Match tier
Confirmed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-08
K
Kartik Balachandran
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Federal Grant PI
High Impact
Professor
Also affiliated: University of Notre Dame (2008); Georgia Institute of Technology (2006–2011); Harvard University (2011–2014); Emory University (2008–2011); The Wallace H. Coulter Department of Biomedical Engineering (2006–2011); Wyss Institute for Biologically Inspired Engineering (2011–2014)
23 h-index
75 pubs
2,310 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Kartik Balachandran's research focuses on the mechanobiology and hemodynamics of cardiovascular diseases, particularly concerning the aortic valve and atrial fibrillation. His work investigates how mechanical forces, such as cyclic stretch and altered shear stress, influence cellular processes like endothelial-mesenchymal transformation and matrix remodeling in aortic valve cusps. This research has implications for understanding and potentially treating degenerative aortic valve disease and calcification.
In addition to his work on valve disease, Balachandran has investigated stroke prevention strategies in patients with atrial fibrillation, contributing to large-scale observational studies. He has also received federal funding from the NIH and NSF for projects exploring microphysiological tissue-chip models. One grant supports the development of a model to study ACE2 SARS-CoV-2-mediated valve disease, while another focuses on the translation potential of a co-cultured cardiomyocyte-on-a-chip heart model. Balachandran leads a research group at the University of Arkansas at Fayetteville and collaborates with several colleagues within the institution.
His scholarly contributions are reflected in a high-impact researcher designation, an h-index of 26, and over 2,800 citations across 90 publications. His recent active status and ongoing research, including work on engineering hybrid polymer-protein nanofibers, indicate continued engagement in the field.
Metrics
- h-index: 23
- Publications: 75
- Citations: 2,310
Positions
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Professor 2023–presentUniversity of Arkansas Department of Biomedical Engineering ORCID
Selected Publications
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Characterization of Human Aortic Valve Cells isolated from Calcified Aortic Valve Replacement Explants: Implications for Calcific Aortic Valve Disease Research (2026)
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Development of a nasal airway-on-chip co-culture model to study particulate matter exposure (2026)
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Characterizing Piezoelectric‐Blended Polydimethylsiloxane for Use as a Mechanoelectrical Responsive Cell Culture Substrate (2025)
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Elucidating the mechanosensitive pathways of physiological and pathological strain on valve cells in a novel human valve-on-chip system (2025)
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The future is fully defined: recombinant fragment E8 of laminin-511 is a viable xenofree alternative to Matrigel for hiPSC culture and differentiation into neurovascular cell types (2024)
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The effect of traumatic injuries on the nervous system (2024)
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Contributors (2024)
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A three-dimensional valve-on-chip microphysiological system implicates cell cycle progression, cholesterol metabolism and protein homeostasis in early calcific aortic valve disease progression (2024)
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A nasal airway-on-chip model to evaluate airflow pre-conditioning during epithelial cell maturation at the air-liquid interface (2024)
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The future is fully defined: recombinant fragment E8 of laminin-511 is a viable xenofree alternative to Matrigel for hiPSC culture and differentiation into neurovascular cell types (2024)
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A Three-Dimensional Valve-on-Chip Microphysiological System Reveals Novel Biomarkers of Early Calcific Aortic Valve Disease Progression (2023)
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Functional Analysis of the Cortical Transcriptome and Proteome Reveal Neurogenesis, Inflammation, and Cell Death after Repeated Traumatic Brain Injury <i>In vivo</i> (2022)
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Effect of Cyclic Uniaxial Mechanical Strain on Endothelial Progenitor Cell Differentiation (2022)
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Aortic valve cell microenvironment: Considerations for developing a valve-on-chip (2021)
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Local Renin-Angiotensin System Signaling Mediates Cellular Function of Aortic Valves (2021)
Federal Grants 2 $486,642 total
NIH
Contact PI
Mar 2022 - Feb 2026
ACE2 SARS-CoV2-mediated valve disease in a microphysiological tissue-chip model
NSF
PI
Sep 2024 - Aug 2026
I-Corps: Translation Potential of a Co-cultured Cardiomyocyte-on-a-Chip Heart Model Platform
Collaboration Network
Top Collaborators
Ishita Tandon
Augusta University
20 shared publications
In database
- Valve interstitial cell shape modulates cell contractility independent of cell phenotype
- The role of fibroblast growth factor 1 and 2 on the pathological behavior of valve interstitial cells in a three-dimensional mechanically-conditioned model
- Elevated Serotonin Interacts with Angiotensin-II to Result in Altered Valve Interstitial Cell Contractility and Remodeling
- Label-free metabolic biomarkers for assessing valve interstitial cell calcific progression
- Label-Free Multiphoton Microscopy for the Detection and Monitoring of Calcific Aortic Valve Disease
Showing 5 of 20 shared publications
Prashanth Ravishankar
University of Arkansas at Fayetteville (US)
13 shared publications
- Anisotropic Fiber-Reinforced Glycosaminoglycan Hydrogels for Heart Valve Tissue Engineering
- Engineering anisotropic biphasic Janus‐type polymer nanofiber scaffold networks via centrifugal jet spinning
- Valve leaflet‐inspired elastomeric scaffolds with tunable and anisotropic mechanical properties
- Valve interstitial cell shape modulates cell contractility independent of cell phenotype
- Using Dimensionless Numbers to Predict Centrifugal Jet-Spun Nanofiber Morphology
Showing 5 of 13 shared publications
Nasya M. Sturdivant
University of Arkansas at Fayetteville
8 shared publications
In database
- Acetazolamide Mitigates Astrocyte Cellular Edema Following Mild Traumatic Brain Injury
- Fabrication of a matrigel–collagen semi-interpenetrating scaffold for use in dynamic valve interstitial cell culture
- Valve interstitial cell shape modulates cell contractility independent of cell phenotype
- Characterization of Biaxial Stretch as an In Vitro Model of Traumatic Brain Injury to the Blood-Brain Barrier
- Blood–Brain Barrier Breakdown and Astrocyte Reactivity Evident in the Absence of Behavioral Changes after Repeated Traumatic Brain Injury
Showing 5 of 8 shared publications
Laís A. Ferreira
University of Arkansas at Fayetteville (US)
7 shared publications
- A nasal airway-on-chip model to evaluate airflow pre-conditioning during epithelial cell maturation at the air-liquid interface
- Functional Analysis of the Cortical Transcriptome and Proteome Reveal Neurogenesis, Inflammation, and Cell Death after Repeated Traumatic Brain Injury <i>In vivo</i>
- The future is fully defined: recombinant fragment E8 of laminin-511 is a viable xenofree alternative to Matrigel for hiPSC culture and differentiation into neurovascular cell types
- Contributors
- The effect of traumatic injuries on the nervous system
Showing 5 of 7 shared publications
Timothy J. Muldoon
University of Arkansas at Fayetteville
6 shared publications
In database
- Characterization of thin poly(dimethylsiloxane)-based tissue-simulating phantoms with tunable reduced scattering and absorption coefficients at visible and near-infrared wavelengths
- Valve interstitial cell contractile strength and metabolic state are dependent on its shape
- Label-free optical biomarkers detect early calcific aortic valve disease in a wild-type mouse model
- High-throughput microfluidic line scan imaging for cytological characterization
- A Fluorescence Imaging Optofluidics Device for Cytologic Morphology Assessment
Showing 5 of 6 shared publications
Ngoc Thien Lam
University of Arkansas at Fayetteville (US)
6 shared publications
- Valve interstitial cell contractile strength and metabolic state are dependent on its shape
- Fabrication of a matrigel–collagen semi-interpenetrating scaffold for use in dynamic valve interstitial cell culture
- Valve interstitial cell shape modulates cell contractility independent of cell phenotype
- The role of fibroblast growth factor 1 and 2 on the pathological behavior of valve interstitial cells in a three-dimensional mechanically-conditioned model
- The Mechanobiology of Drug-Induced Cardiac Valve Disease
Showing 5 of 6 shared publications
Syed F. Ali
University of Arkansas at Little Rock
6 shared publications
In database
- Acetazolamide Mitigates Astrocyte Cellular Edema Following Mild Traumatic Brain Injury
- Characterization of Biaxial Stretch as an In Vitro Model of Traumatic Brain Injury to the Blood-Brain Barrier
- Blood–Brain Barrier Breakdown and Astrocyte Reactivity Evident in the Absence of Behavioral Changes after Repeated Traumatic Brain Injury
- Characterization of uniaxial high-speed stretch as an in vitro model of mild traumatic brain injury on the blood-brain barrier
- Functional Analysis of the Cortical Transcriptome and Proteome Reveal Neurogenesis, Inflammation, and Cell Death after Repeated Traumatic Brain Injury <i>In vivo</i>
Showing 5 of 6 shared publications
Kyle P. Quinn
University of Arkansas at Fayetteville
6 shared publications
In database
- Valve interstitial cell contractile strength and metabolic state are dependent on its shape
- Label-free metabolic biomarkers for assessing valve interstitial cell calcific progression
- Label-Free Multiphoton Microscopy for the Detection and Monitoring of Calcific Aortic Valve Disease
- A three-dimensional valve-on-chip microphysiological system implicates cell cycle progression, cholesterol metabolism and protein homeostasis in early calcific aortic valve disease progression
- Label-free optical biomarkers detect early calcific aortic valve disease in a wild-type mouse model
Showing 5 of 6 shared publications
Asya Ozkızılcık
University of Arkansas at Fayetteville
6 shared publications
In database
- Anisotropic Fiber-Reinforced Glycosaminoglycan Hydrogels for Heart Valve Tissue Engineering
- Aortic valve cell microenvironment: Considerations for developing a valve-on-chip
- Label-free optical biomarkers detect early calcific aortic valve disease in a wild-type mouse model
- Local Renin-Angiotensin System Signaling Mediates Cellular Function of Aortic Valves
- Abstract 16123: <i>In Vitro</i> Valve-on-chip Platform to Assess the Effects of Hemodynamic and Mechanical Stimuli on Early Calcific Disease Progression
Showing 5 of 6 shared publications
Jeffrey C. Wolchok
University of Arkansas at Fayetteville
4 shared publications
In database
- Acetazolamide Mitigates Astrocyte Cellular Edema Following Mild Traumatic Brain Injury
- Valve interstitial cell shape modulates cell contractility independent of cell phenotype
- Repeated In Vitro Impact Conditioning of Astrocytes Decreases the Expression and Accumulation of Extracellular Matrix
- Functional Analysis of the Cortical Transcriptome and Proteome Reveal Neurogenesis, Inflammation, and Cell Death after Repeated Traumatic Brain Injury <i>In vivo</i>
Gustavo Vaca-Diez
University of Arkansas at Fayetteville
4 shared publications
In database
- A three-dimensional valve-on-chip microphysiological system implicates cell cycle progression, cholesterol metabolism and protein homeostasis in early calcific aortic valve disease progression
- A Three-Dimensional Valve-on-Chip Microphysiological System Reveals Novel Biomarkers of Early Calcific Aortic Valve Disease Progression
- Elucidating the mechanosensitive pathways of physiological and pathological strain on valve cells in a novel human valve-on-chip system
- Characterization of Human Aortic Valve Cells isolated from Calcified Aortic Valve Replacement Explants: Implications for Calcific Aortic Valve Disease Research
Héctor Rosas-Hernández
National Center for Toxicological Research
3 shared publications
In database
- Characterization of Biaxial Stretch as an In Vitro Model of Traumatic Brain Injury to the Blood-Brain Barrier
- Characterization of uniaxial high-speed stretch as an in vitro model of mild traumatic brain injury on the blood-brain barrier
- Neurovascular unit components on a chip as a model to study traumatic brain injury
Elvis Cuevas
National Center for Toxicological Research (US)
3 shared publications
- Characterization of Biaxial Stretch as an In Vitro Model of Traumatic Brain Injury to the Blood-Brain Barrier
- Characterization of uniaxial high-speed stretch as an in vitro model of mild traumatic brain injury on the blood-brain barrier
- Neurovascular unit components on a chip as a model to study traumatic brain injury
Susan M. Lantz
National Center for Toxicological Research
3 shared publications
In database
- Characterization of Biaxial Stretch as an In Vitro Model of Traumatic Brain Injury to the Blood-Brain Barrier
- Characterization of uniaxial high-speed stretch as an in vitro model of mild traumatic brain injury on the blood-brain barrier
- Neurovascular unit components on a chip as a model to study traumatic brain injury
William Slikker
National Center for Toxicological Research
3 shared publications
In database
- Characterization of Biaxial Stretch as an In Vitro Model of Traumatic Brain Injury to the Blood-Brain Barrier
- Characterization of uniaxial high-speed stretch as an in vitro model of mild traumatic brain injury on the blood-brain barrier
- Neurovascular unit components on a chip as a model to study traumatic brain injury
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