Biography and Research Information
OverviewAI-generated summary
Wen Ling's research focuses on the cellular and molecular mechanisms underlying bone health and diseases, particularly in the context of aging and cancer. A significant portion of her work investigates the role of mitochondria and specific proteins like Sirt3 in regulating osteoclast function, which is crucial for bone resorption. Her studies have explored how factors such as ionizing radiation and simulated galactic cosmic rays impact mitochondrial metabolism in osteoclasts, leading to bone loss. Ling has also examined the involvement of hematopoietic cytoplasmic adaptor protein Hem1 in osteoclast fusion and bone resorption. In addition to bone biology, her research extends to multiple myeloma, investigating therapeutic targets like PHF19 inhibition and the role of EDNRA-expressing mesenchymal cells in disease progression. She also studies the interaction between mesenchymal stem cells and myeloma cells, focusing on growth and dormancy control. Ling has a publication record of 67 articles, with an h-index of 16 and 1,554 citations. She has collaborated with researchers at the University of Arkansas for Medical Sciences and the University of Arkansas at Fayetteville.
Metrics
- h-index: 17
- Publications: 66
- Citations: 1,562
Selected Publications
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Induction of HMOX1 by mesenchymal stem cell cytotherapy inhibits osteoclastogenesis and myeloma‐induced bone disease (2025)
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EDNRA-Expressing Mesenchymal Cells Are Expanded in Myeloma Interstitial Bone Marrow and Associated with Disease Progression (2023)
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Growth and dormancy control of myeloma cells by mesenchymal stem cells (2023)
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Hematopoietic cytoplasmic adaptor protein Hem1 promotes osteoclast fusion and bone resorption in mice (2022)
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Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice (2022)
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Simulated Galactic Cosmic Rays Modify Mitochondrial Metabolism in Osteoclasts, Increase Osteoclastogenesis and Cause Trabecular Bone Loss in Mice (2021)
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PHF19 inhibition as a therapeutic target in multiple myeloma (2021)
Collaboration Network
Top Collaborators
Kimberly J. Krager
Pharmaceutical Biotechnology (Czechia)
5 shared publications
In database
- Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency
- Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice
- Simulated Galactic Cosmic Rays Modify Mitochondrial Metabolism in Osteoclasts, Increase Osteoclastogenesis and Cause Trabecular Bone Loss in Mice
- Mitochondrial protein deacetylation by SIRT3 in osteoclasts promotes bone resorption with aging in female mice
- Hematopoietic cytoplasmic adaptor protein Hem1 promotes osteoclast fusion and bone resorption in mice
Kimberly Richardson
Institute for Musculoskeletal Health (AU)
5 shared publications
- Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency
- Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice
- Simulated Galactic Cosmic Rays Modify Mitochondrial Metabolism in Osteoclasts, Increase Osteoclastogenesis and Cause Trabecular Bone Loss in Mice
- Mitochondrial protein deacetylation by SIRT3 in osteoclasts promotes bone resorption with aging in female mice
- Hematopoietic cytoplasmic adaptor protein Hem1 promotes osteoclast fusion and bone resorption in mice
Nükhet Aykin‐Burns
Pharmaceutical Biotechnology (Czechia)
5 shared publications
In database
- Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency
- Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice
- Simulated Galactic Cosmic Rays Modify Mitochondrial Metabolism in Osteoclasts, Increase Osteoclastogenesis and Cause Trabecular Bone Loss in Mice
- Mitochondrial protein deacetylation by SIRT3 in osteoclasts promotes bone resorption with aging in female mice
- Hematopoietic cytoplasmic adaptor protein Hem1 promotes osteoclast fusion and bone resorption in mice
Ha‐Neui Kim
Carolina Musculoskeletal Institute
5 shared publications
In database
- Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency
- Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice
- Simulated Galactic Cosmic Rays Modify Mitochondrial Metabolism in Osteoclasts, Increase Osteoclastogenesis and Cause Trabecular Bone Loss in Mice
- Mitochondrial protein deacetylation by SIRT3 in osteoclasts promotes bone resorption with aging in female mice
- Hematopoietic cytoplasmic adaptor protein Hem1 promotes osteoclast fusion and bone resorption in mice
Shmuel Yaccoby
5 shared publications
In database
- PHF19 inhibition as a therapeutic target in multiple myeloma
- EDNRA-Expressing Mesenchymal Cells Are Expanded in Myeloma Interstitial Bone Marrow and Associated with Disease Progression
- Growth and dormancy control of myeloma cells by mesenchymal stem cells
- Induction of HMOX1 by mesenchymal stem cell cytotherapy inhibits osteoclastogenesis and myeloma‐induced bone disease
- Altered mesenchymal and endothelial subsets in interstitial bone marrow and focal lesions in myeloma patients and SCID-hu mice
Maurizio Zangari
Winthrop Rockefeller Foundation
4 shared publications
In database
- PHF19 inhibition as a therapeutic target in multiple myeloma
- EDNRA-Expressing Mesenchymal Cells Are Expanded in Myeloma Interstitial Bone Marrow and Associated with Disease Progression
- Growth and dormancy control of myeloma cells by mesenchymal stem cells
- Altered mesenchymal and endothelial subsets in interstitial bone marrow and focal lesions in myeloma patients and SCID-hu mice
Frits van Rhee
Winthrop Rockefeller Foundation
4 shared publications
In database
- PHF19 inhibition as a therapeutic target in multiple myeloma
- EDNRA-Expressing Mesenchymal Cells Are Expanded in Myeloma Interstitial Bone Marrow and Associated with Disease Progression
- Growth and dormancy control of myeloma cells by mesenchymal stem cells
- Altered mesenchymal and endothelial subsets in interstitial bone marrow and focal lesions in myeloma patients and SCID-hu mice
Aaron Warren
Institute for Musculoskeletal Health
3 shared publications
In database
- Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency
- Mitochondrial protein deacetylation by SIRT3 in osteoclasts promotes bone resorption with aging in female mice
- Hematopoietic cytoplasmic adaptor protein Hem1 promotes osteoclast fusion and bone resorption in mice
Maria Almeida
University of Arkansas for Medical Sciences
3 shared publications
In database
- Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency
- Mitochondrial protein deacetylation by SIRT3 in osteoclasts promotes bone resorption with aging in female mice
- Hematopoietic cytoplasmic adaptor protein Hem1 promotes osteoclast fusion and bone resorption in mice
Carolina Schinke
University of Arkansas for Medical Sciences
3 shared publications
In database
- PHF19 inhibition as a therapeutic target in multiple myeloma
- EDNRA-Expressing Mesenchymal Cells Are Expanded in Myeloma Interstitial Bone Marrow and Associated with Disease Progression
- Growth and dormancy control of myeloma cells by mesenchymal stem cells
Stephanie D. Byrum
Arkansas Children's Hospital
3 shared publications
In database
- Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice
- Mitochondrial protein deacetylation by SIRT3 in osteoclasts promotes bone resorption with aging in female mice
- PHF19 inhibition as a therapeutic target in multiple myeloma
Sharmilan Thanendrarajan
Winthrop Rockefeller Foundation
3 shared publications
In database
- PHF19 inhibition as a therapeutic target in multiple myeloma
- EDNRA-Expressing Mesenchymal Cells Are Expanded in Myeloma Interstitial Bone Marrow and Associated with Disease Progression
- Growth and dormancy control of myeloma cells by mesenchymal stem cells
Bart Barlogie
University of Arkansas for Medical Sciences
2 shared publications
In database
- PHF19 inhibition as a therapeutic target in multiple myeloma
- Induction of HMOX1 by mesenchymal stem cell cytotherapy inhibits osteoclastogenesis and myeloma‐induced bone disease
Syed J. Mehdi
University of Arkansas for Medical Sciences (US)
2 shared publications
- EDNRA-Expressing Mesenchymal Cells Are Expanded in Myeloma Interstitial Bone Marrow and Associated with Disease Progression
- Growth and dormancy control of myeloma cells by mesenchymal stem cells
Sadie Johnson
University of Arkansas for Medical Sciences (US)
2 shared publications
- EDNRA-Expressing Mesenchymal Cells Are Expanded in Myeloma Interstitial Bone Marrow and Associated with Disease Progression
- Growth and dormancy control of myeloma cells by mesenchymal stem cells
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