Dustyn A. Barnette

This is a likely match — the affiliation was inferred from OpenAlex, ORCID, and web sources but has not been fully confirmed. Treat with appropriate caution.

Postdoctoral Fellow

NCTR primary Hendrix College University of Central Arkansas UAMS Ouachita Baptist University

Also affiliated: United States Food and Drug Administration (2013–2024); Arkansas Children's Research Institute (2017)

11 h-index 16 pubs 291 cited

Research Areas

Biomedical Subjects

Links

ORCID Research Group

OverviewAI-generated summary

Dustyn A. Barnette's research focuses on understanding drug-induced liver injury and toxicity, utilizing advanced methodologies and large datasets. Barnette has investigated the use of machine learning to identify potential drug interactions that could lead to liver injury, particularly between non-steroidal anti-inflammatory drugs (NSAIDs) and other medications, by analyzing retrospective electronic health record (EHR) data. Further research has explored the application of MALDI imaging mass spectrometry as a tool for identifying markers of toxicity, including in studies of in utero opioid exposures in mouse fetuses. Barnette also works on developing and utilizing in vitro models, such as co-cultures of human liver cells in liver-chip devices, to study drug-induced liver injury. This work contributes to the broader understanding of drug metabolism and potential adverse effects.

Metrics

h-index: 11
Publications: 16
Citations: 291

Positions

Postdoctoral Fellow 2020–present

National Center for Toxicological Research Division of Systems Biology ORCID
Graduate Research Assistant 2015–2020

University of Arkansas for Medical Sciences Department of Biochemistry and Molecular Biology ORCID
Research Technician 2013–2015

University of Arkansas for Medical Sciences Department of Microbiology and Immunology ORCID
Microbiology Technician 2012–2013

Windsor Foods: Quality Sausage Company Quality Assurance ORCID

Selected Publications

The incorporation of MALDI mass spectrometry imaging in studies to identify markers of toxicity following in utero opioid exposures in mouse fetuses (2024)

Frontiers in Toxicology 1 citation DOI OpenAlex
Co‐Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver‐Chip for the Study of Drug‐Induced Liver Injury (2022)

Current Protocols 34 citations DOI OpenAlex
Discovery of Novel Reductive Elimination Pathway for 10-Hydroxywarfarin (2022)

Frontiers in Pharmacology 1 citation DOI OpenAlex
MALDI imaging mass spectrometry: an emerging tool in neurology (2021)

Metabolic Brain Disease 40 citations DOI OpenAlex
Machine learning liver-injuring drug interactions with non-steroidal anti-inflammatory drugs (NSAIDs) from a retrospective electronic health record (EHR) cohort (2021)

PLoS Computational Biology 46 citations DOI OpenAlex
Meloxicam methyl group determines enzyme specificity for thiazole bioactivation compared to sudoxicam (2020)

Toxicology Letters 24 citations DOI OpenAlex
P166 - The sudoxicam family: Identifying how thiazole structure determines bioactivation relevance (2020)

Drug Metabolism and Pharmacokinetics DOI OpenAlex
Dual mechanisms suppress meloxicam bioactivation relative to sudoxicam (2020)

Toxicology 20 citations DOI OpenAlex
Comprehensive kinetic and modeling analyses revealed CYP2C9 and 3A4 determine terbinafine metabolic clearance and bioactivation (2019)

Biochemical Pharmacology 14 citations DOI OpenAlex
CYP2C19 and 3A4 Dominate Metabolic Clearance and Bioactivation of Terbinafine Based on Computational and Experimental Approaches (2019)

Chemical Research in Toxicology 14 citations DOI OpenAlex
Lamisil (terbinafine) toxicity: Determining pathways to bioactivation through computational and experimental approaches (2018)

Biochemical Pharmacology 16 citations DOI OpenAlex
Modeling the Metabolism and Subsequent Reactivity of Drugs (2017)

The FASEB Journal DOI OpenAlex
Stereospecific Metabolism of R- and S-Warfarin by Human Hepatic Cytosolic Reductases (2017)

Drug Metabolism and Disposition 20 citations DOI OpenAlex
Exposure Cessation During Adulthood Did Not Prevent Immunotoxicity Caused by Developmental Exposure to Low-Level Trichloroethylene in Drinking Water (2017)

Toxicological Sciences 20 citations DOI OpenAlex
Evaluation of Virulence and Antimicrobial Resistance in Salmonella enterica Serovar Enteritidis Isolates from Humans and Chicken- and Egg-Associated Sources (2013)

Foodborne Pathogens and Disease 36 citations DOI OpenAlex