Wen Ling

Researcher

UAMS

Also affiliated: Guangxi University (2024); Soochow University (2016); Soochow University (2014–2016); Longgang Central Hospital (2024); Institute for Musculoskeletal Health (2024); Winthrop Rockefeller Foundation (2019–2025); University of South China (2010)

Faculty Researcher

17 h-index 66 pubs 1,582 cited

Research Areas

Biomedical Subjects

OverviewAI-generated summary

Wen Ling's research investigates mechanisms of bone loss, particularly in contexts of aging, estrogen deficiency, and radiation exposure. Her work has explored the role of mitochondrial sirtuin 3 (SIRT3) in promoting bone resorption in aging or estrogen-deficient female mice, and how ionizing radiation and simulated galactic cosmic rays impact mitochondrial function in osteoclasts, leading to bone loss in mice. Ling has also studied the hematopoietic cytoplasmic adaptor protein Hem1's promotion of osteoclast fusion and bone resorption. Additionally, her research has examined the role of EDNRA-expressing mesenchymal cells in multiple myeloma progression and the control of myeloma cell growth and dormancy by mesenchymal stem cells. Ling is also involved in investigating PHF19 inhibition as a therapeutic target in multiple myeloma. Her scholarly contributions include an h-index of 17 based on 66 publications, with over 1,500 citations. She has established collaborations with researchers at the University of Arkansas for Medical Sciences and the University of Arkansas at Fayetteville.

Metrics

h-index: 17
Publications: 66
Citations: 1,582

Selected Publications

Induction of HMOX1 by mesenchymal stem cell cytotherapy inhibits osteoclastogenesis and myeloma‐induced bone disease (2025)

Clinical and Translational Medicine DOI OpenAlex
EDNRA-Expressing Mesenchymal Cells Are Expanded in Myeloma Interstitial Bone Marrow and Associated with Disease Progression (2023)

Cancers 7 citations DOI OpenAlex
Growth and dormancy control of myeloma cells by mesenchymal stem cells (2023)

Leukemia Research 6 citations DOI OpenAlex
Hematopoietic cytoplasmic adaptor protein Hem1 promotes osteoclast fusion and bone resorption in mice (2022)

Journal of Biological Chemistry 5 citations DOI OpenAlex
Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice (2022)

International Journal of Molecular Sciences 22 citations DOI OpenAlex
Simulated Galactic Cosmic Rays Modify Mitochondrial Metabolism in Osteoclasts, Increase Osteoclastogenesis and Cause Trabecular Bone Loss in Mice (2021)

International Journal of Molecular Sciences 17 citations DOI OpenAlex
PHF19 inhibition as a therapeutic target in multiple myeloma (2021)

Current Research in Translational Medicine 9 citations DOI OpenAlex
The Role of PHF19 As a Promoter of Tumorigenicity and Therapeutic Target in Multiple Myeloma (2019)

Blood DOI OpenAlex
Proliferation and Molecular Risk Score of Low Risk Myeloma Cells Are Increased in High Risk Microenvironment Via Augmented Bioavailability of Growth Factors (2018)

Blood DOI OpenAlex
Mesenchymal Stem Cells Preconditioned with Myeloma Cells from High-Risk Patients Support the Growth of Myeloma Cells from Low-Risk Patients (2016)

Blood 3 citations DOI OpenAlex
Primary myeloma interaction and growth in coculture with healthy donor hematopoietic bone marrow (2015)

BMC Cancer 21 citations DOI OpenAlex
ATRA Upregulates Cell Surface CD1D on Myeloma Cells and Sensitizes Them to iNKT Cell-Mediated Lysis (2014)

Blood 2 citations DOI OpenAlex
Sustained Growth of Primary Myeloma Cells in Coculture with Whole Donor Bone Marrow Is Associated with Induced Secretion of the Microenvironmental Mediator of Cytokinesis, Hemicentin-1 (2014)

Blood 1 citation DOI OpenAlex
Role of Bruton’s tyrosine kinase (BTK) in growth and metastasis of INA6 myeloma cells (2014)

Blood Cancer Journal 12 citations DOI OpenAlex
GPRC5D Is a Cell Surface Plasma Cell Marker Whose Expression Is High In Myeloma Cells and Reduced Following Coculture With Osteoclasts (2013)

Blood 11 citations DOI OpenAlex