C
Research Areas
Biography and Research Information
OverviewAI-generated summary
Cody Ashby is an Assistant Professor at the University of Arkansas for Medical Sciences, leading a research group that focuses on the molecular mechanisms underlying multiple myeloma and related B cell malignancies. His work investigates the evolutionary pathways from precursor stages to advanced disease, including the role of genetic alterations such as chromothripsis.
His research publications explore the molecular makeup of smoldering myeloma, the spatio-temporal evolution of the disease from baseline to relapse-refractory states, and the impact of specific genes like TRIP13 on tumor development. Ashby also studies potential therapeutic strategies, including the use of bispecific CAR-T cells targeting BCMA/CD24, and the suppression of osteolytic bone disease by CST6. His group's multi-omics approach aims to reveal alterations in the immune microenvironment associated with multiple myeloma and its precursor stages.
Ashby has a substantial publication record, with 185 total publications and 3,605 citations, contributing to a highly cited researcher designation. He actively collaborates with researchers at the University of Arkansas for Medical Sciences, including John D. Shaughnessy Jr., Sharmilan Thanendrarajan, Maurizio Zangari, and Michael Bauer, with whom he has co-authored numerous publications.
Metrics
- h-index: 24
- Publications: 177
- Citations: 3,595
Selected Publications
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Rnd3 regulates lung cancer cell invasion and migration independently of ROCK1 signaling via alpha 5 integrin modulation (2026)
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Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells (2026)
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Additional file 1 of Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells (2026)
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Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells (2026)
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Additional file 1 of Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells (2026)
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Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells (2026)
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How Does Age at Diagnosis Influence Multiple Myeloma Survival? Empirical Evidence (2025)
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Polyclonal plasma cell (PolyPC) signature as a key indicator for predicting the progression of MGUS to multiple myeloma (2025)
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Multi-Omics Reveal Immune Microenvironment Alterations in Multiple Myeloma and Its Precursor Stages (2024)
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A novel CCL3-HMGB1 signaling axis regulating osteocyte RANKL expression in multiple myeloma (2024)
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Multi-omics reveal immune microenvironment alterations in multiple myeloma and its precursor stages (2024)
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A Risk Stratification System in Myeloma Patients with Autologous Stem Cell Transplantation (2024)
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A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma (2024)
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Prognostic value of ferritin in ASCT MM patients: integration with GEP models and ISS series systems (2024)
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Bispecific BCMA/CD24 CAR-T cells control multiple myeloma growth (2024)
Grants & Funding
Collaboration Network
Top Collaborators
Frits van Rhee
University of Arkansas for Medical Sciences
32 shared publications
In database
- The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma
- The spatio-temporal evolution of multiple myeloma from baseline to relapse-refractory states
- TRIP13 modulates protein deubiquitination and accelerates tumor development and progression of B cell malignancies
- Bispecific BCMA/CD24 CAR-T cells control multiple myeloma growth
- Epigenomic translocation of H3K4me3 broad domains over oncogenes following hijacking of super-enhancers
Showing 5 of 32 shared publications
Carolina Schinke
University of Arkansas for Medical Sciences
22 shared publications
In database
- The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma
- The spatio-temporal evolution of multiple myeloma from baseline to relapse-refractory states
- Bispecific BCMA/CD24 CAR-T cells control multiple myeloma growth
- Epigenomic translocation of H3K4me3 broad domains over oncogenes following hijacking of super-enhancers
- CST6 suppresses osteolytic bone disease in multiple myeloma by blocking osteoclast differentiation
Showing 5 of 22 shared publications
Brian A. Walker
22 shared publications
- The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma
- The spatio-temporal evolution of multiple myeloma from baseline to relapse-refractory states
- Chromothripsis as a pathogenic driver of multiple myeloma
- Epigenomic translocation of H3K4me3 broad domains over oncogenes following hijacking of super-enhancers
- Structural variants shape the genomic landscape and clinical outcome of multiple myeloma
Showing 5 of 22 shared publications
Gareth J. Morgan
21 shared publications
- The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma
- The spatio-temporal evolution of multiple myeloma from baseline to relapse-refractory states
- Chromothripsis as a pathogenic driver of multiple myeloma
- Epigenomic translocation of H3K4me3 broad domains over oncogenes following hijacking of super-enhancers
- Structural variants shape the genomic landscape and clinical outcome of multiple myeloma
Showing 5 of 21 shared publications
Sharmilan Thanendrarajan
Winthrop Rockefeller Foundation
19 shared publications
In database
- The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma
- The spatio-temporal evolution of multiple myeloma from baseline to relapse-refractory states
- Bispecific BCMA/CD24 CAR-T cells control multiple myeloma growth
- Epigenomic translocation of H3K4me3 broad domains over oncogenes following hijacking of super-enhancers
- CST6 suppresses osteolytic bone disease in multiple myeloma by blocking osteoclast differentiation
Showing 5 of 19 shared publications
Maurizio Zangari
Winthrop Rockefeller Foundation
19 shared publications
In database
- The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma
- The spatio-temporal evolution of multiple myeloma from baseline to relapse-refractory states
- Bispecific BCMA/CD24 CAR-T cells control multiple myeloma growth
- Epigenomic translocation of H3K4me3 broad domains over oncogenes following hijacking of super-enhancers
- CST6 suppresses osteolytic bone disease in multiple myeloma by blocking osteoclast differentiation
Showing 5 of 19 shared publications
Michael Bauer
University of Arkansas for Medical Sciences
14 shared publications
In database
- The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma
- The spatio-temporal evolution of multiple myeloma from baseline to relapse-refractory states
- Chromothripsis as a pathogenic driver of multiple myeloma
- Multi-omics reveal immune microenvironment alterations in multiple myeloma and its precursor stages
- Structural variants shape the genomic landscape and clinical outcome of multiple myeloma
Showing 5 of 14 shared publications
Patrick Blaney
14 shared publications
- Chromothripsis as a pathogenic driver of multiple myeloma
- Structural variants shape the genomic landscape and clinical outcome of multiple myeloma
- Improving prognostic assignment in older adults with multiple myeloma using acquired genetic features, clonal hemopoiesis and telomere length
- Author Correction: Accelerated single cell seeding in relapsed multiple myeloma
- A Clinically Validated Targeted Capture Panel to Identify Translocations, Copy Number Abnormalities, and Mutations in Multiple Myeloma
Showing 5 of 14 shared publications
John D. Shaughnessy
University of Arkansas for Medical Sciences
14 shared publications
In database
- TRIP13 modulates protein deubiquitination and accelerates tumor development and progression of B cell malignancies
- Bispecific BCMA/CD24 CAR-T cells control multiple myeloma growth
- CST6 suppresses osteolytic bone disease in multiple myeloma by blocking osteoclast differentiation
- AKT supports the metabolic fitness of multiple myeloma cells by restricting FOXO activity
- A gene signature can predict risk of MGUS progressing to multiple myeloma
Showing 5 of 14 shared publications
Samer Al Hadidi
Winthrop Rockefeller Foundation
12 shared publications
In database
- Bispecific BCMA/CD24 CAR-T cells control multiple myeloma growth
- Multi-omics reveal immune microenvironment alterations in multiple myeloma and its precursor stages
- High NEK2 expression in myeloid progenitors suppresses T cell immunity in multiple myeloma
- A gene signature can predict risk of MGUS progressing to multiple myeloma
- Concomitant deletion of the short arm (del(1p13.3)) and amplification or gain (1q21) of chromosome 1 by fluorescence in situ hybridization are associated with a poor clinical outcome in multiple myeloma
Showing 5 of 12 shared publications
Fenghuang Zhan
University of Arkansas for Medical Sciences
11 shared publications
In database
- The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma
- TRIP13 modulates protein deubiquitination and accelerates tumor development and progression of B cell malignancies
- CST6 suppresses osteolytic bone disease in multiple myeloma by blocking osteoclast differentiation
- AKT supports the metabolic fitness of multiple myeloma cells by restricting FOXO activity
- Expression of integrin β-7 is epigenetically enhanced in multiple myeloma subgroups with high-risk cytogenetics
Showing 5 of 11 shared publications
Faith E. Davies
NYU Langone Health (US)
11 shared publications
- The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma
- The spatio-temporal evolution of multiple myeloma from baseline to relapse-refractory states
- Chromothripsis as a pathogenic driver of multiple myeloma
- Structural variants shape the genomic landscape and clinical outcome of multiple myeloma
- Mutations in CRBN and other cereblon pathway genes are infrequently associated with acquired resistance to immunomodulatory drugs
Showing 5 of 11 shared publications
Fumou Sun
Winthrop Rockefeller Foundation
11 shared publications
In database
- Bispecific BCMA/CD24 CAR-T cells control multiple myeloma growth
- CST6 suppresses osteolytic bone disease in multiple myeloma by blocking osteoclast differentiation
- Multi-omics reveal immune microenvironment alterations in multiple myeloma and its precursor stages
- High NEK2 expression in myeloid progenitors suppresses T cell immunity in multiple myeloma
- A gene signature can predict risk of MGUS progressing to multiple myeloma
Showing 5 of 11 shared publications
David E. Mery
Winthrop Rockefeller Foundation
11 shared publications
In database
- Bispecific BCMA/CD24 CAR-T cells control multiple myeloma growth
- Multi-omics reveal immune microenvironment alterations in multiple myeloma and its precursor stages
- High NEK2 expression in myeloid progenitors suppresses T cell immunity in multiple myeloma
- A gene signature can predict risk of MGUS progressing to multiple myeloma
- Prognostic value of ferritin in ASCT MM patients: integration with GEP models and ISS series systems
Showing 5 of 11 shared publications
Clyde Bailey
Winthrop Rockefeller Foundation
11 shared publications
In database
- Bispecific BCMA/CD24 CAR-T cells control multiple myeloma growth
- Multi-omics reveal immune microenvironment alterations in multiple myeloma and its precursor stages
- High NEK2 expression in myeloid progenitors suppresses T cell immunity in multiple myeloma
- A gene signature can predict risk of MGUS progressing to multiple myeloma
- Prognostic value of ferritin in ASCT MM patients: integration with GEP models and ISS series systems
Showing 5 of 11 shared publications
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