Lee Ann Jolly
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Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Lee Ann Jolly investigates the progression of thyroid cancers, particularly those driven by genetic mutations such as BrafV600E, HrasG12V, and Pten loss. Her research explores the role of the tumor microenvironment, focusing on how fibroblast-mediated collagen remodeling and immune suppression by myeloid and lymphoid cells contribute to cancer advancement. Jolly has also worked on developing novel models for follicular thyroid cancer that can progress to more aggressive forms, including poorly differentiated and anaplastic thyroid cancer. Her work has examined structural alterations in tumor-draining lymph nodes preceding papillary thyroid carcinoma metastasis and the control of human PLP1 expression through transcriptional regulatory elements.
Metrics
- h-index: 5
- Publications: 20
- Citations: 215
Selected Publications
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Hras G12V induces follicular thyroid cancer with attenuated MAPK activation and increased latency compared to Kras G12D (2026)
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Development of Novel Follicular Thyroid Cancer Models Which Progress to Poorly Differentiated and Anaplastic Thyroid Cancer (2021)
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Structural alterations in tumor‐draining lymph nodes before papillary thyroid carcinoma metastasis (2017)
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Immune Suppression Mediated by Myeloid and Lymphoid Derived Immune Cells in the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by HrasG12V and Pten Loss (2016)
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Fibroblast-Mediated Collagen Remodeling Within the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by BrafV600E and Pten Loss (2016)
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Control of Human PLP1 Expression Through Transcriptional Regulatory Elements and Alternatively Spliced Exons in Intron 1 (2015)
Collaboration Network
Top Collaborators
- Fibroblast-Mediated Collagen Remodeling Within the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by BrafV600E and Pten Loss
- Immune Suppression Mediated by Myeloid and Lymphoid Derived Immune Cells in the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by HrasG12V and Pten Loss
- Development of Novel Follicular Thyroid Cancer Models Which Progress to Poorly Differentiated and Anaplastic Thyroid Cancer
- Structural alterations in tumor‐draining lymph nodes before papillary thyroid carcinoma metastasis
- Hras G12V induces follicular thyroid cancer with attenuated MAPK activation and increased latency compared to Kras G12D
- Fibroblast-Mediated Collagen Remodeling Within the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by BrafV600E and Pten Loss
- Immune Suppression Mediated by Myeloid and Lymphoid Derived Immune Cells in the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by HrasG12V and Pten Loss
- Development of Novel Follicular Thyroid Cancer Models Which Progress to Poorly Differentiated and Anaplastic Thyroid Cancer
- Structural alterations in tumor‐draining lymph nodes before papillary thyroid carcinoma metastasis
- Control of Human PLP1 Expression Through Transcriptional Regulatory Elements and Alternatively Spliced Exons in Intron 1
- Control of Human PLP1 Expression Through Transcriptional Regulatory Elements and Alternatively Spliced Exons in Intron 1
- Control of Human PLP1 Expression Through Transcriptional Regulatory Elements and Alternatively Spliced Exons in Intron 1
- Control of Human PLP1 Expression Through Transcriptional Regulatory Elements and Alternatively Spliced Exons in Intron 1
- Fibroblast-Mediated Collagen Remodeling Within the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by BrafV600E and Pten Loss
- Fibroblast-Mediated Collagen Remodeling Within the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by BrafV600E and Pten Loss
- Fibroblast-Mediated Collagen Remodeling Within the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by BrafV600E and Pten Loss
- Fibroblast-Mediated Collagen Remodeling Within the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by BrafV600E and Pten Loss
- Fibroblast-Mediated Collagen Remodeling Within the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by BrafV600E and Pten Loss
- Structural alterations in tumor‐draining lymph nodes before papillary thyroid carcinoma metastasis
- Structural alterations in tumor‐draining lymph nodes before papillary thyroid carcinoma metastasis
- Structural alterations in tumor‐draining lymph nodes before papillary thyroid carcinoma metastasis
- Development of Novel Follicular Thyroid Cancer Models Which Progress to Poorly Differentiated and Anaplastic Thyroid Cancer
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