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Listed
Presence
Current · Arkansas
Last published
2025
Sources
OpenAlex · ORCID
Refreshed
2026-08-20
Donald J. Johann
Federal Grant PI
High Impact
Professor
Also affiliated: MetroHealth (1996); National Institutes of Health (2004–2013); Fudan University (2021); Association of Military Surgeons of the United States (1996); University of Arkansas Medical Center (2022–2024); Saint Vincent Health System (2020); Catholic Health Initiatives (2020); Fudan University Shanghai Cancer Center (2021); Hospital Municipal São José (2025); Winthrop Rockefeller Foundation (2017–2025); Frederick National Laboratory for Cancer Research (2007–2010); National Cancer Institute (2004–2013); Center for Cancer Research (2004–2012); Food and Drug Administration (2006); MetroHealth Medical Center (1996); Arkansas Department of Agriculture (2015–2024); Division of Cancer Epidemiology and Genetics (2008); State Key Laboratory of Genetic Engineering (2021); University of Oklahoma Health Sciences Center (2006); Case Western Reserve University (1996); University of Nebraska Medical Center (2006); Freie Universität Berlin (1989); Science Applications International Corporation (United States) (2010)
Faculty Researcher
Biomedical Informatics, College of Medicine
23 h-index
117 pubs
2,534 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Donald J. Johann's research focuses on the application of high-throughput sequencing and mass spectrometry techniques to study cancer biomarkers, particularly circulating tumor DNA (ctDNA) for precision oncology and liquid biopsy applications. His work investigates the analytical validity and performance of these assays, aiming to advance the measurement of actionable mutations in ctDNA. This research is supported by a $750,000 NIH/National Institute of General Medical Sciences grant for an advanced next-generation sequencer.
Johann has published extensively on topics related to cancer genomics, including the assessment of oncopanels for detecting small variants and the quality control of next-generation sequencing (NGS) data. His scholarship includes 117 publications with over 2,400 citations, and an h-index of 23. He collaborates with researchers at the University of Arkansas for Medical Sciences and the National Center for Toxicological Research, with whom he has co-authored multiple publications.
His group's work contributes to the development and validation of molecular diagnostic tools for cancer. Recent publications also explore related areas such as the role of exogenous phosphatidic acid in acetaminophen-induced liver injury in mice and the expansion of human papillomavirus-specific T cells in a therapeutic vaccine recipient.
Metrics
- h-index: 23
- Publications: 117
- Citations: 2,534
Selected Publications
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Generic Protocols for the Analytical Validation of Next-Generation Sequencing-Based Circulating Tumor DNA Assays, Version 2.0 (2026)
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Generic Protocols for Analytical Validation of Tumor-Informed Circulating Tumor DNA Assays for Molecular Residual Disease: The Blood Profiling Atlas in Cancer's Molecular Residual Disease Analytical Validation Working Group Consensus Recommendation (2026)
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Lexicon for Clonal Hematopoiesis in Liquid Biopsy (2025)
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Harnessing Native-Resolution 2D Embeddings for Lung Cancer Classification: A Feasibility Study with the RAD-DINO Self-supervised Foundation Model (2025)
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EET-Based Therapeutics Mitigate Sorafenib-Associated Glomerular Cell Damage (2025)
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Augmenting precision medicine via targeted RNA-Seq detection of expressed mutations (2025)
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Recommended Clinical Context and Patient Context Data Elements for Liquid Biopsy Data Submitted to Data Repositories and Data Commons (2025)
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Towards Preanalytical Best Practices for Liquid Biopsy Studies: A BLOODPAC Landscape Analysis (2024)
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Targeted DNA-seq and RNA-seq of Reference Samples with Short-read and Long-read Sequencing (2024)
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A Microdissection Protocol for Proteogenomic Analysis of Histological Sections to Advance Drug Development (2024)
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Advancing drug development by leveraging microdissection for proteogenomic analysis of histological sections. (2024)
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Abstract PO5-02-05: Assessing Vaccine-Mediated Cellular Immune Responses in Patients Receiving Combined Vaccine and Chemotherapy Treatment (2024)
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Assessments of tumor mutational burden estimation by targeted panel sequencing: A comprehensive simulation analysis (2023)
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Liquid biopsy based on circulating tumor DNA for lung cancer: A step toward prevention (2023)
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Contrived Materials and a Data Set for the Evaluation of Liquid Biopsy Tests (2023)
Federal Grants 1 $750,000 total
NIH
Contact PI
Jun 2024 - Jun 2025
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- Scientific and methodological advancement in liquid biopsies to further the development of lung cancer-based precision medicine (Bio 3) U.S. Food and Drug Administration via Arkansas Research Alliance Principal Investigator
- Development and Validation of a Microdissection Method to Advance Precision Medicine in the Clinical Setting - Continuation - Continuation NIH/Nat. Cancer Institute Principal Investigator
- Financial Support for the Breast Cancer Intergroup Correlative Science Studies Breast Cancer Research Foundation via University of Michigan Principal Investigator
- Center for Studies of Host Response to Cancer Therapy NIH Co-Investigator
- Scientific and methodological advancement in liquid biopsies to further the development of lung cancer-based precision medicine U.S. Food and Drug Administration via Arkansas Research Alliance Principal Investigator
Collaboration Network
Top Collaborators
Rebecca Kusko
11 shared publications
- Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology
- A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency
- Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions
- Advancing NGS quality control to enable measurement of actionable mutations in circulating tumor DNA
- Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
Showing 5 of 11 shared publications
Binsheng Gong
United States Food and Drug Administration
10 shared publications
In database
- Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology
- A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency
- Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions
- Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
- Ultra-deep sequencing data from a liquid biopsy proficiency study demonstrating analytic validity
Showing 5 of 10 shared publications
Natalia Novoradovskaya
Agilent Technologies (United States) (US)
10 shared publications
- Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology
- A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency
- Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions
- Advancing NGS quality control to enable measurement of actionable mutations in circulating tumor DNA
- Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
Showing 5 of 10 shared publications
Erich A. Peterson
University of Arkansas for Medical Sciences
9 shared publications
In database
- Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk
- Expansion of Human Papillomavirus-Specific T Cells in Periphery and Cervix in a Therapeutic Vaccine Recipient Whose Cervical High-Grade Squamous Intraepithelial Lesion Regressed
- An advanced molecular medicine case report of a rare human tumor using genomics, pathomics, and radiomics
- NPARS—A Novel Approach to Address Accuracy and Reproducibility in Genomic Data Science
- Effect of Antigen Retrieval on Genomic DNA From Immunodissected Samples
Showing 5 of 9 shared publications
Jennifer S. LoCoco
Illumina (United States) (US)
8 shared publications
- Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology
- Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions
- Advancing NGS quality control to enable measurement of actionable mutations in circulating tumor DNA
- Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
- Targeted DNA-seq and RNA-seq of Reference Samples with Short-read and Long-read Sequencing
Showing 5 of 8 shared publications
Ik Jae Shin
University of Arkansas for Medical Sciences
7 shared publications
In database
- An advanced molecular medicine case report of a rare human tumor using genomics, pathomics, and radiomics
- NPARS—A Novel Approach to Address Accuracy and Reproducibility in Genomic Data Science
- Effect of Antigen Retrieval on Genomic DNA From Immunodissected Samples
- Microdissection Methods Utilizing Single-Cell Subtype Analysis and the Impact on Precision Medicine
- Synergizing microdissection with ddPCR to advance precision oncology.
Showing 5 of 7 shared publications
Jason Muesse
Winthrop Rockefeller Foundation
7 shared publications
In database
- An advanced molecular medicine case report of a rare human tumor using genomics, pathomics, and radiomics
- NPARS—A Novel Approach to Address Accuracy and Reproducibility in Genomic Data Science
- Effect of Antigen Retrieval on Genomic DNA From Immunodissected Samples
- Microdissection Methods Utilizing Single-Cell Subtype Analysis and the Impact on Precision Medicine
- Synergizing microdissection with ddPCR to advance precision oncology.
Showing 5 of 7 shared publications
Fujun Qiu
Burning Rock Biotech (China) (CN)
6 shared publications
- Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology
- Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions
- Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
- Deep oncopanel sequencing reveals fixation time- and within block position-dependent quality degradation in FFPE processed samples
- Additional file 3 of Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
Showing 5 of 6 shared publications
Daniel J. Craig
University of Toledo (US)
6 shared publications
- A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency
- Advancing NGS quality control to enable measurement of actionable mutations in circulating tumor DNA
- Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
- Deep oncopanel sequencing reveals fixation time- and within block position-dependent quality degradation in FFPE processed samples
- Additional file 3 of Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
Showing 5 of 6 shared publications
Todd Richmond
Computational Physics (United States) (US)
6 shared publications
- Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology
- A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency
- Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions
- Advancing NGS quality control to enable measurement of actionable mutations in circulating tumor DNA
- Targeted DNA-seq and RNA-seq of Reference Samples with Short-read and Long-read Sequencing
Showing 5 of 6 shared publications
Guangchun Chen
The University of Texas Southwestern Medical Center (US)
6 shared publications
- Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology
- A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency
- Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions
- Advancing NGS quality control to enable measurement of actionable mutations in circulating tumor DNA
- Targeted DNA-seq and RNA-seq of Reference Samples with Short-read and Long-read Sequencing
Showing 5 of 6 shared publications
Wendell Jones
IQVIA (United States) (US)
6 shared publications
- Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology
- A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency
- Advancing NGS quality control to enable measurement of actionable mutations in circulating tumor DNA
- Ultra-deep sequencing data from a liquid biopsy proficiency study demonstrating analytic validity
- Targeted DNA-seq and RNA-seq of Reference Samples with Short-read and Long-read Sequencing
Showing 5 of 6 shared publications
Jerry Lee
University of Southern California (US)
6 shared publications
- BloodPAC Data Commons for Liquid Biopsy Data
- <scp>BLOODPAC</scp>: Collaborating to chart a path towards blood‐based screening for early cancer detection
- Contrived Materials and a Data Set for the Evaluation of Liquid Biopsy Tests
- Towards Preanalytical Best Practices for Liquid Biopsy Studies: A BLOODPAC Landscape Analysis
- Generic Protocols for Analytical Validation of Tumor-Informed Circulating Tumor DNA Assays for Molecular Residual Disease: The Blood Profiling Atlas in Cancer's Molecular Residual Disease Analytical Validation Working Group Consensus Recommendation
Showing 5 of 6 shared publications
Matthew A. Steliga
Winthrop Rockefeller Foundation
6 shared publications
In database
- An advanced molecular medicine case report of a rare human tumor using genomics, pathomics, and radiomics
- NPARS—A Novel Approach to Address Accuracy and Reproducibility in Genomic Data Science
- Effect of Antigen Retrieval on Genomic DNA From Immunodissected Samples
- Microdissection Methods Utilizing Single-Cell Subtype Analysis and the Impact on Precision Medicine
- Abstract 5038: Applying reproducible genomic data science methods for the analysis of a rare tumor type
Showing 5 of 6 shared publications
Daniel Stetson
AstraZeneca (United States) (US)
5 shared publications
- Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology
- Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
- Deep oncopanel sequencing reveals fixation time- and within block position-dependent quality degradation in FFPE processed samples
- Additional file 3 of Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
- Additional file 2 of Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
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