Match tier
Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-08-15
L
Leena Maddukuri
Researcher
Also affiliated: Vanderbilt University (2010–2013); Institute of Biochemistry and Biophysics, Polish Academy of Sciences (2007–2009); Postgraduate School of Molecular Medicine (2009); Sungkyunkwan University (2013)
Faculty Researcher
18 h-index
40 pubs
683 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Leena Maddukuri's research focuses on DNA damage tolerance and repair mechanisms, particularly in the context of cancer. Her work investigates the roles of specific DNA polymerases, such as Rev1 and DNA polymerase kappa, in processes like DNA replication and the response to DNA damage. Maddukuri has explored how these polymerases interact with DNA structures, including G-quadruplexes, and how their function can be modulated. Her research also examines the impact of inhibiting enzymes like tryptophan 2,3-dioxygenase on DNA repair in glioma cells. Maddukuri collaborates with researchers including Robert L. Eoff and Megan R. Reed at the University of Arkansas for Medical Sciences, and has co-authored multiple publications with them. Her scholarship metrics include an h-index of 18 and 678 total citations.
Metrics
- h-index: 18
- Publications: 40
- Citations: 683
Selected Publications
-
Human REV1 interacts with DHX36 to promote replication and tolerance of G-quadruplex DNA (2026)
-
A Functional Precision Medicine Pipeline Combines Comparative Transcriptomics and Tumor Organoid Modeling to Identify Bespoke Treatment Strategies for Glioblastoma (2021)
-
Deletion of putative xenobiotic response elements (XREs) in hpol κ alters the replication stress response and overall genomic instability in glioblastoma cells (2021)
-
Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes (2021)
-
DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma (2021)
-
Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells (2021)
-
Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs (2021)
-
Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells (2020)
-
Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms (2019)
-
A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells (2018)
-
A Novel Small Molecule Inhibitor of Human DNA Polymerase Eta Modulates the Efficacy of Cisplatin in Cancer Cells (2017)
-
Inhibition of Kynurenine Signaling Decreases Glioblastoma Multiforme Genomic Instability and Sensitizes Cells to Chemotherapeutic Treatment (2017)
-
Investigation of Structure‐Activity Relationships for Small‐Molecule Inhibitors of Human DNA Polymerase Eta (2016)
-
Human Translesion Polymerase κ Exhibits Enhanced Activity and Reduced Fidelity Two Nucleotides from G-Quadruplex DNA (2016)
-
Evidence for the Kinetic Partitioning of Polymerase Activity on G-Quadruplex DNA (2015)
Collaboration Network
Top Collaborators
Megan R. Reed
University of Arkansas for Medical Sciences
6 shared publications
In database
- A Functional Precision Medicine Pipeline Combines Comparative Transcriptomics and Tumor Organoid Modeling to Identify Bespoke Treatment Strategies for Glioblastoma
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
Showing 5 of 6 shared publications
Robert L. Eoff
University of Arkansas for Medical Sciences
6 shared publications
In database
- A Functional Precision Medicine Pipeline Combines Comparative Transcriptomics and Tumor Organoid Modeling to Identify Bespoke Treatment Strategies for Glioblastoma
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
Showing 5 of 6 shared publications
Amit Ketkar
University of Arkansas for Medical Sciences
5 shared publications
In database
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
- Deletion of putative xenobiotic response elements (XREs) in hpol κ alters the replication stress response and overall genomic instability in glioblastoma cells
Justin Leung
University of Arkansas for Medical Sciences (US)
4 shared publications
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
- Deletion of putative xenobiotic response elements (XREs) in hpol κ alters the replication stress response and overall genomic instability in glioblastoma cells
Lane Smith
University of Arkansas for Medical Sciences
2 shared publications
In database
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
Callie Johnson
National Park College (US)
2 shared publications
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
Alyssa Richey
National Park College (US)
2 shared publications
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
Makayla Berry
University of Arkansas for Medical Sciences (US)
2 shared publications
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
Jessica H. Hartman
Medical University of South Carolina (US)
2 shared publications
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
Julie Gunderson
Conway School of Landscape Design
2 shared publications
In database
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
Maroof K. Zafar
University of Arkansas for Medical Sciences
2 shared publications
In database
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma
Analiz Rodriguez
University of Arkansas for Medical Sciences
2 shared publications
In database
- A Functional Precision Medicine Pipeline Combines Comparative Transcriptomics and Tumor Organoid Modeling to Identify Bespoke Treatment Strategies for Glioblastoma
- DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma
Stephanie D. Byrum
Arkansas Children's Hospital
1 shared publication
In database
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
April C.L. Bostian
University of Arkansas for Medical Sciences
1 shared publication
In database
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
Alan J. Tackett
Arkansas Children's Hospital
1 shared publication
In database
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
Similar Researchers
Based on overlapping research topics
Leonard Ferdman
Arkansas State University
Cancer-related molecular mechanisms research
Genomics and Phylogenetic Studies
Molecular Biology Techniques and Applications
Malik Rettiganti
University of Arkansas for Medical Sciences
Cancer-related molecular mechanisms research
Genomics and Phylogenetic Studies
Molecular Biology Techniques and Applications
Amit Ketkar
University of Arkansas for Medical Sciences
DNA Repair Mechanisms
Cancer-related molecular mechanisms research
Genomics and Phylogenetic Studies
Christina D. Miller
University of Arkansas for Medical Sciences
Cancer-related molecular mechanisms research
Genomics and Phylogenetic Studies
Molecular Biology Techniques and Applications
Christophe Bobda
University of Arkansas for Medical Sciences
Cancer-related molecular mechanisms research
Genomics and Phylogenetic Studies
Molecular Biology Techniques and Applications
Clara M. Stiefel
University of Arkansas for Medical Sciences
DNA Repair Mechanisms
Cancer-related molecular mechanisms research
Genomics and Phylogenetic Studies