K
Kartik Balachandran Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Federal Grant PI
High Impact
Professor
faculty
26 h-index
91 pubs
2,765 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Kartik Balachandran's research focuses on developing and utilizing microphysiological systems, often referred to as "organ-on-a-chip" technology, to study disease mechanisms and evaluate potential therapeutic interventions. His work has a significant emphasis on cardiovascular diseases, particularly calcific aortic valve disease (CAVD). He investigates the cellular and molecular processes underlying CAVD progression using advanced techniques such as label-free multiphoton microscopy and three-dimensional valve-on-chip models. These models allow for the study of cell cycle progression, cholesterol metabolism, and protein homeostasis in the context of the aortic valve microenvironment.
In addition to cardiovascular research, Balachandran also applies organ-on-a-chip technology to study other complex biological systems. He has developed a nasal airway-on-chip model to investigate epithelial cell maturation and airflow pre-conditioning. Furthermore, his group has explored the use of such models to study the effects of SARS-CoV-2 on valvular disease, receiving federal funding from the NIH for this work. His research also extends to neuroscience, investigating blood-brain barrier breakdown and astrocyte reactivity following traumatic brain injury, and the functional analysis of the cortical transcriptome and proteome in these conditions.
Balachandran's scholarship is supported by a substantial publication record, with 89 total publications and over 2,700 citations, contributing to his h-index of 26. He has secured federal funding for his research, including a significant NIH grant for his work on ACE2 SARS-CoV-2-mediated valve disease and an NSF grant for the translation potential of a cardiomyocyte-on-a-chip heart model. He actively collaborates with researchers at the University of Arkansas at Fayetteville, including Ishita Tandon, Gustavo Vaca-Diez, Denise Fabiano do Nascimento, and Lance Cordes.
Metrics
- h-index: 26
- Publications: 91
- Citations: 2,765
Selected Publications
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Development of a nasal airway-on-chip co-culture model to study particulate matter exposure (2026)
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Characterizing Piezoelectric‐Blended Polydimethylsiloxane for Use as a Mechanoelectrical Responsive Cell Culture Substrate (2025)
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Elucidating the mechanosensitive pathways of physiological and pathological strain on valve cells in a novel human valve-on-chip system (2025)
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The future is fully defined: recombinant fragment E8 of laminin-511 is a viable xenofree alternative to Matrigel for hiPSC culture and differentiation into neurovascular cell types (2024)
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The effect of traumatic injuries on the nervous system (2024)
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Contributors (2024)
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A three-dimensional valve-on-chip microphysiological system implicates cell cycle progression, cholesterol metabolism and protein homeostasis in early calcific aortic valve disease progression (2024)
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The future is fully defined: recombinant fragment E8 of laminin-511 is a viable xenofree alternative to Matrigel for hiPSC culture and differentiation into neurovascular cell types (2024)
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A Three-Dimensional Valve-on-Chip Microphysiological System Reveals Novel Biomarkers of Early Calcific Aortic Valve Disease Progression (2023)
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Functional Analysis of the Cortical Transcriptome and Proteome Reveal Neurogenesis, Inflammation, and Cell Death after Repeated Traumatic Brain Injury <i>In vivo</i> (2022)
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Effect of Cyclic Uniaxial Mechanical Strain on Endothelial Progenitor Cell Differentiation (2022)
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Aortic valve cell microenvironment: Considerations for developing a valve-on-chip (2021)
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Local Renin-Angiotensin System Signaling Mediates Cellular Function of Aortic Valves (2021)
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Blood–Brain Barrier Breakdown and Astrocyte Reactivity Evident in the Absence of Behavioral Changes after Repeated Traumatic Brain Injury (2021)
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Label-Free Multiphoton Microscopy for the Detection and Monitoring of Calcific Aortic Valve Disease (2021)
Federal Grants 2 $486,642 total
NIH/National Institute of Allergy and Infectious Diseases
Contact PI
Mar 2022 - Feb 2026
ACE2 SARS-CoV2-mediated valve disease in a microphysiological tissue-chip model
NSF
PI
Sep 2024 - Aug 2026
I-Corps: Translation Potential of a Co-cultured Cardiomyocyte-on-a-Chip Heart Model Platform
Collaboration Network
Top Collaborators
Ishita Tandon
University of Arkansas at Fayetteville
10 shared publications
In database
- Label-Free Multiphoton Microscopy for the Detection and Monitoring of Calcific Aortic Valve Disease
- A three-dimensional valve-on-chip microphysiological system implicates cell cycle progression, cholesterol metabolism and protein homeostasis in early calcific aortic valve disease progression
- Effect of Cyclic Uniaxial Mechanical Strain on Endothelial Progenitor Cell Differentiation
- Aortic valve cell microenvironment: Considerations for developing a valve-on-chip
- A nasal airway-on-chip model to evaluate airflow pre-conditioning during epithelial cell maturation at the air-liquid interface
Showing 5 of 10 shared publications
Laís A. Ferreira
University of Arkansas at Fayetteville (US)
7 shared publications
- A nasal airway-on-chip model to evaluate airflow pre-conditioning during epithelial cell maturation at the air-liquid interface
- Functional Analysis of the Cortical Transcriptome and Proteome Reveal Neurogenesis, Inflammation, and Cell Death after Repeated Traumatic Brain Injury <i>In vivo</i>
- The future is fully defined: recombinant fragment E8 of laminin-511 is a viable xenofree alternative to Matrigel for hiPSC culture and differentiation into neurovascular cell types
- Contributors
- The effect of traumatic injuries on the nervous system
Showing 5 of 7 shared publications
Kyle P. Quinn
University of Arkansas at Fayetteville
3 shared publications
In database
- Label-Free Multiphoton Microscopy for the Detection and Monitoring of Calcific Aortic Valve Disease
- A three-dimensional valve-on-chip microphysiological system implicates cell cycle progression, cholesterol metabolism and protein homeostasis in early calcific aortic valve disease progression
- A Three-Dimensional Valve-on-Chip Microphysiological System Reveals Novel Biomarkers of Early Calcific Aortic Valve Disease Progression
Gustavo Vaca-Diez
University of Arkansas at Fayetteville
3 shared publications
In database
- A three-dimensional valve-on-chip microphysiological system implicates cell cycle progression, cholesterol metabolism and protein homeostasis in early calcific aortic valve disease progression
- A Three-Dimensional Valve-on-Chip Microphysiological System Reveals Novel Biomarkers of Early Calcific Aortic Valve Disease Progression
- Elucidating the mechanosensitive pathways of physiological and pathological strain on valve cells in a novel human valve-on-chip system
Denise Fabiano do Nascimento
University of Arkansas at Fayetteville
3 shared publications
In database
- A three-dimensional valve-on-chip microphysiological system implicates cell cycle progression, cholesterol metabolism and protein homeostasis in early calcific aortic valve disease progression
- The future is fully defined: recombinant fragment E8 of laminin-511 is a viable xenofree alternative to Matrigel for hiPSC culture and differentiation into neurovascular cell types
- The future is fully defined: recombinant fragment E8 of laminin-511 is a viable xenofree alternative to Matrigel for hiPSC culture and differentiation into neurovascular cell types
Lance Cordes
University of Arkansas at Fayetteville
3 shared publications
In database
- The future is fully defined: recombinant fragment E8 of laminin-511 is a viable xenofree alternative to Matrigel for hiPSC culture and differentiation into neurovascular cell types
- The future is fully defined: recombinant fragment E8 of laminin-511 is a viable xenofree alternative to Matrigel for hiPSC culture and differentiation into neurovascular cell types
- Characterizing Piezoelectric‐Blended Polydimethylsiloxane for Use as a Mechanoelectrical Responsive Cell Culture Substrate
Celeste Dunn
University of Arkansas at Fayetteville
2 shared publications
In database
- Blood–Brain Barrier Breakdown and Astrocyte Reactivity Evident in the Absence of Behavioral Changes after Repeated Traumatic Brain Injury
- Functional Analysis of the Cortical Transcriptome and Proteome Reveal Neurogenesis, Inflammation, and Cell Death after Repeated Traumatic Brain Injury <i>In vivo</i>
Sara M. Venier
University of Arkansas at Fayetteville
2 shared publications
In database
- Blood–Brain Barrier Breakdown and Astrocyte Reactivity Evident in the Absence of Behavioral Changes after Repeated Traumatic Brain Injury
- Functional Analysis of the Cortical Transcriptome and Proteome Reveal Neurogenesis, Inflammation, and Cell Death after Repeated Traumatic Brain Injury <i>In vivo</i>
Syed F. Ali
National Center for Toxicological Research
2 shared publications
In database
- Blood–Brain Barrier Breakdown and Astrocyte Reactivity Evident in the Absence of Behavioral Changes after Repeated Traumatic Brain Injury
- Functional Analysis of the Cortical Transcriptome and Proteome Reveal Neurogenesis, Inflammation, and Cell Death after Repeated Traumatic Brain Injury <i>In vivo</i>
Asya Ozkızılcık
University of Arkansas at Fayetteville
2 shared publications
In database
- Aortic valve cell microenvironment: Considerations for developing a valve-on-chip
- Local Renin-Angiotensin System Signaling Mediates Cellular Function of Aortic Valves
Prashanth Ravishankar
University of Arkansas at Fayetteville (US)
2 shared publications
- Effect of Cyclic Uniaxial Mechanical Strain on Endothelial Progenitor Cell Differentiation
- Aortic valve cell microenvironment: Considerations for developing a valve-on-chip
Alan E. Woessner
University of Arkansas at Fayetteville
2 shared publications
In database
- A three-dimensional valve-on-chip microphysiological system implicates cell cycle progression, cholesterol metabolism and protein homeostasis in early calcific aortic valve disease progression
- A Three-Dimensional Valve-on-Chip Microphysiological System Reveals Novel Biomarkers of Early Calcific Aortic Valve Disease Progression
Christine Shamblin
Scripps Research Institute (US)
2 shared publications
- A three-dimensional valve-on-chip microphysiological system implicates cell cycle progression, cholesterol metabolism and protein homeostasis in early calcific aortic valve disease progression
- A Three-Dimensional Valve-on-Chip Microphysiological System Reveals Novel Biomarkers of Early Calcific Aortic Valve Disease Progression
Laís Ferreira
University of Arkansas at Fayetteville
2 shared publications
In database
- A three-dimensional valve-on-chip microphysiological system implicates cell cycle progression, cholesterol metabolism and protein homeostasis in early calcific aortic valve disease progression
- A Three-Dimensional Valve-on-Chip Microphysiological System Reveals Novel Biomarkers of Early Calcific Aortic Valve Disease Progression
Amanda Walls
University of Arkansas at Fayetteville
2 shared publications
In database
- A three-dimensional valve-on-chip microphysiological system implicates cell cycle progression, cholesterol metabolism and protein homeostasis in early calcific aortic valve disease progression
- A Three-Dimensional Valve-on-Chip Microphysiological System Reveals Novel Biomarkers of Early Calcific Aortic Valve Disease Progression
Similar Researchers
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