Bethany C. Paxton

Graduate Assistant

UAMS

2 h-index 9 pubs 7 cited

Research Areas

Biomedical Subjects

OverviewAI-generated summary

Bethany C. Paxton's research focuses on molecular mechanisms underlying disease, particularly in the context of cancer and DNA replication. Her work investigates the role of specific proteins, such as REV1 and DHX36, in DNA repair and tolerance of complex DNA structures like G-quadruplexes. This research contributes to understanding how cells handle DNA damage and replication stress, which is relevant to cancer development and treatment resistance.

Further research by Paxton explores therapeutic strategies for multiple myeloma, a type of blood cancer. This includes investigating the potential of targeting the NOTCH3 receptor to eliminate dormant and therapy-resistant cancer cells. Additionally, her work examines methods for restoring bone health in multiple myeloma patients through interventions like sclerostin inhibition. Paxton collaborates with researchers Japneet Kaur, Elena Ambrogini, Aric Anloague, and Sharmin Khan at the University of Arkansas for Medical Sciences.

Metrics

h-index: 2
Publications: 9
Citations: 7

Positions

Graduate Assistant publications 2023–2026

University of Arkansas for Medical Sciences Institution web page

Selected Publications

Human REV1 interacts with DHX36 to promote replication and tolerance of G-quadruplex DNA (2026)

Nucleic Acids Research DOI OpenAlex
Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells (2026)

Figshare DOI OpenAlex
Additional file 1 of Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells (2026)

Figshare DOI OpenAlex
Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells (2026)

Figshare DOI OpenAlex
Additional file 1 of Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells (2026)

Figshare DOI OpenAlex
Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells (2026)

Journal of Experimental & Clinical Cancer Research DOI OpenAlex
Healing of lytic lesions and restoration of bone health in multiple myeloma through sclerostin inhibition (2025)

Experimental Hematology and Oncology 3 citations DOI OpenAlex
Abstract 5099: Notch inhibition as a therapeutic approach to eliminate dormant cancer cells in multiple myeloma (2025)

Cancer Research DOI OpenAlex
Conservation of the insert-2 motif confers Rev1 from different species with an ability to disrupt G-quadruplexes and stimulate translesion DNA synthesis (2023)

RSC Chemical Biology 4 citations DOI OpenAlex