Match tier Confirmed
Presence Current · Arkansas
Last published 2026
Sources OpenAlex · ORCID
Refreshed 2026-10-07

Lee Ann Jolly

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5 h-index 20 pubs 215 cited

  • Humans
  • Thyroid Neoplasms
  • Proto-Oncogene Proteins B-raf
  • Animals
  • Mice
  • Collagen
  • Fibroblasts
  • Cell Proliferation
  • PTEN Phosphohydrolase
  • Tumor Microenvironment
  • Carcinoma, Papillary
  • Coloring Agents
  • Female
  • Lymph Nodes
  • Lymphatic Metastasis

Biography and Research Information

OverviewAI-generated summary

Lee Ann Jolly investigates the progression of thyroid cancers, particularly those driven by genetic mutations such as BrafV600E, HrasG12V, and Pten loss. Her research explores the role of the tumor microenvironment, focusing on how fibroblast-mediated collagen remodeling and immune suppression by myeloid and lymphoid cells contribute to cancer advancement. Jolly has also worked on developing novel models for follicular thyroid cancer that can progress to more aggressive forms, including poorly differentiated and anaplastic thyroid cancer. Her work has examined structural alterations in tumor-draining lymph nodes preceding papillary thyroid carcinoma metastasis and the control of human PLP1 expression through transcriptional regulatory elements.

Metrics

  • h-index: 5
  • Publications: 20
  • Citations: 215

Selected Publications

  • Hras G12V induces follicular thyroid cancer with attenuated MAPK activation and increased latency compared to Kras G12D (2026)
    bioRxiv (Cold Spring Harbor Laboratory) DOI OpenAlex
  • Development of Novel Follicular Thyroid Cancer Models Which Progress to Poorly Differentiated and Anaplastic Thyroid Cancer (2021)
    Cancers 12 citations DOI OpenAlex
  • Structural alterations in tumor‐draining lymph nodes before papillary thyroid carcinoma metastasis (2017)
    Head & Neck 10 citations DOI OpenAlex
  • Immune Suppression Mediated by Myeloid and Lymphoid Derived Immune Cells in the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by HrasG12V and Pten Loss (2016)
    Journal of Clinical & Cellular Immunology 23 citations DOI OpenAlex
  • Fibroblast-Mediated Collagen Remodeling Within the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by BrafV600E and Pten Loss (2016)
    Cancer Research 165 citations DOI OpenAlex
  • Control of Human PLP1 Expression Through Transcriptional Regulatory Elements and Alternatively Spliced Exons in Intron 1 (2015)
    ASN NEURO 5 citations DOI OpenAlex

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Collaboration Network

21 Collaborators 7 Institutions 1 Country

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