Match tier
Likely match
Presence
Current · Arkansas
Last published
2023
Sources
OpenAlex · ORCID
Refreshed
2026-10-06
L
Lemuel A. Brown
This is a likely match — the affiliation was inferred from OpenAlex, ORCID, and web sources but has not been fully confirmed. Treat with appropriate caution.
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Also affiliated: Eastern Washington University (2012); University of Michigan (2017–2021); Southern Illinois University Edwardsville (2016); Texas A&M University (2015)
23 h-index
80 pubs
1,615 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Lemuel A. Brown investigates skeletal muscle aging, regeneration, and the impact of metabolic conditions such as obesity and cancer cachexia on muscle tissue. His research utilizes rodent models to study the cellular and molecular mechanisms underlying muscle dysfunction. Recent work has focused on the role of muscle stem cells and their response to aging and neuromuscular junction perturbations. Brown has also explored the influence of diet-induced obesity and PGC-1α overexpression on skeletal muscle regeneration and fibrosis development.
His scholarship has examined age-related deficiencies in pro-resolving mediators within skeletal muscle, contributing to maladaptive tissue remodeling. Furthermore, Brown's research has investigated sex differences in fibrosis development during cancer cachexia. With an h-index of 23 and over 1,500 citations across 82 publications, his work is recognized as highly cited. He has a history of collaboration with researchers at the University of Arkansas at Fayetteville, including Megan E. Rosa-Caldwell, Tyrone A. Washington, Eleanor R. Schrems, and Wesley S. Haynie, with whom he shares four co-authored publications.
Metrics
- h-index: 23
- Publications: 80
- Citations: 1,615
Selected Publications
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Development of skeletal muscle fibrosis in a rodent model of cancer cachexia (2023)
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Biological Sex Differences of Fibrosis During the Development of Cancer Cachexia (2023)
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Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration (2022)
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The effect of diet-induced obesity on extracellular matrix remodeling during skeletal muscle regeneration (2021)
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Moderators of skeletal muscle maintenance are compromised in sarcopenic obese mice (2020)
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Cancer‐induced cardiac atrophy adversely affects myocardial redox state and mitochondrial oxidative characteristics (2020)
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Graft alignment impacts the regenerative response of skeletal muscle after volumetric muscle loss in a rat model (2020)
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Graft Alignment Impacts the Regenerative Response of Skeletal Muscle after Volumetric Muscle Loss in a Rat Model (2019)
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Regulation of mitochondrial quality following repeated bouts of hindlimb unloading (2019)
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Preliminary study: Leucine Supplementation Exacerbates Muscle Wasting Independent of the Ubiquitin-Proteasome System (2019)
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The Development of Cancer Cachexia Negatively Impacts Skeletal Muscle Extracellular Matrix Remodeling (2019)
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Mitochondrial mRNA translation initiation contributes to oxidative metabolism in the myocardia of aged, obese mice (2019)
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Protein imbalance in the development of skeletal muscle wasting in tumour‐bearing mice (2018)
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Transcriptomic analysis of the development of skeletal muscle atrophy in cancer-cachexia in tumor-bearing mice (2018)
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Cardiac hypertrophy in sarcopenic obese C57BL/6J mice is independent of Akt/mTOR cellular signaling (2018)
Collaboration Network
Top Collaborators
Tyrone A. Washington
University of Arkansas at Fayetteville
56 shared publications
In database
- Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour‐bearing mice
- Protein imbalance in the development of skeletal muscle wasting in tumour‐bearing mice
- Mitochondrial quality control, promoted by PGC-1α, is dysregulated by Western diet-induced obesity and partially restored by moderate physical activity in mice
- Codelivery of Infusion Decellularized Skeletal Muscle with Minced Muscle Autografts Improved Recovery from Volumetric Muscle Loss Injury in a Rat Model
- Diet‐induced obesity alters anabolic signalling in mice at the onset of skeletal muscle regeneration
Showing 5 of 56 shared publications
Nicholas P. Greene
University of Arkansas at Fayetteville
47 shared publications
In database
- Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour‐bearing mice
- Protein imbalance in the development of skeletal muscle wasting in tumour‐bearing mice
- Mitochondrial quality control, promoted by PGC-1α, is dysregulated by Western diet-induced obesity and partially restored by moderate physical activity in mice
- Diet‐induced obesity alters anabolic signalling in mice at the onset of skeletal muscle regeneration
- Cancer cachexia-induced muscle atrophy: evidence for alterations in microRNAs important for muscle size
Showing 5 of 47 shared publications
Richard Perry
University of Arkansas at Fayetteville (US)
46 shared publications
- Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour‐bearing mice
- Protein imbalance in the development of skeletal muscle wasting in tumour‐bearing mice
- Mitochondrial quality control, promoted by PGC-1α, is dysregulated by Western diet-induced obesity and partially restored by moderate physical activity in mice
- Diet‐induced obesity alters anabolic signalling in mice at the onset of skeletal muscle regeneration
- Cancer cachexia-induced muscle atrophy: evidence for alterations in microRNAs important for muscle size
Showing 5 of 46 shared publications
Jacob L. Brown
University of Arkansas at Fayetteville (US)
45 shared publications
- Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour‐bearing mice
- Protein imbalance in the development of skeletal muscle wasting in tumour‐bearing mice
- Mitochondrial quality control, promoted by PGC-1α, is dysregulated by Western diet-induced obesity and partially restored by moderate physical activity in mice
- Diet‐induced obesity alters anabolic signalling in mice at the onset of skeletal muscle regeneration
- Cancer cachexia-induced muscle atrophy: evidence for alterations in microRNAs important for muscle size
Showing 5 of 45 shared publications
David E. Lee
University of Arkansas at Fayetteville (US)
37 shared publications
- Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour‐bearing mice
- Protein imbalance in the development of skeletal muscle wasting in tumour‐bearing mice
- Mitochondrial quality control, promoted by PGC-1α, is dysregulated by Western diet-induced obesity and partially restored by moderate physical activity in mice
- Cancer cachexia-induced muscle atrophy: evidence for alterations in microRNAs important for muscle size
- microRNA‐16 Is Downregulated During Insulin Resistance and Controls Skeletal Muscle Protein Accretion
Showing 5 of 37 shared publications
Megan E. Rosa‐Caldwell
University of Arkansas at Fayetteville
25 shared publications
In database
- Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour‐bearing mice
- Protein imbalance in the development of skeletal muscle wasting in tumour‐bearing mice
- Cancer cachexia-induced muscle atrophy: evidence for alterations in microRNAs important for muscle size
- Transcriptomic analysis of the development of skeletal muscle atrophy in cancer-cachexia in tumor-bearing mice
- Moderate physical activity promotes basal hepatic autophagy in diet-induced obese mice
Showing 5 of 25 shared publications
Wesley S. Haynie
University of Arkansas at Fayetteville
21 shared publications
In database
- Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour‐bearing mice
- Protein imbalance in the development of skeletal muscle wasting in tumour‐bearing mice
- Transcriptomic analysis of the development of skeletal muscle atrophy in cancer-cachexia in tumor-bearing mice
- Cancer‐induced cardiac atrophy adversely affects myocardial redox state and mitochondrial oxidative characteristics
- Autophagy activation, not peroxisome proliferator‐activated receptor γ coactivator 1α, may mediate exercise‐induced improvements in glucose handling during diet‐induced obesity
Showing 5 of 21 shared publications
Megan E. Rosa
University of Arkansas at Fayetteville (US)
17 shared publications
- Mitochondrial quality control, promoted by PGC-1α, is dysregulated by Western diet-induced obesity and partially restored by moderate physical activity in mice
- microRNA‐16 Is Downregulated During Insulin Resistance and Controls Skeletal Muscle Protein Accretion
- Differential Responses to Leucine Supplementation in Young and Aged Mice at the Onset of Skeletal Muscle Regeneration
- Sarcopenic Obesity Alters Ecm-related Gene Expression In Mouse Skeletal Muscle
- Timecourse Of Alterations In Myofiber CSA And Oxidative Phenotype In Progression Of Cancer-cachexia
Showing 5 of 17 shared publications
Michael P. Wiggs
Texas A&M University System (US)
11 shared publications
- Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour‐bearing mice
- Protein imbalance in the development of skeletal muscle wasting in tumour‐bearing mice
- Cancer cachexia-induced muscle atrophy: evidence for alterations in microRNAs important for muscle size
- microRNA‐16 Is Downregulated During Insulin Resistance and Controls Skeletal Muscle Protein Accretion
- Transcriptomic analysis of the development of skeletal muscle atrophy in cancer-cachexia in tumor-bearing mice
Showing 5 of 11 shared publications
Thomas A. Blackwell
University of Arkansas at Fayetteville (US)
9 shared publications
- Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour‐bearing mice
- Cancer cachexia-induced muscle atrophy: evidence for alterations in microRNAs important for muscle size
- Transcriptomic analysis of the development of skeletal muscle atrophy in cancer-cachexia in tumor-bearing mice
- PGC ‐1α4 gene expression is suppressed by the IL ‐6— MEK — ERK 1/2 MAPK signalling axis and altered by resistance exercise, obesity and muscle injury
- Autophagy activation, not peroxisome proliferator‐activated receptor γ coactivator 1α, may mediate exercise‐induced improvements in glucose handling during diet‐induced obesity
Showing 5 of 9 shared publications
James D. Fluckey
Texas A&M University System (US)
7 shared publications
- microRNA‐16 Is Downregulated During Insulin Resistance and Controls Skeletal Muscle Protein Accretion
- Impaired exercise-induced mitochondrial biogenesis in the obese Zucker rat, despite PGC-1α induction, is due to compromised mitochondrial translation elongation
- Regulation of mitochondrial quality following repeated bouts of hindlimb unloading
- PGC ‐1α4 gene expression is suppressed by the IL ‐6— MEK — ERK 1/2 MAPK signalling axis and altered by resistance exercise, obesity and muscle injury
- Canonical Mitochondrial Biogenesis And Mitochondrial Translation Following Multiple Bouts Of Disuse
Showing 5 of 7 shared publications
Jamie Baum
University of Arkansas at Fayetteville
5 shared publications
In database
- Diet‐induced obesity alters anabolic signalling in mice at the onset of skeletal muscle regeneration
- Monocarboxylate transporter expression at the onset of skeletal muscle regeneration
- Differential effects of leucine supplementation in young and aged mice at the onset of skeletal muscle regeneration
- The Akt/mTOR pathway: Data comparing young and aged mice with leucine supplementation at the onset of skeletal muscle regeneration
- The Combined Effect of Obesity & Pulmonary Arterial Hypertension on the Gastrocnemius in Zucker Rats
Jeffrey C. Wolchok
University of Arkansas at Little Rock
5 shared publications
In database
- Codelivery of Infusion Decellularized Skeletal Muscle with Minced Muscle Autografts Improved Recovery from Volumetric Muscle Loss Injury in a Rat Model
- Recovery from volumetric muscle loss injury: A comparison between young and aged rats
- Graft alignment impacts the regenerative response of skeletal muscle after volumetric muscle loss in a rat model
- Moderators of skeletal muscle maintenance are compromised in sarcopenic obese mice
- Graft Alignment Impacts the Regenerative Response of Skeletal Muscle after Volumetric Muscle Loss in a Rat Model
Mats I. Nilsson
Texas A&M University System (US)
4 shared publications
- microRNA‐16 Is Downregulated During Insulin Resistance and Controls Skeletal Muscle Protein Accretion
- Impaired exercise-induced mitochondrial biogenesis in the obese Zucker rat, despite PGC-1α induction, is due to compromised mitochondrial translation elongation
- microRNAs In Skeletal Muscle and Their Response to Resistance Exercise in Insulin Resistant Diabetes
- Cover Image, Volume 117, Number 8, August 2016
Kevin L. Shimkus
Texas A&M University (US)
4 shared publications
- Impaired exercise-induced mitochondrial biogenesis in the obese Zucker rat, despite PGC-1α induction, is due to compromised mitochondrial translation elongation
- Regulation of mitochondrial quality following repeated bouts of hindlimb unloading
- PGC ‐1α4 gene expression is suppressed by the IL ‐6— MEK — ERK 1/2 MAPK signalling axis and altered by resistance exercise, obesity and muscle injury
- Canonical Mitochondrial Biogenesis And Mitochondrial Translation Following Multiple Bouts Of Disuse
Similar Researchers
Based on overlapping research topics
Megan E. Rosa‐Caldwell
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University of Arkansas at Fayetteville
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W J Carter
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