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Listed
Presence
Current · Arkansas
Last published
2023
Sources
OpenAlex · ORCID
Refreshed
2026-10-06
P
Philip J. Breen
High Impact
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Also affiliated: Massachusetts College of Pharmacy and Health Sciences (1981–1988); Altria (United States) (1989); Universidad Nacional Autónoma de México (2006); Colorado State University (1987–1989)
20 h-index
48 pubs
1,934 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Philip J. Breen's research focuses on the intersection of chemistry, pharmacology, and biology, with a particular emphasis on understanding molecular mechanisms and developing potential therapeutic agents. His work has explored the radioprotective effects of tocotrienols, investigating their dual roles as antioxidants and signaling molecules across multiple organ systems. Breen has also investigated compounds with antileukemic properties derived from plant-plant interactions.
His laboratory has conducted pharmacokinetic studies, including an analysis of morphine-6-O-sulfate in rat plasma and brain. Furthermore, Breen's research group has been involved in the development of novel tocotrienol analogues, such as tocoflexol, for potential use as radiomitigators. His scholarship is evidenced by a high-impact designation, with 49 publications and 1,880 citations, and an h-index of 20. He leads a research group and collaborates with several faculty members at the University of Arkansas for Medical Sciences, including Darin E. Jones, David E. Mery, Edward J. Selvik, and Nükhet Aykin‐Burns.
Metrics
- h-index: 20
- Publications: 48
- Citations: 1,934
Selected Publications
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Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects (2023)
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466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator (2023)
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Analysis of Plant–Plant Interactions Reveals the Presence of Potent Antileukemic Compounds (2022)
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A pharmacokinetic study of morphine‐6‐O ‐sulfate in rat plasma and brain (2021)
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Antioxidant Tocols as Radiation Countermeasures (Challenges to be Addressed to Use Tocols as Radiation Countermeasures in Humans) (2018)
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Identification of a melampomagnolide B analog as a potential lead molecule for treatment of acute myelogenous leukemia (2016)
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Corrigendum to “Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity” [J. Ethnopharmacol. 137 (2011) 1055–1059] (2016)
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Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone (2015)
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Cyclodextrins in pharmaceutical formulations I: structure and physicochemical properties, formation of complexes, and types of complex (2015)
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Cyclodextrins in pharmaceutical formulations II: solubilization, binding constant, and complexation efficiency (2015)
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Tocotrienol-Rich Fraction from Rice Bran Demonstrates Potent Radiation Protection Activity (2015)
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The smoking habits of the family influence the uptake of e-cigarettes in US children (2014)
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Drug dissolution: significance of physicochemical properties and physiological conditions (2013)
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Molecular Dynamics Guided Design of Tocoflexol: A New Radioprotectant Tocotrienol with Enhanced Bioavailability (2013)
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Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity (2011)
Grants & Funding
As listed on this researcher's institutional profile.
- Developing Countermeasures for Acute Respiratory Distress Produced by Lunar Dust National Aeronautics & Space Administration via Arkansas Space Grant Consortium
Collaboration Network
Top Collaborators
César M. Compadre
University of Arkansas for Medical Sciences
15 shared publications
In database
- Antimicrobial Activity of Cetylpyridinium Chloride Washes against Pathogenic Bacteria on Beef Surfaces
- Elimination of Salmonella Contamination from Poultry Tissues by Cetylpyridinium Chloride Solutions
- Quaternary Ammonium Compounds Inhibit and Reduce the Attachment of Viable Salmonella typhimurium to Poultry Tissues
- Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity
- Antioxidant Tocols as Radiation Countermeasures (Challenges to be Addressed to Use Tocols as Radiation Countermeasures in Humans)
Showing 5 of 15 shared publications
Shraddha Thakkar
University of Arkansas for Medical Sciences (US)
4 shared publications
- Antioxidant Tocols as Radiation Countermeasures (Challenges to be Addressed to Use Tocols as Radiation Countermeasures in Humans)
- Molecular Dynamics Guided Design of Tocoflexol: A New Radioprotectant Tocotrienol with Enhanced Bioavailability
- Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects
- 466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator
Nükhet Aykin‐Burns
University of Arkansas for Medical Sciences
4 shared publications
In database
- Antioxidant Tocols as Radiation Countermeasures (Challenges to be Addressed to Use Tocols as Radiation Countermeasures in Humans)
- Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects
- Tocotrienol-Rich Fraction from Rice Bran Demonstrates Potent Radiation Protection Activity
- 466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator
Hamid Salari
University of Arkansas for Medical Sciences (US)
4 shared publications
- Elimination of Salmonella Contamination from Poultry Tissues by Cetylpyridinium Chloride Solutions
- Quaternary Ammonium Compounds Inhibit and Reduce the Attachment of Viable Salmonella typhimurium to Poultry Tissues
- Liquid chromatography determination of residue levels on apples treated with cetylpyridinium chloride
- High-performance liquid chromatography determination of residue levels on chicken carcasses treated with cetylpyridinium chloride
Kottayil I. Varughese
University of Arkansas for Medical Sciences (US)
3 shared publications
- Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity
- Molecular Dynamics Guided Design of Tocoflexol: A New Radioprotectant Tocotrienol with Enhanced Bioavailability
- Corrigendum to “Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity” [J. Ethnopharmacol. 137 (2011) 1055–1059]
Kimberly J. Krager
University of Arkansas for Medical Sciences
3 shared publications
In database
- Antioxidant Tocols as Radiation Countermeasures (Challenges to be Addressed to Use Tocols as Radiation Countermeasures in Humans)
- Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects
- Tocotrienol-Rich Fraction from Rice Bran Demonstrates Potent Radiation Protection Activity
Paola E. Ordóñez
Universidad Yachay Tech (EC)
3 shared publications
- Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity
- Corrigendum to “Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity” [J. Ethnopharmacol. 137 (2011) 1055–1059]
- Analysis of Plant–Plant Interactions Reveals the Presence of Potent Antileukemic Compounds
Omar Malagón
Universidad Técnica Particular de Loja (EC)
3 shared publications
- Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity
- Corrigendum to “Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity” [J. Ethnopharmacol. 137 (2011) 1055–1059]
- Analysis of Plant–Plant Interactions Reveals the Presence of Potent Antileukemic Compounds
Mark S. Smeltzer
University of Arkansas for Medical Sciences
3 shared publications
In database
- Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity
- Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone
- Corrigendum to “Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity” [J. Ethnopharmacol. 137 (2011) 1055–1059]
Xiang Zhou
University of Arkansas for Medical Sciences (US)
3 shared publications
- Antimicrobial Activity of Cetylpyridinium Chloride Washes against Pathogenic Bacteria on Beef Surfaces
- Liquid chromatography determination of residue levels on apples treated with cetylpyridinium chloride
- High-performance liquid chromatography determination of residue levels on chicken carcasses treated with cetylpyridinium chloride
Sunil S. Jambhekar
Lake Erie College of Osteopathic Medicine (US)
3 shared publications
- Cyclodextrins in pharmaceutical formulations I: structure and physicochemical properties, formation of complexes, and types of complex
- Cyclodextrins in pharmaceutical formulations II: solubilization, binding constant, and complexation efficiency
- Drug dissolution: significance of physicochemical properties and physiological conditions
Zaineb A.F. Albayati
University of Arkansas for Medical Sciences
3 shared publications
In database
- Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone
- Identification of a melampomagnolide B analog as a potential lead molecule for treatment of acute myelogenous leukemia
- A pharmacokinetic study of morphine‐6‐O ‐sulfate in rat plasma and brain
Peter A. Crooks
University of Arkansas for Medical Sciences
3 shared publications
In database
- Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone
- Identification of a melampomagnolide B analog as a potential lead molecule for treatment of acute myelogenous leukemia
- A pharmacokinetic study of morphine‐6‐O ‐sulfate in rat plasma and brain
Darin E. Jones
University of Arkansas for Medical Sciences
3 shared publications
In database
- Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects
- Analysis of Plant–Plant Interactions Reveals the Presence of Potent Antileukemic Compounds
- 466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator
Awantika Singh
University of Arkansas for Medical Sciences (US)
2 shared publications
- Molecular Dynamics Guided Design of Tocoflexol: A New Radioprotectant Tocotrienol with Enhanced Bioavailability
- 466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator
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