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Biography and Research Information
OverviewAI-generated summary
Leena Maddukuri's research focuses on DNA repair mechanisms and their role in cancer, particularly glioblastoma. She investigates the function of specific DNA polymerases, such as Rev1 and DNA Polymerase Kappa, in managing DNA damage and replication stress. Her work examines how these polymerases interact with complex DNA structures like G-quadruplexes and how their activity impacts genomic stability in cancer cells.
Maddukuri's publications explore the functional consequences of genetic alterations in DNA polymerases, including the deletion of putative xenobiotic response elements in DNA Polymerase Kappa, and its effect on the replication stress response. She also studies the role of enzymes like tryptophan 2,3-dioxygenase in DNA damage tolerance and repair within glioma cells. Her research network includes collaborators at the University of Arkansas for Medical Sciences, with whom she has co-authored multiple publications.
Metrics
- h-index: 18
- Publications: 39
- Citations: 668
Selected Publications
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A Functional Precision Medicine Pipeline Combines Comparative Transcriptomics and Tumor Organoid Modeling to Identify Bespoke Treatment Strategies for Glioblastoma (2021)
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Deletion of putative xenobiotic response elements (XREs) in hpol κ alters the replication stress response and overall genomic instability in glioblastoma cells (2021)
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Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes (2021)
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DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma (2021)
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Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells (2021)
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Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs (2021)
Collaboration Network
Top Collaborators
Megan R. Reed
University of Arkansas for Medical Sciences
6 shared publications
In database
- A Functional Precision Medicine Pipeline Combines Comparative Transcriptomics and Tumor Organoid Modeling to Identify Bespoke Treatment Strategies for Glioblastoma
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
Showing 5 of 6 shared publications
Robert L. Eoff
University of Arkansas for Medical Sciences
6 shared publications
In database
- A Functional Precision Medicine Pipeline Combines Comparative Transcriptomics and Tumor Organoid Modeling to Identify Bespoke Treatment Strategies for Glioblastoma
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
Showing 5 of 6 shared publications
Amit Ketkar
University of Arkansas for Medical Sciences
5 shared publications
In database
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
- Deletion of putative xenobiotic response elements (XREs) in hpol κ alters the replication stress response and overall genomic instability in glioblastoma cells
Justin Leung
University of Arkansas for Medical Sciences (US)
4 shared publications
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
- Deletion of putative xenobiotic response elements (XREs) in hpol κ alters the replication stress response and overall genomic instability in glioblastoma cells
Lane Smith
University of Arkansas for Medical Sciences
2 shared publications
In database
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
Callie Johnson
National Park College (US)
2 shared publications
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
Alyssa Richey
National Park College (US)
2 shared publications
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
Makayla Berry
University of Arkansas for Medical Sciences (US)
2 shared publications
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
Jessica H. Hartman
Medical University of South Carolina (US)
2 shared publications
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
Julie Gunderson
Conway School of Landscape Design
2 shared publications
In database
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
Maroof K. Zafar
University of Arkansas for Medical Sciences
2 shared publications
In database
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma
Analiz Rodriguez
University of Arkansas for Medical Sciences
2 shared publications
In database
- A Functional Precision Medicine Pipeline Combines Comparative Transcriptomics and Tumor Organoid Modeling to Identify Bespoke Treatment Strategies for Glioblastoma
- DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma
Stephanie D. Byrum
Arkansas Children's Hospital
1 shared publication
In database
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
April C.L. Bostian
University of Arkansas for Medical Sciences
1 shared publication
In database
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
Alan J. Tackett
Arkansas Children's Hospital
1 shared publication
In database
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
Similar Researchers
Based on overlapping research topics
J. Leung
University of Arkansas for Medical Sciences
DNA Repair Mechanisms
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Amit Ketkar
University of Arkansas for Medical Sciences
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Robert H. Heflich
National Center for Toxicological Research
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Gary L. Fuller
University of Arkansas at Little Rock
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Page B. McKinzie
National Center for Toxicological Research
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Karen L. McKim
National Center for Toxicological Research
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Carcinogens and Genotoxicity Assessment