Leena Maddukuri

Researcher

University of Arkansas for Medical Sciences

faculty

18 h-index 39 pubs 656 cited

Research Areas

Cancer-related molecular mechanisms research DNA Repair Mechanisms Genomics and Phylogenetic Studies Glioma Diagnosis and Treatment Protein Structure and Dynamics

Links

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OverviewAI-generated summary

Leena Maddukuri's research focuses on molecular mechanisms underlying cancer, particularly glioblastoma. Her work investigates the roles of specific DNA repair and replication proteins, such as DNA polymerase kappa and Human Rev1, in cancer cell behavior and genomic instability. Maddukuri also studies the impact of inhibiting enzymes like tryptophan 2,3-dioxygenase on DNA damage tolerance and repair in glioma cells. She has published 39 papers, accumulating 656 citations and an h-index of 18. Maddukuri frequently collaborates with researchers at the University of Arkansas for Medical Sciences, including Robert L. Eoff and Megan R. Reed, with whom she shares multiple publications.

Metrics

  • h-index: 18
  • Publications: 39
  • Citations: 656

Selected Publications

  • A Functional Precision Medicine Pipeline Combines Comparative Transcriptomics and Tumor Organoid Modeling to Identify Bespoke Treatment Strategies for Glioblastoma (2021) DOI
  • Deletion of putative xenobiotic response elements (XREs) in hpol κ alters the replication stress response and overall genomic instability in glioblastoma cells (2021) DOI
  • Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes (2021) DOI
  • DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma (2021) DOI
  • Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells (2021) DOI
  • Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs (2021) DOI

Collaborators

Researchers in the database who share publications

Robert L. Eoff University of Arkansas for Medical Sciences 6 shared publications Megan R. Reed University of Arkansas for Medical Sciences 6 shared publications Amit Ketkar University of Arkansas for Medical Sciences 5 shared publications Analiz Rodriguez University of Arkansas for Medical Sciences 2 shared publications Julie Gunderson Hendrix College 2 shared publications Lane Smith University of Arkansas for Medical Sciences 2 shared publications Maroof Zafar University of Arkansas for Medical Sciences 2 shared publications Murat Gökden University of Arkansas for Medical Sciences 1 shared publication

Similar Researchers

Based on overlapping research topics

April C.L. Bostian University of Arkansas for Medical Sciences
Cancer-related molecular mechanisms research DNA Repair Mechanisms Glioma Diagnosis and Treatment
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Reine U. Protacio University of Arkansas for Medical Sciences
Cancer-related molecular mechanisms research DNA Repair Mechanisms Genomics and Phylogenetic Studies
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Robert L. Eoff University of Arkansas for Medical Sciences
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Ashtyn Bell University of Arkansas for Medical Sciences
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Emily Bosche Hendrix College
DNA Repair Mechanisms Genomics and Phylogenetic Studies Protein Structure and Dynamics
Good match 3 shared topics