 1 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
- Additional file 3 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
- Additional file 2 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
Showing 5 of 10 shared publications
Ajibola B. Bakare
University of Arkansas at Fayetteville
5 shared publications
In database
- Leigh Syndrome: A Tale of Two Genomes
- Quantifying Mitochondrial Dynamics in Patient Fibroblasts with Multiple Developmental Defects and Mitochondrial Disorders
- Evaluating the Bioenergetics Health Index Ratio in Leigh Syndrome Fibroblasts to Understand Disease Severity
- MitoCellPhe reveals mitochondrial morphologies in single fibroblasts and clustered stem cells
- Cell-Permeable Succinate Increases Mitochondrial Membrane Potential and Glycolysis in Leigh Syndrome Patient Fibroblasts
Edward J. Lesnefsky
Virginia Commonwealth University (US)
3 shared publications
- Leigh Syndrome: A Tale of Two Genomes
- Evaluating the Bioenergetics Health Index Ratio in Leigh Syndrome Fibroblasts to Understand Disease Severity
- Induced pluripotent stem cells derived from patients carrying mitochondrial mutations exhibit altered bioenergetics and aberrant differentiation potential
Vedant Thorat
University School (US)
2 shared publications
- Evaluating the Bioenergetics Health Index Ratio in Leigh Syndrome Fibroblasts to Understand Disease Severity
- Induced pluripotent stem cells derived from patients carrying mitochondrial mutations exhibit altered bioenergetics and aberrant differentiation potential
Thomas LaFramboise
University School (US)
2 shared publications
- Evaluating the Bioenergetics Health Index Ratio in Leigh Syndrome Fibroblasts to Understand Disease Severity
- Induced pluripotent stem cells derived from patients carrying mitochondrial mutations exhibit altered bioenergetics and aberrant differentiation potential
Franklin D. West
University of Georgia (US)
2 shared publications
- Induced pluripotent stem cells derived from patients carrying mitochondrial mutations exhibit altered bioenergetics and aberrant differentiation potential
- Induced pluripotent stem cell models for mitochondrial disorders
Julienne Daniel
University of Arkansas at Fayetteville
1 shared publication
In database
- Quantifying Mitochondrial Dynamics in Patient Fibroblasts with Multiple Developmental Defects and Mitochondrial Disorders
Anapaula Rojas
University of Arkansas at Fayetteville
1 shared publication
In database
- Quantifying Mitochondrial Dynamics in Patient Fibroblasts with Multiple Developmental Defects and Mitochondrial Disorders
Austin Bell
University of Arkansas at Fayetteville
1 shared publication
In database
- Quantifying Mitochondrial Dynamics in Patient Fibroblasts with Multiple Developmental Defects and Mitochondrial Disorders
Similar Researchers
Based on overlapping research topics
Ana Cabrera Ayuso
University of Arkansas at Fayetteville
Mitochondrial Function and Pathology
Metabolism and Genetic Disorders
Disease Mechanisms Research
Monica M. Davis
University of Arkansas for Medical Sciences
Mitochondrial Function and Pathology
Metabolism and Genetic Disorders
Disease Mechanisms Research
Neeraja Boddu
University of Arkansas for Medical Sciences
Metabolism and Genetic Disorders
Disease Mechanisms Research
Molecular Biology Techniques and Applications
Drew A. Beasley
University of Arkansas for Medical Sciences
Metabolism and Genetic Disorders
Disease Mechanisms Research
Molecular Biology Techniques and Applications
Randolph P. Maddox
University of Arkansas for Medical Sciences
Metabolism and Genetic Disorders
Disease Mechanisms Research
Molecular Biology Techniques and Applications
Bradley Hughes
University of Arkansas for Medical Sciences
Metabolism and Genetic Disorders
Disease Mechanisms Research
Molecular Biology Techniques and Applications