Match tier
Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
D
Darin E. Jones
High Impact
Associate Professor
Also affiliated: University of California, Riverside (1998–1999); University of Alabama (1988); Pfizer (United States) (2010–2012); Washington University in St. Louis (2011–2015); Alvin J. Siteman Cancer Center (2014–2015); University of Missouri (1995–1999)
Pharmaceutical Science, College of Pharmacy
22 h-index
64 pubs
1,163 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Darin E. Jones studies the development of small molecule inhibitors for various biological targets, with a recent focus on poly(ADP-ribose) glycohydrolase (PARG) as a target for cancer treatment. His research group has investigated PARG inhibitors that induce replication fork stalling and cancer cell death, as demonstrated in a 2019 publication. This work also includes exploring inhibitors that target SARS-CoV-2 Nsp3 macrodomain, drawing insights from human PARG structures.
Jones's prior research has included the design and synthesis of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex, as well as the discovery of selective mPGES-1 inhibitors for potential anti-inflammatory treatments. His work also encompasses the study of inhibitors for HGFA, Matriptase, and Hepsin serine proteases as a strategy to block cell signaling in cancer. Jones's scholarship metrics include an h-index of 23, with 88 total publications and 1,290 citations. He collaborates with several researchers at the University of Arkansas for Medical Sciences, including Philip J. Breen, Edward J. Selvik, Shobanbabu Bommagani, and David E. Mery.
Metrics
- h-index: 22
- Publications: 64
- Citations: 1,163
Positions
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Associate Professor 2018–presentUniversity of Arkansas for Medical Sciences Pharmaceutical Science, College of Pharmacy Institutional directory
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Associate Professor 2011–2018University of Arkansas at Little Rock Chemistry ORCID
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Washington University in Saint Louis 2010–2011Biochemistry and Molecular Biophysics ORCID
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Pfizer Global Research and Development 1998–2010Discovery Chemistry ORCID
Selected Publications
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Abstract 4033: Chemical trapping of inactive GRB2 dimer unveils a novel cancer vulnerability by coupling replication stress to anti-tumor immunity (2026)
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Structural basis for substrate-assisted catalysis and small-molecule inhibition of alphavirus macrodomains (2026)
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EET-Based Therapeutics Mitigate Sorafenib-Associated Glomerular Cell Damage (2025)
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Chemical screening by time-resolved X-ray scattering to discover allosteric probes (2024)
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Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects (2023)
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Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity (2023)
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466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator (2023)
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Applying HT-SAXS to chemical ligand screening (2022)
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Analysis of Plant–Plant Interactions Reveals the Presence of Potent Antileukemic Compounds (2022)
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An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2 (2021)
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GRB2 enforces homology-directed repair initiation by MRE11 (2021)
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An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation (2021)
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Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors (2021)
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Incorporating HT-SAXS into drug-discovery pipelines (2020)
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Synthesis, Crystallography, and Anti-Leukemic Activity of the Amino Adducts of Dehydroleucodine (2020)
Grants & Funding
As listed on this researcher's institutional profile.
- Pharmacological Modulation of Poly (ADP-ribose) Metabolism NIH/Nat. Cancer Institute via University of Texas Health Science Center at Houston Principal Investigator
- A Plug and Play DOE Approach for Emerging Threats: Taskforce 5 US Department of Energy via Lawrence Berkeley National Laboratory Principal Investigator
- Cellular Functions of Eukaryotic DNA Ligases - Continuation NIH/Nat. Inst. of General Medical Sciences via University of New Mexico Principal Investigator
- PHARMACOLOGICAL MODULATION OF POLY(ADP-RIBOSE) METABOLISM NIH Co-Principal Investigator
- Targeting DNA ligase 1 in Ovarian Cancer NIH/Nat. Cancer Institute via University of New Mexico Principal Investigator
- Structural Cell Biology of DNA Repair Machines Project 3 - PARP: PAR-dependent, phase-transitioned protein assemblies, and DNA repair. NIH/Nat. Cancer Institute via Lawrence Berkeley National Laboratory Principal Investigator
- Preventing immune system dysregulation during deep-space missions by Tocofexol, a modified isomer of vitamin E - AA request National Aeronautics & Space Administration via Arkansas Space Grant Consortium Principal Investigator
Collaboration Network
Top Collaborators
John A. Tainer
The University of Texas MD Anderson Cancer Center (US)
10 shared publications
- Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death
- Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors
- GRB2 enforces homology-directed repair initiation by MRE11
- Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity
- An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation
Showing 5 of 10 shared publications
Davide Moiani
The University of Texas MD Anderson Cancer Center (US)
8 shared publications
- Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death
- Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors
- GRB2 enforces homology-directed repair initiation by MRE11
- An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation
- Chemical screening by time-resolved X-ray scattering to discover allosteric probes
Showing 5 of 8 shared publications
Chris A. Brosey
The University of Texas MD Anderson Cancer Center (US)
6 shared publications
- Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death
- Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors
- Chemical screening by time-resolved X-ray scattering to discover allosteric probes
- An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2
- Applying HT-SAXS to chemical ligand screening
Showing 5 of 6 shared publications
Zamal Ahmed
The University of Texas MD Anderson Cancer Center (US)
6 shared publications
- Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death
- Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors
- GRB2 enforces homology-directed repair initiation by MRE11
- An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation
- An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2
Showing 5 of 6 shared publications
César M. Compadre
University of Arkansas for Medical Sciences
5 shared publications
In database
- Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa, Demonstrates Cytotoxic Activity against Human Leukemia Cells
- Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects
- Synthesis, Crystallography, and Anti-Leukemic Activity of the Amino Adducts of Dehydroleucodine
- Analysis of Plant–Plant Interactions Reveals the Presence of Potent Antileukemic Compounds
- 466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator
Albino Bacolla
The University of Texas MD Anderson Cancer Center (US)
4 shared publications
- Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death
- Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors
- GRB2 enforces homology-directed repair initiation by MRE11
- Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity
Todd Link
The University of Texas MD Anderson Cancer Center (US)
4 shared publications
- Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors
- Chemical screening by time-resolved X-ray scattering to discover allosteric probes
- An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2
- Structural basis for substrate-assisted catalysis and small-molecule inhibition of alphavirus macrodomains
Greg L. Hura
Lawrence Berkeley National Laboratory (US)
4 shared publications
- Chemical screening by time-resolved X-ray scattering to discover allosteric probes
- Applying HT-SAXS to chemical ligand screening
- Incorporating HT-SAXS into drug-discovery pipelines
- Structural basis for substrate-assisted catalysis and small-molecule inhibition of alphavirus macrodomains
Yashraj Gartia
University of Arkansas at Little Rock (US)
3 shared publications
- Nickel Complex Catalyzed Efficient Activation of sp3 and sp2 C–H Bonds for Alkylation and Arylation of Oxygen Containing Heterocyclic Molecules
- A Novel Iron Complex for Cross-Coupling Reactions of Multiple C–Cl Bonds in Polychlorinated Solvents with Grignard Reagents
- Activation of sp3 and sp2 CH bonds of oxygen containing heterocyclic molecules for alkylation and arylation reactions catalyzed by an iron complex
Punnamchandar Ramidi
University of Arkansas at Little Rock (US)
3 shared publications
- Nickel Complex Catalyzed Efficient Activation of sp3 and sp2 C–H Bonds for Alkylation and Arylation of Oxygen Containing Heterocyclic Molecules
- A Novel Iron Complex for Cross-Coupling Reactions of Multiple C–Cl Bonds in Polychlorinated Solvents with Grignard Reagents
- Activation of sp3 and sp2 CH bonds of oxygen containing heterocyclic molecules for alkylation and arylation reactions catalyzed by an iron complex
Anindya Ghosh
University of Arkansas at Little Rock
3 shared publications
In database
- Nickel Complex Catalyzed Efficient Activation of sp3 and sp2 C–H Bonds for Alkylation and Arylation of Oxygen Containing Heterocyclic Molecules
- A Novel Iron Complex for Cross-Coupling Reactions of Multiple C–Cl Bonds in Polychlorinated Solvents with Grignard Reagents
- Activation of sp3 and sp2 CH bonds of oxygen containing heterocyclic molecules for alkylation and arylation reactions catalyzed by an iron complex
Paola E. Ordóñez
Universidad Yachay Tech (EC)
3 shared publications
- Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa, Demonstrates Cytotoxic Activity against Human Leukemia Cells
- Synthesis, Crystallography, and Anti-Leukemic Activity of the Amino Adducts of Dehydroleucodine
- Analysis of Plant–Plant Interactions Reveals the Presence of Potent Antileukemic Compounds
Omar Malagón
Universidad Técnica Particular de Loja (EC)
3 shared publications
- Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa, Demonstrates Cytotoxic Activity against Human Leukemia Cells
- Synthesis, Crystallography, and Anti-Leukemic Activity of the Amino Adducts of Dehydroleucodine
- Analysis of Plant–Plant Interactions Reveals the Presence of Potent Antileukemic Compounds
Mónica L. Guzmán
Cornell University (US)
3 shared publications
- Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa, Demonstrates Cytotoxic Activity against Human Leukemia Cells
- Synthesis, Crystallography, and Anti-Leukemic Activity of the Amino Adducts of Dehydroleucodine
- Analysis of Plant–Plant Interactions Reveals the Presence of Potent Antileukemic Compounds
Runze Shen
The University of Texas MD Anderson Cancer Center (US)
3 shared publications
- Chemical screening by time-resolved X-ray scattering to discover allosteric probes
- Applying HT-SAXS to chemical ligand screening
- Incorporating HT-SAXS into drug-discovery pipelines
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