Wen Ling

Researcher

University of Arkansas for Medical Sciences

faculty

16 h-index 67 pubs 1,552 cited

Research Areas

Bone Metabolism and Diseases Mitochondrial Function and Pathology Cancer-related molecular mechanisms research Multiple Myeloma Research and Treatments Protein Structure and Dynamics Immune Cell Function and Interaction

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OverviewAI-generated summary

Wen Ling's research investigates the molecular mechanisms underlying bone metabolism and resorption, with a particular focus on the role of mitochondria and specific proteins in age-related bone loss and conditions like multiple myeloma. Studies have explored how mitochondrial sirtuins, such as Sirt3, contribute to bone loss in aging or estrogen-deficient states. Investigations have also examined the impact of ionizing radiation and simulated galactic cosmic rays on osteoclast mitochondrial function, leading to increased osteoclastogenesis and trabecular bone loss. Furthermore, research has identified Hematopoietic cytoplasmic adaptor protein Hem1 as a promoter of osteoclast fusion and bone resorption. In the context of multiple myeloma, work has focused on the PHF19 protein as a therapeutic target and the role of EDNRA-expressing mesenchymal cells in disease progression and interstitial bone marrow expansion. The researcher's work also touches upon the control of myeloma cell growth and dormancy by mesenchymal stem cells.

Metrics

  • h-index: 16
  • Publications: 67
  • Citations: 1,552

Selected Publications

  • Induction of HMOX1 by mesenchymal stem cell cytotherapy inhibits osteoclastogenesis and myeloma‐induced bone disease (2025) DOI
  • EDNRA-Expressing Mesenchymal Cells Are Expanded in Myeloma Interstitial Bone Marrow and Associated with Disease Progression (2023) DOI
  • Growth and dormancy control of myeloma cells by mesenchymal stem cells (2023) DOI
  • Hematopoietic cytoplasmic adaptor protein Hem1 promotes osteoclast fusion and bone resorption in mice (2022) DOI
  • Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice (2022) DOI
  • Simulated Galactic Cosmic Rays Modify Mitochondrial Metabolism in Osteoclasts, Increase Osteoclastogenesis and Cause Trabecular Bone Loss in Mice (2021) DOI
  • PHF19 inhibition as a therapeutic target in multiple myeloma (2021) DOI

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