Eric U. Yee
Associate Professor
University of Arkansas for Medical Sciences
faculty
Pathology, College of Medicine
Research Areas
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Biography and Research Information
OverviewAI-generated summary
Eric U. Yee's research focuses on understanding metabolic pathways and their role in disease, particularly in the context of liver health and injury. His work investigates how specific metabolic processes, such as pyruvate and alanine metabolism, contribute to the maintenance of antioxidant capacity and resistance to oxidative stress in the liver. He has explored the protective mechanisms of exogenous compounds like phosphatidic acid, examining their activation of signaling pathways and inter-organ crosstalk in mitigating acetaminophen-induced liver injury.
Further research by Yee delves into the cellular and molecular mechanisms underlying liver disease, including the role of adenosine deaminase 2 produced by monocytes in promoting liver fibrosis in nonalcoholic fatty liver disease. His group also investigates the impact of therapeutic agents, such as budesonide, on inflammatory conditions like clostridioides difficile colitis, and examines the complex interactions between radiation and drug pharmacokinetics, as demonstrated in studies on methamphetamine in rats. Yee also contributes to the field of medical imaging and artificial intelligence, exploring the prediction of pathologist attention in the evaluation of whole slide images of cancer.
With a scholarly output reflected in an h-index of 22 and over 1,543 citations across 94 publications, Yee leads a research group at the University of Arkansas for Medical Sciences. His collaborative network includes several colleagues from the same institution, with whom he has co-authored multiple publications, indicating a strong internal research synergy.
Metrics
- h-index: 22
- Publications: 94
- Citations: 1,543
Selected Publications
- Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models (2025) DOI
- Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model (2025) DOI
- Monensin and Its Analogs Offer a Multi-Targeted Approach to Enhancing Metastatic Breast Cancer Immunogenicity and Cell Death (Abstract ID: 163059) (2025) DOI
- 474 Repositioning monensin: Enhancing anti-cancer activity and immune modulation in breast cancer cells (2025) DOI
- Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract (2024) DOI
- Inter-strain variability in responses to a single administration of the cannabidiol-rich cannabis extract in mice (2024) DOI
- Targeting Tri-Methyl-Histone H3 (Lys27) in Rectal Cancer: A Novel Strategy to Enhance Radiosensitivity and Predict Response to Neoadjuvant Therapy (2023) DOI
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult (2023) DOI
- Budesonide, an anti-inflammatory drug, exacerbate clostridioides difficile colitis in mice (2023) DOI
- S2431 A Rare Case of Esophageal Kaposi Sarcoma Causing Dysphagia (2022) DOI
- Predicting the Visual Attention of Pathologists Evaluating Whole Slide Images of Cancer (2022) DOI
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult in mice (2022) DOI
- Radiation Effects on Methamphetamine Pharmacokinetics and Pharmacodynamics in Rats (2022) DOI
- Adenosine deaminase 2 produced by infiltrative monocytes promotes liver fibrosis in nonalcoholic fatty liver disease (2021) DOI
Collaborators
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