Match tier
Confirmed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
R
Richard D. Beger
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
High Impact
Branch Chief
Also affiliated: Wesleyan University (1995–1998); University of Hawaiʻi at Mānoa (2006–2007); United States Department of Health and Human Services (2009); National Institutes of Health (2000); United States Food and Drug Administration (1999–2026); Center for Drug Evaluation and Research (2020); University of Wisconsin–Madison (1999); Johns Hopkins University (1993); Kangwon National University (2006–2007); Purdue University West Lafayette (1989–1992); Johns Hopkins Medicine (1993); United States Public Health Service (2000); National Institute of Environmental Health Sciences (2000); National Cerebral and Cardiovascular Center (2007); Chugai Research Institute For Medical Science, Inc. (Japan) (2007); Obihiro University of Agriculture and Veterinary Medicine (2007); University of Pennsylvania (1999); University of Birmingham (2016); Kumamoto University (2007)
49 h-index
218 pubs
14,465 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Richard D. Beger, Branch Chief at the National Center for Toxicological Research, focuses on the application of metabolomics in toxicology and precision medicine. His research has explored the development of reporting standards for chemical analysis and data analysis in metabolomics. He has investigated the role of metabolomics in discovering biomarkers for drug-induced hepatotoxicity and nephrotoxicity. His work also includes studies on the metabolic pathways involved in biological processes, such as the isolation of human intestinal bacteria metabolizing isoflavone glycosides and the deletion of LOX-1 in reducing atherogenesis in mice fed a high-cholesterol diet.
Beger has contributed to collaborative projects, including the Collaborative Estrogen Receptor Activity Prediction Project (CERAPP). His scholarly output is substantial, with a high-impact designation reflected in his h-index of 49, over 220 publications, and more than 14,000 citations. His recent activity indicates continued engagement in research, with the most recent publication listed as 2026. Key collaborators include Jinchun Sun, Lisa Pence, Amy L. Inselman, and Kellie A. Woodling, all from the National Center for Toxicological Research.
Metrics
- h-index: 49
- Publications: 218
- Citations: 14,465
Positions
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Branch Chief 1998–presentNational Center for Toxicological Research Division of Systems Biology ORCID
Selected Publications
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Assessing the developmental effects of fentanyl and impacts on lipidomic profiling using neural stem cell models (2025)
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Biomarker-driven drug development for allergic diseases and asthma: An FDA public workshop (2025)
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Untargeted metabolomics and lipidomics in COVID-19 patient plasma reveals disease severity biomarkers (2024)
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The incorporation of MALDI mass spectrometry imaging in studies to identify markers of toxicity following in utero opioid exposures in mouse fetuses (2024)
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Analysis types and quantification methods applied in UHPLC-MS metabolomics research: a tutorial (2024)
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Identification of Proteomic Biomarkers of Acetaminophen-Induced Hepatotoxicity Using Stable Isotope Labeling (2024)
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The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model (2024)
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Current Practices in LC-MS Untargeted Metabolomics: A Scoping Review on the Use of Pooled Quality Control Samples (2023)
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Metabolomics evaluation of the photochemical impact of violet-blue light (405 nm) on ex vivo platelet concentrates (2023)
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Prediction and Experimental Evaluation of the hERG Blocking Potential of Drugs Showing Clinical Signs of Cardiotoxicity (2022)
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Quality assurance and quality control reporting in untargeted metabolic phenotyping: mQACC recommendations for analytical quality management (2022)
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Effects of Serum and Compound Preparation Methods on Delayed Repolarization Evaluation With Human iPSC-CMs (2022)
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Evaluating Cefoperazone-Induced Gut Metabolic Functional Changes in MR1-Deficient Mice (2022)
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Reference materials for MS-based untargeted metabolomics and lipidomics: a review by the metabolomics quality assurance and quality control consortium (mQACC) (2022)
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Serum metabolite profiles predict outcomes in critically ill patients receiving renal replacement therapy (2021)
Collaboration Network
Top Collaborators
Laura K. Schnackenberg
National Center for Toxicological Research
52 shared publications
In database
- Deletion of LOX-1 Reduces Atherogenesis in LDLR Knockout Mice Fed High Cholesterol Diet
- Metabolomics approaches for discovering biomarkers of drug-induced hepatotoxicity and nephrotoxicity
- Metabolomic study of cisplatin-induced nephrotoxicity
- Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS
- Metabonomics of acute kidney injury in children after cardiac surgery
Showing 5 of 52 shared publications
Jinchun Sun
National Center for Toxicological Research
42 shared publications
In database
- Metabolomics approaches for discovering biomarkers of drug-induced hepatotoxicity and nephrotoxicity
- Reference materials for MS-based untargeted metabolomics and lipidomics: a review by the metabolomics quality assurance and quality control consortium (mQACC)
- Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS
- Metabonomics of acute kidney injury in children after cardiac surgery
- Serum metabolomic profiles from patients with acute kidney injury: A pilot study
Showing 5 of 42 shared publications
Jon G. Wilkes
National Center for Toxicological Research (US)
21 shared publications
- Models of Polychlorinated Dibenzodioxins, Dibenzofurans, and Biphenyls Binding Affinity to the Aryl Hydrocarbon Receptor Developed Using 13C NMR Data
- Developing 13C NMR quantitative spectrometric data-activity relationship (QSDAR) models of steroid binding to the corticosteroid binding globulin
- Use of 13C NMR Spectrometric Data To Produce a Predictive Model of Estrogen Receptor Binding Activity
- 13C NMR Quantitative Spectrometric Data-Activity Relationship (QSDAR) Models of Steroids Binding the Aromatase Enzyme
- Modeling Chemical Interaction Profiles: II. Molecular Docking, Spectral Data-Activity Relationship, and Structure-Activity Relationship Models for Potent and Weak Inhibitors of Cytochrome P450 CYP3A4 Isozyme
Showing 5 of 21 shared publications
Lisa Pence
National Center for Toxicological Research
19 shared publications
In database
- Targeted Liquid Chromatography–Mass Spectrometry Analysis of Serum Acylcarnitines in Acetaminophen Toxicity in Children
- Acylcarnitine Profiles in Acetaminophen Toxicity in the Mouse: Comparison to Toxicity, Metabolism and Hepatocyte Regeneration
- Early metabolomics changes in heart and plasma during chronic doxorubicin treatment in B6C3F1 mice
- Discovery of Novel Proteomic Biomarkers for the Prediction of Kidney Recovery from Dialysis-Dependent AKI Patients
- Stability of the Human Plasma Proteome to Pre-analytical Variability as Assessed by an Aptamer-Based Approach
Showing 5 of 19 shared publications
Dan A. Buzatu
National Center for Toxicological Research
14 shared publications
In database
- 13C NMR Quantitative Spectrometric Data-Activity Relationship (QSDAR) Models of Steroids Binding the Aromatase Enzyme
- Modeling Chemical Interaction Profiles: II. Molecular Docking, Spectral Data-Activity Relationship, and Structure-Activity Relationship Models for Potent and Weak Inhibitors of Cytochrome P450 CYP3A4 Isozyme
- Computational identification of a phospholipidosis toxicophore using 13C and 15N NMR-distance based fingerprints
- Partial least square and k-nearest neighbor algorithms for improved 3D quantitative spectral data–activity relationship consensus modeling of acute toxicity
- Comparative Structural Connectivity Spectra Analysis (CoSCoSA) Models of Steroid Binding to the Corticosteroid Binding Globulin
Showing 5 of 14 shared publications
Svetoslav Slavov
National Center for Toxicological Research
14 shared publications
In database
- Computational identification of a phospholipidosis toxicophore using 13C and 15N NMR-distance based fingerprints
- Why are most phospholipidosis inducers also hERG blockers?
- Identification of a metabolic biomarker panel in rats for prediction of acute and idiosyncratic hepatotoxicity
- Partial least square and k-nearest neighbor algorithms for improved 3D quantitative spectral data–activity relationship consensus modeling of acute toxicity
- Complementary PLS and KNN algorithms for improved 3D-QSDAR consensus modeling of AhR binding
Showing 5 of 14 shared publications
Zhijun Cao
National Center for Toxicological Research
13 shared publications
In database
- Immune response proteins as predictive biomarkers of doxorubicin-induced cardiotoxicity in breast cancer patients
- Proteomic analysis of acetaminophen-induced hepatotoxicity and identification of heme oxygenase 1 as a potential plasma biomarker of liver injury
- Early metabolomics changes in heart and plasma during chronic doxorubicin treatment in B6C3F1 mice
- Discovery of Novel Proteomic Biomarkers for the Prediction of Kidney Recovery from Dialysis-Dependent AKI Patients
- Evaluation of the Performance of Lipidyzer Platform and Its Application in the Lipidomics Analysis in Mouse Heart and Liver
Showing 5 of 13 shared publications
Sudeepa Bhattacharyya
Arkansas Children's Hospital
12 shared publications
In database
- Translational biomarkers of acetaminophen-induced acute liver injury
- Potential of extracellular microRNAs as biomarkers of acetaminophen toxicity in children
- Targeted Liquid Chromatography–Mass Spectrometry Analysis of Serum Acylcarnitines in Acetaminophen Toxicity in Children
- Acylcarnitine Profiles in Acetaminophen Toxicity in the Mouse: Comparison to Toxicity, Metabolism and Hepatocyte Regeneration
- Comparison of Bile Acids and Acetaminophen Protein Adducts in Children and Adolescents with Acetaminophen Toxicity
Showing 5 of 12 shared publications
James P. Freeman
National Center for Toxicological Research (US)
12 shared publications
- Isolation of human intestinal bacteria metabolizing the natural isoflavone glycosides daidzin and genistin
- Isolation of an anaerobic intestinal bacterium capable of cleaving the C-ring of the isoflavonoid daidzein
- Microbiological Transformation of Enrofloxacin by the Fungus Mucor ramannianus
- Evaluation of major active components in St. John’s Wort dietary supplements by high-performance liquid chromatography with photodiode array detection and electrospray mass spectrometric confirmation
- In Vitro Cytotoxicity of Nonpolar Constituents from Different Parts of Kava Plant (Piper methysticum)
Showing 5 of 12 shared publications
Jackson O. Lay
National Center for Toxicological Research (US)
12 shared publications
- Isolation of human intestinal bacteria metabolizing the natural isoflavone glycosides daidzin and genistin
- Isolation of an anaerobic intestinal bacterium capable of cleaving the C-ring of the isoflavonoid daidzein
- Microbiological Transformation of Enrofloxacin by the Fungus Mucor ramannianus
- Evaluation of major active components in St. John’s Wort dietary supplements by high-performance liquid chromatography with photodiode array detection and electrospray mass spectrometric confirmation
- Regioselective transformation of ciprofloxacin toN-acetylciprofloxacin by the fungusMucor ramannianus
Showing 5 of 12 shared publications
Li‐Rong Yu
National Center for Toxicological Research (US)
12 shared publications
- Quality assurance and quality control reporting in untargeted metabolic phenotyping: mQACC recommendations for analytical quality management
- Immune response proteins as predictive biomarkers of doxorubicin-induced cardiotoxicity in breast cancer patients
- Proteomic analysis of acetaminophen-induced hepatotoxicity and identification of heme oxygenase 1 as a potential plasma biomarker of liver injury
- Early metabolomics changes in heart and plasma during chronic doxorubicin treatment in B6C3F1 mice
- Discovery of Novel Proteomic Biomarkers for the Prediction of Kidney Recovery from Dialysis-Dependent AKI Patients
Showing 5 of 12 shared publications
Joseph P. Hanig
Center for Drug Evaluation and Research (US)
10 shared publications
- Neuroprotective effect of the chemical chaperone, trehalose in a chronic MPTP-induced Parkinson's disease mouse model
- Metabonomics evaluations of age-related changes in the urinary compositions of male Sprague Dawley rats and effects of data normalization methods on statistical and quantitative analysis
- The Utility of a Rodent Model in Detecting Pediatric Drug-Induced Nephrotoxicity
- Age‐related differences in susceptibility to cisplatin‐induced renal toxicity
- Age‐related differences in susceptibility to toxic effects of valproic acid in rats
Showing 5 of 10 shared publications
Laura P. James
Arkansas Children's Hospital
9 shared publications
In database
- Translational biomarkers of acetaminophen-induced acute liver injury
- Potential of extracellular microRNAs as biomarkers of acetaminophen toxicity in children
- Targeted Liquid Chromatography–Mass Spectrometry Analysis of Serum Acylcarnitines in Acetaminophen Toxicity in Children
- Acylcarnitine Profiles in Acetaminophen Toxicity in the Mouse: Comparison to Toxicity, Metabolism and Hepatocyte Regeneration
- Comparison of Bile Acids and Acetaminophen Protein Adducts in Children and Adolescents with Acetaminophen Toxicity
Showing 5 of 9 shared publications
Pritmohinder S. Gill
Arkansas Children's Hospital
9 shared publications
In database
- Translational biomarkers of acetaminophen-induced acute liver injury
- Potential of extracellular microRNAs as biomarkers of acetaminophen toxicity in children
- Targeted Liquid Chromatography–Mass Spectrometry Analysis of Serum Acylcarnitines in Acetaminophen Toxicity in Children
- Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans
- Comparison of Bile Acids and Acetaminophen Protein Adducts in Children and Adolescents with Acetaminophen Toxicity
Showing 5 of 9 shared publications
Xi Yang
National Center for Toxicological Research (US)
9 shared publications
- Translational biomarkers of acetaminophen-induced acute liver injury
- Potential of extracellular microRNAs as biomarkers of acetaminophen toxicity in children
- Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans
- Metabolomics evaluation of the effects of green tea extract on acetaminophen-induced hepatotoxicity in mice
- Proteomic analysis of acetaminophen-induced hepatotoxicity and identification of heme oxygenase 1 as a potential plasma biomarker of liver injury
Showing 5 of 9 shared publications
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