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Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-08-15
D
Darin E. Jones
High Impact
Associate Professor
Also affiliated: University of California, Riverside (1998–1999); Inova Health System (2007); SRI International (1989); George Mason University (2007); University of Alabama (1988); Pfizer (United States) (2010–2012); Washington University in St. Louis (2011–2015); American Pharmacists Association (2003); University of Alabama at Birmingham (1995); Swansea University (1997–2000); National Institute of Justice (2007); Menlo School (1989); United Utilities (United Kingdom) (2014–2018); Arkansas Department of Agriculture (2026); Vifor Pharma (United States) (2003); Alvin J. Siteman Cancer Center (2014–2015); University of Missouri (1995–1999); University of Otago (1973–1974); University of Sheffield (1999–2001); University of Wales (2000)
Faculty Researcher
Pharmaceutical Science, College of Pharmacy
23 h-index
87 pubs
1,278 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Darin E. Jones' research focuses on understanding molecular mechanisms relevant to disease and developing therapeutic strategies. His work has investigated enzyme inhibitors, with a particular emphasis on those targeting nucleic acid enzymes involved in DNA repair and replication, as well as viral proteins. He has explored the structure-activity relationships of small molecules and employed techniques such as time-resolved X-ray scattering and HT-SAXS for chemical screening to identify novel probes and inhibitors.
His publications include studies on inhibitors for human uracil-DNA glycosylase and SARS-CoV-2 Nsp3 macrodomain, as well as the role of novobiocin in inhibiting Polθ's nucleic acid binding. Jones also investigates radioprotective effects of compounds like tocotrienols. He leads a research group and collaborates with other researchers at the University of Arkansas for Medical Sciences, including Philip J. Breen, Edward J. Selvik, Shobanbabu Bommagani, and David E. Mery.
Jones' scholarship metrics include an h-index of 23, 87 total publications, and 1,268 total citations. He is recognized as a highly cited researcher.
Metrics
- h-index: 23
- Publications: 87
- Citations: 1,278
Selected Publications
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Abstract 4033: Chemical trapping of inactive GRB2 dimer unveils a novel cancer vulnerability by coupling replication stress to anti-tumor immunity (2026)
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Structural basis for substrate-assisted catalysis and small-molecule inhibition of alphavirus macrodomains (2026)
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EET-Based Therapeutics Mitigate Sorafenib-Associated Glomerular Cell Damage (2025)
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Chemical screening by time-resolved X-ray scattering to discover allosteric probes (2024)
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Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects (2023)
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Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity (2023)
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466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator (2023)
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Applying HT-SAXS to chemical ligand screening (2022)
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Analysis of Plant–Plant Interactions Reveals the Presence of Potent Antileukemic Compounds (2022)
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An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2 (2021)
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GRB2 enforces homology-directed repair initiation by MRE11 (2021)
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An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation (2021)
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Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors (2021)
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Incorporating HT-SAXS into drug-discovery pipelines (2020)
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Synthesis, Crystallography, and Anti-Leukemic Activity of the Amino Adducts of Dehydroleucodine (2020)
Grants & Funding
As listed on this researcher's institutional profile.
- Pharmacological Modulation of Poly (ADP-ribose) Metabolism NIH/Nat. Cancer Institute via University of Texas Health Science Center at Houston Principal Investigator
- A Plug and Play DOE Approach for Emerging Threats: Taskforce 5 US Department of Energy via Lawrence Berkeley National Laboratory Principal Investigator
- Cellular Functions of Eukaryotic DNA Ligases - Continuation NIH/Nat. Inst. of General Medical Sciences via University of New Mexico Principal Investigator
- PHARMACOLOGICAL MODULATION OF POLY(ADP-RIBOSE) METABOLISM NIH Co-Principal Investigator
- Targeting DNA ligase 1 in Ovarian Cancer NIH/Nat. Cancer Institute via University of New Mexico Principal Investigator
- Structural Cell Biology of DNA Repair Machines Project 3 - PARP: PAR-dependent, phase-transitioned protein assemblies, and DNA repair. NIH/Nat. Cancer Institute via Lawrence Berkeley National Laboratory Principal Investigator
- Preventing immune system dysregulation during deep-space missions by Tocofexol, a modified isomer of vitamin E - AA request National Aeronautics & Space Administration via Arkansas Space Grant Consortium Principal Investigator
Collaboration Network
Top Collaborators
John A. Tainer
The University of Texas MD Anderson Cancer Center (US)
7 shared publications
- Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors
- GRB2 enforces homology-directed repair initiation by MRE11
- Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity
- An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation
- Chemical screening by time-resolved X-ray scattering to discover allosteric probes
Showing 5 of 7 shared publications
Davide Moiani
The University of Texas MD Anderson Cancer Center (US)
6 shared publications
- Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors
- GRB2 enforces homology-directed repair initiation by MRE11
- An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation
- Chemical screening by time-resolved X-ray scattering to discover allosteric probes
- An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2
Showing 5 of 6 shared publications
Chris A. Brosey
The University of Texas MD Anderson Cancer Center (US)
4 shared publications
- Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors
- Chemical screening by time-resolved X-ray scattering to discover allosteric probes
- An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2
- Applying HT-SAXS to chemical ligand screening
Todd Link
The University of Texas MD Anderson Cancer Center (US)
4 shared publications
- Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors
- Chemical screening by time-resolved X-ray scattering to discover allosteric probes
- An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2
- Structural basis for substrate-assisted catalysis and small-molecule inhibition of alphavirus macrodomains
Zamal Ahmed
The University of Texas MD Anderson Cancer Center (US)
4 shared publications
- Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors
- GRB2 enforces homology-directed repair initiation by MRE11
- An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation
- An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2
Albino Bacolla
The University of Texas MD Anderson Cancer Center (US)
3 shared publications
- Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors
- GRB2 enforces homology-directed repair initiation by MRE11
- Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity
Philip J. Breen
University of Arkansas for Medical Sciences
3 shared publications
In database
- Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects
- Analysis of Plant–Plant Interactions Reveals the Presence of Potent Antileukemic Compounds
- 466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator
César M. Compadre
University of Arkansas for Medical Sciences
3 shared publications
In database
- Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects
- Analysis of Plant–Plant Interactions Reveals the Presence of Potent Antileukemic Compounds
- 466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator
Panagiotis Katsonis
Baylor College of Medicine (US)
2 shared publications
- Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors
- An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2
Shobanbabu Bommagani
University of Arkansas for Medical Sciences
2 shared publications
In database
- Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors
- EET-Based Therapeutics Mitigate Sorafenib-Associated Glomerular Cell Damage
Andy Arvai
Scripps Research Institute (US)
2 shared publications
- Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors
- An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation
Olivier Lichtarge
Baylor College of Medicine (US)
2 shared publications
- Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors
- An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2
Edward J. Selvik
University of Arkansas for Medical Sciences
2 shared publications
In database
- An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation
- Analysis of Plant–Plant Interactions Reveals the Presence of Potent Antileukemic Compounds
Aleem Syed
Dana-Farber Cancer Institute (US)
2 shared publications
- GRB2 enforces homology-directed repair initiation by MRE11
- Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity
Runze Shen
The University of Texas MD Anderson Cancer Center (US)
2 shared publications
- Chemical screening by time-resolved X-ray scattering to discover allosteric probes
- Applying HT-SAXS to chemical ligand screening
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