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Institution-verified
Presence
Current · Arkansas
Last published
2026
Sources
Institutional record
Refreshed
2026-10-09
G
Gunnar Boysen
Sourced from institutional research profiles (UAMS TRI or ARA).
Federal Grant PI
High Impact
Associate Professor -tenured
Also affiliated: University of Vermont (2007); University of North Carolina at Chapel Hill (2004–2025); National Institutes of Health (2006–2009); University of Minnesota (2003–2020); Lovelace Respiratory Research Institute (2007); Royal Marsden NHS Foundation Trust (2017); Institute of Cancer Research (2017); Vanderbilt University (2008); Washington University in St. Louis (2020); University of Arkansas Medical Center (2022–2023); National Institute of Environmental Health Sciences (2006–2009); National Cancer Institute (2008); UNC Lineberger Comprehensive Cancer Center (2007); Masonic Cancer Center (2003)
33 h-index
138 pubs
3,653 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Gunnar Boysen investigates the interactions between chemical exposures and nutritional or lifestyle factors, such as diet and physical activity, to understand their impact on human health. His research employs DNA and protein adducts as biomarkers to study carcinogen metabolism, how it is influenced by dietary components, and the underlying mechanisms that regulate enzyme activities involved in these processes.
Boysen's work also utilizes mass spectrometry-based metabolomic approaches, both targeted and untargeted, to investigate changes in common metabolic pathways resulting from environmental exposures. He has received federal funding from the NIH/National Institute of Environmental Health Sciences for his project "Understanding the origins of the mutational landscape in cancer," totaling $719,050. His scholarship metrics include an h-index of 33, 139 total publications, and 3,585 total citations. He leads a research group at the University of Arkansas for Medical Sciences and collaborates with several colleagues there, including Grover P. Miller, Azemat Jamshidi‐Parsian, Nadia I. Georgieva, and Intawat Nookaew.
Metrics
- h-index: 33
- Publications: 138
- Citations: 3,653
Positions
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Professor - tenured 2026–presentUniversity of Arkansas for Medical Sciences Environmental Health Sciences ORCID
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Associate Professor -tenured publications 2009–2026University of Arkansas for Medical Sciences Institutional directory
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Associate Professor - tenured 2022–2026University of Arkansas for Medical Sciences Environmental Health Sciences ORCID
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Assistant Professor 2008–2022University of Arkansas for Medical Sciences Environmental and Occupational Health ORCID
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Assistant Professor 2007–2008University of North Carolina at Chapel Hill Environmental Sciences and Engineering ORCID
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Director, Biomarker Facility Cores 2006–2008University of North Carolina at Chapel Hill ORCID
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Post-doc 2002–2005University of North Carolina at Chapel Hill Environmental Sciences and Engineering ORCID
Selected Publications
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Abstract LB372: Understanding the origins of the mutational landscape (2026)
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Abstract 2326: Differentiating epigenetic marks and DNA adducts at the KRAS codon 12 mutation hotspot using ONT/ELIGOS sequencing (2026)
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Sex-Specific Formation of 1,2:3,4-Diepoxybutane-Derived Hemoglobin Adducts in 1,3-Butadiene-Exposed Workers (2025)
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Human health risk assessment for exposures to 1,3-butadiene in the United States with input from an independent science advisory panel (2025)
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Investigating the origins of the mutational signatures in cancer (2025)
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Generation of BT-Amide, a Bone-Targeted Pyk2 Inhibitor, Effective <i>via</i> Oral Administration, for the Prevention of Glucocorticoid-Induced Bone Loss (2024)
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CB-839 induces reversible dormancy in lung tumor-cells (2024)
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Acquired Radiation Resistance Induces Thiol-dependent Cisplatin Cross-resistance (2023)
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Climate Change and New Challenges for Rural Communities: Particulate Matter Matters (2023)
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Acquired Radiation Resistance Induces Thiol-dependent Cisplatin Cross-resistance (2023)
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Exploiting nanopore sequencing for characterization and grading of <i>IDH</i>‐mutant gliomas (2023)
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Similar 5F-APINACA Metabolism between CD-1 Mouse and Human Liver Microsomes Involves Different P450 Cytochromes (2022)
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Characterization of population variability of 1,3-butadiene derived protein adducts in humans and mice (2022)
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Nanopore Sequencing for Detection and Characterization of Phosphorothioate Modifications in Native DNA Sequences (2022)
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Current and Future Methodology for Quantitation and Site-Specific Mapping the Location of DNA Adducts (2022)
Federal Grants 1 $719,050 total
NIH
Contact PI
Feb 2025 - Jan 2028
Understanding the origins of the mutational landscape in cancer
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- Lipid Stress and MC4R (Funded by: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK))
- Cancer Prevention and Population Sciences Program UAMS College of Medicine
- ProfilingDoses of Reactive Compounds Derived from various Air Pollutant Exposures Environmental Protection Agency via The Health Effects Institute
- A novel approach for quantitation of N-terminal valine adducts NIH
- Arkansas Center for Clinical and Translational Research NIH
- The Role of N1-Inosine Adducts in Butadiene Mutagenesis NIH
- Systems Biology Based Diagnosis of Lung Cancer (Funded by: UAMS, Translational Research Institute (TRI))
- Monitoring Perfluoroalkyl and Polyfluoroalkyl Substances in Central Arkansas water systems US Department of Interior via University of Arkansas at Fayetteville
- Effects of Genetic Diversity on Carcinogen Metabolism NIH
- Mechanisms of Ethnic/Racial Differences in Lung Cancer Due to Cigarette Smoking NIH/Nat. Cancer Institute via University of Minnesota
- The Role of N1-Inosine Adducts in Butadiene Mutagenesis (Funded by: National Institute for Environmental Health Sciences (NIEHS))
Collaboration Network
Top Collaborators
Grover P. Miller
University of Arkansas for Medical Sciences
21 shared publications
In database
- Metabolism of R- and S-Warfarin by CYP2C19 into Four Hydroxywarfarins
- Novel multi-mode ultra performance liquid chromatography–tandem mass spectrometry assay for profiling enantiomeric hydroxywarfarins and warfarin in human plasma
- 1,3-Butadiene-induced mitochondrial dysfunction is correlated with mitochondrial CYP2E1 activity in Collaborative Cross mice
- CYP2E1 Metabolism of Styrene Involves Allostery
- Lamisil (terbinafine) toxicity: Determining pathways to bioactivation through computational and experimental approaches
Showing 5 of 21 shared publications
Eric R. Siegel
University of Arkansas for Medical Sciences
11 shared publications
In database
- Glutamine drives glutathione synthesis and contributes to radiation sensitivity of A549 and H460 lung cancer cell lines
- Glutaminase inhibitor CB-839 increases radiation sensitivity of lung tumor cells and human lung tumor xenografts in mice
- Use of electronic nicotine delivery systems by pregnantwomen II: Hair biomarkers for exposures to nicotine andtobacco-specific nitrosamines
- Diagnosis of lung tumor types based on metabolomic profiles in lymph node aspirates
- CB-839 induces reversible dormancy in lung tumor-cells
Showing 5 of 11 shared publications
Jessica H. Hartman
University of Arkansas for Medical Sciences (US)
9 shared publications
- Metabolism of R- and S-Warfarin by CYP2C19 into Four Hydroxywarfarins
- 1,3-Butadiene-induced mitochondrial dysfunction is correlated with mitochondrial CYP2E1 activity in Collaborative Cross mice
- CYP2E1 Metabolism of Styrene Involves Allostery
- Cooperative effects for CYP2E1 differ between styrene and its metabolites
- Inhibitory potency of 4-carbon alkanes and alkenes toward CYP2E1 activity
Showing 5 of 9 shared publications
Daniel R. Sappington
University of Arkansas for Medical Sciences (US)
9 shared publications
- Glutamine drives glutathione synthesis and contributes to radiation sensitivity of A549 and H460 lung cancer cell lines
- Diagnosis of lung tumor types based on metabolomic profiles in lymph node aspirates
- Novel isomeric metabolite profiles correlate with warfarin metabolism phenotype during maintenance dosing in a pilot study of 29 patients
- Abstract 1041: Glutamine drives glutathione synthesis and contributes to radiation sensitivity of A549 and H460 lung cancer cell lines
- Abstract 1298: The effect of adipocyte-derived factors on lung cells: Exploring the protective nature of excess weight on lung cancer risk
Showing 5 of 9 shared publications
Intawat Nookaew
University of Arkansas for Medical Sciences
9 shared publications
In database
- Decoding the epitranscriptional landscape from native RNA sequences
- PARP1 Is Up-Regulated in Non-small Cell Lung Cancer Tissues in the Presence of the Cyanobacterial Toxin Microcystin
- Detection and Discrimination of DNA Adducts Differing in Size, Regiochemistry, and Functional Group by Nanopore Sequencing
- Investigating the origins of the mutational signatures in cancer
- Current and Future Methodology for Quantitation and Site-Specific Mapping the Location of DNA Adducts
Showing 5 of 9 shared publications
James A. Swenberg
University of North Carolina at Chapel Hill (US)
7 shared publications
- The formation and biological significance of N7-guanine adducts
- Analysis of 8-oxo-7,8-dihydro-2′-deoxyguanosine by ultra high pressure liquid chromatography–heat assisted electrospray ionization–tandem mass spectrometry
- Exposure-Response of 1,2:3,4-Diepoxybutane–Specific N-Terminal Valine Adducts in Mice and Rats after Inhalation Exposure to 1,3-Butadiene
- Understanding the importance of low‐molecular weight (ethylene oxide‐ and propylene oxide‐induced) DNA adducts and mutations in risk assessment: Insights from 15 years of research and collaborative discussions
- Formation of 1,2:3,4-Diepoxybutane-Specific Hemoglobin Adducts in 1,3-Butadiene Exposed Workers
Showing 5 of 7 shared publications
Rosalind B. Penney
University of Arkansas for Medical Sciences (US)
7 shared publications
- Glutamine drives glutathione synthesis and contributes to radiation sensitivity of A549 and H460 lung cancer cell lines
- PARP1 Is Up-Regulated in Non-small Cell Lung Cancer Tissues in the Presence of the Cyanobacterial Toxin Microcystin
- Potential Role of UGT1A4 Promoter SNPs in Anastrozole Pharmacogenomics
- Diagnosis of lung tumor types based on metabolomic profiles in lymph node aspirates
- Abstract 1041: Glutamine drives glutathione synthesis and contributes to radiation sensitivity of A549 and H460 lung cancer cell lines
Showing 5 of 7 shared publications
Azemat Jamshidi‐Parsian
Winthrop Rockefeller Foundation
7 shared publications
In database
- Decoding the epitranscriptional landscape from native RNA sequences
- Glutamine drives glutathione synthesis and contributes to radiation sensitivity of A549 and H460 lung cancer cell lines
- Glutaminase inhibitor CB-839 increases radiation sensitivity of lung tumor cells and human lung tumor xenografts in mice
- Exploiting nanopore sequencing for characterization and grading of <i>IDH</i>‐mutant gliomas
- CB-839 induces reversible dormancy in lung tumor-cells
Showing 5 of 7 shared publications
Mary A. Schleiff
University of Arkansas for Medical Sciences (US)
7 shared publications
- Significance of Multiple Bioactivation Pathways for Meclofenamate as Revealed through Modeling and Reaction Kinetics
- Impacts of diphenylamine NSAID halogenation on bioactivation risks
- CYP2C9 and 3A4 play opposing roles in bioactivation and detoxification of diphenylamine NSAIDs
- Significance of Competing Metabolic Pathways for 5F-APINACA Based on Quantitative Kinetics
- Bioactivation of Isoxazole-Containing Bromodomain and Extra-Terminal Domain (BET) Inhibitors
Showing 5 of 7 shared publications
Nadia I. Georgieva
University of North Carolina at Chapel Hill
6 shared publications
In database
- Exposure-Response of 1,2:3,4-Diepoxybutane–Specific N-Terminal Valine Adducts in Mice and Rats after Inhalation Exposure to 1,3-Butadiene
- Formation of 1,2:3,4-Diepoxybutane-Specific Hemoglobin Adducts in 1,3-Butadiene Exposed Workers
- Accurate quantitation of standard peptides used for quantitative proteomics
- Exposure profiling of reactive compounds in complex mixtures
- Sex-Specific Formation of 1,2:3,4-Diepoxybutane-Derived Hemoglobin Adducts in 1,3-Butadiene-Exposed Workers
Showing 5 of 6 shared publications
S. Joshua Swamidass
Washington University in St. Louis (US)
6 shared publications
- Lamisil (terbinafine) toxicity: Determining pathways to bioactivation through computational and experimental approaches
- CYP2C19 and 3A4 Dominate Metabolic Clearance and Bioactivation of Terbinafine Based on Computational and Experimental Approaches
- Significance of Multiple Bioactivation Pathways for Meclofenamate as Revealed through Modeling and Reaction Kinetics
- Impacts of diphenylamine NSAID halogenation on bioactivation risks
- Bioactivation of Isoxazole-Containing Bromodomain and Extra-Terminal Domain (BET) Inhibitors
Showing 5 of 6 shared publications
Donald M. Mock
Laboratoire de Biochimie
5 shared publications
In database
- Urinary Excretion of 3-Hydroxyisovaleric Acid and 3-Hydroxyisovaleryl Carnitine Increases in Response to a Leucine Challenge in Marginally Biotin-Deficient Humans
- Measurement of 3-hydroxyisovaleric acid in urine from marginally biotin-deficient humans by UPLC-MS/MS
- Marginal Biotin Deficiency Can Be Induced Experimentally in Humans Using a Cost-Effective Outpatient Design3
- Measurement of Acylcarnitine Substrate to Product Ratios Specific to Biotin-Dependent Carboxylases Offers a Combination of Indicators of Biotin Status in Humans
- In HepG2 Cells, Coexisting Carnitine Deficiency Masks Important Indicators of Marginal Biotin Deficiency
Robert J. Griffin
Winthrop Rockefeller Foundation
5 shared publications
In database
- Glutamine drives glutathione synthesis and contributes to radiation sensitivity of A549 and H460 lung cancer cell lines
- Glutaminase inhibitor CB-839 increases radiation sensitivity of lung tumor cells and human lung tumor xenografts in mice
- CB-839 induces reversible dormancy in lung tumor-cells
- Acquired Radiation Resistance Induces Thiol-dependent Cisplatin Cross-resistance
- Acquired Radiation Resistance Induces Thiol-dependent Cisplatin Cross-resistance
Dakota L. Pouncey
University of Arkansas for Medical Sciences
4 shared publications
In database
- Multiple UDP-glucuronosyltransferases in human liver microsomes glucuronidate both R- and S-7-hydroxywarfarin into two metabolites
- Novel isomeric metabolite profiles correlate with warfarin metabolism phenotype during maintenance dosing in a pilot study of 29 patients
- Significance of Competing Metabolic Pathways for 5F-APINACA Based on Quantitative Kinetics
- Warfarin Metabolite Profiles Reveal the Importance of Factors on Patient Dose‐Responses to Anticoagulant Therapy
Shawna L. Stratton
Laboratoire de Biochimie (FR)
4 shared publications
- Urinary Excretion of 3-Hydroxyisovaleric Acid and 3-Hydroxyisovaleryl Carnitine Increases in Response to a Leucine Challenge in Marginally Biotin-Deficient Humans
- Measurement of 3-hydroxyisovaleric acid in urine from marginally biotin-deficient humans by UPLC-MS/MS
- Marginal Biotin Deficiency Can Be Induced Experimentally in Humans Using a Cost-Effective Outpatient Design3
- Measurement of Acylcarnitine Substrate to Product Ratios Specific to Biotin-Dependent Carboxylases Offers a Combination of Indicators of Biotin Status in Humans
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