B
Binsheng Gong Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Visiting Scientist
faculty
18 h-index
90 pubs
2,985 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Binsheng Gong's research focuses on the analytical validity and performance of genomic sequencing assays, particularly for precision oncology and cancer research. His work has investigated the sensitivity and accuracy of oncopanels in detecting small variants of low allele frequency and the impact of sample processing methods, such as FFPE, on sequencing quality. Gong has also explored the use of circulating tumor DNA (ctDNA) in liquid biopsies for cancer detection and monitoring. His research extends to animal models, examining cancer driver mutations in rats and mice and their correlation with spontaneous neoplasia incidence. Gong has collaborated with researchers from the University of Arkansas for Medical Sciences and the National Center for Toxicological Research on multiple publications. His scholarship metrics include an h-index of 17, with 92 total publications and 2,979 citations.
Metrics
- h-index: 18
- Publications: 90
- Citations: 2,985
Selected Publications
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2025 White Paper on Recent Issues in Bioanalysis: Redosing Patients with AAV Gene Therapy; CRS Immunogenicity Risk; Shedding Assays; NHP Studies Immunogenicity; CMC vs Bioanalytical Assays; Artificial Intelligence-Powered Genomic Pipelines for NGS ( <u>PART 3A</u> – Recommendations on Gene, Cell, and Vaccine Therapies Immunogenicity & Technologies; Biotherapeutics & Biosimilars Immunogenicity Assessment & Clinical Relevance <u>PART 3B</u> – Regulatory Agencies’ Input on Immunogenicity/Technologies of Biotherapeutics, Gene, Cell & Vaccine Therapies) (2025)
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Tissue and Sex‐Specific Performance of a Cancer Driver Based Biomarker in <scp>rasH2</scp> ‐Tg Mice (2025)
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Dissecting Sex‐Specific Pathology in K18‐hACE2 Transgenic Mice Infected With Different SARS‐CoV‐2 Variants (2025)
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Augmenting precision medicine via targeted RNA-Seq detection of expressed mutations (2025)
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Zika and dengue viruses differentially modulate host mRNA processing factors defining its virulence (2025)
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Targeted DNA-seq and RNA-seq of Reference Samples with Short-read and Long-read Sequencing (2024)
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Towards accurate indel calling for oncopanel sequencing through an international pipeline competition at precisionFDA (2024)
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Extend the benchmarking indel set by manual review using the individual cell line sequencing data from the Sequencing Quality Control 2 (SEQC2) project (2024)
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Abstract 2440: Cancer driver mutations as quantitative biomarkers of cancer risk interspecies analyses using CarcSeq (2024)
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Single-cell RNA-sequencing and subcellular spatial transcriptomics facilitate the translation of liver microphysiological systems for regulatory application (2023)
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Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples (2022)
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Ultra-deep multi-oncopanel sequencing of benchmarking samples with a wide range of variant allele frequencies (2022)
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Ultra-deep sequencing data from a liquid biopsy proficiency study demonstrating analytic validity (2022)
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Circulating biomarkers of neurotoxicity: Proteomics approach reveals fluidic endpoints of central nervous system toxicity in a rodent model of neurotoxicity (2021)
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Assessment of Clonal Expansion Using CarcSeq Measurement of Lung Cancer Driver Mutations and Correlation With Mouse Strain- and Sex-Related Incidence of Spontaneous Lung Neoplasia (2021)
Collaboration Network
Top Collaborators
Joshua Xu
National Center for Toxicological Research
15 shared publications
In database
- Ultra-deep sequencing data from a liquid biopsy proficiency study demonstrating analytic validity
- CarcSeq Measurement of Rat Mammary Cancer Driver Mutations and Relation to Spontaneous Mammary Neoplasia
- Targeted DNA-seq and RNA-seq of Reference Samples with Short-read and Long-read Sequencing
- Assessment of Clonal Expansion Using CarcSeq Measurement of Lung Cancer Driver Mutations and Correlation With Mouse Strain- and Sex-Related Incidence of Spontaneous Lung Neoplasia
- Ultra-deep multi-oncopanel sequencing of benchmarking samples with a wide range of variant allele frequencies
Showing 5 of 15 shared publications
Rebecca Kusko
13 shared publications
- Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology
- A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency
- Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions
- Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
- Targeted DNA-seq and RNA-seq of Reference Samples with Short-read and Long-read Sequencing
Showing 5 of 13 shared publications
Natalia Novoradovskaya
10 shared publications
- Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology
- A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency
- Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions
- Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
- Targeted DNA-seq and RNA-seq of Reference Samples with Short-read and Long-read Sequencing
Showing 5 of 10 shared publications
Jennifer S. LoCoco
8 shared publications
- Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology
- Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions
- Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
- Targeted DNA-seq and RNA-seq of Reference Samples with Short-read and Long-read Sequencing
- Deep oncopanel sequencing reveals fixation time- and within block position-dependent quality degradation in FFPE processed samples
Showing 5 of 8 shared publications
Wendell Jones
8 shared publications
- Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology
- A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency
- Ultra-deep sequencing data from a liquid biopsy proficiency study demonstrating analytic validity
- Targeted DNA-seq and RNA-seq of Reference Samples with Short-read and Long-read Sequencing
- Ultra-deep multi-oncopanel sequencing of benchmarking samples with a wide range of variant allele frequencies
Showing 5 of 8 shared publications
Fujun Qiu
7 shared publications
- Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology
- Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions
- Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
- Deep oncopanel sequencing reveals fixation time- and within block position-dependent quality degradation in FFPE processed samples
- Additional file 3 of Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
Showing 5 of 7 shared publications
Daniel Stetson
6 shared publications
- Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology
- Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
- Deep oncopanel sequencing reveals fixation time- and within block position-dependent quality degradation in FFPE processed samples
- Additional file 3 of Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
- Additional file 2 of Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
Showing 5 of 6 shared publications
Robert Sebra
6 shared publications
- Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology
- Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
- Deep oncopanel sequencing reveals fixation time- and within block position-dependent quality degradation in FFPE processed samples
- Additional file 3 of Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
- Additional file 2 of Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
Showing 5 of 6 shared publications
Todd Richmond
6 shared publications
- Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology
- A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency
- Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions
- Targeted DNA-seq and RNA-seq of Reference Samples with Short-read and Long-read Sequencing
- Augmenting precision medicine via targeted RNA-Seq detection of expressed mutations
Showing 5 of 6 shared publications
Guangchun Chen
6 shared publications
- Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology
- A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency
- Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions
- Targeted DNA-seq and RNA-seq of Reference Samples with Short-read and Long-read Sequencing
- Augmenting precision medicine via targeted RNA-Seq detection of expressed mutations
Showing 5 of 6 shared publications
Vinay Kumar Mittal
Thermo Fisher Scientific (United States) (US)
5 shared publications
- Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions
- Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
- Deep oncopanel sequencing reveals fixation time- and within block position-dependent quality degradation in FFPE processed samples
- Additional file 3 of Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
- Additional file 2 of Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
Daniel J. Craig
University of Toledo (US)
5 shared publications
- A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency
- Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
- Deep oncopanel sequencing reveals fixation time- and within block position-dependent quality degradation in FFPE processed samples
- Additional file 3 of Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
- Additional file 2 of Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
Wenzhong Xiao
Harvard University (US)
5 shared publications
- Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
- Targeted DNA-seq and RNA-seq of Reference Samples with Short-read and Long-read Sequencing
- Deep oncopanel sequencing reveals fixation time- and within block position-dependent quality degradation in FFPE processed samples
- Additional file 3 of Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
- Additional file 2 of Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples
Donald J. Johann
Winthrop Rockefeller Foundation
5 shared publications
In database
- A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency
- Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions
- Ultra-deep sequencing data from a liquid biopsy proficiency study demonstrating analytic validity
- Targeted DNA-seq and RNA-seq of Reference Samples with Short-read and Long-read Sequencing
- Augmenting precision medicine via targeted RNA-Seq detection of expressed mutations
Weida Tong
National Center for Toxicological Research (US)
5 shared publications
- Ultra-deep sequencing data from a liquid biopsy proficiency study demonstrating analytic validity
- Targeted DNA-seq and RNA-seq of Reference Samples with Short-read and Long-read Sequencing
- Ultra-deep multi-oncopanel sequencing of benchmarking samples with a wide range of variant allele frequencies
- Single-cell RNA-sequencing and subcellular spatial transcriptomics facilitate the translation of liver microphysiological systems for regulatory application
- Towards accurate indel calling for oncopanel sequencing through an international pipeline competition at precisionFDA
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