M
Mitchell R. McGill
Federal Grant PI
High Impact
Assistant Professor
faculty
Environmental Health Sciences, College of Public Health
46 h-index
148 pubs
12,250 cited
Research Areas
Biography and Research Information
OverviewAI-generated summary
Mitchell R. McGill's research focuses on understanding the mechanisms of drug-induced liver injury, with a particular emphasis on acetaminophen overdose. He investigates the role of cellular metabolism and signaling pathways in the progression and resolution of liver damage. His work explores the generation of inflammatory mediators and the identification of prognostic biomarkers in patients with acute liver failure.
Dr. McGill's federally funded research, supported by a $328,034 grant from the NIH/National Institute of Diabetes and Digestive and Kidney Diseases, specifically examines the role of phosphatidic acid in liver regeneration following acetaminophen overdose. He also studies the hepatotoxicity associated with herbal dietary supplements and the potential for repeated acetaminophen use in patients with liver conditions.
His scholarly contributions include a significant publication record, with an h-index of 45 and over 9,500 citations across 148 publications. Dr. McGill collaborates with researchers at the University of Arkansas for Medical Sciences, including Stefanie Kennon‐McGill, Eric U. Yee, Igor Koturbash, and Felicia D. Allard, with whom he has co-authored multiple publications.
Metrics
- h-index: 46
- Publications: 148
- Citations: 12,250
Selected Publications
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Special Issue “Mechanistic and Prognostic Biomarkers in Liver Diseases” (2025)
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From fructose to the future: liver disease biomarkers and their prognostic value in acute liver failure (2025)
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Detection and Diagnosis of Hepatotoxicity in Experimental and Clinical Settings (2025)
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Kupffer cell expression of macrophage receptor with collagenous structure modulates macrophage gene induction and limits acute liver injury (2025)
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NAPQI is absent in the mouse brain after sub-hepatotoxic and hepatotoxic doses of acetaminophen (2025)
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Minimally invasive clinical biomarkers for use in acetaminophen hepatotoxicity (2024)
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Intracellular signaling mechanisms of acetaminophen-induced cell death (2024)
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Translation of acetaminophen hepatotoxicity mechanisms from models to humans (2024)
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Serum glutamate dehydrogenase activity enables sensitive and specific diagnosis of hepatocellular injury in humans (2024)
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Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract (2024)
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Natural Products That Protect Against Acetaminophen Hepatotoxicity: A Call for Increased Rigor in Preclinical Studies of Dietary Supplements (2024)
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The Role of Mechanistic Biomarkers in Understanding Acetaminophen Hepatotoxicity in Humans (2023)
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The Evolution of Circulating Biomarkers for Use in Acetaminophen/Paracetamol-Induced Liver Injury in Humans: A Scoping Review (2023)
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Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult (2023)
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Hands-Free Analytical Urine Testing Technology Validated for Drug-Facilitated Crime Investigations (2023)
Federal Grants 1 $328,034 total
NIH/National Institute of Diabetes and Digestive and Kidney Diseases
Contact PI
Mar 2024 - Feb 2029
The role of phosphatidic acid in liver regeneration after acetaminophen overdose
Grants & Funding
- In-vitro assessment of the protective effects of selected ingredients against acetaminophen hepatotoxicity Haleon PLC Principal Investigator
- The role of phosphatidic acid in liver regeneration after acetaminophen overdose NIH Principal Investigator
- The role of phosphatidic acid in liver regeneration after acetaminophen overdose NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases Principal Investigator
Collaboration Network
Top Collaborators
Stefanie Kennon‐McGill
University of Arkansas for Medical Sciences
9 shared publications
In database
- Proteomics Indicates Lactate Dehydrogenase Is Prognostic in Acetaminophen-Induced Acute Liver Failure Patients and Reveals Altered Signaling Pathways
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult
- Short‐Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis
- Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk
- Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract
Showing 5 of 9 shared publications
Laura P. James
Arkansas Department of Agriculture (US)
8 shared publications
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult
- Short‐Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis
- Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk
- Hands-Free Analytical Urine Testing Technology Validated for Drug-Facilitated Crime Investigations
- NAPQI is absent in the mouse brain after sub-hepatotoxic and hepatotoxic doses of acetaminophen
Showing 5 of 8 shared publications
Joel H. Vazquez
University of Arkansas for Medical Sciences
8 shared publications
In database
- Proteomics Indicates Lactate Dehydrogenase Is Prognostic in Acetaminophen-Induced Acute Liver Failure Patients and Reveals Altered Signaling Pathways
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult
- Short‐Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis
- Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk
- Redrawing the Map to Novel DILI Biomarkers in Circulation: Where Are We, Where Should We Go, and How Can We Get There?
Showing 5 of 8 shared publications
Hartmut Jaeschke
University of Kansas Medical Center (US)
7 shared publications
- Generation of pro-and anti-inflammatory mediators after acetaminophen overdose in surviving and non-surviving patients
- Proteomics Indicates Lactate Dehydrogenase Is Prognostic in Acetaminophen-Induced Acute Liver Failure Patients and Reveals Altered Signaling Pathways
- Biomarkers of mitotoxicity after acute liver injury: further insights into the interpretation of glutamate dehydrogenase
- Proteomics Indicates Lactate Dehydrogenase is Prognostic in Acetaminophen-induced Acute Liver Failure Patients and Reveals a Role for LKB1-AMPK Signaling
- Intracellular signaling mechanisms of acetaminophen-induced cell death
Showing 5 of 7 shared publications
Jonathan A. Dranoff
VA Connecticut Healthcare System (US)
5 shared publications
- Proteomics Indicates Lactate Dehydrogenase Is Prognostic in Acetaminophen-Induced Acute Liver Failure Patients and Reveals Altered Signaling Pathways
- Short‐Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis
- Su330 EVALUTATION OF THE PHARMACOKINETICS AND SAFETY OF ACETAMINOPHEN IN CIRRHOSIS USING NOVEL BIOMARKERS OF METABOLISM AND LIVER INJURY
- Proteomics Indicates Lactate Dehydrogenase is Prognostic in Acetaminophen-induced Acute Liver Failure Patients and Reveals a Role for LKB1-AMPK Signaling
- Contributors
Eric U. Yee
University of Arkansas for Medical Sciences
5 shared publications
In database
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult
- Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk
- Radiation Effects on Methamphetamine Pharmacokinetics and Pharmacodynamics in Rats
- Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult in mice
Felicia D. Allard
University of Arkansas for Medical Sciences
4 shared publications
In database
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult
- Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk
- Radiation Effects on Methamphetamine Pharmacokinetics and Pharmacodynamics in Rats
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult in mice
Steven C. Curry
University of Arizona (US)
4 shared publications
- Generation of pro-and anti-inflammatory mediators after acetaminophen overdose in surviving and non-surviving patients
- The Evolution of Circulating Biomarkers for Use in Acetaminophen/Paracetamol-Induced Liver Injury in Humans: A Scoping Review
- Minimally invasive clinical biomarkers for use in acetaminophen hepatotoxicity
- Contributors
Igor Koturbash
Office of Dietary Supplements
4 shared publications
In database
- Hepatotoxicity due to herbal dietary supplements: Past, present and the future
- Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract
- Natural Products That Protect Against Acetaminophen Hepatotoxicity: A Call for Increased Rigor in Preclinical Studies of Dietary Supplements
- Methylsulfonylmethane Serves as a Donor of Methyl Groups for Methylation of DNA in Human Liver HepaRG Cells
Jeffery H. Moran
University of Arkansas for Medical Sciences
3 shared publications
In database
- Short‐Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis
- Hands-Free Analytical Urine Testing Technology Validated for Drug-Facilitated Crime Investigations
- Su330 EVALUTATION OF THE PHARMACOKINETICS AND SAFETY OF ACETAMINOPHEN IN CIRRHOSIS USING NOVEL BIOMARKERS OF METABOLISM AND LIVER INJURY
Brian N. Finck
Washington University in St. Louis (US)
3 shared publications
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult
- Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult in mice
Alexander J. Layman
Arkansas Department of Health
3 shared publications
In database
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult
- Natural Products That Protect Against Acetaminophen Hepatotoxicity: A Call for Increased Rigor in Preclinical Studies of Dietary Supplements
- Detection and Diagnosis of Hepatotoxicity in Experimental and Clinical Settings
Horace J. Spencer
University of Arkansas for Medical Sciences
2 shared publications
In database
- Short‐Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis
- Su330 EVALUTATION OF THE PHARMACOKINETICS AND SAFETY OF ACETAMINOPHEN IN CIRRHOSIS USING NOVEL BIOMARKERS OF METABOLISM AND LIVER INJURY
Sandra McCullough
University of Arkansas for Medical Sciences (US)
2 shared publications
- Short‐Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis
- Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk
Samuel E. Mathews
2 shared publications
- Short‐Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis
- Hands-Free Analytical Urine Testing Technology Validated for Drug-Facilitated Crime Investigations
Similar Researchers
Based on overlapping research topics
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National Center for Toxicological Research
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National Center for Toxicological Research
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