Jeffrey C. Wolchok

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

Federal Grant PI

Professor/ DepartmentChairperson

University of Arkansas primary UAMS UA Little Rock

Also affiliated: Grant Medical Center (1998); University of Alaska Anchorage (1997–2001); University of Utah (2008–2010); David Grant USAF Medical Center (1998); Alaska Neurology Center (1999–2003); University of Arkansas Community College at Hope (2015–2019); Plano Orthopedic Sports Medicine & Spine Center (2001); University of California, Davis (1998); The University of Texas Southwestern Medical Center (2001)

Faculty Researcher

17 h-index 49 pubs 793 cited

Research Areas

Biomedical Subjects

Links

ORCID Lab Website Research Group

OverviewAI-generated summary

Jeffrey C. Wolchok's research focuses on skeletal muscle injury, repair, and regeneration, with a particular emphasis on volumetric muscle loss (VML) models in animals. He investigates strategies to enhance functional recovery following such injuries, including the use of cell-derived extracellular matrix fiber scaffolds and the modulation of immune responses through local delivery of factors like IL-10. His work also explores the impact of interventions such as voluntary wheel running and pharmacological supplementation on muscle repair processes, examining outcomes in both young and aged animal models.

Wolchok's research extends to traumatic brain injury (TBI), where he studies the breakdown of the blood-brain barrier and astrocyte reactivity, and the associated changes in the cortical transcriptome and proteome. His funded work includes projects on single-cell RNA sequencing instrumentation and cell-derived extracellular matrix biofiber engineering, supported by grants from the NIH and NSF. He also collaborates with researchers at the University of Arkansas at Fayetteville on projects related to biomedical optics and imaging.

Metrics

h-index: 17
Publications: 49
Citations: 793

Selected Publications

Combined High-Intensity Exercise and Autologous Muscle Grafting Differentially Modulate Myogenesis and Extracellular Matrix Remodeling by Sex in VML-Injured Muscle (2026)

Physiology DOI OpenAlex
Exercise Intensities Modulates Inflammatory Gene Expression to Minced Muscle Repair Following Volumetric Muscle Loss (2026)

Physiology DOI OpenAlex
Aerobic Exercise Training Does Not Attenuate Fibrosis In Autologous Repaired Vml-injured Skeletal Muscle (2025)

Medicine & Science in Sports & Exercise DOI OpenAlex
BOARD # 307: University of Arkansas Biomedical Engineering REU Site: Training in Emerging Biomedical Optics and Imaging Approaches (2025)

DOI OpenAlex
Board 107: Work in Progress: Development of an Innovation Corps-Modeled Bioengineering Course to Promote Entrepreneurial Engagement among Undergraduate Students. (2024)

DOI OpenAlex
<i>In vivo</i> measurement of NADH fluorescence lifetime in skeletal muscle via fiber-coupled time-correlated single photon counting (2023)

Journal of Innovative Optical Health Sciences 3 citations DOI OpenAlex
Cell-Derived Extracellular Matrix Fiber Scaffolds Improve Recovery from Volumetric Muscle Loss (2023)

Tissue Engineering Part A 9 citations DOI OpenAlex
Transcriptome profiling of a synergistic volumetric muscle loss repair strategy (2023)

BMC Musculoskeletal Disorders 8 citations DOI OpenAlex
Prescribing reduced physical activity following volumetric muscle loss not really a good idea (2023)

The Journal of Physiology 1 citation DOI OpenAlex
Local IL-10 delivery modulates the immune response and enhances repair of volumetric muscle loss muscle injury (2023)

Scientific Reports 35 citations DOI OpenAlex
Transcriptome profiling of a synergistic volumetric muscle loss repair strategy (2023)

Research Square 1 citation DOI OpenAlex
Delivery of a tissue derived extracellular matrix gel modulates early fibro-adipogenic cell behavior and improves recovery following both acute and chronic atrophy muscle injury (2022)

Research Square DOI OpenAlex
Local IL-10 delivery modulates the immune response and enhances repair of volumetric muscle loss muscle injury (2022)

Research Square 1 citation DOI OpenAlex
Functional Analysis of the Cortical Transcriptome and Proteome Reveal Neurogenesis, Inflammation, and Cell Death after Repeated Traumatic Brain Injury <i>In vivo</i> (2022)

Neurotrauma Reports 4 citations DOI OpenAlex
Nandrolone supplementation does not improve functional recovery in an aged animal model of volumetric muscle loss injury (2022)

Journal of Tissue Engineering and Regenerative Medicine 7 citations DOI OpenAlex