Match tier Listed
Presence Current · Arkansas
Last published 2026
Sources OpenAlex · ORCID
Refreshed 2026-08-08

Bethany C. Paxton

Researcher

Also affiliated: Winthrop Rockefeller Foundation (2026)

Unknown Researcher

2 h-index 9 pubs 6 cited

  • Receptor, Notch3
  • Humans
  • Multiple Myeloma
  • Drug Resistance, Neoplasm
  • Translesion DNA Synthesis
  • DNA Replication
  • DNA Helicases
  • Nuclear Proteins
  • Nucleotidyltransferases
  • G-Quadruplexes
  • Multifunctional Enzymes
  • Animals
  • Antineoplastic Agents
  • Disease Models, Animal
  • Signal Transduction

Biography and Research Information

OverviewAI-generated summary

Bethany C. Paxton's research focuses on understanding and targeting mechanisms of multiple myeloma, particularly dormant and therapy-resistant cancer cells. Her work investigates the role of Notch3 signaling as a potential therapeutic target to eradicate these resistant myeloma populations. Paxton has also explored the restoration of bone health in multiple myeloma through sclerostin inhibition, examining its effects on lytic lesions. Her research utilizes various models, including cell lines and xenograft assays, to study disease progression and therapeutic interventions. Paxton collaborates with researchers at the University of Arkansas for Medical Sciences, including Japneet Kaur, Elena Ambrogini, Aric Anloague, and Sharmin Khan, with whom she has co-authored multiple publications.

Metrics

  • h-index: 2
  • Publications: 9
  • Citations: 6

Selected Publications

  • Human REV1 interacts with DHX36 to promote replication and tolerance of G-quadruplex DNA (2026)
    Nucleic Acids Research DOI OpenAlex
  • Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells (2026)
    Figshare DOI OpenAlex
  • Additional file 1 of Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells (2026)
    Figshare DOI OpenAlex
  • Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells (2026)
    Figshare DOI OpenAlex
  • Additional file 1 of Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells (2026)
    Open MIND DOI OpenAlex
  • Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells (2026)
    Journal of Experimental & Clinical Cancer Research DOI OpenAlex
  • Healing of lytic lesions and restoration of bone health in multiple myeloma through sclerostin inhibition (2025)
    Experimental Hematology and Oncology 3 citations DOI OpenAlex
  • Abstract 5099: Notch inhibition as a therapeutic approach to eliminate dormant cancer cells in multiple myeloma (2025)
    Cancer Research DOI OpenAlex
  • Conservation of the insert-2 motif confers Rev1 from different species with an ability to disrupt G-quadruplexes and stimulate translesion DNA synthesis (2023)
    RSC Chemical Biology 3 citations DOI OpenAlex

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Collaboration Network

52 Collaborators 11 Institutions 3 Countries

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