D
Darin E. Jones
High Impact
Associate Professor
faculty
Pharmaceutical Science, College of Pharmacy
23 h-index
87 pubs
1,264 cited
Research Areas
Biography and Research Information
OverviewAI-generated summary
Darin E. Jones's research focuses on understanding the molecular mechanisms of enzymes involved in DNA repair and replication, with applications in cancer treatment and antiviral drug development. His work utilizes structure-based drug design and chemical screening methodologies, including time-resolved X-ray scattering and high-throughput small-angle X-ray scattering (HT-SAXS), to identify and characterize novel inhibitors.
His publications include studies on inhibitors targeting human uracil-DNA glycosylase and the SARS-CoV-2 Nsp3 macrodomain, drawing insights from human poly(ADP-ribose) glycohydrolase (PARG) structures. Jones also investigates the role of proteins like GRB2 in DNA repair pathways and has explored the effects of compounds such as novobiocin on DNA replication enzymes. His group's research also extends to the radioprotective effects of tocotrienols.
Jones leads a research group and has a scholarly record reflected by an h-index of 23 and 1,239 total citations across 86 publications. He collaborates with researchers at the University of Arkansas for Medical Sciences, including Philip J. Breen, Edward J. Selvik, Shobanbabu Bommagani, and David E. Mery.
Metrics
- h-index: 23
- Publications: 87
- Citations: 1,264
Selected Publications
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Structural basis for substrate-assisted catalysis and small-molecule inhibition of alphavirus macrodomains (2026)
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EET-Based Therapeutics Mitigate Sorafenib-Associated Glomerular Cell Damage (2025)
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Chemical screening by time-resolved X-ray scattering to discover allosteric probes (2024)
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Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects (2023)
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Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity (2023)
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466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator (2023)
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Applying HT-SAXS to chemical ligand screening (2022)
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Analysis of Plant–Plant Interactions Reveals the Presence of Potent Antileukemic Compounds (2022)
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An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2 (2021)
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GRB2 enforces homology-directed repair initiation by MRE11 (2021)
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An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation (2021)
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Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors (2021)
Grants & Funding
- Pharmacological Modulation of Poly (ADP-ribose) Metabolism NIH/Nat. Cancer Institute - Pass Through: University of Texas Health Science Center at Houston Principal Investigator
- A Plug and Play DOE Approach for Emerging Threats: Taskforce 5 US Department of Energy - Pass Through: Lawrence Berkeley National Laboratory Principal Investigator
- Cellular Functions of Eukaryotic DNA Ligases - Continuation NIH/Nat. Inst. of General Medical Sciences - Pass Through: University of New Mexico Principal Investigator
- PHARMACOLOGICAL MODULATION OF POLY(ADP-RIBOSE) METABOLISM NIH Co-Principal Investigator
- Targeting DNA ligase 1 in Ovarian Cancer NIH/Nat. Cancer Institute - Pass Through: University of New Mexico Principal Investigator
- A Plug and Play DOE Approach for Emerging Threats: Taskforce 5 US Department of Energy - Pass Through: Lawrence Berkeley National Laboratory Principal Investigator
- Structural Cell Biology of DNA Repair Machines Project 3 - PARP: PAR-dependent, phase-transitioned protein assemblies, and DNA repair. NIH/Nat. Cancer Institute - Pass Through: Lawrence Berkeley National Laboratory Principal Investigator
- Preventing immune system dysregulation during deep-space missions by Tocofexol, a modified isomer of vitamin E - AA request National Aeronautics & Space Administration - Pass Through: Arkansas Space Grant Consortium Principal Investigator
Collaboration Network
Top Collaborators
John A. Tainer
The University of Texas MD Anderson Cancer Center (US)
7 shared publications
- Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors
- GRB2 enforces homology-directed repair initiation by MRE11
- Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity
- An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation
- Chemical screening by time-resolved X-ray scattering to discover allosteric probes
Showing 5 of 7 shared publications
Davide Moiani
The University of Texas MD Anderson Cancer Center (US)
6 shared publications
- Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors
- GRB2 enforces homology-directed repair initiation by MRE11
- An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation
- Chemical screening by time-resolved X-ray scattering to discover allosteric probes
- An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2
Showing 5 of 6 shared publications
Chris A. Brosey
The University of Texas MD Anderson Cancer Center (US)
4 shared publications
- Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors
- Chemical screening by time-resolved X-ray scattering to discover allosteric probes
- An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2
- Applying HT-SAXS to chemical ligand screening
Todd Link
The University of Texas MD Anderson Cancer Center (US)
4 shared publications
- Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors
- Chemical screening by time-resolved X-ray scattering to discover allosteric probes
- An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2
- Structural basis for substrate-assisted catalysis and small-molecule inhibition of alphavirus macrodomains
Zamal Ahmed
The University of Texas MD Anderson Cancer Center (US)
4 shared publications
- Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors
- GRB2 enforces homology-directed repair initiation by MRE11
- An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation
- An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2
Philip J. Breen
4 shared publications
In database
- Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects
- Analysis of Plant–Plant Interactions Reveals the Presence of Potent Antileukemic Compounds
- 466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator
- CCDC 2088888: Experimental Crystal Structure Determination
César M. Compadre
4 shared publications
- Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects
- Analysis of Plant–Plant Interactions Reveals the Presence of Potent Antileukemic Compounds
- 466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator
- CCDC 2088888: Experimental Crystal Structure Determination
Albino Bacolla
The University of Texas MD Anderson Cancer Center (US)
3 shared publications
- Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors
- GRB2 enforces homology-directed repair initiation by MRE11
- Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity
Edward J. Selvik
3 shared publications
In database
- An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation
- Analysis of Plant–Plant Interactions Reveals the Presence of Potent Antileukemic Compounds
- CCDC 2088888: Experimental Crystal Structure Determination
Panagiotis Katsonis
Baylor College of Medicine (US)
2 shared publications
- Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors
- An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2
Shobanbabu Bommagani
University of Arkansas for Medical Sciences
2 shared publications
In database
- Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors
- EET-Based Therapeutics Mitigate Sorafenib-Associated Glomerular Cell Damage
Andy Arvai
Scripps Research Institute (US)
2 shared publications
- Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors
- An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation
Olivier Lichtarge
Baylor College of Medicine (US)
2 shared publications
- Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors
- An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2
Aleem Syed
Dana-Farber Cancer Institute (US)
2 shared publications
- GRB2 enforces homology-directed repair initiation by MRE11
- Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity
David E. Mery
2 shared publications
In database
- Analysis of Plant–Plant Interactions Reveals the Presence of Potent Antileukemic Compounds
- CCDC 2088888: Experimental Crystal Structure Determination
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