L
Lemuel A. Brown Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
High Impact
Researcher
faculty
23 h-index
82 pubs
1,554 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Lemuel A. Brown's research investigates mechanisms underlying skeletal muscle health and regeneration, with a particular focus on the impacts of aging, obesity, and disease states like cancer cachexia. His work utilizes animal models, including mice and rats, to explore cellular and molecular processes within skeletal muscle. Recent publications examine age-related deficiencies in pro-resolving mediators and their contribution to maladaptive tissue remodeling, as well as the attenuated response of muscle stem cells to neuromuscular junction perturbations in aging mice.
Brown also studies the role of specific genes and metabolic pathways in muscle stem cell function, such as the regulation of metabolic homeostasis by sestrin proteins and the effects of PGC-1α overexpression on muscle regeneration. His research extends to the development of skeletal muscle fibrosis in rodent models of cancer cachexia, including investigations into biological sex differences in this process. Furthermore, his work addresses the influence of diet-induced obesity on extracellular matrix remodeling during skeletal muscle regeneration.
He has published 82 papers, with 1,528 citations and an h-index of 23. Brown collaborates with several researchers at the University of Arkansas at Fayetteville, including Megan E. Rosa‐Caldwell, Tyrone A. Washington, Eleanor R. Schrems, and Wesley S. Haynie, with whom he has co-authored four publications each. His recent activity indicates continued engagement in research, with his most recent publication dating to 2023.
Metrics
- h-index: 23
- Publications: 82
- Citations: 1,554
Selected Publications
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Development of skeletal muscle fibrosis in a rodent model of cancer cachexia (2023)
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Biological Sex Differences of Fibrosis During the Development of Cancer Cachexia (2023)
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Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration (2022)
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The effect of diet-induced obesity on extracellular matrix remodeling during skeletal muscle regeneration (2021)
Collaboration Network
Top Collaborators
Eleanor R. Schrems
University of Arkansas at Fayetteville
4 shared publications
In database
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- The effect of diet-induced obesity on extracellular matrix remodeling during skeletal muscle regeneration
- Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration
- Biological Sex Differences of Fibrosis During the Development of Cancer Cachexia
Richard Perry
University of Arkansas at Fayetteville (US)
4 shared publications
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- The effect of diet-induced obesity on extracellular matrix remodeling during skeletal muscle regeneration
- Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration
- Biological Sex Differences of Fibrosis During the Development of Cancer Cachexia
Megan E. Rosa‐Caldwell
University of Arkansas at Fayetteville
4 shared publications
In database
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- The effect of diet-induced obesity on extracellular matrix remodeling during skeletal muscle regeneration
- Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration
- Biological Sex Differences of Fibrosis During the Development of Cancer Cachexia
Tyrone A. Washington
University of Arkansas at Fayetteville
4 shared publications
In database
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- The effect of diet-induced obesity on extracellular matrix remodeling during skeletal muscle regeneration
- Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration
- Biological Sex Differences of Fibrosis During the Development of Cancer Cachexia
Jesus A. Castor‐Macias
University of Michigan–Ann Arbor (US)
4 shared publications
- Metabolipidomic profiling reveals an age‐related deficiency of skeletal muscle pro‐resolving mediators that contributes to maladaptive tissue remodeling
- Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging
- Sestrins regulate muscle stem cell metabolic homeostasis
- Author response: Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging
Carlos A. Aguilar
BioSurfaces (United States) (US)
4 shared publications
- Metabolipidomic profiling reveals an age‐related deficiency of skeletal muscle pro‐resolving mediators that contributes to maladaptive tissue remodeling
- Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging
- Sestrins regulate muscle stem cell metabolic homeostasis
- Author response: Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging
Susan V. Brooks
University of Michigan–Ann Arbor (US)
4 shared publications
- Metabolipidomic profiling reveals an age‐related deficiency of skeletal muscle pro‐resolving mediators that contributes to maladaptive tissue remodeling
- Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging
- Sestrins regulate muscle stem cell metabolic homeostasis
- Author response: Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging
Nicholas P. Greene
University of Arkansas at Fayetteville
3 shared publications
In database
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- The effect of diet-induced obesity on extracellular matrix remodeling during skeletal muscle regeneration
- Biological Sex Differences of Fibrosis During the Development of Cancer Cachexia
James F. Markworth
University of Michigan–Ann Arbor (US)
3 shared publications
- Metabolipidomic profiling reveals an age‐related deficiency of skeletal muscle pro‐resolving mediators that contributes to maladaptive tissue remodeling
- Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging
- Author response: Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging
Jacqueline Larouche
BioSurfaces (United States) (US)
3 shared publications
- Metabolipidomic profiling reveals an age‐related deficiency of skeletal muscle pro‐resolving mediators that contributes to maladaptive tissue remodeling
- Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging
- Author response: Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging
Paula Fraczek
University of Michigan–Ann Arbor (US)
3 shared publications
- Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging
- Sestrins regulate muscle stem cell metabolic homeostasis
- Author response: Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging
Wesley S. Haynie
University of Arkansas at Fayetteville
3 shared publications
In database
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration
- Biological Sex Differences of Fibrosis During the Development of Cancer Cachexia
Jacob L. Brown
University of Arkansas at Fayetteville (US)
3 shared publications
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration
- Biological Sex Differences of Fibrosis During the Development of Cancer Cachexia
Mahir Mohiuddin
Georgia Institute of Technology (US)
2 shared publications
- Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging
- Author response: Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging
Jeongmoon J. Choi
The Wallace H. Coulter Department of Biomedical Engineering (US)
2 shared publications
- Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging
- Author response: Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging
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