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Presence
Current · Arkansas
Last published
2025
Sources
OpenAlex · ORCID
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2026-10-06
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Dan A. Buzatu
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Also affiliated: United States Food and Drug Administration (2001–2025); LSU New Orleans (1993–1996)
16 h-index
61 pubs
600 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Dan A. Buzatu conducts research focused on developing and applying computational and analytical methods to study biological and chemical systems. His work includes the development of quantitative structure-activity relationship (QSAR) models, utilizing techniques such as molecular docking and spectral data analysis to predict chemical interactions and biological activities. Buzatu has investigated inhibitors for enzymes like Cytochrome P450 CYP3A4 and explored the computational identification of toxicophores.
In addition to computational approaches, his research involves experimental methods, particularly flow cytometry, for the rapid detection and identification of bacteria, including *Escherichia coli* O157. He has also worked on integrated systems combining flow cytometry with sample preparation and multi-dimensional gating for enhanced sensitivity. Buzatu's work is supported by collaborations with researchers at the National Center for Toxicological Research, with whom he has co-authored multiple publications.
Metrics
- h-index: 16
- Publications: 61
- Citations: 600
Selected Publications
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Examining the viability of five Salmonella enterica subsp. enterica in thymol at 4°C and 25°C using flow cytometry (2025)
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Direct detection and identification of viruses in saliva using a SpecID ionization modified mass spectrometer (2025)
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A flow cytometric assay to detect viability and persistence of Salmonella enterica subsp. enterica serotypes in nuclease-free water at 4 and 25°C (2024)
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Direct Detection and Identification of Viruses in Saliva Using a SpecID™ Ionization Modified Mass Spectrometer (2022)
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Specific Detection and Enumeration of Burkholderia cepacia Complex by Flow Cytometry Using a Fluorescence-Labeled Oligonucleotide Probe (2022)
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Draft Genome Sequence of Ralstonia pickettii Strain NCTR106, Isolated from Milk Carton Paperboard (2022)
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A comparison of culture-based, real-time PCR, droplet digital PCR and flow cytometric methods for the detection of Burkholderia cepacia complex in nuclease-free water and antiseptics (2020)
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Elucidating Olfactory Receptor - Odorant Interactions: Leveraging Drug-Design Ideations (2019)
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Development of models for predicting Torsade de Pointes cardiac arrhythmias using perceptron neural networks (2017)
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Rapid Flow Cytometry Detection of a Single Viable Escherichia coli O157:H7 Cell in Raw Spinach Using a Simplified Sample Preparation Technique (2017)
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Flow‐Cytometry‐Based Method to Detect Escherichia coli and Shigella Spp. Using 16S rRNA‐Based Probe (2017)
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3D-SDAR modeling of hERG potassium channel affinity: A case study in model design and toxicophore identification (2017)
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Feature selection from mass spectra of bacteria for serotyping Salmonella (2016)
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Alignment-independent technique for 3D QSAR analysis (2016)
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Development of a Flow Cytometry-Based Method for Rapid Detection of Escherichia coli and Shigella Spp. Using an Oligonucleotide Probe (2016)
Collaboration Network
Top Collaborators
Jon G. Wilkes
National Center for Toxicological Research (US)
31 shared publications
- An Integrated Flow Cytometry-Based System for Real-Time, High Sensitivity Bacterial Detection and Identification
- Reduction of food matrix interference by a combination of sample preparation and multi-dimensional gating techniques to facilitate rapid, high sensitivity analysis for Escherichia coli serotype O157 by flow cytometry
- 13C NMR Quantitative Spectrometric Data-Activity Relationship (QSDAR) Models of Steroids Binding the Aromatase Enzyme
- Modeling Chemical Interaction Profiles: II. Molecular Docking, Spectral Data-Activity Relationship, and Structure-Activity Relationship Models for Potent and Weak Inhibitors of Cytochrome P450 CYP3A4 Isozyme
- Computational identification of a phospholipidosis toxicophore using 13C and 15N NMR-distance based fingerprints
Showing 5 of 31 shared publications
Richard D. Beger
National Center for Toxicological Research
14 shared publications
In database
- 13C NMR Quantitative Spectrometric Data-Activity Relationship (QSDAR) Models of Steroids Binding the Aromatase Enzyme
- Modeling Chemical Interaction Profiles: II. Molecular Docking, Spectral Data-Activity Relationship, and Structure-Activity Relationship Models for Potent and Weak Inhibitors of Cytochrome P450 CYP3A4 Isozyme
- Computational identification of a phospholipidosis toxicophore using 13C and 15N NMR-distance based fingerprints
- Partial least square and k-nearest neighbor algorithms for improved 3D quantitative spectral data–activity relationship consensus modeling of acute toxicity
- Comparative Structural Connectivity Spectra Analysis (CoSCoSA) Models of Steroid Binding to the Corticosteroid Binding Globulin
Showing 5 of 14 shared publications
Pierre Alusta
National Center for Toxicological Research
13 shared publications
In database
- A comparison of culture-based, real-time PCR, droplet digital PCR and flow cytometric methods for the detection of Burkholderia cepacia complex in nuclease-free water and antiseptics
- Thymol treatment of bacteria prior to matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometric analysis aids in identifying certain bacteria at the subspecies level
- Level 2 validation of a flow cytometric method for detection of Escherichia coli O157:H7 in raw spinach
- Rapid Flow Cytometry Detection of a Single Viable Escherichia coli O157:H7 Cell in Raw Spinach Using a Simplified Sample Preparation Technique
- Improving proton MR spectroscopy of brain tissue for noninvasive diagnostics
Showing 5 of 13 shared publications
A. J. Williams
National Center for Toxicological Research (US)
11 shared publications
- An Integrated Flow Cytometry-Based System for Real-Time, High Sensitivity Bacterial Detection and Identification
- Development of a Flow Cytometry-Based Method for Rapid Detection of Escherichia coli and Shigella Spp. Using an Oligonucleotide Probe
- A comparison of culture-based, real-time PCR, droplet digital PCR and flow cytometric methods for the detection of Burkholderia cepacia complex in nuclease-free water and antiseptics
- Thymol treatment of bacteria prior to matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometric analysis aids in identifying certain bacteria at the subspecies level
- Photobleaching with phloxine B sensitizer to reduce food matrix interference for detection of Escherichia coli serotype O157:H7 in fresh spinach by flow cytometry
Showing 5 of 11 shared publications
Willie M. Cooper
National Center for Toxicological Research (US)
8 shared publications
- An Integrated Flow Cytometry-Based System for Real-Time, High Sensitivity Bacterial Detection and Identification
- Reduction of food matrix interference by a combination of sample preparation and multi-dimensional gating techniques to facilitate rapid, high sensitivity analysis for Escherichia coli serotype O157 by flow cytometry
- Development of a Flow Cytometry-Based Method for Rapid Detection of Escherichia coli and Shigella Spp. Using an Oligonucleotide Probe
- Thymol treatment of bacteria prior to matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometric analysis aids in identifying certain bacteria at the subspecies level
- Photobleaching with phloxine B sensitizer to reduce food matrix interference for detection of Escherichia coli serotype O157:H7 in fresh spinach by flow cytometry
Showing 5 of 8 shared publications
Bruce A. Pearce
National Center for Toxicological Research (US)
7 shared publications
- Modeling Chemical Interaction Profiles: II. Molecular Docking, Spectral Data-Activity Relationship, and Structure-Activity Relationship Models for Potent and Weak Inhibitors of Cytochrome P450 CYP3A4 Isozyme
- Thymol treatment of bacteria prior to matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometric analysis aids in identifying certain bacteria at the subspecies level
- Partial least square and k-nearest neighbor algorithms for improved 3D quantitative spectral data–activity relationship consensus modeling of acute toxicity
- Modeling Chemical Interaction Profiles: I. Spectral Data-Activity Relationship and Structure-Activity Relationship Models for Inhibitors and Non-inhibitors of Cytochrome P450 CYP3A4 and CYP2D6 Isozymes
- Improving proton MR spectroscopy of brain tissue for noninvasive diagnostics
Showing 5 of 7 shared publications
Jerry A. Darsey
University of Arkansas at Little Rock (US)
6 shared publications
- Electronic Properties of Single-Wall Carbon Nanotubes and Their Dependence on Synthetic Methods
- The Determination of Cardiac Surgical Risk Using Artificial Neural Networks
- Use of carbon nanostructures for hydrogen storage for environmentally safe automotive applications
- DIRECT IMPACT CORONA IONIZATION OF BACTERIA FOR RAPID, REPRODUCIBLE IDENTIFICATION VIA SPECTRAL PATTERN RECOGNITION
- Computational Design and Analysis of Nanoscale Logic Circuit Molecules
Showing 5 of 6 shared publications
Svetoslav Slavov
National Center for Toxicological Research
6 shared publications
In database
- Computational identification of a phospholipidosis toxicophore using 13C and 15N NMR-distance based fingerprints
- Partial least square and k-nearest neighbor algorithms for improved 3D quantitative spectral data–activity relationship consensus modeling of acute toxicity
- Complementary PLS and KNN algorithms for improved 3D-QSDAR consensus modeling of AhR binding
- 3D-SDAR modeling of hERG potassium channel affinity: A case study in model design and toxicophore identification
- 13C NMR–Distance Matrix Descriptors: Optimal Abstract 3D Space Granularity for Predicting Estrogen Binding
Showing 5 of 6 shared publications
John B. Sutherland
National Center for Toxicological Research
5 shared publications
In database
- Reduction of food matrix interference by a combination of sample preparation and multi-dimensional gating techniques to facilitate rapid, high sensitivity analysis for Escherichia coli serotype O157 by flow cytometry
- Rapid phenotypic characterization of Salmonella enterica strains by pyrolysis metastable atom bombardment mass spectrometry with multivariate statistical and artificial neural network pattern recognition
- Photobleaching with phloxine B sensitizer to reduce food matrix interference for detection of Escherichia coli serotype O157:H7 in fresh spinach by flow cytometry
- Level 2 validation of a flow cytometric method for detection of Escherichia coli O157:H7 in raw spinach
- Pyrolysis mass spectrometry for distinguishing potential hoax materials from bioterror agents
Ted J. Moskal
Arkansas Biosciences Institute (US)
4 shared publications
- An Integrated Flow Cytometry-Based System for Real-Time, High Sensitivity Bacterial Detection and Identification
- Development of a Flow Cytometry-Based Method for Rapid Detection of Escherichia coli and Shigella Spp. Using an Oligonucleotide Probe
- Level 2 validation of a flow cytometric method for detection of Escherichia coli O157:H7 in raw spinach
- Flow‐Cytometry‐Based Method to Detect Escherichia coli and Shigella Spp. Using 16S rRNA‐Based Probe
Fatemeh Rafii
National Center for Toxicological Research
4 shared publications
In database
- Development of a Flow Cytometry-Based Method for Rapid Detection of Escherichia coli and Shigella Spp. Using an Oligonucleotide Probe
- Photobleaching with phloxine B sensitizer to reduce food matrix interference for detection of Escherichia coli serotype O157:H7 in fresh spinach by flow cytometry
- Pyrolysis mass spectrometry for distinguishing potential hoax materials from bioterror agents
- Method Reproducibility and Spectral Library Assembly for Rapid Bacterial Characterization by Metastable Atom Bombardment Pyrolysis Mass Spectrometry
Youngbeom Ahn
National Center for Toxicological Research
4 shared publications
In database
- A comparison of culture-based, real-time PCR, droplet digital PCR and flow cytometric methods for the detection of Burkholderia cepacia complex in nuclease-free water and antiseptics
- Specific Detection and Enumeration of Burkholderia cepacia Complex by Flow Cytometry Using a Fluorescence-Labeled Oligonucleotide Probe
- A flow cytometric assay to detect viability and persistence of Salmonella enterica subsp. enterica serotypes in nuclease-free water at 4 and 25°C
- Examining the viability of five Salmonella enterica subsp. enterica in thymol at 4°C and 25°C using flow cytometry
Christine V. Summage-West
National Center for Toxicological Research
3 shared publications
In database
- Photobleaching with phloxine B sensitizer to reduce food matrix interference for detection of Escherichia coli serotype O157:H7 in fresh spinach by flow cytometry
- Level 2 validation of a flow cytometric method for detection of Escherichia coli O157:H7 in raw spinach
- Draft Genome Sequence of Ralstonia pickettii Strain NCTR106, Isolated from Milk Carton Paperboard
Larry G. Rushing
National Center for Toxicological Research (US)
3 shared publications
- Rapid phenotypic characterization of Salmonella enterica strains by pyrolysis metastable atom bombardment mass spectrometry with multivariate statistical and artificial neural network pattern recognition
- Pyrolysis mass spectrometry for distinguishing potential hoax materials from bioterror agents
- Method Reproducibility and Spectral Library Assembly for Rapid Bacterial Characterization by Metastable Atom Bombardment Pyrolysis Mass Spectrometry
Olga Tarasenko
University of Arkansas at Little Rock (US)
3 shared publications
- Instrumental improvements and sample preparations that enable reproducible, reliable acquisition of mass spectra from whole bacterial cells
- DIRECT IMPACT CORONA IONIZATION OF BACTERIA FOR RAPID, REPRODUCIBLE IDENTIFICATION VIA SPECTRAL PATTERN RECOGNITION
- DIRECT IMPACT CORONA IONIZATION OF BACTERIA FOR RAPID, REPRODUCIBLE IDENTIFICATION VIA SPECTRAL PATTERN RECOGNITION
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