Laura K. Schnackenberg Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

High Impact

Researcher

National Center for Toxicological Research

faculty

34 h-index 87 pubs 3,499 cited

Research Areas

Pharmacological Effects and Toxicity Studies Drug-Induced Hepatotoxicity and Protection Metabolomics and Mass Spectrometry Studies Mitochondrial Function and Pathology Dialysis and Renal Disease Management Molecular Biology Techniques and Applications Cancer Treatment and Pharmacology

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OverviewAI-generated summary

Laura K. Schnackenberg's research program focuses on the toxicological assessment of chemical compounds and the development of advanced methods for studying drug-induced organ toxicities. Her work investigates the mechanisms by which chemicals, including environmental contaminants and pharmaceutical agents, impact cellular function, particularly within the liver and kidneys. She has published research on the toxicity of tire rubber antiozonants and their transformation products in human hepatocytes, as well as the effects of specific drugs like pexidartinib on mitochondrial function and cell death pathways.

Schnackenberg also explores the application of cutting-edge technologies for toxicity testing and biomarker discovery. This includes utilizing organ-on-a-chip platforms, such as the Emulate® Liver-Chip, for co-culturing human primary liver cells to study drug-induced liver injury. Additionally, her research has involved the discovery of proteomic biomarkers for predicting kidney recovery in patients undergoing dialysis and the analysis of serum metabolite profiles to predict outcomes in critically ill patients receiving renal replacement therapy. She has also investigated the prediction of oncology drug-induced cardiotoxicity using induced pluripotent stem cell-derived cardiomyocytes.

Her scholarly contributions are evidenced by 87 publications and 3,499 citations, with an h-index of 34. Schnackenberg maintains an active research group and collaborates with colleagues at the National Center for Toxicological Research, including Katy S Papineau and Lijun Ren, with whom she has co-authored five publications.

Metrics

  • h-index: 34
  • Publications: 87
  • Citations: 3,499

Selected Publications

  • Challenges and solutions in measuring commonly used biomarkers for drug-induced liver injury in a liver-on-a-chip platform (2025) DOI
  • Toxicity of ubiquitous tire rubber antiozonant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its transformation product 6PPD-quinone (6PPD-Q) in primary human hepatocytes and liver spheroids (2025) DOI
  • Pexidartinib impairs liver mitochondrial functions causing cell death in primary human hepatocytes at clinically relevant concentrations (2025) DOI
  • Predicting oncology drug-induced cardiotoxicity with donor-specific iPSC-CMs—a proof-of-concept study with doxorubicin (2024) DOI
  • Co‐Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver‐Chip for the Study of Drug‐Induced Liver Injury (2022) DOI
  • Serum metabolite profiles predict outcomes in critically ill patients receiving renal replacement therapy (2021) DOI
  • Discovery of Novel Proteomic Biomarkers for the Prediction of Kidney Recovery from Dialysis-Dependent AKI Patients (2021) DOI
  • MALDI imaging mass spectrometry: an emerging tool in neurology (2021) DOI

Collaborators

Researchers in the database who share publications

Katy S Papineau National Center for Toxicological Research 5 shared publications Lijun Ren National Center for Toxicological Research 5 shared publications Dustyn A. Barnette National Center for Toxicological Research 2 shared publications Tucker A. Patterson National Center for Toxicological Research 2 shared publications Gonçalo Gamboa da Costa National Center for Toxicological Research 2 shared publications William B. Mattes National Center for Toxicological Research 2 shared publications Li Pang National Center for Toxicological Research 2 shared publications Qiang Shi National Center for Toxicological Research 2 shared publications

Similar Researchers

Based on overlapping research topics

William B. Mattes National Center for Toxicological Research
Pharmacological Effects and Toxicity Studies Drug-Induced Hepatotoxicity and Protection Metabolomics and Mass Spectrometry Studies
Good match 5 shared topics
Li Pang National Center for Toxicological Research
Pharmacological Effects and Toxicity Studies Drug-Induced Hepatotoxicity and Protection Mitochondrial Function and Pathology
Good match 5 shared topics
Katy S Papineau National Center for Toxicological Research
Pharmacological Effects and Toxicity Studies Drug-Induced Hepatotoxicity and Protection Mitochondrial Function and Pathology
Good match 4 shared topics
Grover Miller University of Arkansas for Medical Sciences
Pharmacological Effects and Toxicity Studies Drug-Induced Hepatotoxicity and Protection Metabolomics and Mass Spectrometry Studies
Good match 4 shared topics
Tsigereda Weldemichael University of Arkansas for Medical Sciences
Pharmacological Effects and Toxicity Studies Drug-Induced Hepatotoxicity and Protection Molecular Biology Techniques and Applications
Good match 4 shared topics
Stanley K. Ellis University of Arkansas for Medical Sciences
Pharmacological Effects and Toxicity Studies Mitochondrial Function and Pathology Molecular Biology Techniques and Applications
Good match 3 shared topics