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Listed
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Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-06
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Leena Maddukuri
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Also affiliated: Vanderbilt University (2010–2013); University of Arkansas Medical Center (2016); Institute of Biochemistry and Biophysics, Polish Academy of Sciences (2007–2009); Postgraduate School of Molecular Medicine (2009); Vanderbilt-Ingram Cancer Center (2012–2013); Sungkyunkwan University (2013); Vanderbilt University Medical Center (2011); Polish Academy of Sciences (2007–2009)
18 h-index
40 pubs
687 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Leena Maddukuri's research focuses on DNA damage tolerance and repair mechanisms, particularly in the context of cancer. Her work investigates the roles of specific DNA polymerases, such as Rev1 and DNA polymerase kappa, in processes like DNA replication and the response to DNA damage. Maddukuri has explored how these polymerases interact with DNA structures, including G-quadruplexes, and how their function can be modulated. Her research also examines the impact of inhibiting enzymes like tryptophan 2,3-dioxygenase on DNA repair in glioma cells. Maddukuri collaborates with researchers including Robert L. Eoff and Megan R. Reed at the University of Arkansas for Medical Sciences, and has co-authored multiple publications with them. Her scholarship metrics include an h-index of 18 and 678 total citations.
Metrics
- h-index: 18
- Publications: 40
- Citations: 687
Selected Publications
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Human REV1 interacts with DHX36 to promote replication and tolerance of G-quadruplex DNA (2026)
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A Functional Precision Medicine Pipeline Combines Comparative Transcriptomics and Tumor Organoid Modeling to Identify Bespoke Treatment Strategies for Glioblastoma (2021)
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Deletion of putative xenobiotic response elements (XREs) in hpol κ alters the replication stress response and overall genomic instability in glioblastoma cells (2021)
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Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes (2021)
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DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma (2021)
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Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells (2021)
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Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs (2021)
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Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells (2020)
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Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms (2019)
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A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells (2018)
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A Novel Small Molecule Inhibitor of Human DNA Polymerase Eta Modulates the Efficacy of Cisplatin in Cancer Cells (2017)
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Inhibition of Kynurenine Signaling Decreases Glioblastoma Multiforme Genomic Instability and Sensitizes Cells to Chemotherapeutic Treatment (2017)
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Investigation of Structure‐Activity Relationships for Small‐Molecule Inhibitors of Human DNA Polymerase Eta (2016)
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Human Translesion Polymerase κ Exhibits Enhanced Activity and Reduced Fidelity Two Nucleotides from G-Quadruplex DNA (2016)
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Evidence for the Kinetic Partitioning of Polymerase Activity on G-Quadruplex DNA (2015)
Collaboration Network
Top Collaborators
Robert L. Eoff
University of Arkansas for Medical Sciences
25 shared publications
In database
- Human Rev1 polymerase disrupts G-quadruplex DNA
- Evidence for the Kinetic Partitioning of Polymerase Activity on G-Quadruplex DNA
- Human Translesion Polymerase κ Exhibits Enhanced Activity and Reduced Fidelity Two Nucleotides from G-Quadruplex DNA
- Kynurenine Signaling Increases DNA Polymerase Kappa Expression and Promotes Genomic Instability in Glioblastoma Cells
- A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells
Showing 5 of 25 shared publications
Amit Ketkar
University of Arkansas for Medical Sciences
19 shared publications
In database
- Human Rev1 polymerase disrupts G-quadruplex DNA
- Evidence for the Kinetic Partitioning of Polymerase Activity on G-Quadruplex DNA
- Human Translesion Polymerase κ Exhibits Enhanced Activity and Reduced Fidelity Two Nucleotides from G-Quadruplex DNA
- A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells
- <i>N</i>-Aroyl Indole Thiobarbituric Acids as Inhibitors of DNA Repair and Replication Stress Response Polymerases
Showing 5 of 19 shared publications
Maroof K. Zafar
University of Arkansas for Medical Sciences
16 shared publications
In database
- Human Rev1 polymerase disrupts G-quadruplex DNA
- Evidence for the Kinetic Partitioning of Polymerase Activity on G-Quadruplex DNA
- Human Translesion Polymerase κ Exhibits Enhanced Activity and Reduced Fidelity Two Nucleotides from G-Quadruplex DNA
- A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells
- The Werner syndrome protein limits the error-prone 8-oxo-dG lesion bypass activity of human DNA polymerase kappa
Showing 5 of 16 shared publications
Megan R. Reed
University of Arkansas for Medical Sciences
12 shared publications
In database
- Kynurenine Signaling Increases DNA Polymerase Kappa Expression and Promotes Genomic Instability in Glioblastoma Cells
- A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells
- A Functional Precision Medicine Pipeline Combines Comparative Transcriptomics and Tumor Organoid Modeling to Identify Bespoke Treatment Strategies for Glioblastoma
- Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
Showing 5 of 12 shared publications
Sarah Eddy
University of Arkansas for Medical Sciences (US)
10 shared publications
- Human Rev1 polymerase disrupts G-quadruplex DNA
- Evidence for the Kinetic Partitioning of Polymerase Activity on G-Quadruplex DNA
- Human Translesion Polymerase κ Exhibits Enhanced Activity and Reduced Fidelity Two Nucleotides from G-Quadruplex DNA
- A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells
- <i>N</i>-Aroyl Indole Thiobarbituric Acids as Inhibitors of DNA Repair and Replication Stress Response Polymerases
Showing 5 of 10 shared publications
Peter A. Crooks
University of Arkansas for Medical Sciences
6 shared publications
In database
- A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells
- <i>N</i>-Aroyl Indole Thiobarbituric Acids as Inhibitors of DNA Repair and Replication Stress Response Polymerases
- Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms
- Identification and characterization of novel small molecule inhibitors of the human Y‐family DNA polymerases
- Investigation of Structure‐Activity Relationships for Small‐Molecule Inhibitors of Human DNA Polymerase Eta
Showing 5 of 6 shared publications
April C.L. Bostian
Arkansas State University
4 shared publications
In database
- Kynurenine Signaling Increases DNA Polymerase Kappa Expression and Promotes Genomic Instability in Glioblastoma Cells
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- Inhibition of Kynurenine Signaling Decreases Glioblastoma Multiforme Genomic Instability and Sensitizes Cells to Chemotherapeutic Treatment
Justin Leung
University of Arkansas for Medical Sciences (US)
4 shared publications
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
- Deletion of putative xenobiotic response elements (XREs) in hpol κ alters the replication stress response and overall genomic instability in glioblastoma cells
Jessica H. Hartman
Medical University of South Carolina (US)
3 shared publications
- <i>N</i>-Aroyl Indole Thiobarbituric Acids as Inhibitors of DNA Repair and Replication Stress Response Polymerases
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
Narsimha Reddy Penthala
University of Arkansas for Medical Sciences
3 shared publications
In database
- A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells
- Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms
- Identification and characterization of novel small molecule inhibitors of the human Y‐family DNA polymerases
Grace E. Coggins
Vanderbilt University (US)
2 shared publications
- <i>N</i>-Aroyl Indole Thiobarbituric Acids as Inhibitors of DNA Repair and Replication Stress Response Polymerases
- Identification and characterization of novel small molecule inhibitors of the human Y‐family DNA polymerases
Narsima R. Penthala
University of Arkansas for Medical Sciences (US)
2 shared publications
- <i>N</i>-Aroyl Indole Thiobarbituric Acids as Inhibitors of DNA Repair and Replication Stress Response Polymerases
- Investigation of Structure‐Activity Relationships for Small‐Molecule Inhibitors of Human DNA Polymerase Eta
R. Stephen Lloyd
Oregon Health & Science University (US)
2 shared publications
- Leukotriene Biosynthesis Inhibitor MK886 Impedes DNA Polymerase Activity
- Identification and characterization of novel small molecule inhibitors of the human Y‐family DNA polymerases
Stephanie D. Byrum
Arkansas Children's Hospital
2 shared publications
In database
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
Alan J. Tackett
Arkansas Children's Hospital
2 shared publications
In database
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
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